Signal-Processing Machines at the Postsynaptic Density

Kennedy, Mary B.

doi:10.1126/science.290.5492.750

Cited by 788Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsGenetics and Neurodevelopmental Disorders

Signal-Processing Machines at the Postsynaptic Density

Kennedy, Mary B.·2000·Science

DOI 10.1126/science.290.5492.750

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Abstract

Dendrites of individual neurons in the vertebrate central nervous system are contacted by thousands of synaptic terminals relaying information about the environment. The postsynaptic membrane at each synaptic terminal is the first place where information is processed as it converges on the dendrite. At the postsynaptic membrane of excitatory synapses, neurotransmitter receptors are attached to large protein “signaling machines” that delicately regulate the strength of synaptic transmission. These machines are visible in the electron microscope and are called the postsynaptic density. By changing synaptic strength in response to neural activity, the postsynaptic density contributes to information processing and the formation of memories.

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Authors: Kennedy, M. B.
Affiliations: California Institute of Technology (US)
Corresponding author: Kennedy, Mary B.
ORCID: Kennedy, Mary B.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2000-10-27
Volume: 290
Issue: 5492
Pages: 750-754
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.290.5492.750
OpenAlex: W2056145172
Cited by: 788
References: 74
Citations by year: 2026: 5 · 2025: 11 · 2024: 16 · 2023: 15 · 2022: 21 · 2021: 33 · 2020: 11 · 2019: 18 · 2018: 12 · 2017: 24 · 2016: 21 · 2015: 24 · 2014: 32 · 2013: 28 · 2012: 31
FWCI: 4.36
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS028710, R01NS017660, NS-17660, NS28710)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: postsynaptic density, neurotransmitter receptors, synaptic transmission, synaptic plasticity, dendrites, excitatory synapses, memory formation
MeSH terms: Homer Scaffolding Proteins, Animals, Carrier Proteins, Dendrites, Humans, Mental Processes, Models, Neurological, Nerve Tissue Proteins, Synaptic Transmission, Neuropeptides, Synaptic Membranes, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Presynaptic Terminals, Calcium-Calmodulin-Dependent Protein Kinases, Receptors, Neurotransmitter, Calcium-Calmodulin-Dependent Protein Kinase Type 2

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Signal-Processing Machines at the Postsynaptic Density

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