Cited by 350Neuroscience and Neuropharmacology ResearchProtein Kinase Regulation and GTPase SignalingSignaling Pathways in Disease

The DOI matches its Crossref record; 60 of the 61 references it cites were found in a registry or an index.

CaMKIIβ Functions As an F-Actin Targeting Module that Localizes CaMKIIα/β Heterooligomers to Dendritic Spines

Open access

Shen, Kang, Teruel, Mary N, Subramanian, Kala, Meyer, Tobias·1998·Neuron

DOI 10.1016/s0896-6273(00)80569-3

Open this paper in CoChat — free account Open PDF

Abstract

Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine protein kinase that regulates long-term potentiation and other forms of neuronal plasticity. Functional differences between the neuronal CaMKIIalpha and CaMKIIbeta isoforms are not yet known. Here, we use green fluorescent protein-tagged (GFP-tagged) CaMKII isoforms and show that CaMKIIbeta is bound to F-actin in dendritic spines and cell cortex while CaMKIIalpha is largely a cytosolic enzyme. When expressed together, the two isoforms form large heterooligomers, and a small fraction of CaMKIIbeta is sufficient to dock the predominant CaMKIIalpha to the actin cytoskeleton. Thus, CaMKIIbeta functions as a targeting module that localizes a much larger number of CaMKIIalpha isozymes to synaptic and cytoskeletal sites of action.

Integrity signals

Registry

Crossref · 10.1016/s0896-6273(00)80569-3

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Control of memory formation through regulated expression of a CaMKII transgene
Mayford, M., Bach, M. E., Huang, Y.-Y., Wang, L., Hawkins, R. D., & Kandel, E. R. (1996) · Science · doi:10.1126/science.274.5293.1678 · Cited by 1,550
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Stevens, C. F., Tonegawa, S., & Wang, Y. (1992) · Science · doi:10.1126/science.1378648 · Cited by 1,472
Sensitivity of CaM Kinase II to the Frequency of Ca 2+ Oscillations
De Koninck, P., & Schulman, H. (1998) · Science · doi:10.1126/science.279.5348.227 · Cited by 1,269
Autophosphorylation at Thr 286 of the α Calcium-Calmodulin Kinase II in LTP and Learning
Giese, K. P., Fedorov, N. B., Filipkowski, R. K., & Silva, A. J. (1998) · Science · doi:10.1126/science.279.5352.870 · Cited by 1,055
Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation
Barria, A., Muller, D., Derkach, V., Griffith, L. C., & Soderling, T. R. (1997) · Science · doi:10.1126/science.276.5321.2042 · Cited by 1,049
Rapid Actin-Based Plasticity in Dendritic Spines
Fischer, M., Kaech, S., Knutti, D., & Matus, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80467-5 · Cited by 905
Evidence for a Role of Dendritic Filopodia in Synaptogenesis and Spine Formation
Ziv, N. E., & Smith, S. J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80283-4 · Cited by 882
Regulation of brain Type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: A Ca2+-triggered molecular switch
Miller, S. (1986) · Cell · doi:10.1016/0092-8674(86)90008-5 · Cited by 864
Contrasting properties of two forms of long-term potentiation in the hippocampus
Nicoll, R. A., & Malenka, R. C. (1995) · Nature · doi:10.1038/377115a0 · Cited by 861
The Multifunctional Calcium/Calmodulin-Dependent Protein Kinase: From Form to Function
Braun, A. P., & Schulman, H. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.002221 · Cited by 820

Show all 61 references

Sorted by citations

Mechanisms of CaMKII action in long-term potentiation
Lisman, J., Yasuda, R., & Raghavachari, S. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3192 · Cited by 1,134
Brain-Specific Phosphorylation of MeCP2 Regulates Activity-Dependent Bdnf Transcription, Dendritic Growth, and Spine Maturation
Zhou, Z., Hong, E. J., Cohen, S., Zhao, W.-N., Ho, H.-Y. H., Schmidt, L., Chen, W. G., Lin, Y., Savner, E., Griffith, E. C., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.037 · Cited by 877
Structure-stability-function relationships of dendritic spines
Kasai, H., Matsuzaki, M., Noguchi, J., Yasumatsu, N., & Nakahara, H. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00162-0 · Cited by 847
Cerebellar Long-Term Depression: Characterization, Signal Transduction, and Functional Roles
Ito, M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1143 · Cited by 855
Signal-Processing Machines at the Postsynaptic Density
Kennedy, M. B. (2000) · Science · doi:10.1126/science.290.5492.750 · Cited by 788
Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity
Okamoto, K.-I., Nagai, T., Miyawaki, A., & Hayashi, Y. (2004) · Nature Neuroscience · doi:10.1038/nn1311 · Cited by 854
A long nuclear‐retained non‐coding RNA regulates synaptogenesis by modulating gene expression
Bernard, D., Prasanth, K. V., Tripathi, V., Colasse, S., Nakamura, T., Xuan, Z., Zhang, M. Q., Sedel, F., Jourdren, L., Coulpier, F., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.199 · Cited by 750
Interaction with the NMDA receptor locks CaMKII in an active conformation
Bayer, K.-U., De Koninck, P., Leonard, A. S., Hell, J. W., & Schulman, H. (2001) · Nature · doi:10.1038/35081080 · Cited by 732
Dynamic Control of CaMKII Translocation and Localization in Hippocampal Neurons by NMDA Receptor Stimulation
Shen, K., & Meyer, T. (1999) · Science · doi:10.1126/science.284.5411.162 · Cited by 673
Self-citation
Neuronal Ca2+/Calmodulin-Dependent Protein Kinase II: The Role of Structure and Autoregulation in Cellular Function
Hudmon, A., & Schulman, H. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135410 · Cited by 666
Structure–function of the multifunctional Ca2+/calmodulin-dependent protein kinase II
HUDMON, A., & SCHULMAN, H. (2002) · Biochemical Journal · doi:10.1042/bj20020228 · Cited by 615
Disruption of Dendritic Translation of CaMKIIα Impairs Stabilization of Synaptic Plasticity and Memory Consolidation
Miller, S., Yasuda, M., Coats, J., Jones, Y., Martone, M. E., & Mayford, M. R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00978-9 · Cited by 520
Untitled work
Lisman (2001) · doi:10.1016/s0896-6273(01)00364-6 · Cited by 480
Calcium/calmodulin signaling controls osteoblast growth and differentiation
Zayzafoon, M. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20675 · Cited by 438
βCaMKII in Lateral Habenula Mediates Core Symptoms of Depression
Li, K., Zhou, T., Liao, L., Yang, Z., Wong, C., Henn, F., Malinow, R., Yates, J. R., & Hu, H. (2013) · Science · doi:10.1126/science.1240729 · Cited by 411
Ca2+/Calmodulin-dependent Protein Kinases
Swulius, M. T., & Waxham, M. N. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8086-2 · Cited by 411
Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus
Krucker, T., Siggins, G. R., & Halpain, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100139797 · Cited by 374
Molecular mechanisms of dendritic spine development and remodeling
Ethell, I. M., & Pasquale, E. B. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.02.003 · Cited by 367
The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structure
Okamoto, K.-I., Narayanan, R., Lee, S. H., Murata, K., & Hayashi, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701656104 · Cited by 328
CaM Kinase: Still Inspiring at 40
Bayer, K. U., & Schulman, H. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.033 · Cited by 314
CaMKII regulation in information processing and storage
Coultrap, S. J., & Bayer, K. U. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.05.003 · Cited by 323
Dendritic spines: from structure to in vivo function
Rochefort, N. L., & Konnerth, A. (2012) · The EMBO Reports · doi:10.1038/embor.2012.102 · Cited by 299
Selective Regulation of Neurite Extension and Synapse Formation by the β but not the α Isoform of CaMKII
Fink, C. C., Bayer, K.-U., Myers, J. W., Ferrell, J. E., Schulman, H., & Meyer, T. (2003) · Neuron · doi:10.1016/s0896-6273(03)00428-8 · Cited by 328
Self-citation
Tetanic Stimulation Leads to Increased Accumulation of Ca2+/Calmodulin-Dependent Protein Kinase II via Dendritic Protein Synthesis in Hippocampal Neurons
Ouyang, Y., Rosenstein, A. J., Kreiman, G., Schuman, E., & Kennedy, M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-18-07823.1999 · Cited by 310
α- and βCaMKII
Thiagarajan, T. C., Piedras-Renterı́a, E. S., & Tsien, R. W. (2002) · Neuron · doi:10.1016/s0896-6273(02)01049-8 · Cited by 292
WNT signaling in neuronal maturation and synaptogenesis
Rosso, S. B., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00103 · Cited by 272
Synaptic Signaling in Learning and Memory
Kennedy, M. B. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016824 · Cited by 270
Persistent accumulation of calcium/calmodulin-dependent protein kinase II in dendritic spines after induction of NMDA receptor-dependent chemical long-term potentiation
Otmakhov, N., Tao-Cheng, J.-H., Carpenter, S., Asrican, B., Dosemeci, A., Reese, T. S., & Lisman, J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2350-04.2004 · Cited by 258
Transition from Reversible to Persistent Binding of CaMKII to Postsynaptic Sites and NR2B
Bayer, K. U., LeBel, É., McDonald, G. L., O’Leary, H., Schulman, H., & Koninck, P. D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3116-05.2006 · Cited by 259
A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme
Chao, L. H., Stratton, M. M., Lee, I., Rosenberg, O. S., Levitz, J., Mandell, D. J., Kortemme, T., Groves, J. T., Schulman, H., & Kuriyan, J. (2011) · Cell · doi:10.1016/j.cell.2011.07.038 · Cited by 258
Mechanisms of Synapse and Dendrite Maintenance and Their Disruption in Psychiatric and Neurodegenerative Disorders
Lin, Y., & Koleske, A. J. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153204 · Cited by 255
A CaMKII-NeuroD Signaling Pathway Specifies Dendritic Morphogenesis
Gaudilliere, B. L., Konishi, Y., de la Iglesia, N., Yao, G.-L., & Bonni, A. (2004) · Neuron · doi:10.1016/s0896-6273(03)00841-9 · Cited by 245
Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules
Allison, D. W., Chervin, A. S., Gelfand, V. I., & Craig, A. M. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04545.2000 · Cited by 245
CaMKII binding to GluN2B is critical during memory consolidation
Halt, A. R., Dallapiazza, R. F., Zhou, Y., Stein, I. S., Qian, H., Juntti, S., Wojcik, S., Brose, N., Silva, A. J., & Hell, J. W. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.482 · Cited by 243
Targeting of calcium/calmodulin-dependent protein kinase II
Colbran, R. J. (2004) · Biochemical Journal · doi:10.1042/bj20031547 · Cited by 241
Organization and evolution of multifunctional Ca2+/CaM-dependent protein kinase genes
Tombes, R. M., Faison, M. O., & Turbeville, J. M. (2003) · Gene · doi:10.1016/j.gene.2003.08.023 · Cited by 226
Mass of the postsynaptic density and enumeration of three key molecules
Chen, X., Vinade, L., Leapman, R. D., Petersen, J. D., Nakagawa, T., Phillips, T. M., Sheng, M., & Reese, T. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505359102 · Cited by 236
Synaptic plasticity and phosphorylation
Lee, H. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.06.003 · Cited by 222
Distribution of Postsynaptic Density (PSD)-95 and Ca2+/Calmodulin-Dependent Protein Kinase II at the PSD
Petersen, J. D., Chen, X., Vinadé, L., Döṣemeci, A., Lisman, J. E., & Reese, T. S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11270.2003 · Cited by 212
Neuronal Ca2+/Calmodulin-Dependent Protein Kinase II-Discovery, Progress in a Quarter of a Century, and Perspective: Implication for Learning and Memory
Yamauchi, T. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.1342 · Cited by 217
Molecular anatomy of the postsynaptic density.
Okabe, S. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.01.006 · Cited by 225
Integrins Control Dendritic Spine Plasticity in Hippocampal Neurons through NMDA Receptor and Ca2+/Calmodulin-Dependent Protein Kinase II-Mediated Actin Reorganization
Shi, Y., & Ethell, I. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4091-05.2006 · Cited by 200
The Roles of CaMKII and F-Actin in the Structural Plasticity of Dendritic Spines: A Potential Molecular Identity of a Synaptic Tag?
Okamoto, K., Bosch, M., & Hayashi, Y. (2009) · Physiology · doi:10.1152/physiol.00029.2009 · Cited by 213
Molecular mechanisms of CaMKII activation in neuronal plasticity
Fink, C. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00327-6 · Cited by 191
Induction of Spine Growth and Synapse Formation by Regulation of the Spine Actin Cytoskeleton
Zito, K., Knott, G. W., Shepherd, G. M., Shenolikar, S., & Svoboda, K. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.022 · Cited by 202
Comparative Analyses of the Three-dimensional Structures and Enzymatic Properties of α, β, γ, and δ Isoforms of Ca2+-Calmodulin-dependent Protein Kinase II
Gaertner, T. R., Kolodziej, S. J., Wang, D., Kobayashi, R., Koomen, J. M., Stoops, J. K., & Waxham, M. N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313597200 · Cited by 193
De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability
Küry, S., van Woerden, G. M., Besnard, T., Proietti Onori, M., Latypova, X., Towne, M. C., Cho, M. T., Prescott, T. E., Ploeg, M. A., Sanders, S., et al. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.10.003 · Cited by 185
CaMKII Isoforms in Learning and Memory: Localization and Function
Zalcman, G., Federman, N., & Romano, A. G. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00445 · Cited by 185
Crystal Structure of a Tetradecameric Assembly of the Association Domain of Ca2+/Calmodulin-Dependent Kinase II
Hoelz, A., Nairn, A. C., & Kuriyan, J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00171-0 · Cited by 182
Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II
Shen, K., Teruel, M. N., Connor, J. H., Shenolikar, S., & Meyer, T. (2000) · Nature Neuroscience · doi:10.1038/78783 · Cited by 206
Self-citation
Regulation of actin dynamics during structural plasticity of dendritic spines: Signaling messengers and actin-binding proteins
Borovac, J., Bosch, M., & Okamoto, K. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.07.001 · Cited by 193
Densin-180 Forms a Ternary Complex with the α-Subunit of Ca2+/Calmodulin-Dependent Protein Kinase II and α-Actinin
Walikonis, R. S., Oguni, A., Khorosheva, E. M., Jeng, C.-J., Asuncion, F. J., & Kennedy, M. B. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00423.2001 · Cited by 181
β-Amyloid Impairs AMPA Receptor Trafficking and Function by Reducing Ca2+/Calmodulin-dependent Protein Kinase II Synaptic Distribution
Gu, Z., Liu, W., & Yan, Z. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806508200 · Cited by 185
The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms
Incontro, S., Díaz-Alonso, J., Iafrati, J., Vieira, M., Asensio, C. S., Sohal, V. S., Roche, K. W., Bender, K. J., & Nicoll, R. A. (2018) · Nature Communications · doi:10.1038/s41467-018-04439-7 · Cited by 171
Actin and the agile spine: How and why do dendritic spines dance?
Halpain, S. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01576-9 · Cited by 169
Developmental expression of the CaM kinase II isoforms: ubiquitous γ- and δ-CaM kinase II are the early isoforms and most abundant in the developing nervous system
Bayer, K. U., Löhler, J., Schulman, H., & Harbers, K. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00131-x · Cited by 167
Functional Implications of the Subunit Composition of Neuronal CaM Kinase II
Brocke, L., Chiang, L. W., Wagner, P. D., & Schulman, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22713 · Cited by 161
A Mechanism for Ca 2+ /Calmodulin-Dependent Protein Kinase II Clustering at Synaptic and Nonsynaptic Sites Based on Self-Association
Hudmon, A., LeBel, E., Roy, H., Sik, A., Schulman, H., Waxham, M. N., & De Koninck, P. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4698-04.2005 · Cited by 159
A Mechanism for the Direct Regulation of T-Type Calcium Channels by Ca2+/Calmodulin-Dependent Kinase II
Welsby, P. J., Wang, H., Wolfe, J. T., Colbran, R. J., Johnson, M. L., & Barrett, P. Q. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-31-10116.2003 · Cited by 155
Rapid Synaptic Remodeling by Protein Kinase C: Reciprocal Translocation of NMDA Receptors and Calcium/Calmodulin-Dependent Kinase II
Fong, D. K., Rao, A., Crump, F. T., & Craig, A. M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02153.2002 · Cited by 150
Activity-driven postsynaptic translocation of CaMKII
Merrill, M. A., Chen, Y., Strack, S., & Hell, J. W. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.10.003 · Cited by 155
A Temporary Gating of Actin Remodeling during Synaptic Plasticity Consists of the Interplay between the Kinase and Structural Functions of CaMKII
Kim, K., Lakhanpal, G., Lu, H. E., Khan, M., Suzuki, A., Kato Hayashi, M., Narayanan, R., Luyben, T. T., Matsuda, T., Nagai, T., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.023 · Cited by 145
Inositol 1,4,5-Trisphosphate 3-Kinase A Associates with F-actin and Dendritic Spines via Its N Terminus
Schell, M. J., Erneux, C., & Irvine, R. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104101200 · Cited by 142
Dendritic spine morphogenesis and plasticity
Lippman, J., & Dunaevsky, A. (2005) · Journal of Neurobiology · doi:10.1002/neu.20149 · Cited by 142
PACAP and glutamate are co-stored in the retinohypothalamic tract
Hannibal, J., Møller, M., Ottersen, O. P., & Fahrenkrug, J. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000306)418:2 · Cited by 224
CaMKII
Shonesy, B. C., Jalan‐Sakrikar, N., Cavener, V. S., & Colbran, R. J. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-420170-5.00003-9 · Cited by 140
βCaMKII controls the direction of plasticity at parallel fiber–Purkinje cell synapses
van Woerden, G. M., Hoebeek, F. E., Gao, Z., Nagaraja, R. Y., Hoogenraad, C. C., Kushner, S. A., Hansel, C., Zeeuw, C. I. D., & Elgersma, Y. (2009) · Nature Neuroscience · doi:10.1038/nn.2329 · Cited by 132
Neuronal excitability and calcium/calmodulin dependent protein kinase type II: location, location, location
Liu, X., & Murray, K. D. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03474.x · Cited by 133
Netrin-1 Induces Axon Branching in Developing Cortical Neurons by Frequency-Dependent Calcium Signaling Pathways
Tang, F., & Kalil, K. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0871-05.2005 · Cited by 127
Synaptic memory and CaMKII
Nicoll, R. A., & Schulman, H. (2023) · Physiological Reviews · doi:10.1152/physrev.00034.2022 · Cited by 126
Multivalent Interactions of Calcium/Calmodulin-dependent Protein Kinase II with the Postsynaptic Density Proteins NR2B, Densin-180, and α-Actinin-2
Robison, A. J., Bass, M. A., Jiao, Y., MacMillan, L. B., Carmody, L. C., Bartlett, R. K., & Colbran, R. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502191200 · Cited by 134
Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression
Song, Q., Fan, C., Wang, P., Li, Y., Yang, M., & Yu, S. Y. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1377-0 · Cited by 126
CaMKII Plays a Nonenzymatic Role in Hippocampal Synaptic Plasticity and Learning by Targeting CaMKII to Synapses
Borgesius, N. Z., van Woerden, G. M., Buitendijk, G. H. S., Keijzer, N., Jaarsma, D., Hoogenraad, C. C., & Elgersma, Y. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5105-10.2011 · Cited by 124
Coordination of Protein Phosphorylation and Dephosphorylation in Synaptic Plasticity
Woolfrey, K. M., & Dell’Acqua, M. L. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.657262 · Cited by 125
Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression
Li, B., Tadross, M. R., & Tsien, R. W. (2016) · Science · doi:10.1126/science.aad3647 · Cited by 121
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory
Fukunaga, K., & Miyamoto, E. (2000) · Neuroscience Research · doi:10.1016/s0168-0102(00)00139-5 · Cited by 121
PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure
Emperador-Melero, J., Wong, M. Y., Wang, S. S. H., de Nola, G., Nyitrai, H., Kirchhausen, T. L., & Kaeser, P. S. (2021) · Nature Communications · doi:10.1038/s41467-021-23116-w · Cited by 102
CaMKIIβ Association with the Actin Cytoskeleton Is Regulated by Alternative Splicing
O'Leary, H., Lasda, E., & Bayer, K. U. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-03-0252 · Cited by 113
Regulation of Signal Transduction by Protein Targeting: The Case for CaMKII
Bayer, K. U., & Schulman, H. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6063 · Cited by 104
Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II
Rosenberg, O. S., Deindl, S., Comolli, L. R., Hoelz, A., Downing, K. H., Nairn, A. C., & Kuriyan, J. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2005.05088.x · Cited by 105
Regulation of the Ca2+/CaM-Responsive Pool of CaMKII by Scaffold-Dependent Autophosphorylation
Lu, C. S., Hodge, J. J. L., Mehren, J. E., Sun, X. X., & Griffith, L. C. (2003) · Neuron · doi:10.1016/s0896-6273(03)00786-4 · Cited by 100
Molecular mechanism of hippocampal long-term potentiation – Towards multiscale understanding of learning and memory
Hayashi, Y. (2022) · Neuroscience Research · doi:10.1016/j.neures.2021.08.001 · Cited by 102
Alternative splicing modulates the frequency‐dependent response of CaMKII to Ca2+ oscillations
Bayer, K. U., Koninck, P. D., & Schulman, H. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf360 · Cited by 112
LTP and adaptation to inactivity: Overlapping mechanisms and implications for metaplasticity
Thiagarajan, T. C., Lindskog, M., Malgaroli, A., & Tsien, R. W. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.030 · Cited by 99
RC3/Neurogranin and Ca2+/Calmodulin-dependent Protein Kinase II Produce Opposing Effects on the Affinity of Calmodulin for Calcium
Gaertner, T. R., Putkey, J. A., & Waxham, M. N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405352200 · Cited by 96
CaMKIIβ binding to stable F-actin in vivo regulates F-actin filament stability
Lin, Y.-C., & Redmond, L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804399105 · Cited by 96
Spine loss and other dendritic abnormalities in epilepsy
Swann, J. W., Al‐Noori, S., Jiang, M., & Lee, C. L. (2000) · Hippocampus · doi:10.1002/1098-1063(2000)10:5 · Cited by 268
Structural rearrangement of CaMKIIα catalytic domains encodes activation
Thaler, C., Koushik, S. V., Puhl, H. L., Blank, P. S., & Vogel, S. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901913106 · Cited by 86
Synaptic Strength of Individual Spines Correlates with Bound Ca 2+ –Calmodulin-Dependent Kinase II
Asrican, B., Lisman, J. E., & Otmakhov, N. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3587-07.2007 · Cited by 85
Calcium/Calmodulin-Stimulated Protein Kinase II (CaMKII): Different Functional Outcomes from Activation, Depending on the Cellular Microenvironment
Rostas, J. A. P., & Skelding, K. A. (2023) · Cells · doi:10.3390/cells12030401 · Cited by 85
Oligomeric structure of α-calmodulin-dependent protein kinase II11Edited by A. R. Fersht
Morris, E. P., & Török, K. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4584 · Cited by 86
Differential Modulation of Ca2+/Calmodulin-dependent Protein Kinase II Activity by Regulated Interactions with N-Methyl-D-aspartate Receptor NR2B Subunits and α-Actinin
Robison, A. J., Bartlett, R. K., Bass, M. A., & Colbran, R. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508189200 · Cited by 84
Postsynaptic actin and neuronal plasticity
Matus, A. I. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00018-5 · Cited by 84
Increased expression of calcium/calmodulin-dependent protein kinase IIβ in frontal cortex in schizophrenia and depression
Novak, G., Seeman, P. M., & Tallerico, T. (2005) · Synapse · doi:10.1002/syn.20211 · Cited by 80
-Ca2+/Calmodulin-Dependent Protein Kinase II Contributes to the Developmental Programming of Anxiety in Serotonin Receptor 1A Knock-Out Mice
Iacono, L. L., & Gross, C. T. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5219-07.2008 · Cited by 82
A Pivotal Role for the Multifunctional Calcium/Calmodulin-Dependent Protein Kinase II in T Cells: From Activation to Unresponsiveness
Lin, M. Y., Żal, T., Ch’en, I. L., Gascoigne, N. R. J., & Hedrick, S. Μ. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5583 · Cited by 80
Multiple Spatial and Kinetic Subpopulations of CaMKII in Spines and Dendrites as Resolved by Single-Molecule Tracking PALM
Lu, H. E., MacGillavry, H. D., Frost, N. A., & Blanpied, T. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4364-13.2014 · Cited by 78
Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) Localization Acts in Concert with Substrate Targeting to Create Spatial Restriction for Phosphorylation
Tsui, J., Inagaki, M., & Schulman, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407653200 · Cited by 78
Physiological and Pathological Roles of CaMKII-PP1 Signaling in the Brain
Shioda, N., & Fukunaga, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms19010020 · Cited by 77
Calcium-Calmodulin-Dependent Protein Kinase II Isoforms Differentially Impact the Dynamics and Structure of the Actin Cytoskeleton
Hoffman, L., Farley, M. M., & Waxham, M. N. (2013) · Biochemistry · doi:10.1021/bi3016586 · Cited by 76

Authors: Shen, K., Teruel, M. N., Subramanian, K., & Meyer, T.
Affiliations: Duke Medical Center (US)
Corresponding author: Meyer, Tobias
ORCID: Shen, Kang
Teruel, Mary N
Meyer, Tobias
Venue: Neuron
Publisher: Elsevier BV
Published: 1998-09
Volume: 21
Issue: 3
Pages: 593-606
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(00)80569-3
OpenAlex: W2146831587
Cited by: 350
References: 61
Citations by year: 2026: 7 · 2025: 4 · 2024: 5 · 2023: 9 · 2022: 9 · 2021: 6 · 2020: 20 · 2019: 14 · 2018: 18 · 2017: 10 · 2016: 7 · 2015: 12 · 2014: 9 · 2013: 21 · 2012: 14
FWCI: 5.41
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5433 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (2r01gm051457-04)
National Institute of General Medical Sciences (GM-48113, GM 51457)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: CaMKIIβ, CaMKIIα, CaMKII isoforms, hetero-oligomers, F-actin binding, dendritic spines, actin cytoskeleton, protein localization, synaptic plasticity, long-term potentiation, neuroplasticity
MeSH terms: Actins, Animals, Cloning, Molecular, Cytoskeleton, Dendrites, Isoenzymes, Luminescent Proteins, Nerve Fibers, Neurons, Phosphorylation, Recombinant Fusion Proteins, Synapses, Transcription, Genetic, Protein Biosynthesis, Tumor Cells, Cultured, 3T3 Cells, Calcium-Calmodulin-Dependent Protein Kinases, Macromolecular Substances, Green Fluorescent Proteins, Mice, Rats, Calcium-Calmodulin-Dependent Protein Kinase Type 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

CaMKIIβ Functions As an F-Actin Targeting Module that Localizes CaMKIIα/β Heterooligomers to Dendritic Spines

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks