Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-864 · Cited by 2,599

Candidate gene for the chromosome 1 familial Alzheimer’s disease locus

Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D. M., Oshima, J., Pettingell, W. H., Yu, C.-E., Jondro, P. D., Schmidt, S. D., Wang, K., et al. (1995) · Science · doi:10.1126/science.7638622 · Cited by 2,577

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

Rogaev, E. I., Sherrington, R., Rogaeva, E. A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., et al. (1995) · Nature · doi:10.1038/376775a0 · Cited by 2,052

The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

Jarrett, J. T., Berger, E. P., & Lansbury, P. T. (1993) · Biochemistry · doi:10.1021/bi00069a001 · Cited by 2,022

8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

Knez, D., Diez‐Iriepa, D., Chioua, M., Gottinger, A., Denic, M., Chantegreil, F., Nachon, F., Brazzolotto, X., Skrzypczak-Wiercioch, A., Meden, A., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.01.013 · Cited by 46

Structural Biology of Presenilins and Signal Peptide Peptidases

Tomita, T., & Iwatsubo, T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.463281 · Cited by 46

Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: Involvement in hippocampal neuronal loss in Alzheimer's disease

Antequera, D., Bolós, M., Spuch, C., Pascual, C., Ferrer, I., Fernández‐Bachiller, M. I., Rodrı́guez-Franco, M. I., & Carro, E. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.009 · Cited by 46

Processing of Mutant β-Amyloid Precursor Protein and the Clinicopathological Features of Familial Alzheimer’s Disease

Bi, C., Bi, S., & Li, B. (2018) · Aging and Disease · doi:10.14336/ad.2018.0425 · Cited by 46

Prionoid Proteins in the Pathogenesis of Neurodegenerative Diseases

Wells, C., Brennan, S. E., Keon, M., & Saksena, N. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00271 · Cited by 46

Recent Advances in the Genetics of Alzheimer's Disease

Levy‐Lahad, E., Tsuang, D. W., & Bird, T. D. (1998) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879801100202 · Cited by 46

Proteomic analysis of brain proteins in APP/PS‐1 human double mutant knock‐in mice with increasing amyloid β‐peptide deposition: Insights into the effects of in vivo treatment with N‐acetylcysteine as a potential therapeutic intervention in mild cognitive impairment and Alzheimer's disease

Robinson, R. A. S., Gururaj Joshi, A., Huang, Q., Rukhsana Sultana, A., Baker, A. S., Cai, J., Pierce, W. M. J., Clair, D. K. S., Markesbery, W. R., & Butterfield, D. A. (2011) · PROTEOMICS · doi:10.1002/pmic.201000523 · Cited by 45

Expression of the Alzheimer’s Disease Mutations AβPP695sw and PSEN1M146I in Double-Transgenic Göttingen Minipigs

Jakobsen, J. E., Johansen, M., Schmidt, M. H., Liu, Y., Li, R., Callesen, H., Melnikova, M., Habekost, M., Matrone, C., Bouter, Y., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160408 · Cited by 45

Genetic deletion of CB1 cannabinoid receptors exacerbates the Alzheimer-like symptoms in a transgenic animal model

Aso, E., Andrés‐Benito, P., & Ferrer, I. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.08.007 · Cited by 45

Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice

Lesuisse, C. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.22.2525 · Cited by 45

Alzheimer disease — when and why?

Price, D. L., Sisodia, S. S., & Borchelt, D. (1998) · Nature Genetics · doi:10.1038/1196 · Cited by 45

Mechanistic complexities of bone loss in Alzheimer’s disease: a review

Frame, G., Bretland, K. A., & Dengler-Crish, C. M. (2020) · Connective Tissue Research · doi:10.1080/03008207.2019.1624734 · Cited by 44

Introducing Amylo-Glo, a novel fluorescent amyloid specific histochemical tracer especially suited for multiple labeling and large scale quantification studies

Schmued, L. C., Raymick, J. B., Tolleson, W. H., Sarkar, S., Zhang, Y.-H., & Bell-Cohn, A. J. (2012) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2012.05.019 · Cited by 44

Disturbances in the control of capillary flow in an aged APPswe/PS1ΔE9 model of Alzheimer's disease

Gutiérrez‐Jiménez, E., Angleys, H., Rasmussen, P. M., West, M. J., Catalini, L., Iversen, N., Jensen, M. S., Frische, S., & Østergaard, L. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.10.006 · Cited by 44

RNA-Seq Analysis of Frontal Cortex and Cerebellum from 5XFAD Mice at Early Stage of Disease Pathology

Kim, K. H., Moon, M., Yu, S.-B., Mook‐Jung, I., & Kim, J. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111793 · Cited by 44

Pharmacological Enhancement of Neuronal Survival

Calabrese, E. J. (2008) · Critical Reviews in Toxicology · doi:10.1080/10408440801981973 · Cited by 44

Interaction between amyloid precursor protein and Nogo receptors regulates amyloid deposition

Zhou, X., Hu, X., He, W., Tang, X., Shi, Q., Zhang, Z., & Yan, R. (2011) · The FASEB Journal · doi:10.1096/fj.11-184325 · Cited by 44

The mouse C1q A-chain sequence alters beta-amyloid-induced complement activation☆

Webster, S. D., Tenner, A. J., Poulos, T. L., & Cribbs, D. H. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00020-2 · Cited by 44

Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer’s disease

Jana, A., Wang, X., Leasure, J. W., Magana, L., Wang, L., Kim, Y.-M., Dodiya, H., Toth, P. T., Sisodia, S. S., & Rehman, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-20889-y · Cited by 43

Regional brain metabolism with cytochrome c oxidase histochemistry in a PS1/A246E mouse model of autosomal dominant Alzheimer's disease: Correlations with behavior and oxidative stress

Strazielle, C., Jazi, R., Verdier, Y., Qian, S., & Lalonde, R. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.08.005 · Cited by 43

Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6

Pérez-Areales, F. J., Garrido, M., Aso, E., Bartolini, M., Simone, A. D., Espargaró, A., Ginex, T., Sabaté, R., Pérez, B., Andrisano, V., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00528 · Cited by 43

Sex‐specific accelerated decay in time/activity‐dependent plasticity and associative memory in an animal model of Alzheimer's disease

Navakkode, S., Gaunt, J. R., Pavón, M. V., Bansal, V. A., Abraham, R. P., Chong, Y. S., Ch’ng, T. H., & Sajikumar, S. (2021) · Aging Cell · doi:10.1111/acel.13502 · Cited by 43

β -Amyloid Peptide Vaccination Results in Marked Changes in Serum and Brain A β Levels in APPswe/PS1ΔE9 Mice, as Detected by SELDI-TOF-Based ProteinChip ® Technology

Vehmas, A. K., Borchelt, D., Price, D. L., McCarthy, D. B., Wills-Karp, M. A., Peper, M. J., Rudow, G. L., Luyinbazi, J., Siew, L. T., & Troncoso, J. C. (2001) · DNA and Cell Biology · doi:10.1089/10445490152717578 · Cited by 43

Apolipoprotein E structural requirements for the formation of SDS-stable complexes with β-amyloid-(1–40): the role of salt bridges

Bentley, N. M., LaDu, M. J., Rajan, C., Getz, G. S., & Reardon, C. A. (2002) · Biochemical Journal · doi:10.1042/bj20020207 · Cited by 43

IntelliCage Automated Behavioral Phenotyping Reveals Behavior Deficits in the 3xTg-AD Mouse Model of Alzheimer’s Disease Associated With Brain Weight

Winslow, W., McDonough, I., Tallino, S., Decker, A., Vural, A. S., & Velázquez, R. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.720214 · Cited by 42

Amyloid-β precursor protein mediates neuronal toxicity of amyloid β through Go protein activation

Vigo, F. S., Kedikian, G., Heredia, L., Heredia, F., Añel, A. D., Rosa, A. L., & Lorenzo, A. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.11.017 · Cited by 42

Low-dose proton radiation effects in a transgenic mouse model of Alzheimer’s disease – Implications for space travel

Rudobeck, E., Bellone, J. A., Szűcs, A. L., Bonnick, K., Mehrotra, S., Badaut, J., Nelson, G. A., Hartman, R. E., & Vlkolinský, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186168 · Cited by 42

Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease

Overk, C., Kelley, C. M., & Mufson, E. J. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.004 · Cited by 42

Proteomic identification of specifically carbonylated brain proteins in APPNLh/APPNLh×PS-1P264L/PS-1P264L human double mutant knock-in mice model of Alzheimer disease as a function of age

Sultana, R., Robinson, R. A. S., Di Domenico, F., Abdul, H. M., Clair, D. K. S., Markesbery, W. R., Cai, J., Pierce, W. M., & Butterfield, D. A. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.06.015 · Cited by 41

4-O-methylhonokiol attenuated β-amyloid-induced memory impairment through reduction of oxidative damages via inactivation of p38 MAP kinase

Lee, Y. K., Choi, I. S., Ban, J. O., Lee, H. J., Lee, U. S., Han, S., Jung, J., Kim, Y. H., Kim, K. H., Oh, K., et al. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.04.002 · Cited by 41

Age-related loss of phospholipid asymmetry in APP /APP x PS-1 /PS-1 human double mutant knock-in mice: Relevance to Alzheimer disease

Lange, M. L. B., Clair, D. K. S., Markesbery, W. R., Studzinski, C. M., Murphy, M. P., & Butterfield, D. A. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.01.004 · Cited by 41

What is the dominant aβ species in human brain tissue? A review

Gregory, G. C., & Halliday, G. M. (2005) · Neurotoxicity Research · doi:10.1007/bf03033774 · Cited by 41

Monogenetic determinants of Alzheimer's disease: APP mutations

Goate, A. (1998) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050218 · Cited by 41

Interleukin-19 Acts as a Negative Autocrine Regulator of Activated Microglia

Horiuchi, H., Parajuli, B., Wang, Y., Azuma, Y., Mizuno, T., Takeuchi, H., & Suzumura, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118640 · Cited by 40

Plaque Deposition Dependent Decrease in 5-HT2A Serotonin Receptor in AβPPswe/PS1dE9 Amyloid Overexpressing Mice

Holm, P. C., Ettrup, A., Klein, A. B., Santini, M. A., El-Sayed, M., Elvang, A. B., Stensbøl, T. B., Mikkelsen, J. D., Knudsen, G. M., & Aznar, S. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100117 · Cited by 40

A Lifespan Observation of a Novel Mouse Model: In Vivo Evidence Supports Aβ Oligomer Hypothesis

Zhang, Y., Lu, L., Jia, J., Jia, L., Geula, C., Pei, J.-J., Xu, Q., Qin, W., Liu, R., Li, D., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085885 · Cited by 40

Longitudinal observation on CSF A?42 levels in young to middle-aged amyloid precursor protein/presenilin-1 doubly transgenic mice

Liu, L., Herukka, S., Minkeviciene, R., vanGroen, T., & Tanila, H. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.08.005 · Cited by 40

Hereditary and Sporadic Forms of Aβ-Cerebrovascular Amyloidosis and Relevant Transgenic Mouse Models

Kumar‐Singh, S. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10041872 · Cited by 40

Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer’s disease mice and correlates with memory deficits in human subjects

Ahmad, F., Das, D., Kommaddi, R. P., Diwakar, L., Gowaikar, R., Rupanagudi, K. V., Bennett, D. A., & Ravindranath, V. (2018) · Scientific Reports · doi:10.1038/s41598-018-31073-6 · Cited by 40

Cellular Cofactors for Amyloid β-Peptide-Induced Cell Stress

Yan, S. D., Roher, A. E., Schmidt, A. M., & Stern, D. M. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65452-1 · Cited by 40

Presenilin-1-Dependent Transcriptome Changes

Mirnics, K., Korade, Ž., Arion, D., Lazarov, O., Unger, T. L., Macioce, M., Sabatini, M., Terrano, D. T., Douglass, K. C., Schor, N. F., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4145-04.2005 · Cited by 40

Anti-amyloid Therapy of Alzheimer’s Disease: Current State and Prospects

Kozin, S. A., Barykin, E. P., Mitkevich, V. A., & Makarov, A. А. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918090079 · Cited by 39

Relevance of transgenic mouse models for Alzheimer's disease

Tai, L. M., Weng, J. M., LaDu, M. J., & Brady, S. T. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.07.007 · Cited by 39

Hydroxytyrosol Acetate Improves the Cognitive Function of APP/PS1 Transgenic Mice in ERβ‐dependent Manner

Qin, C., Hu, S., Zhang, S., Zhao, D., Wang, Y., Li, H., Peng, Y., Shi, L., Xu, X., Wang, C., et al. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000797 · Cited by 39

Neuroinflammatory Cytokines - The Common Thread in Alzheimer Pathogenesis

Griffin, W. S. T., Barger, S. W., & Chairman, D. P. A. V. (2011) · European Neurological Review · doi:10.17925/enr.2011.06.02.89 · Cited by 39

Advances on the Understanding of the Origins of Synaptic Pathology in AD

Lacor, P. N. (2007) · Current Genomics · doi:10.2174/138920207783769530 · Cited by 40

Immunotherapeutic approaches for Alzheimer’s disease in transgenic mouse models

Wısnıewskı, T., & Boutajangout, A. (2009) · Brain Structure and Function · doi:10.1007/s00429-009-0236-2 · Cited by 39

Magnesium boosts the memory restorative effect of environmental enrichment in Alzheimer's disease mice

Huang, Y., Huang, X., Zhang, L., Han, F., Pang, K., Li, X., & Shen, J. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12775 · Cited by 39

The Effects of Soluble A.β Oligomers on Neurodegeneration in Alzheimer's Disease

Brouillette, J. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990498 · Cited by 39

Subfield and layer-specific depletion in calbindin-D28K, calretinin and parvalbumin immunoreactivity in the dentate gyrus of amyloid precursor protein/presenilin 1 transgenic mice

Popović, M., Caballero-Bleda, M., Kadish, I., & Van Groen, T. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.023 · Cited by 38

Enzymatic Characteristics of I213T Mutant Presenilin-1/γ-Secretase in Cell Models and Knock-in Mouse Brains

Shimojo, M., Sahara, N., Mizoroki, T., Funamoto, S., Morishima‐Kawashima, M., Kudo, T., Takeda, M., Ihara, Y., Ichinose, H., & Takashima, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801279200 · Cited by 38

Hereditary spastic paraplegia: gain-of-function mechanisms revealed by new transgenic mouse

Qiang, L., Piermarini, E., Muralidharan, H., Yu, W., Leo, L., Hennessy, L., Fernandes, S., Connors, T. M., Yates, P. L., Swift, M. L., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy419 · Cited by 38

Traceable Nano‐Biohybrid Complexes by One‐Step Synthesis as CRISPR‐Chem Vectors for Neurodegenerative Diseases Synergistic Treatment

Shen, J., Lü, Z., Wang, J., Hao, Q., Ji, W., Wu, Y., Peng, H., Zhao, R., Yang, J., Li, Y., et al. (2021) · Advanced Materials · doi:10.1002/adma.202101993 · Cited by 38

Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer’s disease

Deng, Y., Bi, M., Delerue, F., Forrest, S. L., Chan, G., van der Hoven, J., van Hummel, A., Feiten, A., Lee, S., Martínez-Valbuena, I., et al. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02457-w · Cited by 38

The effects of JWB1-84-1 on memory-related task performance by amyloid Aβ transgenic mice and by young and aged monkeys

SOOD, A., WARRENBEACH, J., Webster, S. J., Terry, A. V., & Buccafusco, J. J. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.06.028 · Cited by 38

Central cholinergic functions in human amyloid precursor protein knock-in/presenilin-1 transgenic mice

Hartmann, J., Erb, C., Ebert, U., Baumann, K., Popp, A., König, G., & Klein, J. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.02.038 · Cited by 38

β‐Amyloid protein converting enzyme 1 and brain‐specific type II membrane protein BRI3: binding partners processed by furin

Wickham, L., Benjannet, S., Marcinkiewicz, E., Chrétien, M., & Seidah, N. G. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02840.x · Cited by 38

What transgenic mice tell us about neurodegenerative disease

Gurney, M. E. (2000) · BioEssays · doi:10.1002/(sici)1521-1878(200003)22:3 · Cited by 38

Neurofilament light gene deletion exacerbates amyloid, dystrophic neurite, and synaptic pathology in the APP/PS1 transgenic model of Alzheimer's disease

Fernandez-Martos, C. M., King, A. E., Atkinson, R. A. K., Woodhouse, A., & Vickers, J. C. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.07.003 · Cited by 38

Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels

Köhler, C., Ebert, U., Baumann, K., & Schröder, H. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.04.009 · Cited by 37

APOE3, but Not APOE4, Bone Marrow Transplantation Mitigates Behavioral and Pathological Changes in a Mouse Model of Alzheimer Disease

Yang, Y. J., Cudaback, E., Jorstad, N. L., Hemingway, J. F., Hagan, C. E., Melief, E. J., Li, X., Yoo, T., Khademi, S. B., Montine, K. S., et al. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.05.009 · Cited by 37

Differential alteration of hippocampal function and plasticity in females and males of the APPxPS1 mouse model of Alzheimer's disease

Richetin, K., Petsophonsakul, P., Roybon, L., Guiard, B. P., & Rampon, C. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.05.025 · Cited by 37

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

Gabbouj, S., Natunen, T., Koivisto, H., Jokivarsi, K. T., Takalo, M., Marttinen, M., Wittrahm, R., Kemppainen, S., Naderi, R., Posado-Fernández, A., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.11.008 · Cited by 37

Rapid Detection of Protein Aggregates in the Brains of Alzheimer Patients and Transgenic Mouse Models of Amyloidosis

Xu, G., Gonzales, V., & Borchelt, D. R. (2002) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200207000-00010 · Cited by 37

Genetically altered transgenic models of Alzheimer’s disease

Masliah, E., & Rockenstein, E. M. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6781-6_20 · Cited by 37

Differences in Synaptic Dysfunction Between rTg4510 and APP/PS1 Mouse Models of Alzheimer’s Disease

Gelman, S., Palma, J. D., Tombaugh, G. C., & Ghavami, A. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170457 · Cited by 36

Cholesterol and Amyloid-β: Evidence for a Cross-Talk between Astrocytes and Neuronal Cells

Canepa, E., Borghi, R., Viña, J., Traverso, N., Gambini, J., Domenicotti, C., Marinari, U. M., Poli, G., Pronzato, M. A., & Ricciarelli, R. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110053 · Cited by 36

Transthyretin Accelerates Vascular Aβ Deposition in a Mouse Model of Alzheimer's Disease

Wati, H., Kawarabayashi, T., Matsubara, E., Kasai, A., Hirasawa, T., Kubota, T., Harigaya, Y., Shoji, M., & Maeda, S. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00166.x · Cited by 36

Object Recognition Memory and Cholinergic Parameters in Mice Expressing Human Presenilin 1 Transgenes

Vaucher, E., Fluit, P., Chishti, M. A., Westaway, D. A., Mount, H. T. J., & Kar, S. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7915 · Cited by 36

GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer's disease

Bozoyan, L., Audoy-Rémus, J., Dumas, A., Filali, M., Lacroix, S., Rivest, S., Tremblay, M., & Vallières, L. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.08.351 · Cited by 36

Why therapies for Alzheimer’s disease do not work: Do we have consensus over the path to follow?

Amtul, Z. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.09.003 · Cited by 35

The effect of aging on the subcellular distribution of estrogen receptor‐alpha in the cholinergic neurons of transgenic and wild‐type mice

Kalesnykas, G., Roschier, U., Puoliväli, J. T., Wang, J., & Miettinen, R. A. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03953.x · Cited by 35

Amyloid β peptides overexpression in retinal pigment epithelial cells via AAV-mediated gene transfer mimics AMD-like pathology in mice

Prasad, T., Zhu, P., Verma, A., Chakrabarty, P., Rosario, A. M., Golde, T. E., & Li, Q. (2017) · Scientific Reports · doi:10.1038/s41598-017-03397-2 · Cited by 35

Synaptic and extrasynaptic distribution of NMDA receptors in the cortex of Alzheimer's disease patients

Escamilla, S., Badillos-Rodríguez, R., Comella, J. X., Solé, M., Pérez‐Otaño, I., Sanchez-Mut, J. V., Sáez‐Valero, J., & Cuchillo‐Ibáñez, I. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14125 · Cited by 35

Transcriptional regulation of the presenilin-1 gene: implication in Alzheimer's disease

Hriday, K. D. (2007) · Frontiers in bioscience · doi:10.2741/2723 · Cited by 34

In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment

Westman, E., Spenger, C., Öberg, J., Reyer, H., Pahnke, J., & Wahlund, L. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-33 · Cited by 34

Luteinizing hormone as a key player in the cognitive decline of Alzheimer's disease

Burnham, V. L., & Thornton, J. E. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.010 · Cited by 34

Mechanisms of Neural and Behavioral Dysfunction in Alzheimer’s Disease

Wesson, D. W., Nixon, R. A., Levy, E., & Wilson, D. A. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8177-1 · Cited by 34

Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235

Huang, X. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00242-5 · Cited by 34

Amyloid-β containing isoaspartate 7 as potential biomarker and drug target in Alzheimer's disease

Kozin, S. A., Mitkevich, V. A., & Makarov, A. А. (2016) · Mendeleev Communications · doi:10.1016/j.mencom.2016.07.001 · Cited by 33

Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease

Zhang, J., Wu, N., Wang, S., Yao, Z., Xiao, F., Lu, J., & Chen, B. (2021) · Aging Cell · doi:10.1111/acel.13380 · Cited by 33

Effect of long-term cannabidiol on learning and anxiety in a female Alzheimer’s disease mouse model

Chesworth, R., Cheng, D., Staub, C., & Karl, T. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.931384 · Cited by 33

FDG–PET imaging, EEG and sleep phenotypes as translational biomarkers for research in Alzheimer's disease

Platt, B., Welch, A., & Riedel, G. (2011) · Biochemical Society Transactions · doi:10.1042/bst0390874 · Cited by 33

Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice

Priller, C., Mitteregger, G., Paluch, S., Vassallo, N., Staufenbiel, M., Kretzschmar, H. A., Jucker, M., & Herms, J. W. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.10.016 · Cited by 33

Genetic variants associated with neurodegenerative Alzheimer disease in natural models

Salazar, C., Valdivia, G., Ardiles, Á. O., Ewer, J., & Palacios, A. G. (2016) · Biological Research · doi:10.1186/s40659-016-0072-9 · Cited by 33

Altered glutamate clearance in ascorbate deficient mice increases seizure susceptibility and contributes to cognitive impairment in APP/PSEN1 mice

Mi, D. J., Dixit, S., Warner, T. A., Kennard, J. A., Scharf, D. A., Kessler, E. S., Moore, L. M., Consoli, D. C., Bown, C. W., Dukes, A. J., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.08.002 · Cited by 33

Delivery of exogenous proteins by mesenchymal stem cells attenuates early memory deficits in a murine model of Alzheimer's disease

Li, A., Zhao, J., Fan, C., Zhu, L., Huang, C., Li, Q., Gan, D., Wen, C., Chen, M., & Lu, D. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.10.012 · Cited by 32

AstroDot – a new method for studying the spatial distribution of mRNA in astrocytes

Oudart, M., Tortuyaux, R., Mailly, P., Mazaré, N., Boulay, A.-C., & Cohen‐Salmon, M. (2020) · Journal of Cell Science · doi:10.1242/jcs.239756 · Cited by 32

Emerging Promise of Immunotherapy for Alzheimer’s Disease: A New Hope for the Development of Alzheimer’s Vaccine

Kabir, M. T., Uddin, M. S., Mathew, B., Das, P. K., Perveen, A., & Ashraf, G. M. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200422105156 · Cited by 32

Microglia and its Genetics in Alzheimer's Disease

Liang, X., Wu, H., Colt, M., Guo, X., Pluimer, B. R., Zeng, J., Dong, S., & Zhao, Z. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666211105140732 · Cited by 32

TMP21 degradation is mediated by the ubiquitin‐proteasome pathway

Liu, S., Bromley‐Brits, K., Xia, K., Mittelholtz, J., Wang, R., & Song, W. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06497.x · Cited by 32

Alzheimer?s disease?a sum greater than its parts?

Adlard, P. A., & Cummings, B. J. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.12.016 · Cited by 32

Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease

Soto, I., Grabowska, W. A., Onos, K. D., Graham, L. C., Jackson, H. M., Simeone, S. N., & Howell, G. R. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.02.025 · Cited by 32

Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum

Hu, X., Hu, Z., Li, Z., Ruan, C., Qiu, W., Pan, A., Li, C.-Q., Cai, Y., Shen, L., Chu, Y., et al. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00045 · Cited by 32

Overview on Rodent Models of Alzheimer's Disease

Dodart, J., & May, P. C. (2005) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0922s33 · Cited by 32

Protein markers for Alzheimer disease in the frontal cortex and cerebellum

Verdile, G., Gnjec, A., Miklossy, J., Fonte, J., Veurink, G., Bates, K. A., Kakulas, B. A., Mehta, P. D., Milward, E. A., Tan, N., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000141848.45315.a6 · Cited by 32

Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain

Kondo, M., Shiono, M., Itoh, G., Takei, N., Matsushima, T., Maeda, M., Taru, H., Hata, S., Yamamoto, T., Saito, Y., et al. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-35 · Cited by 32

What Can Rodent Models Tell Us About Cognitive Decline in Alzheimer's Disease?

Davis, S., & Laroche, S. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:3:249 · Cited by 32

Insights into Aβ and Presenilin from a Canine Model of Human Brain Aging

Head, E., & Torp, R. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0476 · Cited by 32

Current neuroimaging techniques in Alzheimer's disease and applications in animal models.

Zhang, L., Chang, R. C., Chu, L., & Mak, H. K. (2012) · Europe PMC (PubMed Central) · Cited by 31

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

Holcomb, L., Gordon, M. N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., et al. (1998) · Nature Medicine · doi:10.1038/nm0198-097 · Cited by 1,386

FAD mutant PS-1 gene-targeted mice: increased Aβ42 and Aβ deposition without APP overproduction

Flood, D. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00330-x · Cited by 131

Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice

Lamb, B. T., Bardel, K. A., Kulnane, L. S., Anderson, J. J., Holtz, G., Wagner, S. L., Sisodia, S. S., & Hoeger, E. J. (1999) · Nature Neuroscience · doi:10.1038/11154 · Cited by 102

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation

Chui, D.-H., Tanahashi, H., Ozawa, K., Ikeda, S., Checler, F., Ueda, O., Suzuki, H., Araki, W., Inoue, H., Shirotani, K., et al. (1999) · Nature Medicine · doi:10.1038/8438 · Cited by 364

Presenilin Proteins and the Pathogenesis of Early-Onset Familial Alzheimer’s Disease: β-Amyloid Production and Parallels to Prion Diseases

Westaway, D. A., Carlson, G. A., Bergeron, C., Lévesque, G., Sherrington, R., Yao, H., Strome, R., Perry, B. J., Davies, A., Gandy, S., et al. (1998) · Springer eBooks · doi:10.1007/978-1-4899-1896-3_17 · Cited by 1