The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The bHLH Transcription Factor Olig2 Promotes Oligodendrocyte Differentiation in Collaboration with Nkx2.2
Open accessAbstract
Olig2, a basic helix-loop-helix (bHLH) transcription factor, is expressed in a restricted domain of the spinal cord ventricular zone that sequentially generates motoneurons and oligodendrocytes. Just prior to oligo-dendrocyte precursor formation, the domains of Olig2 and Nkx2.2 expression switch from being mutually exclusive to overlapping, and Neurogenins1 and 2 are extinguished within this region. Coexpression of Olig2 with Nkx2.2 in the spinal cord promotes ectopic and precocious oligodendrocyte differentiation. Both proteins function as transcriptional repressors in this assay. This effect is blocked by forced expression of Neurogenin1. By contrast, misexpression of Olig2 alone derepresses Neurogenins and promotes motoneuron differentiation. Olig2 therefore functions sequentially in motoneuron and oligodendrocyte fate specification. This dual action is enabled by spatio-temporal changes in the expression domains of other transcription factors with which Olig2 functionally interacts.
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Citations
Cites
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
Zhou, Q., Wang, S., & Anderson, D. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)80898-3 · Cited by 789
Self-citationWhite, P. M., & Anderson, D. J. (1999) · Development · doi:10.1242/dev.126.19.4351 · Cited by 66
Self-citation
Cited by
The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification
Zhou, Q., & Anderson, D. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00677-3 · Cited by 1,059
“In recent years, a great factor appears to function in both cases as a transcripdeal has been learned about the transcriptional control tional repressor (Novitch et al., 2001; Zhou et al., 2001).”
BackgroundMethodInfluentialSelf-citationRegulation of innate immune responses in the brain
Rivest, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2565 · Cited by 843
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McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches
Machold, R., Hayashi, S., Rutlin, M., Muzumdar, M. D., Nery, S., Corbin, J. G., Gritli-Linde, A., Dellovade, T., Porter, J. A., Rubin, L. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00561-0 · Cited by 710
Regulation of oligodendrocyte differentiation and myelination
Emery, B. (2010) · Science · doi:10.1126/science.1190927 · Cited by 653
Metadata
- Authors
- Zhou, Q., Choi, G., & Anderson, D. J.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2001-09
- Volume
- 31
- Issue
- 5
- Pages
- 791-807
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2146517909
- Cited by
- 605
- References
- 3
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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