Cited by 401Obsessive-Compulsive Spectrum DisordersHair Growth and DisordersGenetics and Neurodevelopmental Disorders

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Hoxb8 Is Required for Normal Grooming Behavior in Mice

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Greer, Joy M., Capecchi, Mario R.·2002·Neuron

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Abstract

Repertoires of grooming behaviors critical to survival are exhibited by most animal species, including humans. Genes that influence this complex behavior are unknown. We report that mice with disruptions of Hoxb8 show, with 100% penetrance, excessive grooming leading to hair removal and lesions. Additionally, these mice excessively groom normal cagemates. We have been unable to detect any skin or PNS abnormalities in Hoxb8 mutants. These observations suggest that the excessive, pathological grooming exhibited by these mice results from CNS abnormalities. Consistent with this interpretation, we demonstrate Hoxb8 expression in regions of the adult mouse CNS previously implicated in the control of grooming. The aberrant behavior observed in Hoxb8 mutants is not unlike that of humans suffering from the OC-spectrum disorder, trichotillomania. Interestingly, Hoxb8 is expressed in regions of the CNS known as the "OCD-circuit."

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Toward a neurobiology of obsessive-compulsive disorder
Graybiel, A. M., & Rauch, S. L. (2000) · Neuron · doi:10.1016/s0896-6273(00)00113-6 · Cited by 864 · cited 1×
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Background
Neuroimaging and frontal–subcortical circuitry in obsessive–compulsive disorder
Saxena, S., Brody, A. L., Schwartz, J. M., & Baxter, L. R. (1998) · British Journal of Psychiatry · doi:10.1192/s0007125000297870 · Cited by 831

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Corrigendum to “Alterations in grooming activity and syntax in heterozygous SERT and BDNF knockout mice: The utility of behavior-recognition tools to characterize mutant mouse phenotypes”
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Authors: Greer, J. M., & Capecchi, M. R.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Capecchi, Mario R.
ORCID: Capecchi, Mario R.
Venue: Neuron
Publisher: Elsevier BV
Published: 2002-01
Volume: 33
Issue: 1
Pages: 23-34
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(01)00564-5
OpenAlex: W2155060440
Cited by: 401
References: 46
Citations by year: 2026: 10 · 2025: 12 · 2024: 14 · 2023: 9 · 2022: 11 · 2021: 22 · 2020: 5 · 2019: 15 · 2018: 14 · 2017: 22 · 2016: 17 · 2015: 19 · 2014: 20 · 2013: 18 · 2012: 25
FWCI: 19.87
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4215 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: Hoxb8, grooming, obsessive-compulsive disorder, trichotillomania, hair removal
MeSH terms: Aging, Alleles, Animals, Animals, Newborn, Behavior, Animal, Bone and Bones, Brain, Brain Chemistry, Disease Models, Animal, Female, Genotype, Grooming, Male, Mice, Neurologic Mutants, Nerve Net, Obsessive-Compulsive Disorder, Phenotype, RNA, Messenger, Skin, Mice, Knockout, Homeodomain Proteins, Mice

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Hoxb8 Is Required for Normal Grooming Behavior in Mice

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