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Cited by 401Obsessive-Compulsive Spectrum DisordersHair Growth and DisordersGenetics and Neurodevelopmental Disorders

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Hoxb8 Is Required for Normal Grooming Behavior in Mice

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Greer, Joy M., Capecchi, Mario R.·2002·Neuron
DOI 10.1016/s0896-6273(01)00564-5
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Abstract

Repertoires of grooming behaviors critical to survival are exhibited by most animal species, including humans. Genes that influence this complex behavior are unknown. We report that mice with disruptions of Hoxb8 show, with 100% penetrance, excessive grooming leading to hair removal and lesions. Additionally, these mice excessively groom normal cagemates. We have been unable to detect any skin or PNS abnormalities in Hoxb8 mutants. These observations suggest that the excessive, pathological grooming exhibited by these mice results from CNS abnormalities. Consistent with this interpretation, we demonstrate Hoxb8 expression in regions of the adult mouse CNS previously implicated in the control of grooming. The aberrant behavior observed in Hoxb8 mutants is not unlike that of humans suffering from the OC-spectrum disorder, trichotillomania. Interestingly, Hoxb8 is expressed in regions of the CNS known as the "OCD-circuit."

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Metadata

Authors
Greer, J. M., & Capecchi, M. R.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Capecchi, Mario R.
ORCID
Capecchi, Mario R.
Venue
Neuron
Publisher
Elsevier BV
Published
2002-01
Volume
33
Issue
1
Pages
23-34
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/s0896-6273(01)00564-5
OpenAlex
W2155060440
Cited by
401
References
46
Citations by year
2026: 10 · 2025: 12 · 2024: 14 · 2023: 9 · 2022: 11 · 2021: 22 · 2020: 5 · 2019: 15 · 2018: 14 · 2017: 22 · 2016: 17 · 2015: 19 · 2014: 20 · 2013: 18 · 2012: 25
FWCI
19.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Health Sciences › Medicine › Dermatology › Hair Growth and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
Hoxb8, grooming, obsessive-compulsive disorder, trichotillomania, hair removal
MeSH terms
Aging, Alleles, Animals, Animals, Newborn, Behavior, Animal, Bone and Bones, Brain, Brain Chemistry, Disease Models, Animal, Female, Genotype, Grooming, Male, Mice, Neurologic Mutants, Nerve Net, Obsessive-Compulsive Disorder, Phenotype, RNA, Messenger, Skin, Mice, Knockout, Homeodomain Proteins, Mice

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