Antagonistic sensory cues generate gustatory plasticity in Caenorhabditis elegans

Hukema, Renate K; Rademakers, Suzanne; Dekkers, Martijn PJ; Burghoorn, Jan; Jansen, Gert

doi:10.1038/sj.emboj.7600940

Cited by 111Neurobiology and Insect Physiology ResearchIon Channels and ReceptorsBiochemical Analysis and Sensing Techniques

Antagonistic sensory cues generate gustatory plasticity in Caenorhabditis elegans

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Hukema, Renate K, Rademakers, Suzanne, Dekkers, Martijn PJ, Burghoorn, Jan, Jansen, Gert·2006·The EMBO Journal

DOI 10.1038/sj.emboj.7600940PMC PMC1383522

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Abstract

Caenorhabditis elegans shows chemoattraction to 0.1-200 mM NaCl, avoidance of higher NaCl concentrations, and avoidance of otherwise attractive NaCl concentrations after prolonged exposure to NaCl (gustatory plasticity). Previous studies have shown that the ASE and ASH sensory neurons primarily mediate attraction and avoidance of NaCl, respectively. Here we show that balances between at least four sensory cell types, ASE, ASI, ASH, ADF and perhaps ADL, modulate the response to NaCl. Our results suggest that two NaCl-attraction signalling pathways exist, one of which uses Ca(2+)/cGMP signalling. In addition, we provide evidence that attraction to NaCl is antagonised by G-protein signalling in the ASH neurons, which is desensitised by the G-protein-coupled receptor kinase GRK-2. Finally, the response to NaCl is modulated by G-protein signalling in the ASI and ADF neurons, a second G-protein pathway in ASH and cGMP signalling in neurons exposed to the body fluid.

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C. elegans CFAP-20 participates in several sensory and physiological processes that depend on various types of non-motile cilia: gustatory plasticity, lifespan control, locomotion (roaming), and body size determination.
“Yet, C. elegans CFAP-20 participates in several sensory and physiological processes that depend on various types of non-motile cilia: ability to sense and learn to avoid salt in the absence of food (gustatory plasticity); lifespan control; locomotion (roaming); and, body size determination40,42,47–51.”
From The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision (2022) · cites this paper as [40]
The paper’s Model for gustatory plasticity section identifies several proteins involved in salt-avoidance plasticity, but does not identify CFAP-20 among them. A search for CFAP-20 found no passage linking it to gustatory plasticity, lifespan, roaming, or body size; the References list mentions other work on body size and lifespan, not a CFAP-20 finding. (LLM, conf=0.78)
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Authors: Hukema, R. K., Rademakers, S., Dekkers, M. P., Burghoorn, J., & Jansen, G.
Affiliations: Erasmus MC (NL)
Corresponding author: Jansen, Gert
ORCID: Hukema, Renate K
Dekkers, Martijn PJ
Jansen, Gert
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 2006-01-12
Volume: 25
Issue: 2
Pages: 312-322
ISSN: 0261-4189 (ISSN-L)
1460-2075
DOI: 10.1038/sj.emboj.7600940
PMC: PMC1383522
OpenAlex: W2164646000
Cited by: 111
References: 60
Citations by year: 2026: 2 · 2025: 9 · 2024: 10 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 3 · 2014: 3 · 2013: 13 · 2012: 5
FWCI: 2.78
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: The EMBO Journal (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords: Caenorhabditis elegans, G protein signaling, cGMP signaling, salt avoidance, biological fluids
MeSH terms: Animals, Calcium, Chemotaxis, Cues, Cyclic GMP, Models, Biological, Neuronal Plasticity, Neurons, Afferent, Sodium Chloride, Species Specificity, Taste, Signal Transduction, Caenorhabditis elegans, GTP-Binding Proteins, beta-Adrenergic Receptor Kinases

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Antagonistic sensory cues generate gustatory plasticity in Caenorhabditis elegans

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