Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory

Emotion circuits in the brain

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Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

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Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

Favata, M. F., Horiuchi, K. Y., Manos, E. J., Daulerio, A. J., Stradley, D. A., Feeser, W. S., Dyk, D. E. V., Pitts, W. J., Earl, R. A., Hobbs, F. W., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18623 · Cited by 3,016

Synaptic Plasticity and Memory: An Evaluation of the Hypothesis

Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794

Molecular basis of long-term plasticity underlying addiction

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Addiction and the brain: The neurobiology of compulsion and its persistence

Hyman, S. E., & Malenka, R. C. (2001) · Nature reviews. Neuroscience · doi:10.1038/35094560 · Cited by 1,337

Addiction, Dopamine, and the Molecular Mechanisms of Memory

Berke, J. D., & Hyman, S. E. (2000) · Neuron · doi:10.1016/s0896-6273(00)81056-9 · Cited by 1,184

Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens

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A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation

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Understanding Ras: ‘it ain’t over ’til it’s over’

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Fear conditioning is associated with altered integration of PLC and ERK signaling in the hippocampus

BUCKLEY, C., & Caldwell, K. E. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.09.013 · Cited by 20

Activation of the ERK signalling pathway contributes to the adaptive changes in rat hearts during naloxone‐induced morphine withdrawal

Almela, P., Milanés, M. V., & Laorden, M. L. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707301 · Cited by 20

Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein

Kretz, P. F., Wagner, C., Mikhaleva, A., Montillot, C., Hugel, S., Morella, I., Kannan, M., Fischer, M., Milhau, M., Yalçın, İ., et al. (2023) · Genome biology · doi:10.1186/s13059-023-03092-8 · Cited by 23

Understanding copy number variations through their genes: a molecular view on 16p11.2 deletion and duplication syndromes

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Memory reconsolidation of an inhibitory avoidance task in mice involves cytosolic ERK2 bidirectional modulation

Krawczyk, M. C., Blake, M. G., Baratti, C. M., Romano, A. G., Boccia, M. M., & Feld, M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.019 · Cited by 19

Enhancing cognition through pharmacological and environmental interventions: Examples from preclinical models of neurodevelopmental disorders

Morè, L., Lauterborn, J. C., Papaleo, F., & Brambilla, R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.02.003 · Cited by 20

Mental retardation and autism associated with recurrent 16p11.2 microdeletion: incomplete penetrance and variable expressivity

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Regulation of ERK1/2 phosphorylation by acute and chronic morphine – implications for the role of cAMP‐responsive element binding factor (CREB)‐dependent and Ets‐like protein‐1 (Elk‐1)‐dependent transcription; small interfering RNA‐based strategy

Ligeza, A., Wawrzczak‐Bargieła, A., Kamińska, D., Korostyński, M., & Przewłocki, R. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06531.x · Cited by 20

Activation of extracellular signal-regulated kinase (ERK) and ΔFosB in emotion-associated neural circuitry after asymptotic levels of active avoidance behavior are attained

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The pleiotropic spectrum of proximal 16p11.2 CNVs

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Animal Models of General Cognitive Ability for Genetic Research into Cognitive Functioning

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In vivo and in vitro attenuation of naloxone-precipitated experimental opioid withdrawal syndrome by insulin and selective KATP channel modulator

Singh, P. K., Sharma, B., Gupta, S., & Sharma, B. M. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3680-5 · Cited by 18

The anterior cingulate ERK pathway contributes to regulation of behavioral excitement and hedonic activity

Creson, T. K., Hao, Y., Engel, S. R., Shen, Y., Hamidi, A., Zhuo, M., Manji, H. K., & Chen, G. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00697.x · Cited by 18

16p11.2 deletion accelerates subpallial maturation and increases variability in human iPSC-derived ventral telencephalic organoids

Fetit, R., Barbato, M. I., Theil, T., Pratt, T., & Price, D. J. (2023) · Development · doi:10.1242/dev.201227 · Cited by 17

Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders

Kim, J., Vanrobaeys, Y. S., Kelvington, B. A., Peterson, Z. J., Baldwin, E., Gaine, M. E., Nickl‐Jockschat, T., & Abel, T. G. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02411-0 · Cited by 19

MAPK activation in the hippocampus in vivo is correlated with experimental setting

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Distinct Roles for Extracellular Signal-Regulated Kinase 1 (ERK1) and ERK2 in the Structure and Production of a Primate Gammaherpesvirus

Woodson, E. N., & Kedes, D. H. (2012) · Journal of Virology · doi:10.1128/jvi.00695-12 · Cited by 17

Dopamine-Glutamate Interactions in Reward-Related Incentive Learning

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Effects of docosanyl ferulate, a constituent of Withania somnifera, on ethanol- and morphine-elicited conditioned place preference and ERK phosphorylation in the accumbens shell of CD1 mice

Maccioni, R., Serra, M., Marongiu, J., Cottiglia, F., Maccioni, E., Bassareo, V., Morelli, M., Kasture, S. B., & Acquas, E. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06069-w · Cited by 17

Acute inhibition of corticostriatal synaptic transmission in the rat dorsal striatum by ethanol

Choi, S. J., Kim, K., Cho, H. S., Kim, S.-Y., Cho, Y. J., Hahn, S. J., & Sung, K.-W. (2006) · Alcohol · doi:10.1016/j.alcohol.2006.12.004 · Cited by 17

Neurons as Immunomodulators: From Rapid Neural Activity to Prolonged Regulation of Cytokines and Microglia

Wood, L. B., & Singer, A. C. (2025) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-110122-120158 · Cited by 17

Relevance of ERK1/2 Post-retrieval Participation on Memory Processes: Insights in Their Particular Role on Reconsolidation and Persistence of Memories

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Gene expression in sheep carotid arteries: major changes with maturational development

Goyal, R., & Longo, L. D. (2012) · Pediatric Research · doi:10.1038/pr.2012.57 · Cited by 16

Copy-Number Variations Associated with Autism Spectrum Disorder

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Psychostimulants, Madness, Memory... and RGS Proteins?

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Cannabidiol decreases motivation for cocaine in a behavioral economics paradigm but does not prevent incubation of craving in mice

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Aromatized testosterone attenuates contextual generalization of fear in male rats

Lynch, J. F., Vanderhoof, T. S., Winiecki, P., Latsko, M. S., Riccio, D. C., & Jasnow, A. M. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.06.007 · Cited by 17

Planar Cell Polarity Gene Mutations in Autism Spectrum Disorder, Intellectual Disabilities, and Related Deletion/Duplication Syndromes

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ERK signaling is required for eye-specific retino-geniculate segregation

Naska, S., Cenni, M. C., Menna, E., & Maffei, L. (2004) · Development · doi:10.1242/dev.01212 · Cited by 14

Signal transduction mechanisms in memory disorders

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Dopaminergic Dysregulation in Prefrontal Cortex of Rhesus Monkeys Following Cocaine Self-Administration

McIntosh, S., Howell, L. L., & Hemby, S. E. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00088 · Cited by 16

Enhanced Dopamine D1 and BDNF Signaling in the Adult Dorsal Striatum but not Nucleus Accumbens of Prenatal Cocaine Treated Mice

Tropea, T. F., Kabir, Z. D., Kaur, G., Rajadhyaksha, A. M., & Kosofsky, B. E. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00067 · Cited by 14

Dorsal Hippocampus ERK2 Signaling Mediates Anxiolytic-Related Behavior in Male Rats

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A novel mouse brain slice preparation of the hippocampo–accumbens pathway

Matthews, R. T., Coker, O., & Winder, D. G. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.02.001 · Cited by 14

B-raf Alternative Splicing Is Dispensable for Development but Required for Learning and Memory Associated with the Hippocampus in the Adult Mouse

Valluet, A., Hmitou, I., Davis, S., Druillennec, S., Larcher, M., Laroche, S., & Eychène, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015272 · Cited by 14

Prefrontal microRNA-221 Mediates Environmental Enrichment-Induced Increase of Locomotor Sensitivity to Nicotine

Gomez, A. M., Altomare, D., Sun, W., Midde, N. M., Ji, H., Shtutman, M. S., Turner, J. R., Creek, K. E., & Zhu, J. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv090 · Cited by 14

Brain region-specific effects of cGMP-dependent kinase II knockout on AMPA receptor trafficking and animal behaviorPreprint

Kim, S., Pick, J. E., Abera, S., Khatri, L., Ferreira, D. D. P., Sathler, M. F., Morison, S. L., Hofmann, F. B., & Ziff, E. B. (2016) · Learning & Memory · doi:10.1101/lm.042960.116 · Cited by 14

Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse

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δ‐Opioid receptors stimulate ERK1/2 activity in NG108‐15 hybrid cells by integrin‐mediated transactivation of TrkA receptors

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STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance

Kim, Y., Kang, Y. M., Park, H.-Y., Lee, J.-R., Yu, D., Murata, T., Gondo, Y., Hwang, J. H., Kim, Y., Lee, C., et al. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.1 · Cited by 12

Atorvastatin Prevents Glutamate Uptake Reduction Induced by Quinolinic Acid Via MAPKs Signaling

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Role of nucleus accumbens μ opioid receptors in the effects of morphine on ERK1/2 phosphorylation

Rosas, M., Porru, S., Fenu, S., Ruiu, S., Peana, A. T., Papale, A., Brambilla, R., Chiara, G. D., & Acquas, E. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4340-8 · Cited by 12

Chronic Nicotine Mitigates Aberrant Inhibitory Motor Learning Induced by Motor Experience under Dopamine Deficiency

Koranda, J. L., Krok, A. C., Xu, J., Contractor, A., McGehee, D. S., Beeler, J. A., & Zhuang, X. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2754-15.2016 · Cited by 13

Targeting Ras/ERK signaling in the striatum: will it help?

Brambilla, R. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001291 · Cited by 12

Mathematical modeling reveals the functional implications of the different nuclear shuttling rates of Erk1 and Erk2

Harrington, H. A., Komorowski, M., Beguerisse-Díaz, M., Ratto, G. M., & Stumpf, M. P. H. (2012) · Physical Biology · doi:10.1088/1478-3975/9/3/036001 · Cited by 11

Development of the fear regulation system from early adolescence to young adulthood in female mice

Matsuda, S., Matsuzawa, D., Ishii, D., Tomizawa, H., & Shimizu, E. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.03.007 · Cited by 11

Differential sensitivity of ethanol-elicited ERK phosphorylation in nucleus accumbens of Sardinian alcohol-preferring and -non preferring rats

Rosas, M., Zaru, A., Sabariego, M., Giugliano, V., Carboni, E., Colombo, G., & Acquas, E. (2014) · Alcohol · doi:10.1016/j.alcohol.2014.04.002 · Cited by 11

NMDAR dependent intracellular responses associated with cocaine conditioned place preference behavior

Nygard, S. K., Klambatsen, A., Balouch, B., Quiñones-Jenab, V., & Jenab, S. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.09.047 · Cited by 11

Region-specific changes in markers of neuroplasticity revealed in HIV-1 transgenic rats by low-dose methamphetamine

Ohene‐Nyako, M., Persons, A. L., & Napier, T. C. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1701-6 · Cited by 11

Prenatal exposure to lambda-cyhalothrin impairs memory in developing rats: Role of NMDA receptor induced post-synaptic signalling in hippocampus

Dhuriya, Y. K., Srivastava, P., Shukla, R. K., Gupta, R., Singh, D., Parmar, D., Pant, A. B., & Khanna, V. K. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.04.011 · Cited by 10

Distinct roles for ERK1 and ERK2 in pathophysiology of CNS

Yu, C. G. (2012) · Frontiers in Biology · doi:10.1007/s11515-012-1220-4 · Cited by 10

Ifenprodil attenuates the acquisition and expression of methamphetamine-induced behavioral sensitization and activation of Ras-ERK1/2 cascade in the caudate putamen

Li, L., Qiao, C., Chen, G., Qian, H., Hou, Y., Li, T., & Liu, X. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.08.022 · Cited by 10

Polymorphism of ERK/PTPRR Genes in Major Depressive Disorder at Resting-State Brain Function

Wang, Y., Li, L., Cheng, X., Cao, X., Liu, Z., Sun, N., Zhang, A., Li, X., & Zhang, K. (2017) · Developmental Neuropsychology · doi:10.1080/87565641.2017.1306527 · Cited by 9

A single amino-acid change in ERK1/2 makes the enzyme susceptible to PP1 derivatives

Endo, S., Satoh, Y., Shah, K., & Takishima, K. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.179 · Cited by 9

Analysis of a Protein Network Related to Copy Number Variations in Autism Spectrum Disorder

Schuch, J. B., Paixão‐Côrtes, V. R., Longo, D., Roman, T., Riesgo, R. D. S., Ranzan, J., Becker, M. M., Riegel, M., & Schüler‐Faccini, L. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01343-7 · Cited by 9

Upregulation of hippocampal extracellular signal-regulated kinase (ERK)–2 induces antidepressant-like behavior in the rat forced swim test.

Iñiguez, S. D., Parise, L. F., Lobo, M. K., Flores‐Ramirez, F. J., Garcia-Carachure, I., Warren, B. L., & Robison, A. J. (2019) · Behavioral Neuroscience · doi:10.1037/bne0000303 · Cited by 9

ERK1/2 protein and mRNA levels in human blood are linked to smoking behavior

Lenz, B., Klafki, H., Hillemacher, T., Frieling, H., Clepce, M., Gossler, A., Thuerauf, N., Winterer, G., Kornhuber, J., & Bleich, S. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00264.x · Cited by 8

Estradiol treatment in preadolescent females enhances adolescent spatial memory and differentially modulates hippocampal region-specific phosphorylated ERK labeling

Wartman, B. C., Keeley, R. J., & Holahan, M. R. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.09.018 · Cited by 8

Combining chemo-, hormonal and targeted therapies to treat breast cancer (Review)

McCubrey, J. A., Bonati, A., Libra, M., Stivala, F., Martelli, A. M., Franklin, R. A., Navolanic, P. M., & Steelman, L. S. (2008) · Molecular Medicine Reports · doi:10.3892/mmr.1.2.139 · Cited by 8

5F peptide promotes endothelial differentiation of bone marrow stem cells through activation of ERK1/2 signaling

Zhang, J., Cui, Y., Li, X., Xiao, Y., Liu, L., Jia, F., He, J., Xie, X., Parthasarathy, S., Hao, H., et al. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173051 · Cited by 8

Fear memory-induced alterations in the mRNA expression of G proteins in the mouse brain and the impact of immediate posttraining treatment with morphine

Zelek-Molik, A., Costanzi, M., Rafa–Zabłocka, K., Kreiner, G., Roman, A., Vetulani, J., Rossi‐Arnaud, C., Cestari, V., & Nalepa, I. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.04.001 · Cited by 8

Inhibition of MEK1 signaling pathway in the liver ameliorates insulin resistance

Ueyama, A., Ban, N., Fukazawa, M., Hirayama, T., Takeda, M., Yata, T., Muramatsu, H., Hoshino, M., Yamamoto, M., Matsuo, M., et al. (2016) · Journal of Diabetes Research · doi:10.1155/2016/8264830 · Cited by 7

Neuregulin1β improves cognitive dysfunction and up-regulates expression of p-ERK1/2 in rats with chronic omethoate poisoning

Rong, L., Ding, K., Zhang, M., & Guo, Y. (2015) · Behavioral and Brain Functions · doi:10.1186/s12993-014-0050-8 · Cited by 7

Partial Rodent Genetic Models for Bipolar Disorder

Chen, G., Henter, I. D., & Manji, H. K. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_63 · Cited by 8

Differential effects of the MEK inhibitor SL327 on the acquisition and expression of ethanol-elicited conditioned place preference and aversion in mice

Rosas, M., Porru, S., Longoni, R., Spina, L., Peana, A. T., Collu, M., & Acquas, E. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116675514 · Cited by 7

Analysis of 5-HT–Induced Short-Term Facilitation atAplysiaSensorimotor Synapse During Bursts: Increased Synaptic Gain That Does Not Require ERK Activation

Phares, G. A., & Byrne, J. H. (2005) · Journal of Neurophysiology · doi:10.1152/jn.01261.2004 · Cited by 7

Extracellular Signal-Regulated Kinase 1 and 2 Are Not Required for GnRH Neuron Development and Normal Female Reproductive Axis Function in Mice

Wierman, M. E., Xu, M., Pierce, A., Bliesner, B., Bliss, S. P., & Roberson, M. S. (2012) · Neuroendocrinology · doi:10.1159/000331389 · Cited by 6

Large-scale analysis of posttranslational modifications in the hippocampus of patients with Alzheimer’s disease using pI shift and label-free quantification without enrichment

Kang, T., Kim, J. H., Hong, I., Park, N., Heinsen, H., Lee, J., Ravid, R., Ferrer, I., Yoo, J. S., Kwon, K., et al. (2014) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-014-7933-2 · Cited by 6

Active avoidance learning differentially activates ERK phosphorylation in the primary auditory and visual cortices of Roman high- and low-avoidance rats

Sabariego, M., Rosas, M., Piludu, M. A., Acquas, E., Giorgi, O., & Corda, M. G. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.12.009 · Cited by 6

Disrupting the Interaction of nNOS with CAPON Prevents the Reinstatement of Morphine Conditioned Place Preference

Kou, X., Xian, J.-Y., Huang, Z., Tao, Y., Lin, Y., Qin, C., Wu, H., Chang, L., Luo, C., & Zhu, D. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab234 · Cited by 5

Molecular mechanism and candidate biomarkers of morphine for analgesia and addiction effects

Wang, T., Chen, X., & Zeng, K. (2022) · Annals of Translational Medicine · doi:10.21037/atm-21-7037 · Cited by 5

Localization and Trafficking of Fluorescently Tagged ERK1 and ERK2

Marchi, M., Parra, R., Costa, M., & Ratto, G. M. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-795-2_17 · Cited by 5

Lactate dynamics in Parkinson’s disease: striatal circuit vulnerability, biomarker potential, and therapeutic windows

Kong, J., Yang, Z., Wang, Y., Liu, L., Liu, Y., & Chen, W. (2026) · Molecular Medicine · doi:10.1186/s10020-026-01551-z · Cited by 4

Synergistic efficacy and diminished adverse effect profile of composite treatment of several ADHD medications

Park, D., Mabunga, D. F. N., Adil, K. J., Ryu, O., Valencia, S. T., Kim, R.-E., Kim, H. J., Cheong, J. H., Kwon, K. J., Kim, H. Y., et al. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108494 · Cited by 5

Proteomic and transcriptomic analysis of visual long-term memory in Drosophila melanogaster

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Spinal glucocorticoid receptor‑regulated chronic morphine tolerance may be through extracellular signal‑regulated kinase 1/2

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The Organization and Integrative Function of the Post-Synaptic Proteome

Grant, S. G. N., Husi, H., Choudhary, J. S., Cumiskey, M. A., Blackstock, W. P., & Armstrong, J. D. (2003) · Springer eBooks · doi:10.1007/978-1-4615-0039-1_2 · Cited by 4

Estradiol and Sex Differences in Generalized Fear

Adkins, J. M., Jasnow, A. M., & Lynch, J. F. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190645908.003.0026 · Cited by 3

Mammalian MAP Kinases

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The Extracellular Signal-Regulated Kinase (ERK) Cascade in Neuronal Cell Signaling

Orellana, D. I., Morella, I., Indrigo, M. T., Papale, A., & Brambilla, R. (2012) · Neuromethods · doi:10.1007/978-1-61779-824-5_8 · Cited by 3

Targeting Survival Cascades Induced by Activation of Ras/Raf/MEK/ERK and PI3K/Akt Pathways to Sensitize Cancer Cells to Therapy

McCubrey, J. A., Franklin, R. A., Bertrand, F. E., Taylor, J. R., Chappell, W. H., Midgett, M. L., Wong, E. W. T., Abrams, S. L., Stadelman, K. M., Misaghian, N., et al. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-474-2_7 · Cited by 3

Characterization of NimA-related Kinase 10 (NEK10): A Role in Checkpoint Control

Moniz, L. S. (2010) · TSpace (University of Toronto) · Cited by 3

Exploring the impact of nonsynonymous SNPs of human MAPK3 gene associated with depression using computational approaches

Chauhan, A., & Jain, C. K. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149801 · Cited by 2

Trimetazidine protects against doxorubicin-induced chemobrain in rats: Insights into energy imbalance and neuroinflammation

Eldmnawy, A. T., Tolba, M. F., Elghazaly, H. A., & Wahdan, S. A. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178339 · Cited by 2

Synaptic Triad in the Neostriatum

Klug, J. R., Deutch, A. Y., Colbran, R. J., & Winder, D. J. (2011) · Frontiers in neuroscience · doi:10.1201/b11284-5 · Cited by 2

Acute Cocaine Differentially Induces PKA Phosphorylation Substrates in Male and Female Rats

Zhou, W.-L. S. L., Vanya, A. N., & Jenab, Q. J. S. (2015) · Journal of Addiction Research & Therapy · doi:10.4172/2155-6105.1000236 · Cited by 2

Spatiotemporal expression of Rap1 and Ras mediates the acquisition and reinstatement of methamphetamine-induced conditioned place preference in mice via extracellular signal-regulated kinase activation

Qian, H., Xiao, J., Shang, Q., Wang, J., Liang, M., Gao, B., Chen, G., Li, T., & Liu, X. (2021) · Neuroreport · doi:10.1097/wnr.0000000000001686 · Cited by 2

Aprepitant as plausible inhibitor of MAPK/ERK2 pathway to ameliorate neurological deficits post traumatic brain injury

Badyal, P., Kaur, H., Dhingra, N., Bhandari, R., & Kuhad, A. (2022) · Medical Hypotheses · doi:10.1016/j.mehy.2022.110909 · Cited by 2

The Role of Mitogen-Activated Protein Kinase in Treatment Strategies for Fear and Drug Addiction

Mary, R., Andrew, J., & Hyun, J. (2012) · InTech eBooks · doi:10.5772/36756 · Cited by 2

ERK1 nucleocytoplasmic shuttling rate depends on specific N-terminal aminoacids

Marchi, M., Pancrazi, L., Maffei, M., Ratto, G. M., & Costa, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.06.044 · Cited by 2

Critical Roles of the Raf/MEK/ERK Pathway in Apoptosis and Drug Resistance

McCubrey, J. A., Bertrand, F. E., Steelman, L. S., Chang, F., Terrian, D. M., & Franklin, R. A. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-199-4_5 · Cited by 2

Cognition in Rodents

Janus, C., Galsworthy, M. J., Wolfer, D. P., & Welzl, H. (2009) · Springer eBooks · doi:10.1007/978-0-387-76727-7_11 · Cited by 2

Algebraic Method for the Analysis of Signaling Crosstalk

Matsubara, Y. J., Kikuchi, S., Sugimoto, M., Oka, K., & Tomita, M. (2008) · Artificial Life · doi:10.1162/artl.2008.14.1.81 · Cited by 2

Mutant Mouse Models of Bipolar Disorder

Dirks, A., Groenink, L., & Olivier, B. (2006) · Contemporary clinical neuroscience · doi:10.1007/978-1-59745-058-4_13 · Cited by 2

Acute Tramadol Administration Induces the Expression of pERK1/2 in Different Limbic and Pain Processing Structures

Omara-Reda, H., Ouachikh, O., Durif, F., & Hafidi, A. (2020) · doi:10.29011/2576-957x.100030 · Cited by 2

Study on the Regulation of Synaptic Function by Ca2+/Calmodulin-dependent Protein Kinase II

Fujishiro, H. (2006) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.126.337 · Cited by 2

Emerging Research towards the Understanding and Treatment of Autism

Wang, P. P., Hammond, R., Postma, F. R., & Healy, A. M. (2012) · Royal Society of Chemistry eBooks · doi:10.1039/9781849734943-00384 · Cited by 1

Contributions of ERK signaling in the striatum to instrumental learning and performance

Shiflett, M. W., & Balleine, B. W. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.12.010 · Cited by 94

Extracellular Signal-Regulated Kinase, Synaptic Plasticity, and Memory

Thiels, E., & Klann, E. (2001) · Reviews in the Neurosciences · doi:10.1515/revneuro.2001.12.4.327 · Cited by 98

Ras-grf1 regulates striatum-dependent behavioural plasticity, long term synaptic signalling and responses to drugs of abuse

FASANO, S. G., Orban, P., Valjent, E., Vara, H., Putignano, E., Centonze, D., A., P., Saulle, E., Maldonado, R. J., Chapman, P., et al. (2004) · Institutional Research Information System University of Turin (University of Turin)

Molecular Psychology: Roles for the ERK MAP Kinase Cascade in Memory

Adams, J. P., & Sweatt, J. D. (2002) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.42.082701.145401 · Cited by 598

Contributions of extracellular-signal regulated kinase 1/2 activity to the memory trace

Ramos, S. O., Feld, M., & Fustiñana, M. S. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.988790 · Cited by 43