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Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory
Open accessAbstract
Extracellular signal-regulated kinases (ERK1 and 2) are synaptic signaling components necessary for several forms of learning. In mice lacking ERK1, we observe a dramatic enhancement of striatum-dependent long-term memory, which correlates with a facilitation of long-term potentiation in the nucleus accumbens. At the cellular level, we find that ablation of ERK1 results in a stimulus-dependent increase of ERK2 signaling, likely due to its enhanced interaction with the upstream kinase MEK. Consistently, such activity change is responsible for the hypersensitivity of ERK1 mutant mice to the rewarding properties of morphine. Our results reveal an unexpected complexity of ERK-dependent signaling in the brain and a critical regulatory role for ERK1 in the long-term adaptive changes underlying striatum-dependent behavioral plasticity and drug addiction.
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“During development, ERK1 and ERK2 have divergent functions since ERK1 null mice are grossly viable and fertile while ERK2 null mice are embryonic lethal7–9.”
From Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse (2019) · cites this paper as [7]
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Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
Pearson, G. W., Robinson, F. L., Gibson, T. B., Xu, B.-E., Karandikar, M. S., Berman, K. S., & Cobb, M. H. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.2.0428 · Cited by 4,111
Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase
Favata, M. F., Horiuchi, K. Y., Manos, E. J., Daulerio, A. J., Stradley, D. A., Feeser, W. S., Dyk, D. E. V., Pitts, W. J., Earl, R. A., Hobbs, F. W., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18623 · Cited by 3,016
Synaptic Plasticity and Memory: An Evaluation of the Hypothesis
Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794
Molecular basis of long-term plasticity underlying addiction
Nestler, E. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35053570 · Cited by 1,893
Addiction and the brain: The neurobiology of compulsion and its persistence
Hyman, S. E., & Malenka, R. C. (2001) · Nature reviews. Neuroscience · doi:10.1038/35094560 · Cited by 1,337
Addiction, Dopamine, and the Molecular Mechanisms of Memory
Berke, J. D., & Hyman, S. E. (2000) · Neuron · doi:10.1016/s0896-6273(00)81056-9 · Cited by 1,184
Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens
Nicola, S. M., Surmeier, D. J., & Malenka, R. C. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.185 · Cited by 931
A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation
English, J. D., & Sweatt, J. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19103 · Cited by 860
Understanding Ras: ‘it ain’t over ’til it’s over’
Shields, J. M., Pruitt, K., McFall, A. J., Maddox, A. S., & Der, C. J. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01740-2 · Cited by 784
Research works printed but not linked: 1
- Pearson, 2001, Mitogen-activated protein (MAP) kinase pathways, Endocr. Rev., 22, 153
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Barruet, E. (2010) · theses.fr (ABES) · doi:10.70675/cec9bcb6zf928z447az86f0z3fd140c4e8c9
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Biever, A. (2016) · theses.fr (ABES) · doi:10.70675/d51e3b2cz4ba2z4930z8686z2d89c7f3949d
Li, W., He, Z., Li, F., & Wu, N. (2026) · Physiology & Behavior · doi:10.1016/j.physbeh.2026.115348
Usluer, E., Ülker, A. Y., & Kaplan, İ. (2026) · Developmental Neurobiology · doi:10.1002/dneu.70038
Martinez‐Finley, E. J. (2010) · UNM’s Digital Repository (University of New Mexico)
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Metadata
- Authors
- Mazzucchelli, C., Vantaggiato, C., Ciamei, A., Fasano, S., Pakhotin, P., Krezel, W., Welzl, H., Wolfer, D. P., Pagès, G., Valverde, O., Marowsky, A., Porrazzo, A., Orban, P. C., Maldonado, R., Ehrengruber, M. U., Cestari, V., Lipp, H.-P., Chapman, P. F., Pouysségur, J., & Brambilla, R.
- Affiliations
- National Research Council (IT)
- Cardiff University (GB)
- University of Zurich (CH)
- Centre National de la Recherche Scientifique (FR)
- Universitat Pompeu Fabra (ES)
- Corresponding author
- Brambilla, Riccardo
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 34
- Issue
- 5
- Pages
- 807-820
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1967318257
- Cited by
- 456
- References
- 41
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 8 · 2020: 11 · 2019: 14 · 2018: 17 · 2017: 15 · 2016: 22 · 2015: 18 · 2014: 23 · 2013: 20 · 2012: 31
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 4095 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- ERK1, ERK2, MEK, MAPK signaling, striatum, synaptic plasticity, long-term potentiation, nucleus accumbens, learning and memory, morphine reward, drug addiction, behavioral plasticity, knockout mice
- MeSH terms
- Amygdala, Animals, Avoidance Learning, Behavior, Animal, Cognition Disorders, Corpus Striatum, Female, Hippocampus, Male, Memory, Morphine, Motor Activity, Mutation, Nerve Net, Nervous System Malformations, Synaptic Transmission, Nucleus Accumbens, Up-Regulation, Presynaptic Terminals, Long-Term Potentiation, Mice, Knockout, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, MAP Kinase Kinase Kinases, Mitogen-Activated Protein Kinase 3, Mice
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