The DOI matches its Crossref record; 180 of the 180 references it cites were found in a registry or an index.
The Human Hippocampus and Spatial and Episodic Memory
Open accessAbstract
Finding one's way around an environment and remembering the events that occur within it are crucial cognitive abilities that have been linked to the hippocampus and medial temporal lobes. Our review of neuropsychological, behavioral, and neuroimaging studies of human hippocampal involvement in spatial memory concentrates on three important concepts in this field: spatial frameworks, dimensionality, and orientation and self-motion. We also compare variation in hippocampal structure and function across and within species. We discuss how its spatial role relates to its accepted role in episodic memory. Five related studies use virtual reality to examine these two types of memory in ecologically valid situations. While processing of spatial scenes involves the parahippocampus, the right hippocampus appears particularly involved in memory for locations within an environment, with the left hippocampus more involved in context-dependent episodic or autobiographical memory.
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In the citing paper
“Intriguingly, similar brain networks to the classic episodic memory network (also replicated in this study with the RM > RO contrast) has also been activated in a variety of other circumstances including navigation (Burgess et al., 2002; Hartley et al., 2003; Spiers and Maguire, 2006), spatial tasks (Maguire et al., 2003; Kumaran and Maguire, 2005), episodic future thinking (Atance and O'Neill, 2”
From Using Imagination to Understand the Neural Basis of Episodic Memory (2007) · cites this paper as Burgess et al., 2002
In the citing paper
“The tolerance to partial losses of spatial information has been proposed to be a key characteristic of the mammalian hippocampus-dependent map-like spatial memory”
From Spatial Cognition in Teleost Fish: Strategies and Mechanisms (2021) · cites this paper as [76]
In the citing paper
“The hippocampus of tetrapods seems to be essential in tasks requiring the formation of a memory of the spatial relationships of multiple elements and cues of the environment and those demanding the flexible expression of previously acquired spatial knowledge [72,73,75,76].”
From Spatial Cognition in Teleost Fish: Strategies and Mechanisms (2021) · cites this paper as [76]
In the citing paper
“In mammals, allocentric navigation is thought to involve the operation of an extended cortico-hippocampal network that conveys highly processed visual and multisensory information to the hippocampal circuits for further processing and transformation into “world-centered” relational spatial representations [74,76,79,188,189,190,191,192].”
From Spatial Cognition in Teleost Fish: Strategies and Mechanisms (2021) · cites this paper as [76]
In the citing paper
“The part of the human brain responsible for this task is also one of the most primitive parts of the brain (Burgess 2002).”
From Beyond replication: the quantification of route models in the north jazira, iraq (2016) · cites this paper as Burgess 2002
In the citing paper
“Based on studies of patients with injury to the medial temporal lobe, it is well-accepted that the hippocampus is crucial to the establishment of episodic memory (Burgess et al., 2002; Eichenbaum, 2013; Squire and Zola-Morgan, 1991; Tulving and Markowitsch, 1998).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Burgess et al., 2002
In the citing paper
“Prior neuropsychological research has consistently indicated the dominance of the right hemisphere in processing spatial information (Spiers et al. 2001; Burgess et al. 2001, 2002)”
From Hippocampal and Retrosplenial Goal Distance Coding After Long-term Consolidation of a Real-World Environment (2019) · cites this paper as Burgess et al. 2002
In the citing paper
“The human hippocampus plays a vital role in the formation of declarative memories, most prominently of which, in the formation of episodic and spatiotemporal memories (Burgess et al., 2002).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Burgess et al., 2002
Citations
Cites
Voxel-Based Morphometry—The Methods
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LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS
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Neurogenesis in the adult human hippocampus
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Place navigation impaired in rats with hippocampal lesions
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The hippocampus as a cognitive map
Passingham, R. E. (1979) · Neuroscience · doi:10.1016/0306-4522(79)90015-0 · Cited by 5,128
The Medial Temporal Lobe Memory System
Squire, L. R., & Zola-Morgan, S. (1991) · Science · doi:10.1126/science.1896849 · Cited by 3,282
Navigation-related structural change in the hippocampi of taxi drivers
Maguire, E. A., Gadian, D. G., Johnsrude, I. S., Good, C. D., Ashburner, J., Frackowiak, R. S. J., & Frith, C. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.070039597 · Cited by 3,225
Self-citationA cortical representation of the local visual environment
Epstein, R. A., & Kanwisher, N. (1998) · Nature · doi:10.1038/33402 · Cited by 3,096
Research works printed but not linked: 3
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- Becker, 2001, A model of spatial recall, mental imagery and neglect, Neural Information Processing Systems, 13, 96
- Maguire, 2000, Patterns of hippocampal-cortical interaction dissociate temporal lobe memory subsystems, Hippocampus, 10, 475, 10.1002/1098-1063(2000)10:4<475::AID-HIPO14>3.0.CO;2-X · DOI
Cited by
Sorted by citations
Memory, navigation and theta rhythm in the hippocampal-entorhinal system
Buzsáki, G., & Moser, E. I. (2013) · Nature Neuroscience · doi:10.1038/nn.3304 · Cited by 1,847
Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Yoo, J., Ho, K. O., Yu, G.-Q., Kreitzer, A., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.025 · Cited by 1,653
Hippocampal volume and depression: a meta-analysis of MRI studies
Videbech, P., & Ravnkilde, B. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.1957 · Cited by 1,590
Eichenbaum (2004) · doi:10.1016/j.neuron.2004.08.028 · Cited by 1,464
What does the retrosplenial cortex do?
Vann, S. D., Aggleton, J. P., & Maguire, E. A. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2733 · Cited by 1,409
Self-citation
Metadata
- Authors
- Burgess, N., Maguire, E. A., & O'Keefe, J.
- Affiliations
- University College London (GB)
- UCL Queen Square Institute of Neurology (GB)
- Corresponding author
- Burgess, Neil
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 35
- Issue
- 4
- Pages
- 625-641
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1970006557
- Cited by
- 2,401
- References
- 180
- Citations by year
- 2026: 79 · 2025: 113 · 2024: 134 · 2023: 113 · 2022: 121 · 2021: 141 · 2020: 138 · 2019: 138 · 2018: 152 · 2017: 135 · 2016: 144 · 2015: 113 · 2014: 119 · 2013: 95 · 2012: 81
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- hippocampus, spatial memory, episodic memory, spatial framework, dimensionality, orientation, self-motion, parahippocampal cortex, right hippocampus, left hippocampus, autobiographical memory, virtual reality, medial temporal lobe
- MeSH terms
- Animals, Hippocampus, Humans, Functional Laterality, Memory, Memory Disorders, Motion Perception, Nerve Net, Orientation, Space Perception, User-Computer Interface, Maze Learning
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