The DOI matches its Crossref record; 46 of the 47 references it cites were found in a registry or an index.
Functional Inactivation of a Fraction of Excitatory Synapses in Mice Deficient for the Active Zone Protein Bassoon
Open accessAbstract
Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites of synaptic vesicle docking and fusion. Our data show that the loss of Bassoon causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses. At these synapses, vesicles are clustered and docked in normal numbers but are unable to fuse. Phenotypically, the loss of Bassoon causes spontaneous epileptic seizures. These data show that Bassoon is not essential for synapse formation but plays an essential role in the regulated neurotransmitter release from a subset of glutamatergic synapses.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Partial knockout of bassoon causes partial lethality and impairs neurotransmitter release (Altrock et al., 2003)”
From The Presynaptic Active Zone (2012) · cites this paper as Altrock et al., 2003
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589
Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,491
The synaptic vesicle cycle: a cascade of protein–protein interactions
Südhof, T. C. (1995) · Nature · doi:10.1038/375645a0 · Cited by 1,991
Tsodyks, M. V., & Markram, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.719 · Cited by 1,634
(1991) · Medical Entomology and Zoology · Cited by 1,512
Short-Term Synaptic Plasticity
Zucker, R. S. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.12.030189.000305 · Cited by 1,450
Synaptic assembly of the brain in the absence of neurotransmitter secretion.
Verhage, M., Maia, A., Plomp, J., Brussaard, A., Heeroma, J., Vermeer, H., Toonen, R., Hammer, R., van den Berg, T. K., Missler, M., et al. (2000) · Science · doi:10.1126/science.287.5454.864 · Cited by 1,387
Definition of the readily releasable pool of vesicles at hippocampal synapses.
Rosenmund, C., & Stevens, C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80146-4 · Cited by 1,084
Self-citationMunc13-1 is essential for fusion competence of glutamatergic synaptic vesicles
Augustin, I., Rosenmund, C., Südhof, T. C., & Brose, N. (1999) · Nature · doi:10.1038/22768 · Cited by 787
Self-citation
Research works printed but not linked: 1
- Dresbach, 2003, Functional regions of the presynaptic cytomatrix protein Bassoon, Mol. Cell. Neurosci., in press
Cited by
Sorted by citations
Südhof, T. C. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.012 · Cited by 1,062
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Rietveld, C. A., Medland, S. E., Derringer, J., Yang, J., Esko, T., Martin, N. W., Westra, H.-J., Shakhbazov, K., Abdellaoui, A., Agrawal, A., et al. (2013) · Science · doi:10.1126/science.1235488 · Cited by 827
Bruchpilot Promotes Active Zone Assembly, Ca 2+ Channel Clustering, and Vesicle Release
Kittel, R. J., Wichmann, C., Rasse, T. M., Fouquet, W., Schmidt, M., Schmid, A., Wagh, D. A., Pawlu, C., Kellner, R. R., Willig, K. I., et al. (2006) · Science · doi:10.1126/science.1126308 · Cited by 772
Hair cell synaptic ribbons are essential for synchronous auditory signalling
Khimich, D., Nouvian, R., Pujol, R., Dieck, S. T., Egner, A., Gundelfinger, E. D., & Moser, T. (2005) · Nature · doi:10.1038/nature03418 · Cited by 583
Self-citationVesicular Glutamate Transporters 1 and 2 Target to Functionally Distinct Synaptic Release Sites
Fremeau, R. T., Kam, K., Qureshi, T., Johnson, J., Copenhagen, D. R., Storm‐Mathisen, J., Chaudhry, F. A., Nicoll, R. A., & Edwards, R. H. (2004) · Science · doi:10.1126/science.1097468 · Cited by 504
Metadata
- Authors
- Altrock, W. D., tom Dieck, S., Sokolov, M., Meyer, A. C., Sigler, A., Brakebusch, C., Fässler, R., Richter, K., Boeckers, T. M., Potschka, H., Brandt, C., Löscher, W., Grimberg, D., Dresbach, T., Hempelmann, A., Hassan, H., Balschun, D., Frey, J. U., Brandstätter, J. H., Garner, C. C., Rosenmund, C., & Gundelfinger, E. D.
- Affiliations
- Leibniz Institute for Neurobiology (DE)
- Max Planck Institute for Biophysical Chemistry (DE)
- Max Planck Society (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- University of Münster (DE)
- University of Veterinary Medicine Hannover, Foundation (DE)
- Max Planck Institute for Brain Research (DE)
- Stanford University (US)
- Corresponding author
- Gundelfinger, Eckart D.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 37
- Issue
- 5
- Pages
- 787-800
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2091013445
- Cited by
- 258
- References
- 47
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 11 · 2021: 7 · 2020: 11 · 2019: 8 · 2018: 8 · 2017: 13 · 2016: 9 · 2015: 9 · 2014: 11 · 2013: 14 · 2012: 13
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (5p01ag006569-13, 5p50hd032901-05)
- National Institute on Aging (P01 AG06569)
- National Institute of Neurological Disorders and Stroke (R01NS039471, R01-NS39471)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50 HD32901)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- bassoon, active zone, excitatory synapses, glutamatergic synapses, synaptic vesicle fusion, synaptic vesicle docking, synaptic transmission, synaptogenesis, mouse mutants
- MeSH terms
- Animals, Cells, Cultured, Hippocampus, Male, Mice, Mutant Strains, Mutation, Nerve Tissue Proteins, Neurons, Synapses, Excitatory Postsynaptic Potentials, Gene Silencing, Mice, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
