Boeckers, Tobias M.

Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders

Durand, C. M., Betancur, C., Boeckers, T. M., Bockmann, J., Chaste, P., Fauchereau, F., Nygren, G., Rastam, M., Gillberg, I. C., Anckarsäter, H., et al. (2007) · Nature Genetics

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 1,602

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

Freischmidt, A., Wieland, T., Richter, B., Ruf, W., Schaeffer, V., Müller, K., Marroquin, N., Nordin, F., Hübers, A., Weydt, P., et al. (2015) · Nature Neuroscience

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 786

Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2

Schmeisser, M. J., Ey, E., Wegener, S., Bockmann, J., Stempel, A. V., Kuebler, A., Janssen, A.-L., Udvardi, P. T., Shiban, E., Spilker, C., et al. (2012) · Nature

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 638

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments

Leblond, C. S., Nava, C., Polge, A., Gauthier, J., Huguet, G., Lumbroso, S., Giuliano, F., Stordeur, C., Depienne, C., Mouzat, K., et al. (2014) · PLoS Genetics

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 630

Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders

Leblond, C. S., Heinrich, J., Delorme, R., Proepper, C., Betancur, C., Huguet, G., Konyukh, M., Chaste, P., Ey, E., Rastam, M., et al. (2012) · PLoS Genetics

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 429

ProSAP/Shank proteins – a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease

Boeckers, T. M., Bockmann, J., Kreutz, M. R., & Gundelfinger, E. D. (2002) · Journal of Neurochemistry

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 349

An Architectural Framework That May Lie at the Core of the Postsynaptic Density

Baron, M. K., Boeckers, T. M., Vaida, B., Faham, S., Gingery, M., Sawaya, M. R., Salyer, D., Gundelfinger, E. D., & Bowie, J. U. (2006) · Science

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 292

Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation

Naumann, M., Pal, A., Goswami, A., Lojewski, X., Japtok, J., Vehlow, A., Naujock, M., Günther, R., Jin, M., Stanslowsky, N., et al. (2018) · Nature Communications

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

Cited by 275

Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon

Altrock, W. D., tom Dieck, S., Sokolov, M., Meyer, A. C., Sigler, A., Brakebusch, C., Fässler, R., Richter, K., Boeckers, T. M., Potschka, H., et al. (2003) · Neuron

Neuroscience and Neuropharmacology ResearchCellular transport and secretion

Cited by 258

Proline-Rich Synapse-Associated Protein-1/Cortactin Binding Protein 1 (ProSAP1/CortBP1) Is a PDZ-Domain Protein Highly Enriched in the Postsynaptic Density

Boeckers, T. M., Kreutz, M. R., Winter, C., Zuschratter, W., Smalla, K.-H., Sanmarti-Vila, L., Wex, H., Langnaese, K., Bockmann, J., Garner, C. C., et al. (1999) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 257

Postsynaptic ProSAP/Shank scaffolds in the cross-hair of synaptopathies

Grabrucker, A. M., Schmeisser, M. J., Schoen, M., & Boeckers, T. M. (2011) · Trends in Cell Biology

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 233

Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation

Grabrucker, A. M., Knight, M. J., Proepper, C., Bockmann, J., Joubert, M., Rowan, M., Nienhaus, G. U., Garner, C. C., Bowie, J. U., Kreutz, M. R., et al. (2011) · The EMBO Journal

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 228

Neurocan Is Dispensable for Brain Development

Zhou, X.-H., Brakebusch, C., Matthies, H., Oohashi, T., Hirsch, E., Moser, M., Krug, M., Seidenbecher, C. I., Boeckers, T. M., Rauch, U., et al. (2001) · Molecular and Cellular Biology

Proteoglycans and glycosaminoglycans researchNeurogenesis and neuroplasticity mechanisms

Cited by 206

Proline-Rich Synapse-Associated Proteins ProSAP1 and ProSAP2 Interact with Synaptic Proteins of the SAPAP/GKAP Family

Boeckers, T. M., Winter, C., Smalla, K.-H., Kreutz, M. R., Bockmann, J., Seidenbecher, C., Garner, C. C., & Gundelfinger, E. D. (1999) · Biochemical and Biophysical Research Communications

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 200

Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders

Grabrucker, S., Jannetti, L., Eckert, M., Gaub, S., Chhabra, R., Pfaender, S., Mangus, K., Reddy, P. P., Rankovic, V., Schmeisser, M. J., et al. (2014) · Brain

Genetics and Neurodevelopmental DisordersTrace Elements in Health

Cited by 175

Linkage of the Actin Cytoskeleton to the Postsynaptic Density via Direct Interactions of Abp1 with the ProSAP/Shank Family

Qualmann, B., Boeckers, T. M., Jeromin, M., Gundelfinger, E. D., & Kessels, M. M. (2004) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 134

Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation

Proepper, C., Johannsen, S., Liebau, S., Dahl, J., Vaida, B., Bockmann, J., Kreutz, M. R., Gundelfinger, E. D., & Boeckers, T. M. (2007) · The EMBO Journal

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 124

C‐terminal synaptic targeting elements for postsynaptic density proteins ProSAP1/Shank2 and ProSAP2/Shank3

Boeckers, T. M., Liedtke, T., Spilker, C., Dresbach, T., Bockmann, J., Kreutz, M. R., & Gundelfinger, E. D. (2005) · Journal of Neurochemistry

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 113

A role for zinc in postsynaptic density asSAMbly and plasticity?

Gundelfinger, E. D., Boeckers, T. M., Baron, M. K., & Bowie, J. U. (2006) · Trends in Biochemical Sciences

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 98

Scaffold Proteins at the Postsynaptic Density

Verpelli, C., Schmeisser, M. J., Sala, C., & Boeckers, T. M. (2012) · Advances in Experimental Medicine and Biology

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 92

Temporal-spatial expression and novel biochemical properties of the memory-related protein KIBRA

Johannsen, S., Duning, K., Pavenstädt, H., Kremerskothen, J., & Boeckers, T. M. (2008) · Neuroscience

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 91

TBX3 Directs Cell-Fate Decision toward Mesendoderm

Weidgang, C. E., Russell, R., Tata, P. R., Kühl, S. J., Illing, A., Müller, M., Lin, Q., Brunner, C., Boeckers, T. M., Bauer, K., et al. (2013) · Stem Cell Reports

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 78

Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to-cell transport

Tosi, G., Vilella, A., Chhabra, R., Schmeisser, M. J., Boeckers, T. M., Ruozi, B., Vandelli, M. A., Forni, F., Zoli, M., & Grabrucker, A. M. (2014) · Journal of Controlled Release

Nanoparticle-Based Drug DeliveryBarrier Structure and Function Studies

Cited by 56

Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS

Aly, A., Laszlo, Z. I., Rajkumar, S., Demir, T., Hindley, N., Lamont, D. J., Lehmann, J., Seidel, M., Sommer, D., Franz-Wachtel, M., et al. (2023) · Acta Neuropathologica

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 21