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Synaptic Transmission and Plasticity in the Absence of AMPA Glutamate Receptor GluR2 and GluR3
Open accessAbstract
The AMPA glutamate receptor (AMPAR) subunits GluR2 and GluR3 are thought to be important for synaptic targeting/stabilization of AMPARs and the expression of hippocampal long-term depression (LTD). In order to address this hypothesis genetically, we generated and analyzed knockout mice deficient in the expression of both GluR2 and GluR3. We show here that the double knockout mice are severely impaired in basal synaptic transmission, demonstrating that GluR2/3 are essential to maintain adequate synaptic transmission in vivo. However, these mutant mice are competent in establishing several forms of long-lasting synaptic changes in the CA1 region of the hippocampus, including LTD, long-term potentiation (LTP), depotentiation, and dedepression, indicating the presence of GluR2/3-independent mechanisms of LTD expression and suggesting that AMPA receptor GluR1 alone is capable of various forms of synaptic plasticity.
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“Hippocampal LTD is still observed in knock-outs of GluA2/3 (Meng et al., 2003), but not in neurons expressing GluA2 fused to the GluA1 C-tail (Zhou et al., 2017).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Meng et al., 2003
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Glutamate Receptor Ion Channels: Structure, Regulation, and Function
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AMPA receptor trafficking at excitatory synapses
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Metadata
- Authors
- Meng, Y., Zhang, Y., & Jia, Z.
- Affiliations
- University of Toronto (CA)
- Hospital for Sick Children (CA)
- Corresponding author
- Jia, Zhengping
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2003-07
- Volume
- 39
- Issue
- 1
- Pages
- 163-176
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2056366478
- Cited by
- 251
- References
- 56
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 2 · 2018: 12 · 2017: 14 · 2016: 10 · 2015: 6 · 2014: 11 · 2013: 13 · 2012: 12
- FWCI
- 5.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- AMPA receptors, GluR2, GluR3, GluR1, synaptic transmission, synaptic plasticity, long-term depression, long-term potentiation, depotentiation, hippocampal CA1, knockout mice, synaptic targeting
- MeSH terms
- Animals, Electrophysiology, Female, Hippocampus, Immunohistochemistry, Male, Microscopy, Electron, Synaptic Transmission, Neuronal Plasticity, Organ Culture Techniques, Immunoblotting, Long-Term Potentiation, Receptors, AMPA, Mice, Knockout, Excitatory Postsynaptic Potentials, Long-Term Synaptic Depression, Mice
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