Cited by 251Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsGenetics and Neurodevelopmental Disorders

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Synaptic Transmission and Plasticity in the Absence of AMPA Glutamate Receptor GluR2 and GluR3

Open access

Meng, Yanghong, Zhang, Yu, Jia, Zhengping·2003·Neuron

DOI 10.1016/s0896-6273(03)00368-4

Open this paper in CoChat — free account Open PDF

Abstract

The AMPA glutamate receptor (AMPAR) subunits GluR2 and GluR3 are thought to be important for synaptic targeting/stabilization of AMPARs and the expression of hippocampal long-term depression (LTD). In order to address this hypothesis genetically, we generated and analyzed knockout mice deficient in the expression of both GluR2 and GluR3. We show here that the double knockout mice are severely impaired in basal synaptic transmission, demonstrating that GluR2/3 are essential to maintain adequate synaptic transmission in vivo. However, these mutant mice are competent in establishing several forms of long-lasting synaptic changes in the CA1 region of the hippocampus, including LTD, long-term potentiation (LTP), depotentiation, and dedepression, indicating the presence of GluR2/3-independent mechanisms of LTD expression and suggesting that AMPA receptor GluR1 alone is capable of various forms of synaptic plasticity.

Integrity signals

Registry

Crossref · 10.1016/s0896-6273(03)00368-4

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Cloned Glutamate Receptors
Hollmann, M., & Heinemann, S. F. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.000335 · Cited by 4,056
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.
Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W., & Roder, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8424 · Cited by 2,328
Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction
Hayashi, Y., Shi, S.-H., Esteban, J. A., Piccini, A., Poncer, J.-C., & Malinow, R. (2000) · Science · doi:10.1126/science.287.5461.2262 · Cited by 1,524
Rapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation
Shi, S.-H., Hayashi, Y., Petralia, R. S., Zaman, S. H., Wenthold, R. J., Svoboda, K., & Malinow, R. (1999) · Science · doi:10.1126/science.284.5421.1811 · Cited by 1,276
Subunit-Specific Rules Governing AMPA Receptor Trafficking to Synapses in Hippocampal Pyramidal Neurons
Shi, S.-H., Hayashi, Y., Esteban, J. A., & Malinow, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00321-x · Cited by 1,094
GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors
Dong, H., O’Brien, R., Fung, E. T., Lanahan, A. A., Worley, P. F., & Huganir, R. L. (1997) · Nature · doi:10.1038/386279a0 · Cited by 888
Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons
Wenthold, R., Petralia, R., Blahos J, II, & Niedzielski, A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-01982.1996 · Cited by 850
Regulation of AMPA receptors during synaptic plasticity
Song, I., & Huganir, R. L. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02270-1 · Cited by 798
Importance of AMPA Receptors for Hippocampal Synaptic Plasticity But Not for Spatial Learning
Zamanillo, D., Sprengel, R., Hvalby, Ø., Jensen, V., Burnashev, N., Rozov, A., Kaiser, K. M. M., Köster, H. J., Borchardt, T., Worley, P., et al. (1999) · Science · doi:10.1126/science.284.5421.1805 · Cited by 791
Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD
Beattie, E. C., Carroll, R. C., Yu, X., Morishita, W., Yasuda, H., von Zastrow, M., & Malenka, R. C. (2000) · Nature Neuroscience · doi:10.1038/81823 · Cited by 745
Postsynaptic signaling and plasticity mechanisms
Sheng, M., & Kim, M. J. (2002) · Science · doi:10.1126/science.1075333 · Cited by 731
Regulation of AMPA Receptor–Mediated Synaptic Transmission by Clathrin-Dependent Receptor Internalization
Man, H., Lin, J., Ju, W. H., Ahmadian, G., Liu, L., Becker, L. E., Sheng, M., & Wang, Y. T. (2000) · Neuron · doi:10.1016/s0896-6273(00)81067-3 · Cited by 711
Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity
Lüscher, C., Xia, H., Beattie, E. C., Carroll, R. C., von Zastrow, M., Malenka, R. C., & Nicoll, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)81119-8 · Cited by 692
Abnormal Spine Morphology and Enhanced LTP in LIMK-1 Knockout Mice
Meng, Y., Zhang, Y., Tregoubov, V., Janus, C., Cruz, L., Jackson, M., Lu, W.-Y., MacDonald, J. F., Wang, J. Y., Falls, D. L., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00758-4 · Cited by 688
Self-citation
Synaptic plasticity and dynamic modulation of the postsynaptic membrane
Lüscher, C., Nicoll, R. A., Malenka, R. C., & Müller, D. (2000) · Nature Neuroscience · doi:10.1038/75714 · Cited by 662
Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons
Passafaro, M., Piëch, V., & Sheng, M. (2001) · Nature Neuroscience · doi:10.1038/nn0901-917 · Cited by 655
Long-Term Depression in Hippocampus
Bear, M. F., & Abraham, W. C. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.002253 · Cited by 616
Two Distinct Forms of Long-Term Depression Coexist in CA1 Hippocampal Pyramidal Cells
Oliet, S. H. R., Malenka, R. C., & Nicoll, R. A. (1997) · Neuron · doi:10.1016/s0896-6273(00)80336-0 · Cited by 578
Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization
Lin, J., Ju, W. H., Foster, K. A., Lee, S. H., Ahmadian, G., Wyszynski, M. W., Wang, Y. T., & Sheng, M. (2000) · Nature Neuroscience · doi:10.1038/81814 · Cited by 562
Clustering of AMPA Receptors by the Synaptic PDZ Domain–Containing Protein PICK1
Xia, J., Zhang, X., Staudinger, J. L., & Huganir, R. L. (1999) · Neuron · doi:10.1016/s0896-6273(00)80689-3 · Cited by 561
Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins
Chung, H. J., Xia, J., Scannevin, R. H., Zhang, X., & Huganir, R. L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07258.2000 · Cited by 558
NSF Binding to GluR2 Regulates Synaptic Transmission
Nishimune, A., Isaac, J. T. R., Molnár, E., Noël, J., Nash, S. R., Tagaya, M., Collingridge, G. L., Nakanishi, S., & Henley, J. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80517-6 · Cited by 545
Enhanced LTP in Mice Deficient in the AMPA Receptor GluR2
Jia, Z., Agopyan, N., Miu, P., Xiong, Z., Henderson, J., Gerlai, R. T., Taverna, F. A., Velumian, A. A., MacDonald, J. F., Carlen, P. L., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80225-1 · Cited by 497
Self-citation
Expression of Cerebellar Long-Term Depression Requires Postsynaptic Clathrin-Mediated Endocytosis
Wang, Y. T., & Linden, D. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)81066-1 · Cited by 484
Role of ampa receptor endocytosis in synaptic plasticity
Carroll, R. C., Beattie, E. C., von Zastrow, M., & Malenka, R. C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35072500 · Cited by 448
Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD
Lee, S. H., Liu, L., Wang, Y. T., & Sheng, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01024-3 · Cited by 441
Postnatal synaptic potentiation: delivery of GluR4-containing AMPA receptors by spontaneous activity
Zhu, J. J., Esteban, J. A., Hayashi, Y., & Malinow, R. (2000) · Nature Neuroscience · doi:10.1038/80614 · Cited by 437
Dynamin-dependent endocytosis of ionotropic glutamate receptors
Carroll, R. C., Beattie, E. C., Xia, H., Lüscher, C., Altschuler, Y., Nicoll, R. A., Malenka, R. C., & von Zastrow, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.14112 · Cited by 423
SAP97 Is Associated with the α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor GluR1 Subunit
Leonard, A. S., Davare, M. A., Horne, M. C., Garner, C. C., & Hell, J. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.31.19518 · Cited by 421
Interaction of the N-Ethylmaleimide–Sensitive Factor with AMPA Receptors
Song, I., Kamboj, S. K., Xia, J., Dong, H., Liao, D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80548-6 · Cited by 399
Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins
Xia, J., Chung, H. J., Wihler, C., Huganir, R. L., & Linden, D. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)00128-8 · Cited by 383
Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression
Kim, C., Chung, H. J., Lee, H., & Huganir, R. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211132798 · Cited by 364
Novel Anchorage of GluR2/3 to the Postsynaptic Density by the AMPA Receptor–Binding Protein ABP
Srivastava, S., Osten, P., Vilim, F. S., Khatri, L., Inman, G. J., States, B. A., Daly, C., deSouza, S., Abagyan, R. A., Valtschanoff, J. G., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80568-1 · Cited by 360
The AMPA Receptor GluR2 C Terminus Can Mediate a Reversible, ATP-Dependent Interaction with NSF and α- and β-SNAPs
Osten, P., Srivastava, S., Inman, G. J., Vilim, F. S., Khatri, L., Lee, L. M., States, B. A., Einheber, S., Milner, T. A., Hanson, P. I., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80518-8 · Cited by 358
RNA Editing at Arg607 Controls AMPA Receptor Exit from the Endoplasmic Reticulum
Greger, I. H., Khatri, L., & Ziff, E. B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00693-1 · Cited by 350
PICK1 Targets Activated Protein Kinase Cα to AMPA Receptor Clusters in Spines of Hippocampal Neurons and Reduces Surface Levels of the AMPA-Type Glutamate Receptor Subunit 2
Perez, J. L., Khatri, L., Chang, C., Srivastava, S., Osten, P., & Ziff, E. B. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05417.2001 · Cited by 330
PDZ Proteins Interacting with C-Terminal GluR2/3 Are Involved in a PKC-Dependent Regulation of AMPA Receptors at Hippocampal Synapses
Daw, M. I., Chittajallu, R., Bortolotto, Z. A., Dev, K. K., Duprat, F., Henley, J. M., Collingridge, G. L., & Isaac, J. T. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00160-4 · Cited by 323
Receptor trafficking and the plasticity of excitatory synapses
Barry, M. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00329-x · Cited by 310
Regulation of AMPA Receptor GluR1 Subunit Surface Expression by a 4.1N-Linked Actin Cytoskeletal Association
Shen, L., Liang, F., Walensky, L. D., & Huganir, R. L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-07932.2000 · Cited by 305
Surface Expression of AMPA Receptors in Hippocampal Neurons Is Regulated by an NSF-Dependent Mechanism
Noël, J., Ralph, G. S., Pickard, L., Williams, J., Molnár, E., Uney, J. B., Collingridge, G. L., & Henley, J. M. (1999) · Neuron · doi:10.1016/s0896-6273(00)80786-2 · Cited by 298
Hippocampal LTD Expression Involves a Pool of AMPARs Regulated by the NSF–GluR2 Interaction
Lüthi, A., Chittajallu, R., Duprat, F., Palmer, M. J., Benke, T. A., Kidd, F. L., Henley, J. M., Isaac, J. T. R., & Collingridge, G. L. (1999) · Neuron · doi:10.1016/s0896-6273(00)80852-1 · Cited by 298
Mutagenesis Reveals a Role for ABP/GRIP Binding to GluR2 in Synaptic Surface Accumulation of the AMPA Receptor
Osten, P., Khatri, L., Perez, J. L., Köhr, G., Giese, G., Daly, C., Schulz, T. W., Wensky, A. K., Lee, L. M., & Ziff, E. B. (2000) · Neuron · doi:10.1016/s0896-6273(00)00039-8 · Cited by 295
LTP of AMPA and NMDA Receptor–Mediated Signals: Evidence for Presynaptic Expression and Extrasynaptic Glutamate Spill-Over
Kullmann, D. M., Erdemli, G., & Asztély, F. (1996) · Neuron · doi:10.1016/s0896-6273(00)80178-6 · Cited by 289
Disruption of AMPA receptor GluR2 clusters following long‐term depression induction in cerebellar Purkinje neurons
Matsuda, S., Launey, T., Mikawa, S., & Hirai, H. (2000) · The EMBO Journal · doi:10.1093/emboj/19.12.2765 · Cited by 275
Phosphorylation of Serine‐880 in GluR2 by Protein Kinase C Prevents Its C Terminus from Binding with Glutamate Receptor‐Interacting Protein
Matsuda, S., Mikawa, S., & Hirai, H. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.731765.x · Cited by 263
Characterization of the Glutamate Receptor-Interacting Proteins GRIP1 and GRIP2
Dong, H., Zhang, P., Song, I., Petralia, R. S., Liao, D., & Huganir, R. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-16-06930.1999 · Cited by 243
The protein kinase Cα binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits
Dev, K. K., Nishimune, A., Henley, J. M., & Nakanishi, S. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(98)00230-5 · Cited by 212
NSF ATPase and α-/β-SNAPs Disassemble the AMPA Receptor-PICK1 Complex
Hanley, J. G., Khatri, L., Hanson, P. I., & Ziff, E. B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00638-4 · Cited by 197
Differential roles for NSF and GRIP/ABP in AMPA receptor cycling
Braithwaite, S. P., Xia, H., & Malenka, R. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102156099 · Cited by 131
Interactions between AMPA receptors and intracellular proteins
Braithwaite, S. P., Meyer, G. R. Y. D., & Henley, J. M. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(99)00171-9 · Cited by 83
Use-dependent AMPA receptor block in mice lacking GluR2 suggests postsynaptic site for LTP expression
Mainen, Z. F., Jia, Z., Roder, J., & Malinow, R. (1998) · Nature Neuroscience · doi:10.1038/2812 · Cited by 67
Self-citation
CBP7 codes for a co‐factor required in conjunction with a mitochondrial maturase for splicing of its cognate intervening sequence.
Muroff, I., & Tzagoloff, A. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07464.x · Cited by 40
AMPA receptor attrition in long-term depression.
Kullmann, D. (1999) · Neuron · doi:10.1016/s0896-6273(00)80841-7 · Cited by 7

Sorted by citations

LTP and LTD
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms
Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323
AMPA receptor trafficking at excitatory synapses
Bredt, D. S., & Nicoll, R. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00640-8 · Cited by 1,150
Synaptic AMPA receptor plasticity and behavior
Kessels, H. W., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.015 · Cited by 993

See all 251

Authors: Meng, Y., Zhang, Y., & Jia, Z.
Affiliations: University of Toronto (CA)
Hospital for Sick Children (CA)
Corresponding author: Jia, Zhengping
ORCID: Zhang, Yu
Jia, Zhengping
Venue: Neuron
Publisher: Elsevier BV
Published: 2003-07
Volume: 39
Issue: 1
Pages: 163-176
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(03)00368-4
OpenAlex: W2056366478
Cited by: 251
References: 56
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 2 · 2018: 12 · 2017: 14 · 2016: 10 · 2015: 6 · 2014: 11 · 2013: 13 · 2012: 12
FWCI: 5.61
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3669 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: AMPA receptors, GluR2, GluR3, GluR1, synaptic transmission, synaptic plasticity, long-term depression, long-term potentiation, depotentiation, hippocampal CA1, knockout mice, synaptic targeting
MeSH terms: Animals, Electrophysiology, Female, Hippocampus, Immunohistochemistry, Male, Microscopy, Electron, Synaptic Transmission, Neuronal Plasticity, Organ Culture Techniques, Immunoblotting, Long-Term Potentiation, Receptors, AMPA, Mice, Knockout, Excitatory Postsynaptic Potentials, Long-Term Synaptic Depression, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Synaptic Transmission and Plasticity in the Absence of AMPA Glutamate Receptor GluR2 and GluR3

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks