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Neuronal Adaptation to Visual Motion in Area MT of the Macaque
Open accessAbstract
The responsivity of primary sensory cortical neurons is reduced following prolonged adaptation, but such adaptation has been little studied in higher sensory areas. Adaptation to visual motion has strong perceptual effects, so we studied the effect of prolonged stimulation on neuronal responsivity in the macaque's area MT, a cortical area whose importance to visual motion perception is well established. We adapted MT neurons with sinusoidal gratings drifting in the preferred or null direction. Preferred adaptation reduced the responsiveness of MT cells, primarily by changing their contrast gain, and this effect was spatially specific within the receptive field. Null adaptation reduced the ability of null gratings to inhibit the response to a simultaneously presented preferred stimulus. While both preferred and null adaptation alter MT responses, these effects probably do not occur in MT neurons but are likely to reflect adaptation-induced changes in contrast gain earlier in the visual pathway.
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“Adaptation enables high sensitivity to small changes in stimulus features over a large range of intensities, and is found across sensory systems5,17,26,105,210–216.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [213]
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Cites
Spatiotemporal energy models for the perception of motion
Adelson, E. H., & Bergen, J. R. (1985) · Journal of the Optical Society of America A · doi:10.1364/josaa.2.000284 · Cited by 3,442
Normalization of cell responses in cat striate cortex
Heeger, D. J. (1992) · Visual Neuroscience · doi:10.1017/s0952523800009640 · Cited by 1,835
Synaptic depression and cortical gain control
Abbott, L. F., Varela, J. A., Sen, K., & Nelson, S. B. (1997) · Science · doi:10.1126/science.275.5297.221 · Cited by 1,690
Tsodyks, M. V., & Markram, H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.719 · Cited by 1,634
Maunsell, J., & van Essen, D. (1983) · The Journal of Neuroscience · doi:10.1523/jneurosci.03-12-02563.1983 · Cited by 1,602
Maunsell, J. H. R., & Essen, D. C. V. (1983) · Journal of Neurophysiology · doi:10.1152/jn.1983.49.5.1127 · Cited by 1,462
Neuronal correlates of a perceptual decision
Newsome, W. T., Britten, K. H., & Movshon, J. A. (1989) · Nature · doi:10.1038/341052a0 · Cited by 1,177
Self-citationZeki, S. (1974) · The Journal of Physiology · doi:10.1113/jphysiol.1974.sp010452 · Cited by 982
A model of neuronal responses in visual area MT
Simoncelli, E. P., & Heeger, D. J. (1998) · Vision Research · doi:10.1016/s0042-6989(97)00183-1 · Cited by 941
Silver Staining of Myelin by Means of Physical Development
Gallyas, F. (1979) · Neurological Research · doi:10.1080/01616412.1979.11739553 · Cited by 936
Chapter 9 Visual adaptation and retinal gain controls
Shapley, R. M., & Enroth‐Cugell, C. (1984) · Progress in Retinal Research · doi:10.1016/0278-4327(84)90011-7 · Cited by 888
Nature and Interaction of Signals From the Receptive Field Center and Surround in Macaque V1 Neurons
Cavanaugh, J. R., Bair, W., & Movshon, J. A. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00692.2001 · Cited by 784
Self-citationCoding of image contrast in central visual pathways of the macaque monkey
Sclar, G., Maunsell, J. H. R., & Lennie, P. (1990) · Vision Research · doi:10.1016/0042-6989(90)90123-3 · Cited by 663
Tootell, R. B. H., Reppas, J. B., Dale, A. M., Look, R. B., Sereno, M. I., Malach, R., Brady, T. J., & Rosen, B. R. (1995) · Nature · doi:10.1038/375139a0 · Cited by 659
Microstimulation in visual area MT: effects on direction discrimination performance
Salzman, C., Murasugi, C., Britten, K., & Newsome, W. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-06-02331.1992 · Cited by 657
Glass-coated platinum-plated tungsten microelectrodes
Merrill, E. G., & Ainsworth, A. (1972) · Medical & Biological Engineering & Computing · doi:10.1007/bf02476084 · Cited by 592
Multiple visual areas in the caudal superior temporal sulcus of the macaque
Desimone, R., & Ungerleider, L. G. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902480203 · Cited by 588
Contrast gain control in the cat's visual system
Ohzawa, I., Sclar, G., & Freeman, R. D. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.54.3.651 · Cited by 517
Adaptation-Induced Plasticity of Orientation Tuning in Adult Visual Cortex
Dragoi, V., Sharma, J., & Sur, M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00103-3 · Cited by 495
Pattern-selective adaptation in visual cortical neurones
Movshon, J. A., & Lennie, P. (1979) · Nature · doi:10.1038/278850a0 · Cited by 465
Self-citationEvidence for a Physiological Explanation of the Waterfall Phenomenon and Figural After-effects
Barlow, H. B., & Hill, R. (1963) · Nature · doi:10.1038/2001345a0 · Cited by 461
Rapid Adaptation in Visual Cortex to the Structure of Images
Müller, J. R., Metha, A. B., Krauskopf, J., & Lennie, P. (1999) · Science · doi:10.1126/science.285.5432.1405 · Cited by 458
The response of area MT and V1 neurons to transparent motion
Snowden, R., Treue, S., Erickson, R. G., & Andersen, R. A. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-09-02768.1991 · Cited by 457
Anstis, S., Verstraten, F. A. J., & Mather, G. (1998) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(98)01142-5 · Cited by 409
Synaptic Depression and the Temporal Response Characteristics of V1 Cells
Chance, F. S., Nelson, S. B., & Abbott, L. F. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04785.1998 · Cited by 403
Separate channels for the analysis of the shape and the movement of a moving visual stimulus
Tolhurst, D. J. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010239 · Cited by 399
A Tonic Hyperpolarization Underlying Contrast Adaptation in Cat Visual Cortex
Carandini, M., & Ferster, D. (1997) · Science · doi:10.1126/science.276.5314.949 · Cited by 372
Contrast gain control in the cat visual cortex
Ohzawa, I., Sclar, G., & Freeman, R. D. (1982) · Nature · doi:10.1038/298266a0 · Cited by 348
Neural Correlate of Perceptual Adaptation to Gratings
Maffei, L., Fiorentini, A., & Bisti, S. (1973) · Science · doi:10.1126/science.182.4116.1036 · Cited by 338
Membrane Mechanisms Underlying Contrast Adaptation in Cat Area 17In Vivo
Sanchez-Vives, M. V., Nowak, L. G., & McCormick, D. A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04267.2000 · Cited by 315
Visual Motion Analysis for Pursuit Eye Movements in Area MT of Macaque Monkeys
Lisberger, S. G., & Movshon, J. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02224.1999 · Cited by 311
Self-citationTransparent motion perception as detection of unbalanced motion signals. II. Physiology
Qian, N., & Andersen, R. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-12-07367.1994 · Cited by 302
Neuronal Basis of the Motion Aftereffect Reconsidered
Huk, A. C., Ress, D. B., & Heeger, D. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00452-4 · Cited by 299
Motion Opponency in Visual Cortex
Heeger, D. J., Boynton, G. M., Demb, J. B., Seidemann, E., & Newsome, W. T. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-16-07162.1999 · Cited by 283
Spatial contrast adaptation characteristics of neurones recorded in the cat's visual cortex.
Albrecht, D. G., Farrar, S. B., & Hamilton, D. B. (1984) · The Journal of Physiology · doi:10.1113/jphysiol.1984.sp015092 · Cited by 278
Local precision of visuotopic organization in the middle temporal area (MT) of the macaque
Albright, T. D., & Desimone, R. (1987) · Experimental Brain Research · doi:10.1007/bf00235981 · Cited by 277
Contrast adaptation in striate cortex of macaque
Sclar, G., Lennie, P., & DePriest, D. D. (1989) · Vision Research · doi:10.1016/0042-6989(89)90087-4 · Cited by 259
Adaptation to Temporal Contrast in Primate and Salamander Retina
Chander, D., & Chichilnisky, E. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09904.2001 · Cited by 240
Figural After-Effects and Apparent Size
Sutherland, N. (1961) · Quarterly Journal of Experimental Psychology · doi:10.1080/17470216108416498 · Cited by 233
A theory about the functional role and synaptic mechanism of visual after-effects
Barlow, H. B. (1991) · Vision · doi:10.1017/cbo9780511626197.034 · Cited by 227
Temporal dynamics of contrast gain in single cells of the cat striate cortex
Bonds, A. B. (1991) · Visual Neuroscience · doi:10.1017/s0952523800006258 · Cited by 224
Aftereffect of Seen Motion with a Stabilized Retinal Image
Sekuler, R., & Ganz, L. (1963) · Science · doi:10.1126/science.139.3553.419 · Cited by 194
Vautin, R. G., & Berkley, M. A. (1977) · Journal of Neurophysiology · doi:10.1152/jn.1977.40.5.1051 · Cited by 183
Priebe, N. J., Churchland, M. M., & Lisberger, S. G. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00852.2001 · Cited by 162
Contrast Gain Reduction in Fly Motion Adaptation
Harris, R. A., O’Carroll, D. C., & Laughlin, S. B. (2000) · Neuron · doi:10.1016/s0896-6273(00)00136-7 · Cited by 154
Wainwright, M. J., Schwartz, O., & Simoncelli, E. P. (2002) · Cited by 141
Direction-specific adaptation in area MT of the owl monkey
Petersen, S. E., Baker, J. F., & Allman, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)91105-9 · Cited by 141
Contrast Dependence of Response Normalization in Area MT of the Rhesus Macaque
Heuer, H. W., & Britten, K. H. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00255.2002 · Cited by 136
Transparent motion perception as detection of unbalanced motion signals. III. Modeling
Ning Qian, A., Andersen, R. A., & Adelson, E. H. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-12-07381.1994 · Cited by 135
Wezel, R. J. A. V., & Britten, K. H. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00276.2002 · Cited by 133
Adaptation in single units in visual cortex: The tuning of aftereffects in the spatial domain
SAUL, A. B., & Cynader, M. (1989) · Visual Neuroscience · doi:10.1017/s0952523800003527 · Cited by 125
Malone, B. J., Scott, B. H., & Semple, M. N. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04625.2002 · Cited by 124
He, S., Cohen, E. R., & Hu, X. P. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00512-x · Cited by 121
Recovery of fMRI Activation in Motion Area MT Following Storage of the Motion Aftereffect
Culham, J. C., Dukelow, S. P., Vilis, T., Hassard, F. A., Gati, J. S., Menon, R. S., & Goodale, M. A. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.1.388 · Cited by 120
Motion Processing in the Macaque: Revisited with Functional Magnetic Resonance Imaging
Tolias, A. S., Smirnakis, S. M., Augath, M. A., Trinath, T., & Logothetis, N. K. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08594.2001 · Cited by 117
Tsodyks, M. V., & Markram, H. (1997) · Cited by 111
Is spatial adaptation an after‐effect of prolonged inhibition?
Dealy, R. S., & Tolhurst, D. J. (1974) · The Journal of Physiology · doi:10.1113/jphysiol.1974.sp010652 · Cited by 106
The time course of direction-selective adaptation in simple and complex cells in cat striate cortex
Giaschi, D. E., Douglas, R., Marlin, S., & Cynader, M. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.5.2024 · Cited by 86
Orthogonal motion after-effect illusion predicted by a model of cortical motion processing
Grunewald, A., & Lankheet, M. J. (1996) · Nature · doi:10.1038/384358a0 · Cited by 78
Mechanisms Underlying Somatosensory Cortical Dynamics: II. In vitro Studies
Lee, C.-J., Whitsel, B. L., & Tommerdahl, M. (1992) · Cerebral Cortex · doi:10.1093/cercor/2.2.107 · Cited by 74
Pattern adaptation in cat visual cortex is a co-operative phenomenon
Vidyasagar, T. R. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90360-g · Cited by 71
Natural Image Statistics and Divisive Normalization
Wainwright, M. J., Schwartz, O., & Simoncelli, E. P. (2002) · The MIT Press eBooks · doi:10.7551/mitpress/5583.003.0015 · Cited by 71
Direction-selective adaptation in simple and complex cells in cat striate cortex
Marlin, S., Hasan, S. J., & Cynader, M. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.59.4.1314 · Cited by 69
Probabilistic Models of the Brain.
Long, D. M. (2002) · Neurosurgery Quarterly · doi:10.1097/00013414-200212000-00005 · Cited by 67
The Network of Brain Areas Involved in the Motion Aftereffect
Taylor, J. G., Schmitz, N., Ziemons, K., Grosse-Ruyken, M.-L., Gruber, O., Mueller-Gaertner, H. W., & Shah, N. J. (2000) · NeuroImage · doi:10.1006/nimg.1999.0529 · Cited by 65
Adaptation in single units in visual cortex: The tuning of aftereffects in the temporal domain
SAUL, A. B., & Cynader, M. (1989) · Visual Neuroscience · doi:10.1017/s0952523800003539 · Cited by 59
Contrast adaptation and excitatory amino acid receptors in cat striate cortex
McLean, J., & Palmer, L. A. (1996) · Visual Neuroscience · doi:10.1017/s0952523800007720 · Cited by 57
Spatial frequency adaptation: Threshold elevation and perceived contrast
Snowden, R. J., & Hammett, S. T. (1996) · Vision Research · doi:10.1016/0042-6989(95)00263-4 · Cited by 55
Mechanisms Underlying Somatosensory Cortical Dynamics: I. In vivo Studies
Lee, C., & Whitsel, B. L. (1992) · Cerebral Cortex · doi:10.1093/cercor/2.2.81 · Cited by 53
Neural correlates of motion after-effects in cat striate cortical neurones: monocular adaptation
Hammond, P., Mouat, G. S. V., & Smith, A. T. (1988) · Experimental Brain Research · doi:10.1007/bf00248495 · Cited by 51
Contrast adaptation in cat visual cortex is not mediated by GABA
DeBruyn, E. J., & Bonds, A. B. (1986) · Brain Research · doi:10.1016/0006-8993(86)90036-3 · Cited by 50
Neural Correlates of Contrast Detection at Threshold
Thiele, A., Dobkins, K. R., & Albright, T. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)81207-6 · Cited by 45
Difference of Spatial Frequency Selectivity between Static and Flicker Motion Aftereffects
Ashida, H., & Osaka, N. (1994) · Perception · doi:10.1068/p231313 · Cited by 41
Movement aftereffects in the visual cortex.
von der Heydt, R., Hänny, P., & Adorjani, C. (1978) · PubMed · Cited by 34
Position-specific adaptation in simple cell receptive fields of the cat striate cortex
Marlin, S., Douglas, R. M., & Cynader, M. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.5.1769 · Cited by 33
Position-specific adaptation in complex cell receptive fields of the cat striate cortex
Marlin, S., Douglas, R., & Cynader, M. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.6.2209 · Cited by 16
Research works printed but not linked: 1
- Chandler, 1969, Subroutine STEPIT, Behav. Sci., 14, 81
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BackgroundResultInfluentialSelf-citationAdaptation: from single cells to BOLD signals
Krekelberg, B., Boynton, G. M., & Wezel, R. J. A. V. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.02.008 · Cited by 496
How MT cells analyze the motion of visual patterns
Rust, N. C., Mante, V., Simoncelli, E. P., & Movshon, J. A. (2006) · Nature Neuroscience · doi:10.1038/nn1786 · Cited by 516
Self-citationState-Dependency of Transcranial Magnetic Stimulation
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Background
Metadata
- Authors
- Kohn, A., & Movshon, J. A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Kohn, Adam
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 39
- Issue
- 4
- Pages
- 681-691
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2141145724
- Cited by
- 353
- References
- 76
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 9 · 2023: 14 · 2022: 9 · 2021: 14 · 2020: 13 · 2019: 17 · 2018: 16 · 2017: 12 · 2016: 20 · 2015: 10 · 2014: 15 · 2013: 10 · 2012: 25
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Eye Institute (R01EY002017, EY 02017)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- area MT, macaque, contrast gain, preferred direction, null directions, drifting gratings, receptive fields, motion perception
- MeSH terms
- Adaptation, Physiological, Animals, Macaca, Male, Motion Perception, Neurons, Photic Stimulation, Visual Cortex, Contrast Sensitivity
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