Cited by 271Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesCytokine Signaling Pathways and Interactions

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Leptin signalling

Sweeney, Gary·2002·Cellular Signalling

DOI 10.1016/s0898-6568(02)00006-2

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Abstract

The identification of leptin as the product of the obesity (ob) gene has been followed by extensive research identifying a wide spectrum of physiological effects elicited by this adipose-derived hormone. These effects are mediated via a family of cytokine-like receptor isoforms distributed in both the central nervous system and periphery. The signal transduction pathways regulated by leptin are diverse and include those characteristic of both cytokine and growth factor receptor signalling. This review describes the structure and function of leptin receptors and summarizes recent progress that has been made in characterizing the increasing number of signal transduction pathways regulated by leptin.

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Authors: Sweeney, G.
Affiliations: York University (CA)
Corresponding author: Sweeney, Gary
ORCID: Sweeney, Gary
Venue: Cellular Signalling
Publisher: Elsevier BV
Published: 2002-08
Volume: 14
Issue: 8
Pages: 655-663
ISSN: 0898-6568 (ISSN-L)
DOI: 10.1016/s0898-6568(02)00006-2
OpenAlex: W4247302633
Cited by: 271
References: 114
Citations by year: 2026: 5 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 8 · 2015: 11 · 2014: 16 · 2013: 16 · 2012: 15
FWCI: 2.02
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cellular Signalling (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: leptin, leptin receptor, signal transduction, obesity-related genes, adipokines, cytokine receptor signalling, central nervous system, periphery
MeSH terms: Animals, Nitric Oxide, Phosphoproteins, Proteins, Receptors, Cell Surface, 3',5'-Cyclic-AMP Phosphodiesterases, Signal Transduction, Protein Tyrosine Phosphatases, Protein Serine-Threonine Kinases, Phosphatidylinositol 3-Kinases, Leptin, rho GTP-Binding Proteins, MAP Kinase Signaling System, Intracellular Signaling Peptides and Proteins, Receptors, Leptin, Protein Tyrosine Phosphatase, Non-Receptor Type 11

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