Leptin signalling

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326

Signal transduction by the JNK group of MAP kinases

Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237

STATs and Gene Regulation

Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979

Identification and expression cloning of a leptin receptor, OB-R.

Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496

Obesity and insulin resistance

Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,345

Abnormal splicing of the leptin receptor in diabetic mice

Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327

The p38 signal transduction pathway Activation and function

Ono, K., & Han, J. (2000) · Cellular Signalling · doi:10.1016/s0898-6568(99)00071-6 · Cited by 1,571

Leptin

Ahima, R. S., & Flier, J. S. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.413 · Cited by 1,428

The Leptin Receptor

Tartaglia, L. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6093 · Cited by 1,289

Leptin stimulates endogenous cholesterol synthesis in human monocytes: New role of an old player in atherosclerotic plaque formation

Kosztáczky, B., Fóris, G., Paragh, G., Seres, I., Zsíros, E., Koncsos, P., Balogh, Z., & Paragh, G. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.04.012 · Cited by 17

Apical leptin induces chloride secretion by intestinal epithelial cells and in a rat model of acute chemotherapy-induced colitis

Hoda, R. M., Scharl, M. M., Keely, S. J., McCole, D. F., & Barrett, K. E. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00320.2009 · Cited by 16

Leptin Up-Regulates the Lactogenic Effect of Prolactin in the Bovine Mammary Gland In Vitro

Feuermann, Y., Shamay, A., & Mabjeesh, S. J. (2008) · Journal of Dairy Science · doi:10.3168/jds.2008-0988 · Cited by 16

Implication of Leptin-Signaling Proteins and Epstein-Barr Virus in Gastric Carcinomas

Choi, E., Byeon, S., Kim, S. H., Lee, H. J., Kwon, H. J., Ahn, H.-S., Kim, D. H., & Chang, M. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130839 · Cited by 16

Attenuation of Signaling and Nitric Oxide Production following Prolonged Leptin Exposure in Human Aortic Endothelial Cells

Blanquicett, C., Graves, A. S., Kleinhenz, D. J., & Hart, C. M. (2007) · Journal of Investigative Medicine · doi:10.2310/6650.2007.00017 · Cited by 16

Lordosis facilitation by leptin in ovariectomized, estrogen-primed rats requires simultaneous or sequential activation of several protein kinase pathways

García‐Juárez, M., Beyer, C., Gómora‐Arrati, P., Domínguez‐Ordóñez, R., Lima-Hernández, F. J., Eguibar, J. R., Galicia-Aguas, Y. L., Etgen, A. M., & González‐Flores, O. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.05.014 · Cited by 15

Leptin modulates gene expression in the heart and cardiomyocytes towards mitigating ischemia-induced damage

Alkhaleq, H. A., Kornowski, R., Waldman, M., Levy, E., Zemel, R. R., Nudelman, V., Shainberg, A., Miskin, R., & Hochhauser, E. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112373 · Cited by 15

Leptin-based therapeutics

Scolaro, L. M., Cassone, M., Kolaczynski, J. W., Ötvös, L., & Surmacz, E. (2010) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.10.61 · Cited by 15

Leptin receptor activation increases Sam68 tyrosine phosphorylation and expression in human trophoblastic cells

Sánchez-Jiménez, F., Pérez‐Pérez, A., González-Yanes, C., Najib, S., Varone, C. L., & Sánchez‐Margalet, V. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.10.014 · Cited by 15

Effects of Leptin on Hypothalamic Arcuate Neurons in Wistar and Zucker Rats: An In Vitro Study

Nagamori, K., Ishibashi, M., Shiraishi, T., Oomura, Y., & Sasaki, K. (2003) · Experimental Biology and Medicine · doi:10.1177/153537020322801010 · Cited by 15

Egr-1 mediates leptin-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells

Xie, X., Li, S., Zhu, Y., Liu, L., Ke, R., Wang, J., Yan, X., Yang, L., Gao, L., Zang, W., et al. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-03-0141 · Cited by 14

Leptin Alters Adrenal Responsiveness by Decreasing Expression of ACTH-R, StAR, and P450c21 in Hypoxemic Fetal Sheep

Su, Y., Carey, L. C., Rose, J. C., & Pulgar, V. M. (2012) · Reproductive Sciences · doi:10.1177/1933719112442246 · Cited by 14

Impact of non-oncological factors on tumor recurrence after liver transplantation in hepatocellular carcinoma patients

Gu, X., Zheng, W.-P., Teng, D., Sun, J.-S., & Zheng, H. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i9.2749 · Cited by 14

Obesity-related leptin receptor polymorphisms and gallstones disease

Méndez‐Sánchez, N., Bermejo-Martínez, L., Chávez-Tapia, N. C., Zamora‐Valdés, D., Sánchez-Lara, K., Uribe-Ramos, M. H., Ponciano‐Rodríguez, G., González, H. A. B., Ramos, M. H., & Uribe, M. (2006) · Annals of Hepatology · doi:10.1016/s1665-2681(19)32025-3 · Cited by 12

Leptin and Its Derivatives: A Potential Target for Autoimmune Diseases

Han, H., & Zhou, W. (2019) · Current Drug Targets · doi:10.2174/1389450120666190729120557 · Cited by 12

Leptin Receptor in Childhood Acute Leukemias

Górska, E., Popko, K., & Wasik, M. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-4549-0_20 · Cited by 12

Exploring Leptin Antagonism in Ophthalmic Cell Models

Scolaro, L. M., Parrino, C., Coroniti, R., Otvos, L. J., & Surmacz, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076437 · Cited by 11

Obesity abrogates the concentration-dependent effect of leptin on endogenous cholesterol synthesis in human monocytes

Balogh, Z., Fóris, G., Kónya, G., Paragh, G., Köbling, T., Padra, J. T., Sarang, Z., & Paragh, G. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.06.012 · Cited by 10

Effect of estrodiol on leptin receptors expression in regulating fat distribution and adipocyte genesis

Li, W., Xu, L., Chen, Y., Li, M., Cheng, M., Xu, W., Zhuang, J., & Zhang, J. (2016) · Gynecological Endocrinology · doi:10.3109/09513590.2015.1130810 · Cited by 10

Leptin inhibits the Na+/K+ ATPase in Caco-2 cells via PKC and p38MAPK

Zein, O. E., Usta, J. A., Moussawi, L. E., & Kreydiyyeh, S. I. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.12.004 · Cited by 10

Leptin inhibits lysophosphatidic acid‐induced intracellular calcium rise by a protein kinase C‐dependent mechanism

Eiras-Penas, S., Camiña, J. P., Díaz-Rodríguez, E., Gualillo, O., & Casanueva, F. F. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20046 · Cited by 10

La leptine est-elle le maillon manquant entre l’arthrose et l’obésité ?

Terlain, B. L., Dumond, H., Presle, N., Mainard, D., Bianchi, A., Lœuille, D., Netter, P., & Pottie, P. (2005) · Annales Pharmaceutiques Françaises · doi:10.1016/s0003-4509(05)82273-4 · Cited by 9

Insulin and leptin relations in obesity: a multimedia approach

Yokaichiya, D. K., Galembeck, E., Torres, B. B., Silva, J. A. D., & de Araújo, D. R. (2008) · AJP Advances in Physiology Education · doi:10.1152/advan.00014.2007 · Cited by 9

Associations between metabolic dysfunction-associated fatty liver disease and atherosclerotic cardiovascular disease

Wen, W., Fan, H., Zhang, S., Hu, S., Chen, C., Tang, J., You, Y., Wang, C., Li, J., Luo, L., et al. (2024) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2024.06.022 · Cited by 8

Leptin receptor is expressed by epidermis and skin appendages in dog

Mercati, F., Maranesi, M., Dall’Aglio, C., Scocco, P., Pascucci, L., Boiti, C., & Ceccarelli, P. (2014) · Acta Histochemica · doi:10.1016/j.acthis.2014.07.011 · Cited by 8

Are common leptin promoter polymorphisms associated with restenosis after coronary stenting?

Vašků, J. B., Hlinomaz, O., & Vašků, A. (2007) · Heart and Vessels · doi:10.1007/s00380-007-0980-2 · Cited by 8

Leptin, a Novel Predictor of Lung Function in Heart Failure

Sierra‐Johnson, J., Romero‐Corral, A., Somers, V. K., Olson, L. J., & Johnson, B. D. (2008) · CHEST Journal · doi:10.1378/chest.07-2751 · Cited by 8

Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia

Kosztáczky, B., Fóris, G., Seres, I., Balogh, Z., Fülöp, P., Koncsos, P., & Paragh, G. (2006) · Neuropeptides · doi:10.1016/j.npep.2006.08.004 · Cited by 7

Synergistic Activation of LEPR and ADRB2 Induced by Leptin Enhances Reactive Oxygen Specie Generation in Triple-Negative Breast Cancer Cells

Liu, C. X., Yu, J. X., Du, Y., Xie, Y., Song, X., Liu, C. X., Yan, Y., Wang, Y., & Qin, J. (2024) · Cancer Research and Treatment · doi:10.4143/crt.2024.368 · Cited by 6

Leptin and insulin induce mutual resistance for nitric oxide synthase III activation in adipocytes

Mehebik‐Mojaat, N., Ribière, C., Niang, F., Forest, C. D., & Jaubert, A. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22331 · Cited by 7

Effects of chronic leptin administration on nitric oxide production and immune responsiveness of greenfinches

Lõhmus, M., Sild, E., Hõrak, P., & Björklund, M. (2011) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2011.01.002 · Cited by 6

A New Nomogram for Predicting Early Weight Loss Outcomes in Patients with Obesity Following Laparoscopic Sleeve Gastrectomy

Wu, W., Zhao, L., Yuan, C., Yang, M., Song, Y., Xu, Z., Li, Z., Lu, Y., Zhou, X., Wang, D., et al. (2025) · Obesity Surgery · doi:10.1007/s11695-025-07798-5 · Cited by 6

Leptin-mediated proinflammatory bone marrow environment in acquired aplastic anemia

Gao, M., Ge, M., Huo, J., Ren, X., Li, X., Shao, Y., Huang, J., Zhang, J., Wang, M., Nie, N., et al. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155829 · Cited by 5

Leptin Drives Breast Cancer Aggressiveness Acting Through the Activation of the NCOA1/STAT3 Pathway

Ayed, K., Gorrab, A., Bouguerra, H., Akrout, R., Sami, Z., Almawi, W. Y., Boughriba, R., Choukri, K., Bacha, D., Pagano, A., et al. (2026) · Medical Sciences · doi:10.3390/medsci14010032 · Cited by 4

Weight Loss Drugs and Cardiovascular Risks

Poirier, P. (2010) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-010-0148-y · Cited by 4

Recombinant Bovine Growth Hormone-Induced Metabolic Remodelling Enhances Growth of Gilthead Sea-Bream (Sparus aurata): Insights from Stable Isotopes Composition and Proteomics

Blasco, J., Vélez, E. J., Perelló-Amorós, M., Azizi, S., Capilla, E., Fernández‐Borràs, J., & Gutiérrez, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313107 · Cited by 4

Nutritional regulation of leptin signaling

Ribière, C., & Plut, C. (2005) · Current Hypertension Reports · doi:10.1007/s11906-005-0049-5 · Cited by 4

Modulation of intestinal L-glutamate transport by luminal leptin

Fanjul, C., Barrenetxe, J., Lostao, M., & Ducroc, R. (2015) · Journal of physiology and biochemistry · doi:10.1007/s13105-015-0414-z · Cited by 4

C-terminal domain of Chk1 regulates its subcellular location and kinase activity for DNA repair

Ning, L., Wang, H., San, D., & Sang, J. (2011) · Chinese Science Bulletin · doi:10.1007/s11434-011-4538-4 · Cited by 3

Presence and distribution of leptin and its receptor in the minor salivary glands of the donkey

Dall’Aglio, C., Bazzucchi, C., Mercati, F., & Ceccarelli, P. (2015) · Acta Histochemica · doi:10.1016/j.acthis.2015.03.001 · Cited by 3

Adipocytokines in obese Ghanaian subjects with or without type 2 diabetes

Adams, Y., Ofori, E. K., Asare‐Anane, H., Amanquah, S. D., Ababio, G. K., Abendau, E., & Nabia, R. (2018) · BMC Research Notes · doi:10.1186/s13104-018-3149-4 · Cited by 3

Roles of Leptin in Cancer Progression

Kang, Y., & Moon, A. (2010) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2010.18.4.363 · Cited by 3

The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1.

Kinsella, J. M., Laidlaw, H. A., Tang, T., Harvey, J., Sutherland, C. D., & Ashford, M. L. J. (2004) · BMC Pharmacology · doi:10.1186/1471-2210-4-17 · Cited by 3

Exercise combined with heat treatment improves insulin resistance in diet-induced obese rats

Zhao, J., Feng, Y., Rao, Z., Li, H., Xu, J., Cui, S., & Lai, L. (2023) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2023.103651 · Cited by 2

Obesity and Inflammation

Sengupta, S., & Avtanski, D. B. (2023) · Contemporary Endocrinology · doi:10.1007/978-3-031-39721-9_2 · Cited by 3

Activation of Hypothalamic ATP‐Sensitive K+ Channels by the Aminoguanidine Carboxylate BVT.12777

Mirshamsi, S., Laidlaw, H. A., Spanswick, D. C., & Ashford, M. L. J. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01299.x · Cited by 2

Leptin’s potential mechanisms in ICU-acquired weakness

Li, M., Yang, L., Li, T., Miao, Y., Yang, J., Chen, S., Ma, X., & Xie, P. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02748-7 · Cited by 1

Haemodynamical Variables Versus Endothelial Hormones in Hypertensive and Type 2 Diabetic Patients With Endothelial Dysfunction

Fouillioux, C., Contreras, F., Lares, M., Magaldi, L., Velasco, M., Mayda, C. L., Pacheco, B., Rojas, J., Chacín, M., Cano, R., et al. (2010) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e3181c2de61 · Cited by 1

β-Cell Function in Obese-Hyperglycemic Mice (ob /ob Mice)

Lindström, P. (2014) · Springer eBooks · doi:10.1007/978-94-007-6686-0_15 · Cited by 1

Prognostic roles of leptin‐signaling proteins, PD‐L1, and tumor‐infiltrating lymphocytes in surgically‐resected biliary tract cancers

Byeon, S., Chang, M. S., Cho, H. J., Park, J. H., Kim, K. H., Park, J. H., Choi, I. S., Kim, W. K., Han, D., Ahn, H. S., et al. (2022) · Journal of Surgical Oncology · doi:10.1002/jso.27140 · Cited by 1

Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model

Masloh, S., Chevrel, A., Culot, M., Perrocheau, A., Kalia, Y. N., Frehel, S., Gaussin, R., Gosselet, F., Huet, S., Labouebe, M. Z., et al. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16010116 · Cited by 1

Impact of Inflammation and Innate Immunity Response in Obesity Mediated Diabetes

Pugia, M. J. (2015) · Springer eBooks · doi:10.1007/978-3-319-21927-1_1 · Cited by 1

Impact of Obesity on Female Reproductive Health

Olatinwo, M. O., Harp, D., Thompson, W. E., Park, H.-K., & Mathews, R. P. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_17 · Cited by 1

Leptin and Cognitive Function

Harvey, J. (2013) · Wiley eBooks · doi:10.1002/9781118395318.ch30

Obesity and Cardiac Dysfunction

Sweeney, G., Litwin, S. E., & Abel, E. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_14

Protein-Tyrosine Phosphatases: Linking Metabolism and Cancer

Bence, K. K. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3649-6_12

Convergence of leptin and insulin signaling networks in obesity

Sutherland, C. D., & Ashford, M. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9780511541643.006

Mineralocorticoid Receptor and Leptin: A Dangerous Liaison in the Obese Heart

Marín‐Royo, G., Luaces, M., Cachofeiro, V., & Martínez‐Martínez, E. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.87236

Biodiversity of the Adipocyte-Derived Hormone, Leptin

Manjunathan, R., Kasiviswanathan, D., & Jayaraman, S. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.100576

β-Cell Function in Obese-Hyperglycemic Mice (ob /ob Mice)

Lindström, P. (2014) · Springer eBooks · doi:10.1007/978-94-007-6884-0_15-2

Components of Metabolic Syndrome

(2007) · Springer eBooks · doi:10.1007/978-1-84628-911-8_2

Looking Farther Afield

Ross, J. A. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.906.13.6

Immunometabolism mRNA expression phenotypes and reprogramming of CD14 in T2DM with or without CVD

Bendaya, I., Jemaa, A. B., Sahraoui, G., Kharrat, M., Sdiri, W., & Oueslati, R. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110665

Leptin and Insulin Interaction Modulates Pancreatic Nitric Oxide Levels in Diabetic Rats

lmazer, N. Y., Kapucu, A. E., Gürevin, E. G., unova, S. Ü., Kandil, A., Tansel, C. D., Uyaner, L., & Dar, K. A. (2024) · International Journal of Pharmacology · doi:10.3923/ijp.2024.1292.1300

Rôle de la leptine dans le cancer colorectal humain

Aloulou, N. (2008) · theses.fr (ABES) · doi:10.70675/e2c04884z8b88z4505zb030z25b3719965c0

Périodes critiques pour la croissance et le développement mammaire lors d’une alimentation obésogène chez la lapine et la souris : implication de la leptine

Hue-Beauvais, C. (2014) · theses.fr (ABES) · doi:10.70675/cb28a764zae60z4902zac3az172b5412f4cc

Rôle des macrophages dans le remodelage pathologique du tissu adipeux au cours de l'obésité

Askia, H. (2022) · theses.fr (ABES) · doi:10.70675/0d09beffzcdaez4950za6c0z29a0dd68a41b

When Fat Goes Astray: Your Liver and Pancreas Get Into Trouble

Chen, Y., Ding, L., Zhao, S., Wang, W. B., Zhong, J., & Yan, Q. (2026) · Portal hypertension & cirrhosis · doi:10.1002/poh2.70049

The physiology of leptin in avians: A review

Wright, M., Lee, J., & Lee, K. (2026) · Poultry Science · doi:10.1016/j.psj.2026.107435

Split immunomodulatory impact of leptin on human myeloid cells: key role of IDO1 in counteracting the immunostimulatory effect of leptin

Dong, B., Rosario, S. R., Luo, W., Brinkman, A., Slomba, R. T., Berlinski, J., Hsiao, H.-H., Zhang, Y., Wang, J., Vadehra, D., et al. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag211

Gut microbiota as a modulator of HDAC: insights into Alzheimer’s disease treatment

Verma, E., Mishra, S., Chellammal, H. S. J., Khandige, P. S., & Gasmi, A. (2026) · Pharmacological Reports · doi:10.1007/s43440-026-00897-9 · Cited by 1

Intracellular signalling pathways activated by leptin

Frühbeck, G. (. (2006) · Deposito Adademico Digital Universidad De Navarra (University of Navarra) · Cited by 745

Signal transduction mediated by leptin and its receptor

Guang, S. (2008) · Shengming de Huaxue

One Receptor for Multiple Pathways: Focus on Leptin Signaling

Gómez, R., Conde, J., Scotece, M., & Gualillo, O. (2011) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781849733434-00044

Chapter 3. One Receptor for Multiple Pathways: Focus on Leptin Signaling

Gómez, R., Conde, J., Scotece, M., & Gualillo, O. (2011) · RSC drug discovery/RSC drug discovery series · doi:10.1039/9781849733434-00044

Leptin‐induced signal transduction pathways

Hegyi, K., Fülöp, K., Kovács, K., Tóth, S., & Falus, A. (2004) · Cell Biology International · doi:10.1016/j.cellbi.2003.12.003 · Cited by 250