Cited by 292Estrogen and related hormone effectsNuclear Receptors and SignalingGenomics and Chromatin Dynamics

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Nuclear receptors: integration of multiple signalling pathways through phosphorylation

Rochette-Egly, Cécile·2003·Cellular Signalling

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Abstract

Nuclear receptors (NRs) orchestrate the transcription of specific gene networks in response to binding of their cognate ligand. They also act as mediators in a variety of signalling pathways through integrating diverse phosphorylation events. NR phosphorylation concerns all three major domains, the N-terminal activation function (AF-1), the ligand-binding and the DNA binding domains. Often, phosphorylation of NRs by kinases that are associated with general transcription factors (e.g. cdk7 within TFIIH), or activated in response to a variety of signals (MAPKs, Akt, PKA, PKC), facilitates the recruitment of coactivators or of components of the transcription machinery and, therefore, cooperates with the ligand to enhance transcription activation. But phosphorylation can also contribute to the termination of the ligand response through inducing DNA dissociation or NR degradation or through decreasing ligand affinity. These different modes of regulation reveal an unexpected complexity of the dynamics of NR-mediated transcription. In addition, deregulation of NR phosphorylation may impact their action in certain diseases or cancers.

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Authors: Rochette-Egly, C.
Venue: Cellular Signalling
Publisher: Elsevier BV
Published: 2003-04
Volume: 15
Issue: 4
Pages: 355-366
ISSN: 0898-6568 (ISSN-L)
DOI: 10.1016/s0898-6568(02)00115-8
OpenAlex: W2056128228
Cited by: 291
References: 136
Citations by year: 2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 2 · 2019: 7 · 2018: 5 · 2017: 8 · 2016: 7 · 2015: 12 · 2014: 15 · 2013: 21 · 2012: 10
FWCI: 2.14
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cellular Signalling (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: nuclear receptors, phosphorylation, transcriptional regulation, transcriptional coactivator, ligand-binding domain, DNA-binding domain, mitogen-activated protein kinase, Akt, protein kinase A, protein kinase C, CDK7, TFIIH, transcription termination, ligand dissociation, cancer
MeSH terms: Animals, Cell Nucleus, DNA-Binding Proteins, Hormones, Humans, Neoplasms, Phosphorylation, Protein Binding, RNA, Messenger, Transcription, Genetic, Signal Transduction, Down-Regulation, Up-Regulation, Protein Serine-Threonine Kinases, Receptors, Cytoplasmic and Nuclear

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Nuclear receptors: integration of multiple signalling pathways through phosphorylation

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