Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase

Rogatsky, Inez; Logan, Susan K.; Garabedian, Michael J.

doi:10.1073/pnas.95.5.2050

Cited by 297Estrogen and related hormone effectsProtein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase

Open access

Rogatsky, Inez, Logan, Susan K., Garabedian, Michael J.·1998·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.95.5.2050PMC PMC19245

Open this paper in CoChat — free account

Abstract

The mitogen-activated protein kinases ERK (extracellular signal-regulated kinase), JNK (c-Jun N-terminal kinase), and p38 phosphorylate and activate transcription factors that promote proliferative and inflammatory responses, whereas glucocorticoid receptor (GR) activation inhibits cell growth and inflammation. We demonstrate that JNK and ERK but not p38 phosphorylate GR in vitro primarily at Ser-246. Selective activation of either ERK or JNK in vivo inhibits GR-mediated transcriptional activation, which depends on receptor phosphorylation at Ser-246 by JNK but not ERK. Thus, JNK inhibits GR transcriptional activation by direct receptor phosphorylation, whereas ERK does so indirectly. We propose that phosphorylation of GR by JNK or of a GR cofactor by ERK provides mechanisms to ensure the rapid inhibition of GR-dependent gene expression when it conflicts with mitogenic or proinflammatory signals.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.95.5.2050

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Inhibition of GR function by activation of ERK is believed to be in part related to phosphorylation of GR cofactors.
“Inhibition of GR function by activation of ERK is believed to be in part related to phosphorylation of GR cofactors.65”
From Cytokines and Glucocorticoid Receptor Signaling (2009) · cites this paper as [65]
MAPK (ERK and JNK) can decrease GR nuclear transport and affinity to cofactors via phosphorylation.
“Reciprocally, MAPK (ERK and JNK) can decrease GR nuclear transport and affinity to cofactors via phosphorylation (Rogatsky et al., 1998).”
From The Stressed CNS: When Glucocorticoids Aggravate Inflammation (2009) · cites this paper as Rogatsky et al., 1998

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
Dérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., & Davis, R. J. (1994) · Cell · doi:10.1016/0092-8674(94)90380-8 · Cited by 3,188 · see citing works
A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells
Han, J., Lee, J. D., Bibbs, L., & Ulevitch, R. J. (1994) · Science · doi:10.1126/science.7914033 · Cited by 2,647 · see citing works
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine
Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7420 · Cited by 2,244 · see citing works
The mitogen-activated protein kinase signal transduction pathway
Davis, R. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82362-6 · Cited by 2,112 · see citing works
Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase
Kato, S., Endoh, H., Masuhiro, Y., Kitamoto, T., Uchiyama, S., Sasaki, H., Masushige, S., Gotoh, Y., Nishida, E., Kawashima, H., et al. (1995) · Science · doi:10.1126/science.270.5241.1491 · Cited by 1,964 · see citing works
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
Hibi, M., Lin, A., Smeal, T., Minden, A., & Karin, M. (1993) · Genes & Development · doi:10.1101/gad.7.11.2135 · Cited by 1,886 · see citing works
STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS
Yamamoto, K. R. (1985) · Annual Review of Genetics · doi:10.1146/annurev.ge.19.120185.001233 · Cited by 1,872 · see citing works
Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
Minden, A., Lin, A., Claret, F.-X., Abo, A., & Karin, M. (1995) · Cell · doi:10.1016/s0092-8674(05)80019-4 · Cited by 1,481 · see citing works
Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway
Gupta, S., Campbell, D., Dérijard, B., & Davis, R. J. (1995) · Science · doi:10.1126/science.7824938 · Cited by 1,440 · see citing works
Current Protocols in Molecular Biology
(2018) · Current Protocols in Molecular Biology · doi:10.1002/(issn)1934-3647 · Cited by 1,395 · see citing works
MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway
Raingeaud, J., Whitmarsh, A. J., Barrett, T., Dérijard, B., & Davis, R. J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.1247 · Cited by 1,280 · see citing works
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
Buday, L., & Downward, J. (1993) · Cell · doi:10.1016/0092-8674(93)90146-h · Cited by 1,064 · see citing works
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
Rozakis-Adcock, M., Fernley, R. T., Wade, J. D., Pawson, T. J., & Bowtell, D. D. L. (1993) · Nature · doi:10.1038/363083a0 · Cited by 1,009 · see citing works
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
Sánchez, I., Hughes, R. T., Mayer, B. J., Yee, K. O., Woodgett, J. R., Avruch, J., Kyriakls, J. M., & Zon, L. I. (1994) · Nature · doi:10.1038/372794a0 · Cited by 970 · see citing works
Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase
Wang, X., & Ron, D. (1996) · Science · doi:10.1126/science.272.5266.1347 · Cited by 885 · see citing works
Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2
Chardin, P., Camonis, J., Gale, N. W., Aelst, L. V., Schlessinger, J., Wigler, M. H., & Bar‐Sagi, D. (1993) · Science · doi:10.1126/science.8493579 · Cited by 799 · see citing works
A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos
Olivier, J. P. (1993) · Cell · doi:10.1016/0092-8674(93)90170-u · Cited by 537 · see citing works
ATF‐2 contains a phosphorylation‐dependent transcriptional activation domain.
Livingstone, C., Patel, G., & Jones, N. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07167.x · Cited by 494 · see citing works
c-Jun N-Terminal Phosphorylation Correlates with Activation of the JNK Subgroup but Not the ERK Subgroup of Mitogen-Activated Protein Kinases
Minden, A., Lin, A., Smeal, T., Dérijard, B., Cobb, M. H., Davis, R. J., & Karin, M. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.10.6683 · Cited by 467 · see citing works
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway
Aronheim, A., Engelberg, D., Li, N., Al-Alawi, N., Schlessinger, J., & Karin, M. (1994) · Cell · doi:10.1016/0092-8674(94)90271-2 · Cited by 458 · see citing works
Signal Transduction by Tumor Necrosis Factor Mediated by JNK Protein Kinases
Sluss, H. K., Barrett, T., Dérijard, B., & Davis, R. J. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8376 · Cited by 457 · see citing works
A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells
Sleigh, M. J. (1986) · Analytical Biochemistry · doi:10.1016/0003-2697(86)90180-6 · Cited by 397 · see citing works
Cytokine modulation by glucocorticoids: mechanisms and actions in cellular studies.
Brattsand, R., & Linden, M. (1996) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1996.22164025.x · Cited by 361 · see citing works
The regulation of AP-1 activity by mitogen-activated protein kinases
Karin, M., & Marshall, C. J. (1996) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1996.0008 · Cited by 332 · see citing works
Molecular mechanisms of anti‐inflammatory action of glucocorticoids
Cato, A. C. B., & Wade, E. J. (1996) · BioEssays · doi:10.1002/bies.950180507 · Cited by 307 · see citing works
Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase
Westwick, J. K., Weitzel, C., Minden, A., Karin, M., & Brenner, D. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47207-9 · Cited by 293 · see citing works
Mitogen-Activated and Cyclin-Dependent Protein Kinases Selectively and Differentially Modulate Transcriptional Enhancement by the Glucocorticoid Receptor
Krstic–Demonacos, M., Rogatsky, I., Yamamoto, K. R., & Garabedian, M. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.7.3947 · Cited by 268 · see citing works
Self-citation
Mouse glucocorticoid receptor phosphorylation status influences multiple functions of the receptor protein
Webster, J. C., Jewell, C. M., Bodwell, J. E., Munck, A., Sar, M., & Cidlowski, J. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.14.9287 · Cited by 261 · see citing works
Characterization of a Monoclonal Antibody to the Rat Liver Glucocorticoid Receptor*
Gametchu, B., & Harrison, R. W. (1984) · Endocrinology · doi:10.1210/endo-114-1-274 · Cited by 260 · see citing works
Glucocorticoid Receptor-Mediated Cell Cycle Arrest Is Achieved through Distinct Cell-Specific Transcriptional Regulatory Mechanisms
Rogatsky, I., Trowbridge, J. M., & Garabedian, M. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.6.3181 · Cited by 257 · see citing works
Self-citation
Signal Transduction by Tumor Necrosis Factor Mediated by JNK Protein Kinases
Sluss, H. K., Barrett, T., Dérijard, B., et al. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.8376-8384.1994 · Cited by 116 · see citing works
c-Jun N-Terminal Phosphorylation Correlates with Activation of the JNK Subgroup but Not the ERK Subgroup of Mitogen-Activated Protein Kinases
Minden, A., Lin, A., Smeal, T., et al. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.10.6683-6688.1994 · Cited by 116 · see citing works
Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac.
Xu, X., Barry, D. C., Settleman, J. E., Schwartz, M. A., & Bokoch, G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31553-3 · Cited by 92 · see citing works
Molecular Mechanisms of Immunosuppression and Anti-Inflammatory Activities by Glucocorticoids
DiDonato, J. A., Saatcioglu, F., & Karin, M. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm/154.2_pt_2.s11 · Cited by 77 · see citing works
RNA movement between the nucleus and the cytoplasm
Lee, M. S., & Silver, P. A. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80131-1 · Cited by 37 · see citing works

Flagged first, then by citations

Research works printed but not linked: 4

[11]Davis R J. J Biol Chem. 1993;268:14553–14556. [PubMed] [Google Scholar]
[15]Westwick J K, Weitzel C, Minden A, Karin M, Brenner D A. J Biol Chem. 1994;269:26396–26401. [PubMed] [Google Scholar]
[24]Krstic M D. Ph.D. thesis. San Francisco: Univ. of California; 1995. [Google Scholar]
[32]Xu X, Barry D C, Settleman J, Schwartz M A, Bokoch G M. J Biol Chem. 1994;269:23569–23574. [PubMed] [Google Scholar]

Sorted by citations

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1
Delerive, P., De Bosscher, K., Besnard, S., Vanden Berghe, W., Peters, J. M., Gonzalez, F. J., Fruchart, J.-C., Tedgui, A., Haegeman, G., & Staels, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32048 · Cited by 1,089 · see citing works
The Interplay between the Glucocorticoid Receptor and Nuclear Factor-κB or Activator Protein-1: Molecular Mechanisms for Gene Repression
De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898 · see citing works
The promise of retinoids to fight against cancer
Altucci, L., & Gronemeyer, H. (2001) · Nature Reviews Cancer · doi:10.1038/35106036 · Cited by 773 · see citing works
Regulation of glucose homeostasis by glucocorticoids
Kuo, T., McQueen, A., Chen, T.-C., & Wang, J.-C. (2015) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-2895-8_5 · Cited by 723 · see citing works
Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression
Pace, T. W. W., Hu, F., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.08.009 · Cited by 621 · see citing works
Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection
Silverman, M. N., Pearce, B. D., Biron, C. A., & Miller, A. H. (2005) · Viral Immunology · doi:10.1089/vim.2005.18.41 · Cited by 506 · see citing works
The human glucocorticoid receptor: molecular basis of biologic function
Nicolaides, N. C., Galata, Z., Kino, T., Chrousos, G. P., & Charmandari, E. (2010) · Steroids · doi:10.1016/j.steroids.2009.09.002 · Cited by 436 · see citing works
The Stressed CNS: When Glucocorticoids Aggravate Inflammation
Sorrells, S. F., Caso, J. R., Munhoz, C. D., & Sapolsky, R. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.032 · Cited by 425 · see citing works
Cytokines and Glucocorticoid Receptor Signaling
Pace, T. W. W., & Miller, A. H. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04984.x · Cited by 339 · see citing works
Modulation of Glucocorticoid Receptor Function via Phosphorylation
ISMAILI, N., & GARABEDIAN, M. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.007 · Cited by 318 · see citing works
Self-citation
Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases
Beck, I. M. E., Vanden Berghe, W., Vermeulen, L., Yamamoto, K. R., Haegeman, G., & De Bosscher, K. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0013 · Cited by 298 · see citing works
Nuclear receptors: integration of multiple signalling pathways through phosphorylation
Rochette-Egly, C. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(02)00115-8 · Cited by 291 · see citing works
Glucocorticoid Receptor Phosphorylation Differentially Affects Target Gene Expression
Chen, W., Dang, T., Blind, R. D., Wang, Z., Cavasotto, C. N., Hittelman, A. B., Rogatsky, I., Logan, S. K., & Garabedian, M. J. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0219 · Cited by 280 · see citing works
Self-citation
Glucocorticoids exacerbate lipopolysaccharide-induced signaling in the frontal cortex and hippocampus in a dose-dependent manner
Munhoz, C. D., Sorrells, S. F., Caso, J. R., Scavone, C., & Sapolsky, R. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0303-09.2010 · Cited by 169 · see citing works
Glycogen Synthase Kinase 3β-Mediated Serine Phosphorylation of the Human Glucocorticoid Receptor Redirects Gene Expression Profiles
Galliher-Beckley, A. J., Williams, J. G., Collins, J. B., & Cidlowski, J. A. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00808-08 · Cited by 136 · see citing works
Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease
Craig, C. F., Filippone, R. T., Stavely, R., Bornstein, J. C., Apostolopoulos, V., & Nurgali, K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02354-1 · Cited by 124 · see citing works
Role for Hsp90-Associated Cochaperone p23 in Estrogen Receptor Signal Transduction
Knoblauch, R., & Garabedian, M. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3748 · Cited by 126 · see citing works
Self-citation
Differential recruitment of glucocorticoid receptor phospho-isoforms to glucocorticoid-induced genes
Blind, R. D., & Garabedian, M. J. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.01.002 · Cited by 120 · see citing works
Self-citation
Glucocorticoid and thyroid hormone receptors in mitochondria of animal cells
Scheller, K., Seibel, P., & Sekerist, C. E. (2003) · International review of cytology · doi:10.1016/s0074-7696(02)22011-2 · Cited by 73 · see citing works
Kinases and protein phosphorylation as regulators of steroid hormone action
Weigel, N. L., & Moore, N. L. (2007) · Nuclear Receptor Signaling · doi:10.1621/nrs.05005 · Cited by 72 · see citing works
c-Jun N-Terminal Kinase Contributes to Aberrant Retinoid Signaling in Lung Cancer Cells by Phosphorylating and Inducing Proteasomal Degradation of Retinoic Acid Receptor α
Srinivas, H., Juroske, D. M., Kalyankrishna, S., Cody, D. D., Price, R. E., Xu, X.-C., Narayanan, R., Weigel, N. L., & Kurie, J. M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.3.1054-1069.2005 · Cited by 68 · see citing works
Cytokines Alter Glucocorticoid Receptor Phosphorylation in Airway Cells
Bouazza, B., Krytska, K., Debba-Pavard, M., Amrani, Y., Honkanen, R. E., Tran, J., & Tliba, O. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0364oc · Cited by 61 · see citing works
Altered glucocorticoid receptor signaling cascade in lymphocytes of bipolar disorder patients
Spiliotaki, M., Salpeas, V., Malitas, P., Alevizos, V., & Moutsatsou, P. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.02.006 · Cited by 58 · see citing works
Determinants of the heightened activity of glucocorticoid receptor translational isoforms
Bender, I. K., Cao, Y., & Lu, N. Z. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1009 · Cited by 19 · see citing works

Inhibitory Effect of Fig Wine on LPS‐induced NF‐kB Activation by Suppression of ERK1/2, p38, and JNK phosphorylation in RAW 264.7 Cells
Jeong, M., Cha, J., Park, K., et al. (2006) · The FASEB Journal · doi:10.1096/fasebj.20.4.a183
Protein expression and phosphorylation of mitogen-acttvated protein kinases in murine kupffer cells induced by lipopolysiaccharide (LPS)
Zhang, Y., Jiang, J., & Ji, S. (2002) · Europe PMC (PubMed Central)
Age-associated changes in MAPK activation in fast- and slow-twitch skeletal muscle of the F344/NNiaHSD X Brown Norway/BiNia rat model
Mylabathula, D. B., Rice, K. M., Wang, Z., Uddemarri, S., Kinnard, R. S., & Blough, E. R. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.11.001 · Cited by 33 · see citing works
Activation of Signaling Cascades by Weak Extremely Low Frequency Electromagnetic Fields
Kapri-Pardes, E., Hanoch, T., Maik-Rachline, G., Murbach, M., Bounds, P. L., Kuster, N., & Seger, R. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000481977 · Cited by 27 · see citing works
The ERK and p38MAPK Pathways as Targets for Anti-Inflammatory Therapy
Hitti, E., & Kotlyarov, A. (2007) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/187152307779939741 · Cited by 11 · see citing works

Authors: Rogatsky, I., Logan, S. K., & Garabedian, M. J.
Affiliations: NYU Langone Health (US)
ORCID: Rogatsky, Inez
Logan, Susan K.
Garabedian, Michael J.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1998-03-03
Volume: 95
Issue: 5
Pages: 2050-2055
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.95.5.2050
PMC: PMC19245
OpenAlex: W1976548850
Cited by: 297
References: 35
Citations by year: 2026: 4 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 1 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 6 · 2016: 6 · 2015: 11 · 2014: 8 · 2013: 13 · 2012: 13
FWCI: 7.07
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: glucocorticoid receptor, c-Jun N-terminal kinase, ERK, p38 MAPK, receptor phosphorylation, transcriptional activation, mitogen-activated protein kinase, inflammation, cell proliferation, gene expression regulation
MeSH terms: Animals, Dexamethasone, HeLa Cells, Humans, Peptide Mapping, Phosphopeptides, Phosphorylation, Receptors, Glucocorticoid, Recombinant Fusion Proteins, Osteosarcoma, Serine, Transcription Factors, Transcription, Genetic, Transfection, Tumor Cells, Cultured, Calcium-Calmodulin-Dependent Protein Kinases, Mitogen-Activated Protein Kinases, JNK Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks