Pilocarpine-induced status epilepticus results in mossy fiber sprouting and spontaneous seizures in C57BL/6 and CD-1 mice
Abstract
Several rodent models are available to study the cellular mechanisms associated with the development of temporal lobe epilepsy (TLE), but few have been successfully transferred to inbred mouse strains commonly used in genetic mutation studies. We examined spontaneous seizure development and correlative axon sprouting in the dentate gyrus of CD-1 and C57BL/6 mice after systemic injection of pilocarpine. Pilocarpine induced seizures and status epilepticus (SE) after systemic injection in both strains, although SE onset latency was greater for C57BL/6 mice. There were also animals of both strains which did not experience SE after pilocarpine treatment. After a period of normal behavior for several days after the pilocarpine treatment, spontaneous tonic-clonic seizures were observed in most CD-1 mice and all C57BL/6 that survived pilocarpine-induced SE. Robust mossy fiber sprouting into the inner molecular layer was observed after 4-8 weeks in mice from both strains which had experienced SE, and cell loss was apparent in the hippocampus. Mossy fiber sprouting and spontaneous seizures were not observed in mice that did not experience a period of SE. These results indicate that pilocarpine induces spontaneous seizures and mossy fiber sprouting in both CD-1 and C57BL/6 mouse strains. Unlike systemic kainic acid treatment, the pilocarpine model offers a potentially useful tool for studying TLE development in genetically modified mice raised on the C57BL/6 background.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
At seven days after SE, the dorsal hippocampus displays disruptions in electrical patterns in all hippocampal layers.
“At seven days after SE and during periods of immobility in freely-moving mice, although convulsive seizures were not observed (Racine’s score > 3), consistent with previous observations [34, 35] the dorsal hippocampus displayed disruptions in electrical patterns, mainly in all hippocampal layers (Fig. 2A).”
From Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin D1 (2015) · cites this paper as [35]
Chronic recurrent seizures are a consequence of pilocarpine-induced status epilepticus in all adult mice.
“Since chronic recurrent seizures are a consequence of pilocarpine-induced SE in all adult mice [27, 34, 35]”
From Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin D1 (2015) · cites this paper as [35]
The pilocarpine model of temporal lobe epilepsy in adult mice shows an onset of recurrent spontaneous seizures 7 days after status epilepticus that can continue for at least 7 weeks.
“The pilocarpine model of TLE in adult mice shows an onset of recurrent spontaneous seizures 7 days after SE that can continue for at least 7 weeks [27, 34, 35].”
From Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin D1 (2015) · cites this paper as [35]
Cites
Modification of seizure activity by electrical stimulation: II. Motor seizure
Racine, R. J. (1972) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(72)90177-0 · Cited by 7,141 · see citing works
Ben-Ari, Y. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90299-4 · Cited by 1,753 · see citing works
Jasper's Basic Mechanisms of the Epilepsies
(2012) · Oxford University Press eBooks · doi:10.1093/med/9780199746545.001.0001 · Cited by 1,161 · see citing works
Mossy fiber synaptic reorganization in the epileptic human temporal lobe
Sutula, T. P., Cascino, G. D., Cavazos, J. E., Parada, I., & Ramirez, L. F. (1989) · Annals of Neurology · doi:10.1002/ana.410260303 · Cited by 1,152 · see citing works
Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats
Tauck, D., & Nadler, J. V. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-04-01016.1985 · Cited by 1,087 · see citing works
Mello, L. E., Cavalheiro, É. A., Tan, A. M., Kupfer, W. R., Pretorius, J. K., Babb, T. L., & Finch, D. M. (1993) · Epilepsia · doi:10.1111/j.1528-1157.1993.tb02123.x · Cited by 696 · see citing works
Synaptic reorganization by mossy fibers in human epileptic fascia dentata
Babb, T. L., Kupfer, W. R., Pretorius, J. K., Crandall, P. H., & Levesque, M. F. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90380-7 · Cited by 656 · see citing works
Ben‐Ari, Y., Tremblay, E. C., RICHE, D., Ghilini, G., & Naquet, R. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90193-7 · Cited by 649 · see citing works
Schauwecker, P. E., & Steward, O. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4103 · Cited by 510 · see citing works
Bouilleret, V., Ridoux, V., Depaulis, A., Marescaux, C., Nehlig, A., & Salle, G. L. G. L. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00401-1 · Cited by 427 · see citing works
Turski, W. A., Cavalheiro, É. A., Bortolotto, Z. A., Mello, L. M., Schwarz, M., & Turski, L. (1984) · Brain Research · doi:10.1016/0006-8993(84)90177-x · Cited by 383 · see citing works
Nadler, J. V., Perry, B. W., & Cotman, C. W. (1980) · Brain Research · doi:10.1016/0006-8993(80)90825-2 · Cited by 374 · see citing works
Hellier, J. L., Patrylo, P. R., Buckmaster, P. S., & Dudek, F. E. (1998) · Epilepsy Research · doi:10.1016/s0920-1211(98)00017-5 · Cited by 367 · see citing works
Wuarin, J., & Dudek, F. E. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04438.1996 · Cited by 347 · see citing works
Cronin, J., & Dudek, F. E. (1988) · Brain Research · doi:10.1016/0006-8993(88)90681-6 · Cited by 336 · see citing works
Obenaus, A., Esclapez, M., & Houser, C. R. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-10-04470.1993 · Cited by 316 · see citing works
Physiologic and Morphologic Characteristics of Granule Cell Circuitry in Human Epileptic Hippocampus
Franck, J. E., Pokorny, J., Kunkel, D. D., & Schwartzkroin, P. A. (1995) · Epilepsia · doi:10.1111/j.1528-1157.1995.tb02566.x · Cited by 271 · see citing works
The Pilocarpine Model of Epilepsy in Mice
Cavalheiro, É. A., Santos, N. F., & Priel, M. R. (1996) · Epilepsia · doi:10.1111/j.1528-1157.1996.tb00541.x · Cited by 198 · see citing works
Increased Sensitivity to Seizures in Mice Lacking Cellular Prion Protein
Walz, R., Amaral, O. B., Rockenbach, I. C., Roesler, R., Izquierdo, I., Cavalheiro, É. A., Martins, V. R., & Brentani, H. (1999) · Epilepsia · doi:10.1111/j.1528-1157.1999.tb01583.x · Cited by 183 · see citing works
Excitatory Synaptic Input to Granule Cells Increases With Time After Kainate Treatment
Wuarin, J., & Dudek, F. E. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.3.1067 · Cited by 171 · see citing works
Longo, B. M., & Mello, L. E. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00267-x · Cited by 158 · see citing works
Cholinergic modulation of excitatory synaptic transmission in the CA3 area of the hippocampus
Vogt, K. E., & Regehr, W. G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00075.2001 · Cited by 149 · see citing works
Genetic Approaches to Neurotrauma Research: Opportunities and Potential Pitfalls of Murine Models
Steward, O., Schauwecker, P. E., Guth, L., Zhang, Z., Fujiki, M., Inman, D. M., Wrathall, J. R., Kempermann, G., Gage, F. H., Saatman, K. E., et al. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7040 · Cited by 146 · see citing works
Patrylo, P. R., & Dudek, F. E. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.1.418 · Cited by 135 · see citing works
Dudek, F. E., & Spitz, M. C. (1997) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199703000-00002 · Cited by 115 · see citing works
Bouilleret, V., Schwaller, B., Schurmans, S., Celio, M. R., & Fritschy, J. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00017-8 · Cited by 105 · see citing works
Short- and Long-Term Changes in CA1 Network Excitability After Kainate Treatment in Rats
Smith, B. N., & Dudek, F. E. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.1.1 · Cited by 103 · see citing works
Self-citationNorepinephrine is required for the anticonvulsant effect of the ketogenic diet
Szot, P., Weinshenker, D., Rho, J. M., Storey, T. W., & Schwartzkroin, P. A. (2001) · Developmental Brain Research · doi:10.1016/s0165-3806(01)00213-9 · Cited by 92 · see citing works
Abusaad, I., Mackay, D., Zhao, J., Stanford, P., Collier, D. A., & Everall, I. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990614)408:4 · Cited by 77 · see citing works
Estradiol induces a phasic Fos response in the hippocampal CA1 and CA3 regions of adult female rats
Rudick, C., & Woolley, C. (2000) · Hippocampus · doi:10.1002/1098-1063(2000)10:3 · Cited by 56 · see citing works
Genetic Dissection of the Signals That Induce Synaptic Reorganization
Schauwecker, P. E., Ramirez, J. J., & Steward, O. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7251 · Cited by 55 · see citing works
Chevassus-au-Louis, N., Ben‐Ari, Y., & Vergnes, M. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00932-9 · Cited by 52 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The pilocarpine model of temporal lobe epilepsy
Curia, G., Longo, D., Biagini, G., Jones, R. S. G., & Avoli, M. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.04.019 · Cited by 1,043 · see citing works
A role for leukocyte-endothelial adhesion mechanisms in epilepsy
Fabene, P. F., Mora, G. N., Martinello, M., Rossi, B., Merigo, F., Ottoboni, L., Bach, S., Angiari, S., Benati, D., Chakir, A., et al. (2008) · Nature Medicine · doi:10.1038/nm.1878 · Cited by 509 · see citing works
Long, Q., Upadhya, D., Hattiangady, B., Kim, D.-K., An, S. Y., Shuai, B., Prockop, D. J., & Shetty, A. K. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703920114 · Cited by 401 · see citing works
Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model
Borges, K. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00086-4 · Cited by 396 · see citing works
GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior
Hunt, R. F., Girskis, K. M., Rubenstein, J. L. R., Álvarez-Buylla, A., & Baraban, S. C. (2013) · Nature Neuroscience · doi:10.1038/nn.3392 · Cited by 300 · see citing works
Seizures accelerate functional integration of adult-generated granule cells
Overstreet-Wadiche, L. S., Bromberg, D. A., Bensen, A. L., & Westbrook, G. L. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5508-05.2006 · Cited by 266 · see citing works
Seizure-Induced Oxidative Stress in Temporal Lobe Epilepsy
Puttachary, S., Sharma, S., Stark, S., & Thippeswamy, T. (2015) · BioMed Research International · doi:10.1155/2015/745613 · Cited by 262 · see citing works
Mesial Temporal Lobe Epilepsy: Pathogenesis, Induced Rodent Models and Lesions
Sharma, A. K., Reams, R. Y., Jordan, W. H., Miller, M. A., Thacker, H. L., & Snyder, P. W. (2007) · Toxicologic Pathology · doi:10.1080/01926230701748305 · Cited by 263 · see citing works
Animal models of temporal lobe epilepsy following systemic chemoconvulsant administration
Lévesque, M., Avoli, M., & Bernard, C. (2015) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2015.03.009 · Cited by 243 · see citing works
Oxidative stress in the hippocampus after pilocarpine‐induced status epilepticus in Wistar rats
de Freitas, R. M., Vasconcelos, S. M. M., de Souza, F. C. F., Viana, G. S. D. B., & Fonteles, M. M. D. F. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2004.04537.x · Cited by 220 · see citing works
Cunningham, M., Cho, J.-H., Leung, A., Savvidis, G., Ahn, S., Moon, M., Lee, P. K. J., Han, J. J., Azimi, N., Kim, K.-S., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.10.006 · Cited by 218 · see citing works
Behavioral alterations in the pilocarpine model of temporal lobe epilepsy in mice
Gröticke, I., Hoffmann, K., & Löscher, W. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.06.021 · Cited by 210 · see citing works
Posttraumatic epilepsy after controlled cortical impact injury in mice
Hunt, R. F., Scheff, S. W., & Smith, B. N. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.10.005 · Cited by 207 · see citing works
Self-citationSecreted Frizzled-Related Protein 3 Regulates Activity-Dependent Adult Hippocampal Neurogenesis
Jang, M., Bonaguidi, M. A., Kitabatake, Y., Sun, J., Song, J., Kang, E., Jun, H., Zhong, C., Su, Y., Guo, J. U., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.11.021 · Cited by 198 · see citing works
Rosenberg, E. C., Patra, P. H., & Whalley, B. J. (2017) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2016.11.006 · Cited by 193 · see citing works
Walter, C., Murphy, B. L., Pun, R. Y. K., Spieles-Engemann, A. L., & Danzer, S. C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0431-07.2007 · Cited by 189 · see citing works
Neural circuit mechanisms of post–traumatic epilepsy
Hunt, R. F., Boychuk, J. A., & Smith, B. N. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00089 · Cited by 173 · see citing works
Self-citationMüller, C. J., Gröticke, I., Bankstahl, M., & Löscher, W. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.05.035 · Cited by 169 · see citing works
Wang, Z., Zhou, L., An, D., Xu, W., Wu, C., Sha, S., Li, Y., Zhu, Y., Chen, A., Du, Y., et al. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1612-3 · Cited by 149 · see citing works
Mouri, G., Jimenez-Mateos, E. M., Engel, T., Dunleavy, M., Hatazaki, S., Paucard, A., Matsushima, S., Taki, W., & Henshall, D. C. (2008) · Brain Research · doi:10.1016/j.brainres.2008.03.061 · Cited by 149 · see citing works
Bazan, N. G. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.09.003 · Cited by 148 · see citing works
Mirrione, M. M., Schiffer, W. K., Fowler, J. S., Alexoff, D. L., Dewey, S. L., & Tsirka, S. E. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.06.032 · Cited by 139 · see citing works
Semaphorins in Adult Nervous System Plasticity and Disease
Carulli, D., de Winter, F., & Verhaagen, J. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.672891 · Cited by 137 · see citing works
Song, Y.-J., Tian, X.-B., Zhang, S., Zhang, Y.-X., Li, X., Li, D., Cheng, Y., Zhang, J.-N., Kang, C.-S., & Zhao, W. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.073 · Cited by 135 · see citing works
Bhaskaran, M. D., & Smith, B. N. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.01.021 · Cited by 116 · see citing works
Self-citationBarros, D. O., Xavier, S. M. L., Barbosa, C. O., Silva, R. F. M., de Freitas, R. L. M., Maia, F. D. P., Oliveira, A. A., de Freitas, R. M., & Takahashi, R. N. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.01.057 · Cited by 110 · see citing works
Hunt, R. F., Scheff, S. W., & Smith, B. N. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0032-11.2011 · Cited by 104 · see citing works
Self-citationLévesque, M., Biagini, G., de Curtis, M., Gnatkovsky, V., Pitsch, J., Wang, S., & Avoli, M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.08.020 · Cited by 103 · see citing works
Mirrione, M. M., Konomos, D. K., Gravanis, I., Dewey, S. L., Aguzzi, A., Heppner, F. L., & Tsirka, S. E. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.04.001 · Cited by 103 · see citing works
Hunt, R. F., Scheff, S. W., & Smith, B. N. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00957.2009 · Cited by 101 · see citing works
Self-citationWang, L., Liu, Y.-H., Huang, Y., & Chen, L.-W. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.097 · Cited by 101 · see citing works
Mazarati, A. M., Lü, X., Shinmei, S., Badie-Mahdavi, H., & Bartfai, T. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.052 · Cited by 99 · see citing works
de Freitas, R. M. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.07.037 · Cited by 96 · see citing works
Müller, C. J., Bankstahl, M., Gröticke, I., & Löscher, W. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.07.020 · Cited by 93 · see citing works
Henderson, K. W., Gupta, J., Tagliatela, S., Litvina, E. Y., Zheng, X., Zandt, M. A. V., Woods, N. I., Grund, E. M., Lin, D., Royston, S. E., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0005-14.2014 · Cited by 91 · see citing works
Danzer, S. C., & McNamara, J. O. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3846-04.2004 · Cited by 90 · see citing works
Persistent decrease in multiple components of the perineuronal net following status epilepticus
McRae, P. A., Baranov, E., Rogers, S. L., & Porter, B. E. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08268.x · Cited by 85 · see citing works
The Pilocarpine Model of Seizures
Cavalheiro, É. A., Naffah‐Mazzacoratti, M. D. G., Mello, L. E., & Leite, J. P. (2006) · Elsevier eBooks · doi:10.1016/b978-012088554-1/50037-2 · Cited by 85 · see citing works
Hilar mossy cell circuitry controlling dentate granule cell excitability
Jinde, S., Zsiros, V., & Nakazawa, K. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00014 · Cited by 84 · see citing works
Differences in sensitivity to the convulsant pilocarpine in substrains and sublines of C57BL/6 mice
Müller, C. J., Gröticke, I., Hoffmann, K., Schughart, K., & Löscher, W. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00490.x · Cited by 84 · see citing works
Strain differences in seizure-induced cell death following pilocarpine-induced status epilepticus
Schauwecker, P. E. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.08.013 · Cited by 83 · see citing works
Majores, M., Schoch, S., Lie, A. A., & Becker, A. J. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01062.x · Cited by 82 · see citing works
Bhaskaran, M. D., & Smith, B. N. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010683 · Cited by 82 · see citing works
Self-citationButler, C. R., Boychuk, J. A., & Smith, B. N. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00163 · Cited by 79 · see citing works
Self-citationLiu, J.-T., Wu, S., Zhang, H., & Kuang, F. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0653-0 · Cited by 74 · see citing works
Chrzaszcz, M., Venkatesan, C., Dragisic, T., Watterson, D. M., & Wainwright, M. S. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2009.1227 · Cited by 76 · see citing works
Maisano, X., Litvina, E. Y., Tagliatela, S., Aaron, G. B., Grabel, L. B., & Naegele, J. R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2683-11.2012 · Cited by 73 · see citing works
Smeland, O. B., Hadera, M. G., McDonald, T. S., Sonnewald, U., & Borges, K. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.54 · Cited by 73 · see citing works
Murphy, B. L., Hofacer, R. D., Faulkner, C., Loepke, A. W., & Danzer, S. C. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03463.x · Cited by 70 · see citing works
Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy
Pitsch, J., Schoch, S., Gueler, N., Flor, P. J., van der Putten, H., & Becker, A. J. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.03.003 · Cited by 68 · see citing works
LSD1 Neurospecific Alternative Splicing Controls Neuronal Excitability in Mouse Models of Epilepsy
Rusconi, F., Paganini, L., Braida, D., Ponzoni, L., Toffolo, E., Maroli, A., Landsberger, N., Bedogni, F., Turco, E., Pattini, L., et al. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu070 · Cited by 66 · see citing works
de Freitas, R. M., Nascimento, V. S., Vasconcelos, S. M. M., de Sousa, F. C. F., Viana, G. S. D. B., & Fonteles, M. M. D. F. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.04.060 · Cited by 65 · see citing works
Yan, X.-X., Cai, Y., Shelton, J., Deng, S.-H., Luo, X.-G., Oddo, S., LaFerla, F. M., Cai, H., Rose, G. M., & Patrylo, P. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048782 · Cited by 64 · see citing works
Kim, G. W., Kim, H.-J., Cho, K.-J., Kim, H.-W., Cho, Y.-J., & Lee, B. I. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.008 · Cited by 63 · see citing works
Gnatek, Y., Zimmerman, G., Goll, Y., Najami, N., Soreq, H., & Friedman, A. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00066 · Cited by 63 · see citing works
Kharatishvili, I., Shan, Z., She, D. T., Foong, S., Kurniawan, N. D., & Reutens, D. C. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0528-4 · Cited by 61 · see citing works
Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy
Danzer, S. C., He, X., Loepke, A. W., & McNamara, J. O. (2009) · Hippocampus · doi:10.1002/hipo.20589 · Cited by 61 · see citing works
Naegele, J. R., Maisano, X., Yang, J. N., Royston, S. E., & Ribeiro, E. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.01.019 · Cited by 58 · see citing works
Persistent seizure control in epileptic mice transplanted with gamma‐aminobutyric acid progenitors
Casalia, M. L., Howard, M. A., & Baraban, S. C. (2017) · Annals of Neurology · doi:10.1002/ana.25021 · Cited by 58 · see citing works
Germain, N. D., Banda, E. C., Becker, S., Naegele, J. R., & Grabel, L. B. (2013) · Stem Cells and Development · doi:10.1089/scd.2012.0264 · Cited by 57 · see citing works
Ahmad, M. (2013) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2013.01.002 · Cited by 55 · see citing works
Posttraumatic seizures and epilepsy in adult rats after controlled cortical impact
Kelly, K. M., Miller, E. R., Lepsveridze, E., Kharlamov, E. A., & Mtchedlishvili, Z. (2015) · Epilepsy Research · doi:10.1016/j.eplepsyres.2015.09.009 · Cited by 54 · see citing works
Hadera, M. G., Smeland, O. B., McDonald, T. S., Tan, K. N., Sonnewald, U., & Borges, K. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12610 · Cited by 53 · see citing works
The promise of an interneuron‐based cell therapy for epilepsy
Sebe, J. Y., & Baraban, S. C. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20813 · Cited by 51 · see citing works
Chen, J., Larionov, S., Pitsch, J., Hoerold, N., Ullmann, C., Elger, C. E., Schramm, J., & Becker, A. J. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.11.008 · Cited by 48 · see citing works
Júnior, H. V. N., Fonteles, M. M. D. F., & de Freitas, R. M. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.3.8488 · Cited by 48 · see citing works
Welzel, L., Schidlitzki, A., Twele, F., Anjum, S. M. M., & Löscher, W. (2019) · Epilepsia · doi:10.1111/epi.16406 · Cited by 48 · see citing works
McAuliffe, J. J., Bronson, S. L., Hester, M. S., Murphy, B. L., Dahlquist‐Topalá, R., Richards, D. A., & Danzer, S. C. (2011) · Hippocampus · doi:10.1002/hipo.20726 · Cited by 47 · see citing works
Umpierre, A. D., Bennett, I. V., Nebeker, L. D., Newell, T. G., Tian, B. B., Thomson, K. E., White, H. S., White, J. A., & Wilcox, K. S. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.02.014 · Cited by 47 · see citing works
Itoh, K., Inamine, M., Oshima, W., Kotani, M., Chiba, Y., Ueno, M., & Ishihara, Y. (2015) · Brain Research · doi:10.1016/j.brainres.2015.03.005 · Cited by 46 · see citing works
The epilepsies: Complex challenges needing complex solutions
Tejada, J., Costa, K. M., Bertti, P., & Garcia‐Cairasco, N. (2012) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2012.09.029 · Cited by 46 · see citing works
Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy
Buckmaster, P. S., & Haney, M. M. (2012) · Epilepsy Research · doi:10.1016/j.eplepsyres.2012.05.012 · Cited by 46 · see citing works
Borges, K., McDermott, D. L., & Dingledine, R. J. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.03.019 · Cited by 46 · see citing works
An Acquired Channelopathy Involving Thalamic T-Type Ca2+Channels after Status Epilepticus
Graef, J. D., Nordskog, B. K., Wiggins, W. F., & Godwin, D. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0198-09.2009 · Cited by 45 · see citing works
KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring
Homma, N., Zhou, R., Naseer, M. I., Chaudhary, A., Al-Qahtani, M. H., & Hirokawa, N. (2018) · eLife · doi:10.7554/elife.30935 · Cited by 44 · see citing works
Yue, J., He, J., Wei, Y., Shen, K., Wu, K., Yang, X., Liu, S., Zhang, C., & Yang, H. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1718-7 · Cited by 44 · see citing works
Singh, S. P., He, X., McNamara, J. O., & Danzer, S. C. (2013) · Hippocampus · doi:10.1002/hipo.22169 · Cited by 43 · see citing works
Rozmer, K., Gao, P., Araújo, M. G. L., Khan, M. T., Liu, J., Rong, W., Tang, Y., Franke, H., Krügel, U., Fernandes, M. J. D. S., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw178 · Cited by 43 · see citing works
Recurrent excitation in the dentate gyrus of a murine model of temporal lobe epilepsy
Winokur, R. S., Kubal, T. E., Liu, D., Davis, S. F., & Smith, B. N. (2004) · Epilepsy Research · doi:10.1016/j.eplepsyres.2004.01.002 · Cited by 43 · see citing works
Self-citationBasement membrane protein nidogen‐1 shapes hippocampal synaptic plasticity and excitability
Vasudevan, A., Ho, M. S. P., Weiergräber, M., Nischt, R., Schneider, T., Lie, A. A., Smyth, N. R., & Köhling, R. (2009) · Hippocampus · doi:10.1002/hipo.20660 · Cited by 42 · see citing works
Fan, J., Dong, X., Tang, Y., Wang, X., Lin, D., Gong, L., Chen, C., Jiang, J., Shen, W., Xu, A., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14224 · Cited by 43 · see citing works
LaSarge, C. L., Santos, V. R., & Danzer, S. C. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.12.029 · Cited by 40 · see citing works
Musto, A. E., Walker, C. P., Petasis, N. A., & Bazan, N. G. (2015) · PLOS ONE · doi:10.1371/journal.pone.0116543 · Cited by 39 · see citing works
Contributions of mature granule cells to structural plasticity in temporal lobe epilepsy
Santos, V. R., de Castro, O. W., Pun, R. Y. K., Hester, M. S., Murphy, B. L., Loepke, A. W., Garcia‐Cairasco, N., & Danzer, S. C. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.034 · Cited by 39 · see citing works
Bankstahl, M., Müller, C. J., Wilk, E., Schughart, K., & Löscher, W. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.02.004 · Cited by 39 · see citing works
FREITAS, R. M., de Sousa, F. C. F., Viana, G. S. D. B., & Fonteles, M. M. D. F. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.01.028 · Cited by 39 · see citing works
Functional disruption of stress modulatory circuits in a model of temporal lobe epilepsy
Wulsin, A. C., Franco, A. C. G., Romancheck, C., Morano, R. L., Smith, B. L., Packard, B. A., Danzer, S. C., & Herman, J. P. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197955 · Cited by 38 · see citing works
Self-citationEarly detonation by sprouted mossy fibers enables aberrant dentate network activity
Hendricks, W. D., Westbrook, G. L., & Schnell, E. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821227116 · Cited by 36 · see citing works
Alhaj, M. W., Zaitone, S. A., & Moustafa, Y. M. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000127 · Cited by 36 · see citing works
Zhang, Y., Guo-en, C., Yang, Q., Lu, Q.-C., Li, S., & Ju, G. (2010) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2010.02.008 · Cited by 36 · see citing works
Kadiyala, S. B., Yannix, J. Q., Nalwalk, J. W., Papandrea, D., Beyer, B. S., Herron, B. J., & Ferland, R. J. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3232-14.2016 · Cited by 35 · see citing works
Kwak, S., Kim, J., Kim, S. C., Kwon, O., Choi, S., & Kang, T. (2008) · Brain Research · doi:10.1016/j.brainres.2008.04.026 · Cited by 35 · see citing works
Short-Term Depression of Sprouted Mossy Fiber Synapses from Adult-Born Granule Cells
Hendricks, W. D., Chen, Y., Bensen, A. L., Westbrook, G. L., & Schnell, E. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0761-17.2017 · Cited by 31 · see citing works
Hunt, R. F., Haselhorst, L. A., Schoch, K. M., Bach, E. C., Rios-Pilier, J., Scheff, S. W., Saatman, K. E., & Smith, B. N. (2011) · Epilepsy Research · doi:10.1016/j.eplepsyres.2011.10.011 · Cited by 34 · see citing works
Self-citationAdaptive Mossy Cell Circuit Plasticity after Status Epilepticus
Butler, C. R., Westbrook, G. L., & Schnell, E. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1008-21.2022 · Cited by 32 · see citing works
Wang, S., Li, X., Zhou, S., Sun, D.-X., Wang, H., Cheng, P.-F., Ma, X., Liu, L., Liu, J.-X., Wang, F., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061687 · Cited by 31 · see citing works
Shiha, A. A., de Cristóbal, J., Delgado, M., de la Rosa, R. F., Bascuñana, P., Pozo, M. A., & García‐García, L. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.12.009 · Cited by 30 · see citing works
BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice
Yan, X.-X., Cai, Y., Zhang, X.-M., Luo, X.-G., Cai, H., Rose, G. M., & Patrylo, P. R. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.01.003 · Cited by 29 · see citing works
Mitsuya, K., Nitta, N., & Suzuki, F. (2009) · Epilepsia · doi:10.1111/j.1528-1167.2009.02055.x · Cited by 30 · see citing works
Induction of Temporal Lobe Epilepsy in Mice with Pilocarpine
Arshad, M., & Naegele, J. R. (2020) · BIO-PROTOCOL · doi:10.21769/bioprotoc.3533 · Cited by 29 · see citing works
- Authors
- Shibley, H., & Smith, B. N.
- Affiliations
- Tulane University (US)
- Corresponding author
- Smith, Bret N.
- ORCID
- Smith, Bret N.
- Venue
- Epilepsy Research
- Publisher
- Elsevier BV
- Published
- 2002-04
- Volume
- 49
- Issue
- 2
- Pages
- 109-120
- ISSN
- 0920-1211 (ISSN-L)
- OpenAlex
- W2042575144
- Cited by
- 201
- References
- 32
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 11 · 2020: 12 · 2019: 12 · 2018: 10 · 2017: 8 · 2016: 12 · 2015: 10 · 2014: 9 · 2013: 15 · 2012: 15
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Epilepsy Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Louisiana Board of Regents
- Tulane University
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- pilocarpine, status epilepticus, mossy fiber sprouting, temporal lobe epilepsy, spontaneous seizures, dentate gyrus, hippocampal neuronal loss, C57BL/6 mice, ICR mice, mouse strain differences, kainic acid model, inbred mouse models
- MeSH terms
- Animals, Convulsants, Male, Mice, Inbred C57BL, Mice, Inbred Strains, Neurons, Pilocarpine, Seizures, Status Epilepticus, Cell Death, Dentate Gyrus, Mossy Fibers, Hippocampal, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review