Psychotic illness after prenatal exposure to the 1953 Dutch Flood Disaster
Abstract
We tested the hypothesis that maternal stress during pregnancy increases the risk of non-affective psychosis for the child. The concept of non-affective psychosis includes the ICD categories schizophrenic disorder, paranoid state and other non-organic psychosis. Data from the Dutch Psychiatric Registry were examined for an effect of the Flood Disaster of 1 February 1953. On this day, a gale caused a flood in the South-west of The Netherlands and 1835 people perished. Our study concerned the 19 villages where mortality exceeded 0.25%. The risk of non-affective psychosis for the cohort born in the period February-October 1953 was compared to the risks for the cohorts born in the corresponding periods of the previous and subsequent 2 years. The relative risk of non-affective psychosis for those exposed during gestation was 1.8 [95% Confidence Interval (CI): 0.9-3.5]. Thus, our study failed to demonstrate a significant association between prenatal exposure to maternal stress and risk of non-affective psychosis. The possible explanations for this finding are discussed.
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Maternal exposure to natural disasters, war, or stressful life events is associated with increased prevalence of psychopathology in offspring.
“and maternal exposure to natural disasters, war or stressful life events have been associated with increased prevalence of psychopathology in the offspring (van Os & Selten, 1998; Selten et al., 1999; Watson et al., 1999; Beversdorf et al., 2005; Khashan et al., 2008).”
From High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. (2010) · cites this paper as Selten et al., 1999
Cites
Applied Regression Analysis and Other Multivariable Methods
Walker, E., Kleinbaum, D. G., Kupper, L. L., & Muller, K. E. (1989) · Technometrics · doi:10.2307/1270375 · Cited by 8,538 · see citing works
Schizophrenia After Prenatal Exposure to the Dutch Hunger Winter of 1944-1945
Susser, E. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120071010 · Cited by 727 · see citing works
Prenatal exposure to maternal stress and subsequent schizophrenia
van Os, J., & Selten, J. (1998) · The British Journal of Psychiatry · doi:10.1192/bjp.172.4.324 · Cited by 481 · see citing works
Self-citationPrenatal Loss of Father and Psychiatric Disorders
HUTTUNEN, M. O. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770280039004 · Cited by 372 · see citing works
Unwantedness of a Pregnancy and Schizophrenia in the Child
Myhrman, A., Rantakallio, P. T., Isohanni, M. K., Jones, P. B., & Partanen, U. (1996) · The British Journal of Psychiatry · doi:10.1192/bjp.169.5.637 · Cited by 200 · see citing works
Evidence Against Maternal Influenza as a Risk Factor for Schizophrenia
Selten, J., & Slaets, J. P. J. (1994) · The British Journal of Psychiatry · doi:10.1192/bjp.164.5.674 · Cited by 65 · see citing works
Self-citationvan Os, J., & Selten, J. P. (1998) · Schizophrenia Research · doi:10.1016/s0920-9964(97)88329-6 · Cited by 7 · see citing works
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Antenatal maternal stress and long‐term effects on child neurodevelopment: how and why?
Talge, N. M., Neal, C., Glover, V., & the Early Stress, T. R. A. P. S. N. F. A. N. E. O. C. A. A. M. H. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01714.x · Cited by 1,349 · see citing works
The environment and susceptibility to schizophrenia
Brown, A. S. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.09.003 · Cited by 664 · see citing works
Babenko, O., Kovalchuk, I., & Metz, G. A. S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.013 · Cited by 513 · see citing works
Huizink, A. C., Mulder, E. J. H., & Buitelaar, J. K. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.1.115 · Cited by 473 · see citing works
Buss, C., Davis, E. P., Muftuler, L. T., Head, K., & Sandman, C. A. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.07.010 · Cited by 435 · see citing works
The effects of prenatal stress on temperament and problem behavior of 27-month-old toddlers
Gutteling, B. M., de Weerth, C., Willemsen-Swinkels, S. H. N., Huizink, A. C., Mulder, E. J. H., Visser, G. H. A., & Buitelaar, J. K. (2005) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-005-0435-1 · Cited by 230 · see citing works
Prenatal Programming of Mental Illness: Current Understanding of Relationship and Mechanisms
Kim, D. R., Bale, T. L., & Epperson, C. N. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-014-0546-9 · Cited by 203 · see citing works
Glucocorticoid hormones and early brain development in schizophrenia
Ph.D., J. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00396-7 · Cited by 199 · see citing works
Sex-specificity in transgenerational epigenetic programming
Dunn, G. A., Morgan, C. P., & Bale, T. L. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.05.004 · Cited by 198 · see citing works
Jablensky, A. (2003) · Schizophrenia · doi:10.1002/9780470987353.ch12 · Cited by 59 · see citing works
- Authors
- Selten, J.-P., van der Graaf, Y., van Duursen, R., Gispen-de Wied, C. C., & Kahn, R. S.
- Affiliations
- Utrecht University (NL)
- Corresponding author
- Selten, Jean-Paul
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 1999-02
- Volume
- 35
- Issue
- 3
- Pages
- 243-245
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2080949425
- Cited by
- 84
- References
- 7
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 4
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- prenatal stress, maternal stress
- MeSH terms
- Disasters, Female, Humans, Male, Netherlands, Pregnancy, Prenatal Exposure Delayed Effects, Psychotic Disorders, Registries, Schizophrenia, Stress, Psychological, Cohort Studies, Maternal Exposure
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