Cited by 198Birth, Development, and HealthEpigenetics and DNA MethylationGenetic Syndromes and Imprinting

Sex-specificity in transgenerational epigenetic programming

Dunn, Gregory A., Morgan, Christopher P., Bale, Tracy L.·2011·Hormones and Behavior

Abstract

Prenatal programming of the epigenome is a critical determinant in offspring outcome and stands at the interface between environment and genetics. Maternal experiences such as stress and obesity are associated with a host of neurodevelopmental and metabolic diseases, some of which have been characterized into the second and third generations. The mechanism through which determinants such as maternal diet or stress contribute to disease development likely involves a complex interaction between the maternal environment, placental changes, and epigenetic programming of the embryo. While we have begun to more fully appreciate and explore the epigenome in determination of disease risk, we know little as to the contribution embryo sex makes in epigenetic regulation. This review discusses the importance of sex differences in the transmission and inheritance of traits that are generated in the prenatal environment using models of maternal stress and diet.

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Crossref · 10.1016/j.yhbeh.2010.05.004

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  • Previous studies have shown that epigenetics is an important contributor to the sex differences in brain functions and vulnerability to diseases.

    “Previous studies have shown that epigenetics is an important contributor to the sex differences in brain functions and vulnerability to diseases [12–16]”

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Authors
Dunn, G. A., Morgan, C. P., & Bale, T. L.
Affiliations
University of Pennsylvania (US)
Corresponding author
Bale, Tracy L.
Venue
Hormones and Behavior
Publisher
Elsevier BV
Published
2011-03
Volume
59
Issue
3
Pages
290-295
ISSN
0018-506X (ISSN-L)
OpenAlex
W2093483466
Cited by
198
References
82
Citations by year
2026: 3 · 2025: 2 · 2024: 11 · 2023: 9 · 2022: 4 · 2021: 27 · 2020: 11 · 2019: 10 · 2018: 8 · 2017: 12 · 2016: 15 · 2015: 16 · 2014: 22 · 2013: 16 · 2012: 19
FWCI
2.26
Type
journal article
Language
en
Open access
closed
Locations
  • Hormones and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Keywords
sex differences, prenatal programming, maternal stress, maternal diet, placenta, embryo sex, epigenetic inheritance, neurodevelopmental disorders, metabolic disorders, offspring outcomes
MeSH terms
Animals, Female, Male, Pregnancy, Prenatal Exposure Delayed Effects, Sex Characteristics, Sex Factors, Stress, Physiological, Epigenesis, Genetic

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