Prenatal Programming of Mental Illness: Current Understanding of Relationship and Mechanisms

Kim, Deborah R.; Bale, Tracy L.; Epperson, C. Neill

doi:10.1007/s11920-014-0546-9

Cited by 203Birth, Development, and HealthMaternal Mental Health During Pregnancy and PostpartumStress Responses and Cortisol

Prenatal Programming of Mental Illness: Current Understanding of Relationship and Mechanisms

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Kim, Deborah R., Bale, Tracy L., Epperson, C. Neill·2015·Current Psychiatry Reports

DOI 10.1007/s11920-014-0546-9PMC PMC4458064

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Abstract

The British epidemiologist Dr. David J. Barker documented the relationship between infant birth weight and later onset of hypertension, coronary heart disease, insulin resistance, and type II diabetes. A stressful in utero environment can cause long-term consequences for offspring through prenatal programming. Prenatal programming most commonly occurs through epigenetic mechanisms and can be dependent on the type and timing of exposure as well as the sex of the fetus. In this review, we highlight the most recent evidence that prenatal programming is implicated in the development of psychiatric disorders in offspring exposed to maternal stress during pregnancy. Methodological differences between studies contribute to unavoidable heterogeneity in study findings. Current data suggest that fetal exposure to maternal hypothalamic-pituitary-adrenal axis dysregulation, excessive glucocorticoids, and inflammation with resulting epigenetic changes at both the placental and fetal levels are important areas of continued investigation.

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Untreated maternal depression can have deleterious effects.
“untreated maternal depression can have deleterious effects.10”
From Pregnancy and the Acceptability of Computer-Based Versus Traditional Mental Health Treatments (2017) · cites this paper as [10]
The prenatal period is critically important in the development and long-term health of the offspring.
“The prenatal period is critically important in the development and long-term health of the offspring”
From Pregnancy and the Acceptability of Computer-Based Versus Traditional Mental Health Treatments (2017) · cites this paper as [10]

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García‐Cáceres, C., Lagunas, N., Calmarza-Font, I., Azcoitia, Í., Diz-Chaves, Y., García‐Segura, L. M., Baquedano, E., Frago, L. M., Argente, J., & Chowen, J. A. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.05.006 · Cited by 91 · see citing works
Functional Programming of the Autonomic Nervous System by Early Life Immune Exposure: Implications for Anxiety
Sominsky, L., Fuller, E. A., Bondarenko, E., Ong, L. K., Averell, L., Nalivaiko, E., Dunkley, P. R., Dickson, P. W., & Hodgson, D. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057700 · Cited by 90 · see citing works
No relation between risk of schizophrenia and prenatal exposure to influenza in Holland
Susser, E., Lin, S. P., Brown, A. S., Lumey, L. H., & Erlenmeyer‐Kimling, L. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.6.922 · Cited by 90 · see citing works
Is There a Fetal Origin of Depression? Evidence from the Mater University Study of Pregnancy and Its Outcomes
Alati, R., Lawlor, D. A., Mamun, A. A., Williams, G. M., Najman, J. M., O'Callaghan, M. J., & Bor, W. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwk036 · Cited by 87 · see citing works
Psychotic illness after prenatal exposure to the 1953 Dutch Flood Disaster
Selten, J.-P., van der Graaf, Y., van Duursen, R., Gispen-de Wied, C. C., & Kahn, R. S. (1999) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00143-1 · Cited by 84 · see citing works
Elevated levels of measles antibodies in children with autism
Singh, V. K., & Jensen, R. L. (2003) · Pediatric Neurology · doi:10.1016/s0887-8994(02)00627-6 · Cited by 76 · see citing works
Maternal Stress and Infant Mortality
Class, Q. A., Khashan, A. S., Lichtenstein, P., Långström, N., & D'Onofrio, B. M. (2013) · Psychological Science · doi:10.1177/0956797612468010 · Cited by 72 · see citing works
Neonatal lipopolysaccharide exposure alters central cytokine responses to stress in adulthood in Wistar rats
Walker, A. K., Nakamura, T., & Hodgson, D. M. (2010) · Stress · doi:10.3109/10253890.2010.489977 · Cited by 69 · see citing works
Neurodevelopmental consequences of maternal distress: what do we really know?
Schuurmans, C., & Kurrasch, D. M. (2012) · Clinical Genetics · doi:10.1111/cge.12049 · Cited by 68 · see citing works
Maternal prenatal symptoms of depression and down regulation of placental monoamine oxidase A expression
Blakeley, P. M., Capron, L. E., Jensen, A. B., O'Donnell, K. J., & Glover, V. (2013) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2013.07.002 · Cited by 63 · see citing works
Are infant size and growth related to burden of disease in adulthood? A systematic review of literature
Fisher, D. J., Baird, J., Payne, L., Lucas, P. J., Kleijnen, J., Roberts, H. M., & Law, C. (2006) · International Journal of Epidemiology · doi:10.1093/ije/dyl130 · Cited by 60 · see citing works
Early maternal stress and health behaviours and offspring expression of psychosis in adolescence
SPAUWEN, J., A, L. K. M., Lieb, R., Wïttchen, H., & van Os, J. (2004) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2004.00429.x · Cited by 54 · see citing works
At Issue: The Problem of Obstetrical Complications and Schizophrenia
Zornberg, G. L., Buka, S. L., & Tsuang, M. T. (2000) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033449 · Cited by 45 · see citing works
No relationship between risk of schizophrenia and prenatal exposure to stress during the Six-Day War or Yom Kippur War in Israel
Selten, J., Cantor‐Graae, E., Nahon, D., Levav, I., Aleman, A., & Kahn, R. S. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00375-4 · Cited by 44 · see citing works
Perinatal maternal life events and psychotic experiences in children at twelve years in a birth cohort study
Dorrington, S., Zammit, S., Asher, L., Evans, J., Heron, J., & Lewis, G. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.11.006 · Cited by 42 · see citing works
Fetal growth restriction and the development of major depression
Vasiliadis, H., Gilman, S. E., & Buka, S. L. (2008) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2008.01168.x · Cited by 40 · see citing works
Prenatal Maternal Bereavement and Congenital Heart Defects in Offspring: A Registry-Based Study
Zhu, J. L., Olsen, J., Sørensen, H. T., Li, J., Nohr, E. A., Obel, C., Vestergaard, M., & Olsen, M. S. (2013) · PEDIATRICS · doi:10.1542/peds.2012-3024 · Cited by 38 · see citing works
Attention-Deficit/Hyperactivity Disorder
Gaynes, B. N., Christian, R. B., Saavedra, L. M., Wines, R., Jonas, D. E., Viswanathan, M., Ellis, A. R., Woodell, C., & Carey, T. S. (2014) · Journal of Psychiatric Practice · doi:10.1097/01.pra.0000445245.46424.25 · Cited by 26 · see citing works
Could Autism Be Treated Prenatally?
Zimmerman, A. W., & Connors, S. L. (2014) · Science · doi:10.1126/science.1250214 · Cited by 22 · see citing works
The marriage‐related risk factors during maternal pregnancy in children with attention‐deficit hyperactivity disorder
Lee, C., Chang, Y. ‐., & Lung, F. ‐. (2006) · Child Care Health and Development · doi:10.1111/j.1365-2214.2006.00587.x · Cited by 11 · see citing works

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From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways
Rogers, G. B., Keating, D. J., Young, R. L., Wong, M.-L., Licinio, J., & Wesselingh, S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.50 · Cited by 969 · see citing works
Sex differences and stress across the lifespan
Bale, T. L., & Epperson, C. N. (2015) · Nature Neuroscience · doi:10.1038/nn.4112 · Cited by 751 · see citing works
Self-citation
Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms
Yehuda, R., & Lehrner, A. (2018) · World Psychiatry · doi:10.1002/wps.20568 · Cited by 730 · see citing works
Epidemiology and risk factors for bipolar disorder
Rowland, T., & Marwaha, S. (2018) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125318769235 · Cited by 513 · see citing works
Sex differences in nucleus accumbens transcriptome profiles associated with susceptibility versus resilience to subchronic variable stress
Hodes, G. E., Pfau, M. L., Purushothaman, I., Ahn, H. F., Golden, S. A., Christoffel, D. J., Magida, J., Brancato, A., Takahashi, A., Flanigan, M. E., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1392-15.2015 · Cited by 395 · see citing works
Distress during pregnancy: Epigenetic regulation of placenta glucocorticoid-related genes and fetal neurobehavior
Monk, C., Feng, T., Lee, S., Krupska, I., Champagne, F. A., & Tycko, B. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15091171 · Cited by 304 · see citing works
Epigenetic responses and the developmental origins of health and disease
Goyal, D., Limesand, S. W., & Goyal, R. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0009 · Cited by 289 · see citing works
Inflammation: A Proposed Intermediary Between Maternal Stress and Offspring Neuropsychiatric Risk
Hantsoo, L., Kornfield, S., Anguera, M. C., & Epperson, C. N. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.08.018 · Cited by 269 · see citing works
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Maternal prenatal stress phenotypes associate with fetal neurodevelopment and birth outcomes
Walsh, K., McCormack, C. A., Webster, R., Pinto, A., Lee, S., Feng, T., Krakovsky, H. S., O’Grady, S. M., Tycko, B., Champagne, F. A., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1905890116 · Cited by 258 · see citing works
The placenta and neurodevelopment: sex differences in prenatal vulnerability
Bale, T. L. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.4/tbale · Cited by 236 · see citing works
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The Epigenetic Link between Prenatal Adverse Environments and Neurodevelopmental Disorders
Kundaković, M., & Jarić, I. (2017) · Genes · doi:10.3390/genes8030104 · Cited by 227 · see citing works
Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?
O’Mahony, S. M., Clarke, G., Dinan, T. G., & Cryan, J. F. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.068 · Cited by 203 · see citing works
Sex Differences in Vulnerability to Prenatal Stress: a Review of the Recent Literature
Sutherland, S. L., & Brunwasser, S. M. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0961-4 · Cited by 194 · see citing works
Alterations in amygdala–prefrontal circuits in infants exposed to prenatal maternal depression
Posner, J., Cha, J., Roy, A. K., Peterson, B. S., Bansal, R., Gustafsson, H. C., Raffanello, E., Gingrich, J., & Monk, C. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.146 · Cited by 184 · see citing works
Anxiety Disorders Among Women: A Female Lifespan Approach
Hantsoo, L., & Epperson, C. N. (2017) · Focus · doi:10.1176/appi.focus.20160042 · Cited by 183 · see citing works
Self-citation
Annual Research Review: Critical windows – the microbiota-gut-brain axis in neurocognitive development
Cowan, C. S. M., Dinan, T. G., & Cryan, J. F. (2020) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13156 · Cited by 176 · see citing works
Maternal influences on fetal brain development: The role of nutrition, infection and stress, and the potential for intergenerational consequences
Fitzgerald, E., Hor, K., & Drake, A. J. (2020) · Early Human Development · doi:10.1016/j.earlhumdev.2020.105190 · Cited by 136 · see citing works
Glucocorticoids as Mediators of Adverse Outcomes of Prenatal Stress
Krontira, A. C., Cruceanu, C., & Binder, E. B. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.03.008 · Cited by 115 · see citing works
Somatic Comorbidity in Schizophrenia: Some Possible Biological Mechanisms Across the Life Span
Dieset, I., Andreassen, O. A., & Haukvik, U. K. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw028 · Cited by 108 · see citing works
The Global Burden and Risk of Perinatal Mental Illness and Substance Use Amongst Migrant Women: A Systematic Review and Meta-Analysis
Stevenson, K., Fellmeth, G. L., Edwards, S., Calvert, C., Bennett, P. R., Campbell, O. M. R., & Fuhr, D. C. (2022) · The Lancet Public Health · doi:10.1016/s2468-2667(22)00342-5 · Cited by 108 · see citing works
Individualized Family-Centered Developmental Care
Lisanti, A. J., Vittner, D. J., Medoff-Cooper, B. S., Fogel, J., Wernovsky, G., & Butler, S. (2018) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000546 · Cited by 105 · see citing works
Early-life adversity and long-term neurobehavioral outcomes: epigenome as a bridge?
Vaiserman, A. M., & Koliada, A. K. (2017) · Human Genomics · doi:10.1186/s40246-017-0129-z · Cited by 96 · see citing works
Adverse Childhood Experiences and Risk for First-Episode Major Depression During the Menopause Transition
Epperson, C. N., Sammel, M. D., Bale, T. L., Kim, D. R., Conlin, S. E., Scalice, S., Freeman, K., & Freeman, E. W. (2017) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.16m10662 · Cited by 96 · see citing works
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Maternal substance use during pregnancy and offspring conduct problems: A meta-analysis
Ruisch, I. H., Dietrich, A., Glennon, J. C., Buitelaar, J. K., & Hoekstra, P. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.014 · Cited by 90 · see citing works
DNA Methylation and Psychiatric Disorders
Liu, C., Jiao, C., Wang, K., & Yuan, N. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.01.006 · Cited by 85 · see citing works
Parental stress and resilience in CHD: a new frontier for health disparities research
Lisanti, A. J. (2018) · Cardiology in the Young · doi:10.1017/s1047951118000963 · Cited by 83 · see citing works
Association of Prenatal Maternal Anxiety With Fetal Regional Brain Connectivity
De Asis-Cruz, J., Krishnamurthy, D., Zhao, L., Kapse, K., Vezina, G., Andescavage, N., Quistorff, J., Lopez, C., & Limperopoulos, C. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.22349 · Cited by 81 · see citing works
Oxytocin receptor expression patterns in the human brain across development
Rokicki, J., Kaufmann, T., de Lange, A. G., van der Meer, D., Bahrami, S., Sartorius, A. M., Haukvik, U. K., Steen, N. E., Schwarz, E., Stein, D. J., et al. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01305-5 · Cited by 74 · see citing works
Extending the developmental origins of disease model: Impact of preconception stress exposure on offspring neurodevelopment
Keenan, K., Hipwell, A. E., Class, Q. A., & Mbayiwa, K. (2018) · Developmental Psychobiology · doi:10.1002/dev.21773 · Cited by 77 · see citing works
Prenatal Maternal Stress and the Cascade of Risk to Schizophrenia Spectrum Disorders in Offspring
Lipner, E., Murphy, S. K., & Ellman, L. M. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1085-1 · Cited by 67 · see citing works
Parvalbumin interneuron alterations in stress-related mood disorders: A systematic review
Perlman, G., Tanti, A., & Mechawar, N. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100380 · Cited by 65 · see citing works
The Gut Microbiome–Brain Crosstalk in Neurodegenerative Diseases
Ghezzi, L., Cantoni, C., Rotondo, E., & Galimberti, D. (2022) · Biomedicines · doi:10.3390/biomedicines10071486 · Cited by 58 · see citing works
Accelerated aging in the brain, epigenetic aging in blood, and polygenic risk for schizophrenia
Teeuw, J., Ori, A. P. S., Brouwer, R. M., de Zwarte, S. M. C., Schnack, H. G., Pol, H. E. H., & Ophoff, R. A. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.04.005 · Cited by 52 · see citing works
Implications of early life stress on fetal metabolic programming of schizophrenia: A focus on epiphenomena underlying morbidity and early mortality
García‐Rizo, C., & Bitanihirwe, B. K. Y. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109910 · Cited by 55 · see citing works
Heart rate variability is associated with disease severity in psychosis spectrum disorders
Benjamin, B. R., Valstad, M., Elvsåshagen, T., Jönsson, E. G., Moberget, T., Winterton, A., Haram, M., Høegh, M. C., Lagerberg, T. V., Steen, N. E., et al. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110108 · Cited by 52 · see citing works
High glucocorticoid levels during gestation activate the inflammasome in hippocampal oligodendrocytes of the offspring
Maturana, C. J., Aguirre, A., & Sáez, J. C. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22409 · Cited by 51 · see citing works
Evolutionary Significance of the Neuroendocrine Stress Axis on Vertebrate Immunity and the Influence of the Microbiome on Early-Life Stress Regulation and Health Outcomes
Ortega, V. A., Mercer, E. M., Giesbrecht, G. F., & Arrieta, M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.634539 · Cited by 51 · see citing works
Does Prenatal Maternal Distress Contribute to Sex Differences in Child Psychopathology?
Hicks, L. M., Swales, D. A., Garcia, S. E., Driver, C., & Davis, E. P. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-0992-5 · Cited by 51 · see citing works
Teeth as Potential New Tools to Measure Early-Life Adversity and Subsequent Mental Health Risk: An Interdisciplinary Review and Conceptual Model
Davis, K. A., Mountain, R. V., Pickett, O. R., Besten, P. K. D., Bidlack, F. B., & Dunn, E. C. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.09.030 · Cited by 51 · see citing works
The Intergenerational Effects of Intimate Partner Violence in Pregnancy: Mediating Pathways and Implications for Prevention
Murray, A. L., Kaiser, D. E., Valdebenito, S., Hughes, C. H., Băban, A., Fernando, A. D., Madrid, B. J., Ward, C. L., Osafo, J., Dunne, M. P., et al. (2018) · Trauma Violence & Abuse · doi:10.1177/1524838018813563 · Cited by 52 · see citing works
Natural disaster stress during pregnancy is linked to reprogramming of the placenta transcriptome in relation to anxiety and stress hormones in young offspring
Nomura, Y., Rompala, G., Pritchett, L., Aushev, V., Chen, J., & Hurd, Y. L. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01123-z · Cited by 48 · see citing works
Developmental pathways towards mood disorders in adult life: Is there a role for sleep disturbances?
Palagini, L., Domschke, K., Benedetti, F., Foster, F., Wulff, K., & Riemann, D. W. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.09.011 · Cited by 50 · see citing works
Trauma-Related Dissociation Is Linked With Maladaptive Personality Functioning
Granieri, A., Guglielmucci, F., Costanzo, A., Caretti, V., & Schimmenti, A. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00206 · Cited by 50 · see citing works
Prenatal diet and children's trajectories of hyperactivity–inattention and conduct problems from 3 to 8 years: the EDEN mother–child cohort
Galéra, C., Heude, B., Forhan, A., Bernard, J. Y., Peyre, H., van der Waerden, J. E. B., Pryor, L., Bouvard, M. P., Melchior, M., Lioret, S., et al. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12898 · Cited by 46 · see citing works
Prenatal stress and the development of psychopathology: Lifestyle behaviors as a fundamental part of the puzzle
de Weerth, C. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000494 · Cited by 46 · see citing works
Probiotic supplementation improves the cognitive function and the anxiety-like behaviors in the stressed rats.
Hadizadeh, M., Hamidi, G. A., & Salami, M. (2019) · PubMed Central · doi:10.22038/ijbms.2019.33956.8078 · Cited by 48 · see citing works
Prenatal glucocorticoids exposure and fetal adrenal developmental programming
Chen, Y., He, Z., Chen, G., Liu, M., & Wang, H. (2019) · Toxicology · doi:10.1016/j.tox.2019.152308 · Cited by 47 · see citing works
Maternal Distress during Pregnancy and the Postpartum Period: Underlying Mechanisms and Child’s Developmental Outcomes—A Narrative Review
Jeličić, L., Veselinović, A., Ćirović, M., Jakovljevic, V. L., Raičević, S., & Subotić, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213932 · Cited by 50 · see citing works
Hypothalamic-pituitary-adrenal axis and autonomic nervous system reactivity in children prenatally exposed to maternal depression: A systematic review of prospective studies
Bleker, L. S., van Dammen, L., Leeflang, M., Limpens, J., Roseboom, T. J., & de Rooij, S. R. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.033 · Cited by 44 · see citing works
How prenatal exposures shape the infant brain: Insights from infant neuroimaging studies
Dufford, A. J., Spann, M. N., & Scheinost, D. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.017 · Cited by 41 · see citing works
Maternal infection requiring hospitalization during pregnancy and attention-deficit hyperactivity disorder in offspring: a quasi-experimental family-based study.
Ginsberg, Y., D'Onofrio, B., Rickert, M., Class, Q., Rosenqvist, M. A., Almqvist, C., Lichtenstein, P., & Larsson, H. (2018) · Journal of Child Psychology and Psychiatry and Allied Disciplines · doi:10.1111/jcpp.12959 · Cited by 34 · see citing works
Universal depression prevention: An umbrella review of meta-analyses
Hoare, E., Collins, S., Marx, W., Callaly, E., Moxham‐Smith, R., Cuijpers, P. J., Holte, A., Nierenberg, A. A., Reavley, N. J., Christensen, H. M., et al. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.10.006 · Cited by 44 · see citing works
The mechanism of enriched environment repairing the learning and memory impairment in offspring of prenatal stress by regulating the expression of activity-regulated cytoskeletal-associated and insulin-like growth factor-2 in hippocampus
Guan, S., Fu, Y., Zhao, F., Liu, H., Chen, X.-H., Qi, F., Liu, Z., & Ng, T. B. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-020-00929-7 · Cited by 40 · see citing works
The neuroscience and context of adolescent depression
Henje, E., Ho, T. C., Connolly, C. G., LeWinn, K. Z., Sacchet, M. D., Tymofiyeva, O., Weng, H. Y., & Yang, T. T. (2015) · Acta Paediatrica · doi:10.1111/apa.13299 · Cited by 42 · see citing works
Environmental influences on placental programming and offspring outcomes following maternal immune activation
Estevez, K. J. N., Rondón-Ortiz, A. N., Nguyen, J., & Kentner, A. C. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.08.192 · Cited by 39 · see citing works
Hormone levels in neonatal hair reflect prior maternal stress exposure during pregnancy
Kapoor, A., Lubach, G. R., Ziegler, T. E., & Coe, C. L. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.010 · Cited by 38 · see citing works
Chromosomal and environmental contributions to sex differences in the vulnerability to neurological and neuropsychiatric disorders: Implications for therapeutic interventions
Pallier, P. N., Ferrara, M., Romagnolo, F., Ferretti, M. T., Soreq, H., & Cerase, A. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102353 · Cited by 35 · see citing works
An Unconditional Prenatal Income Supplement Reduces Population Inequities In Birth Outcomes
Brownell, M. D., Nickel, N. C., Chartier, M., Enns, J. E., Chateau, D. G., Sarkar, J., Burland, E., Jutte, D. P., Taylor, C. R., & Katz, A. (2018) · Health Affairs · doi:10.1377/hlthaff.2017.1290 · Cited by 35 · see citing works
Challenges in the use of animal models and perspectives for a translational view of stress and psychopathologies
Barroca, N. C. B., Santa, G. D., Suchecki, D., Garcia‐Cairasco, N., & Umeoka, E. H. D. L. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104771 · Cited by 36 · see citing works
Partial Support for an Interaction Between a Polygenic Risk Score for Major Depressive Disorder and Prenatal Maternal Depressive Symptoms on Infant Right Amygdalar Volumes
Acosta, H., Kantojärvi, K., Hashempour, N., Pelto, J., Scheinin, N. M., Lehtola, S. J., Lewis, J. D., Fonov, V. S., Collins, D. L., Evans, A., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa158 · Cited by 34 · see citing works
Effects of Maternal Prenatal Stress: Mechanisms, Implications, and Novel Therapeutic Interventions
Tobón, A. L., Diaz‐Stransky, A., Ross, D. A., & Stevens, H. E. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.09.011 · Cited by 31 · see citing works
Differential patterning of genes involved in serotonin metabolism and transport in extra-embryonic tissues of the mouse
Wu, H., Choi, S., & Levitt, P. R. (2016) · Placenta · doi:10.1016/j.placenta.2016.03.013 · Cited by 32 · see citing works
Sex Differences in Verbal Memory Predict Functioning Through Negative Symptoms in Early Psychosis
Buck, G., Lavigne, K. M., Makowski, C., Joober, R., MALLA, A. K., & Lepage, M. (2020) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaa054 · Cited by 32 · see citing works
Pregnancy and the Acceptability of Computer-Based Versus Traditional Mental Health Treatments
Hantsoo, L., Podcasy, J., Sammel, M., Epperson, C. N., & Kim, D. R. (2017) · Journal of Women's Health · doi:10.1089/jwh.2016.6255 · Cited by 27 · see citing works
Self-citation
A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring
Vanderplow, A. M., Kermath, B. A., Bernhardt, C. R., Gums, K. T., Seablom, E. N., Radcliff, A. B., Ewald, A. C., Jones, M. V., Baker, T. L., Watters, J. J., et al. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001502 · Cited by 31 · see citing works
Basic Environmental Supports for Positive Brain and Cognitive Development in the First Year of Life
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Prenatal Programming of Psychopathology: The Role of Epigenetic Mechanisms / PRENATALNO PROGRAMIRANJE PSIHIJATRIJSKIH POREMEĆAJA: ULOGA EPIGENETSKIH MEHANIZAMA
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Authors: Kim, D. R., Bale, T. L., & Epperson, C. N.
Affiliations: University of Pennsylvania (US)
Corresponding author: Kim, Deborah R.
ORCID: Bale, Tracy L.
Epperson, C. Neill
Venue: Current Psychiatry Reports
Publisher: Springer Science and Business Media LLC
Published: 2015-01-24
Volume: 17
Issue: 2
Pages: 5-5
ISSN: 1523-3812 (ISSN-L)
1535-1645
DOI: 10.1007/s11920-014-0546-9
PMC: PMC4458064
OpenAlex: W2073798115
Cited by: 203
References: 105
Citations by year: 2026: 2 · 2025: 12 · 2024: 16 · 2023: 17 · 2022: 27 · 2021: 22 · 2020: 24 · 2019: 19 · 2018: 23 · 2017: 18 · 2016: 17 · 2015: 6
FWCI: 3.25
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Current Psychiatry Reports (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Pfizer
National Institutes of Health (5r01mh091258-05)
National Institute of Mental Health (P50MH099910, MH087597, MH 091258, R01MH073030, K23MH092399, MH 073030, R01 MH-091258, MH09910, R01MH087597)
National Institute on Drug Abuse (K24DA030301)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: prenatal programming, maternal stress, mental illness, epigenetics, fetal programming, hypothalamic-pituitary-adrenal axis, glucocorticoids, placental inflammation, fetal inflammation, birth weight, Barker hypothesis, offspring development
MeSH terms: Animals, Mental Disorders, Female, Humans, Male, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Sex Factors, Stress, Physiological, Stress, Psychological

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Prenatal Programming of Mental Illness: Current Understanding of Relationship and Mechanisms

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