Cited by 199Schizophrenia research and treatmentStress Responses and CortisolMaternal Mental Health During Pregnancy and Postpartum

Glucocorticoid hormones and early brain development in schizophrenia

Ph.D., J·2002·Neuropsychopharmacology

Abstract

While genetic factors play a role in the etiology of schizophrenia, environmental factors contribute to the etiology of the disorder as well. If a woman is exposed during the second trimester of gestation to stressors such as the death of a loved one, influenza infection, or natural and man-made disasters, her baby has an increased risk of developing schizophrenia later in life. A common mechanism may mediate the effects of these diverse risk factors: a stress response during a restricted period of gestation may affect fetal brain development and, given the appropriate genetic predisposition, result in schizophrenia in adult life. Findings in animals exposed to prenatal stress strengthen the hypothesis that exposure to high glucocorticoid levels and/or other components of the stress response increases the risk of schizophrenia. These clinical and preclinical studies could be used to develop hypotheses that could then be tested in patients with schizophrenia.

Integrity signals

Registry

Crossref · 10.1016/s0893-133x(01)00396-7

Cites

124 of 124 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In humans, prenatal stress is a prominent risk factor for the development of schizophrenia in adult offspring.

    “In humans, prenatal stress is a prominent risk factor for the development of schizophrenia in adult offspring (van Os and Selten, 1998;Koenig et al., 2002).”

    From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Koenig et al., 2002

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Ph.D., J.
Affiliations
University of Maryland, Baltimore (US)
Corresponding author
Ph.D., J
Venue
Neuropsychopharmacology
Published
2002-08
Volume
27
Issue
2
Pages
309-318
ISSN
0893-133X (ISSN-L)
OpenAlex
W2131140619
Cited by
199
References
124
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 15 · 2015: 10 · 2014: 15 · 2013: 10 · 2012: 13
FWCI
1.67
Type
journal article
Language
en
Open access
closed
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Whitehall Foundation
  • National Alliance for Research on Schizophrenia and Depression
  • National Institutes of Health (5r01dk052382-03)
  • Novartis Pharma
  • National Institute of Mental Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK52382)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
schizophrenia, glucocorticoids, prenatal stress, fetal brain development, maternal stress exposure, stress response, environmental risk factors, genetic susceptibility, prenatal glucocorticoid exposure
MeSH terms
Animals, Brain, Environmental Exposure, Female, Glucocorticoids, Humans, Influenza, Human, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Risk Factors, Schizophrenia, Stress, Physiological, Neurotransmitter Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review