FGF signaling is required for anterior but not posterior specification of the murine liver bud
Open accessAbstract
Background: The definitive endoderm arises as a naive epithelial sheet that produces the entire gut tube and associated organs including the liver, pancreas and lungs. Murine explant studies demonstrate that fibroblast growth factor (FGF) signaling from adjacent tissues is required to induce hepatic gene expression from isolated foregut endoderm. The requirement of FGF signaling during liver development is examined by means of small molecule inhibition during whole embryo culture. Results: Loss of FGF signaling before hepatic induction results in morphological defects and gene expression changes that are confined to the anterior liver bud. In contrast the posterior portion of the liver bud remains relatively unaffected. Because FGF is thought to act as a morphogen during endoderm organogenesis, the ventral pancreas was also examined after FGF inhibition. Although the size of the ventral pancreas is not affected, loss of FGF signaling results in a significantly higher density of ventral pancreas cells. Conclusions: The requirement for FGF‐mediated induction of hepatic gene expression differs across the anterior/posterior axis of the developing liver bud. These results underscore the importance of studying tissue differentiation in the context of the whole embryo. Developmental Dynamics 244:431–443, 2015. © 2014 Wiley Periodicals, Inc.
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FGF and BMP signaling have previously been shown to coordinate the specification of anterior and posterior hepatic endodermal populations, respectively.
“while FGF and BMP signaling have previously been shown to coordinate the specification of anterior and posterior hepatic endodermal populations, respectively”
From Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages (2020) · cites this paper as Wang et al., 2015
The Discussion reports that reduced FGF signaling has severe effects on specification of the anterior liver bud but little effect on the posterior bud. It proposes BMP as a candidate signal for posterior induction and says studies are ongoing; it does not say BMP’s posterior role had previously been shown. The indexed passages provide no page numbers. (LLM, conf=0.90)
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Rôle des FGFs endocrines et leurs récepteurs au cours de la fibrose pulmonaire idiopathique
Ghanem, M. (2023) · theses.fr (ABES) · doi:10.70675/fd0d64f8zacf4z4856z9b1az66d4df37a332
- Authors
- Wang, J., Rhee, S., Palaria, A., & Tremblay, K. D.
- Affiliations
- University of Massachusetts Amherst (US)
- Corresponding author
- Tremblay, Kimberly D.
- Venue
- Developmental Dynamics
- Publisher
- Wiley
- Published
- 2014-10-23
- Volume
- 244
- Issue
- 3
- Pages
- 431-443
- ISSN
- 1058-8388 (ISSN-L)
- 1097-0177
- PMC
- PMC4344927
- OpenAlex
- W2153326882
- Cited by
- 40
- References
- 63
- Citations by year
- 2026: 1 · 2023: 5 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 3 · 2016: 4 · 2015: 4
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Developmental Dynamics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01DK87753)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Keywords
- FGF signaling, anterior-posterior axis, definitive endoderm, foregut endoderm, ventral pancreas, whole embryo culture, small molecule inhibition, liver development, morphogens
- MeSH terms
- Animals, Endoderm, Fibroblast Growth Factors, Liver, Organ Specificity, Signal Transduction, Gene Expression Regulation, Developmental, Organogenesis, Mice
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