msh may play a conserved role in dorsoventral patterning of the neuroectoderm and mesoderm

D'Alessio, Marina; Frasch, Manfred

doi:10.1016/s0925-4773(96)00583-7

Cited by 126Developmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanismsNeurobiology and Insect Physiology Research

msh may play a conserved role in dorsoventral patterning of the neuroectoderm and mesoderm

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D'Alessio, Marina, Frasch, Manfred·1996·Mechanisms of Development

DOI 10.1016/s0925-4773(96)00583-7

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Abstract

Many of the mechanisms that govern the patterning of the Drosophila neuroectoderm and mesoderm are still unknown. Here we report the sequence, expression, and regulation of the homeobox gene msh, which is likely to play an important role in the early patterning events of these two tissue primordia. msh expression is first observed in late blastoderm embryos and occurs in longitudinal bands of cells that are fated to become lateral neuroectoderm. This expression is under the control of dorsoventral axis-determination genes and depends on dpp-mediated repression in the dorsal half of the embryo and on fib-(EGF-) mediated repression ventrally. The bands of msh expression define the cells that will form the lateral columns of proneural gene expression and give rise to the lateral row of SI neuroblasts. This suggests that msh may be one of the upstream regulators of the achaete-scute (AS-C) genes and may play a role that is analogous to that of the homeobox gene vnd/NK2 in the medial sector of the neuroectoderm. During neuroblast segregation, msh expression is maintained in a subset of neuroblasts, indicating that msh, like vnd/NK2, could function in both dorsoventral patterning of the neuroectoderm and neuroblast specification. The later phase of msh expression that occurs after the first wave of neuroblast segregation in defined ectodermal and mesodermal clusters of cells points to similar roles of msh in patterning and cell fate specification of the peripheral nervous system, dorsal musculature, and the fat body. A comparison of the expression patterns of the vertebrate homologs of msh, vnd/NK2, and AS-C genes reveals striking similarities in dorsoventral patterning of the Drosophila and vertebrate neuroectoderm and indicates that genetic circuitries in neural patterning are evolutionarily conserved.

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The similar spatial distribution of Nkx2.2 and Msx1 and Msx3 expression to that of vnd and msh suggests a conserved mechanism of DV patterning across species.
“The similar spatial distribution of Nkx2.2 and Msx1 and Msx3 expression to that of vnd and msh, respectively suggests a conserved mechanism of DV patterning across species (D' Alessio and Frasch 1996;Wang et al. 1996).”
From Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity (1998) · cites this paper as D' Alessio and Frasch 1996
msh expression in the dorsal neuroectoderm is mirrored by Msx1 transcription in the dorsal neural tube.
“Similarly msh expression in the dorsal neuroectoderm is mirrored by Msx1 transcription in the dorsal neural tube (D' Alessio and Frasch 1996;Isshiki et al. 1997).”
From Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity (1998) · cites this paper as D' Alessio and Frasch 1996

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The role of the msh homeobox gene during Drosophila neurogenesis: implication for the dorsoventral specification of the neuroectoderm
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Role of en and novel interactions between msh, ind, and vnd in dorsoventral patterning of the Drosophila brain and ventral nerve cord
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Vnd/nkx, ind/gsh, and msh/msx: conserved regulators of dorsoventral neural patterning?
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Normal Expression and the Effects of Ectopic Expression of the Drosophila muscle segment homeobox (msh) Gene Suggest a Role in Differentiation and Patterning of Embryonic Muscles
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Authors: D'Alessio, M., & Frasch, M.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Frasch, Manfred
ORCID: Frasch, Manfred
Venue: Mechanisms of Development
Publisher: Elsevier BV
Published: 1996-08
Volume: 58
Issue: 1-2
Pages: 217-231
ISSN: 0925-4773 (ISSN-L)
DOI: 10.1016/s0925-4773(96)00583-7
OpenAlex: W1974215719
Cited by: 126
References: 88
Citations by year: 2026: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 2
FWCI: 5.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6194 d)
Locations: Mechanisms of Development (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: melanocyte-stimulating hormone, homeobox genes, dorsoventral patterning, neuroectoderm, mesoderm, Drosophila, proneural genes, Dpp signaling, FGF signaling, fat body
MeSH terms: Age Factors, Amino Acid Sequence, Animals, Base Sequence, Drosophila, Ectoderm, Embryo, Nonmammalian, Fat Body, Mesoderm, Molecular Sequence Data, Proto-Oncogene Proteins, Tissue Distribution, Homeodomain Proteins, Insect Proteins, Body Patterning, Drosophila Proteins, Wnt1 Protein, Hedgehog Proteins

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msh may play a conserved role in dorsoventral patterning of the neuroectoderm and mesoderm

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