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Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages
Open accessAbstract
Whole mount in situ hybridisation was used to study the embryonic expression of the mouse HMG box-containing genes Sox1, Sox2 and Sox3 between 6.5 and 9.0 days post coitum (dpc). Sox2 and Sox3 are expressed in the epiblast and extraembryonic ectoderm of the egg cylinder, becoming restricted to the prospective neural plate and chorion at the onset of gastrulation. Sox3 is upregulated in the posterior ectoderm during late streak and neural plate stages and is concomitantly downregulated in the chorion. Sox1 transcripts are first detected in the neural fold ectoderm at the headfold stage. During early somitogenesis, all three genes are expressed in the neuroectoderm, and Sox2 and Sox3 are also expressed in the primitive streak ectoderm, gut endoderm and prospective sensory placodes.
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“Similarly, Sox2 is expressed in both ectoderm and endoderm libraries corresponding to published expression patterns [38].”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [38]
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Cites
In situ hybridization; a practical approach
(1993) · International Journal of Biochemistry · doi:10.1016/0020-711x(93)90093-t · Cited by 1,240
Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope
Downs, K. M., & Davies, T. J. (1993) · Development · doi:10.1242/dev.118.4.1255 · Cited by 582
A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2
Collignon, J., Sockanathan, S., Hacker, A., Cohen‐Tannoudji, M., Norris, D. P., Rastan, S., Stevanović, M. J., Goodfellow, P. N., & Lovell-Badge, R. H. (1996) · Development · doi:10.1242/dev.122.2.509 · Cited by 496
Pevny, L., & Lovell-Badge, R. H. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80147-5 · Cited by 489
A role for SOX1 in neural determination
Pevny, L., Sockanathan, S., Placzek, M., & Lovell-Badge, R. H. (1998) · Development · doi:10.1242/dev.125.10.1967 · Cited by 475
Uwanogho, D., Rex, M., Cartwright, E. J., Pearl, G., Healy, C., Scotting, P. J., & Sharpe, P. T. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(94)00299-3 · Cited by 391
Sox1 directly regulates the gamma -crystallin genes and is essential for lens development in micePreprint
Nishiguchi, S., Wood, H. B., Kondoh, H., Lovell-Badge, R. H., & Episkopou, V. (1998) · Genes & Development · doi:10.1101/gad.12.6.776 · Cited by 290
Self-citationClonal Analysis of Cell Fate During Gastrulation and Early Neurulation in the Mouse
Lawson, K. A., & Pedersen, R. A. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514221.ch2 · Cited by 177
Preventing the loss of competence for neural induction: HGF/SF, L5 and Sox-2
Streit, A., Sockanathan, S., Pérez, L., Rex, M., Scotting, P. J., Sharpe, P. T., Lovell-Badge, R. H., & Stern, C. D. (1997) · Development · doi:10.1242/dev.124.6.1191 · Cited by 159
Establishment and Organization of Germ Layers in the Gastrulating Mouse Embryo
Tam, P., & Beddington, R. S. P. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514221.ch3 · Cited by 152
Cited by
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Wei, Q., & Condie, B. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026795 · Cited by 29
Hebsgaard, J. B., Nelander, J., Sabelström, H., Jönsson, M. E., Stott, S., & Parmar, M. (2009) · Glia · doi:10.1002/glia.20877 · Cited by 30
“5, immunofluorescence staining for TH, SOX2 (Pevny and Lovell-Badge, 1997; Wood and Episkopou, 1999) and the radial glial marker Vimentin shows Vimentin-positive radial fibers spanning from the ventricular wall through the SOX2-positive VZ and the TH-positive mantle zone to the pia surface (Fig.”
BackgroundPurinergic receptors in neurogenic processes
Ribeiro, D. E., Glaser, T., Oliveira‐Giacomelli, Á., & Ulrich, H. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.12.013 · Cited by 29
Sox2-mediated differential activation of Six3.2 contributes to forebrain patterning
Beccari, L. L., Conte, I., Cisneros, E., & Bovolenta, P. (2011) · Development · doi:10.1242/dev.067660 · Cited by 29
“…more widely expressed in the forebrain (Bovolenta et al., 1998; Manuel and Price, 2005; Oliver et al., 1995; Simeone et al., 1992) or, like Sox2 (Zappone et al., 2000), even throughout the neural tube, raising the as yet unanswered question of how their activity contributes to the identity of…”
Sankar, S., Yellajoshyula, D., Zhang, B., Teets, B. W., Rockweiler, N. B., & Kroll, K. L. (2016) · Scientific Reports · doi:10.1038/srep37412 · Cited by 30
Battersby, A., Jones, R., Lilley, K. S., McFarlane, R. J., Braig, H. R., Allen, N. D., & Wakeman, J. A. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.030 · Cited by 29
Expression pattern of the Sox31 gene during Zebrafish embryonic development
Girard, F., Crémazy, F. G. E., Berta, P., & Renucci, A. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00491-3 · Cited by 29
Ectoderm, endoderm, and the evolution of heterodont dentitions
Ohazama, A., Haworth, K. E., Ota, M. S., Khonsari, R. H., & Sharpe, P. T. (2010) · genesis · doi:10.1002/dvg.20634 · Cited by 28
Anbazhagan, R., & Senthilkumaran, B. (2014) · Sexual Development · doi:10.1159/000368864 · Cited by 28
“The role of Sox3 in neural development and function has been well established [Wood and Episkopou, 1999; Dee et al., 2008] and has been shown to be a permissive factor for sensory placode formation, which plays an important role in sensory organ development in O. latipes [Koster et al., 2000].”
BackgroundSOX2 hypomorphism disrupts development of the prechordal floor and optic cup
Langer, L., Taranova, O., Sulik, K. K., & Pevny, L. (2012) · Mechanisms of Development · doi:10.1016/j.mod.2012.04.001 · Cited by 27
“One possible explanation involves the other SOXB1 family members, SOX1 and SOX3, which are also broadly expressed in the developing neural tube, where their functions are thought to be partially redundant (Wood and Episkopou, 1999; Bylund et al., 2003; Graham et al., 2003).”
Inefficient development of syncytiotrophoblasts in the Atp11a -deficient mouse placenta
Ochiai, Y., Suzuki, C., Segawa, K., Uchiyama, Y., & Nagata, S. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2200582119 · Cited by 27
Harvey, N. T., Hughes, J. N., Lonic, A., Yap, C., Long, C. E., Rathjen, P. D., & Rathjen, J. (2010) · Journal of Cell Science · doi:10.1242/jcs.047530 · Cited by 27
“Sox2, which is a marker of the pluripotent lineage (Wood and Episkopou, 1999), was expressed in ES cells, then was reduced by about 15% in EBMs at day 1 (EBM1) and maintained at approximately 50% ES cell expression level until day 9 (EBM9) (Fig.”
BackgroundInduced pluripotent stem cells (iPSCs)—a new era of reprogramming
Kang, L., Kou, Z., Zhang, Y., & Gao, S. (2010) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/s1673-8527(09)60060-6 · Cited by 26
“Sox2 is a member of SRY-related HMG-box transcription factor family which expressed in early embryo, ICM, epiblast, and germ cells like Oct4, and besides that it became restricted to the prospective neural plate and chorion and associated with the developing central nervous system after gastrulation (Yuan et al., 1995…”
BackgroundWagner, J. T., & Podrabsky, J. E. (2015) · EvoDevo · doi:10.1186/2041-9139-6-2 · Cited by 26
“the strong upregulation of sox3 at 30% epiboly in zebrafish [27], sox3 is downregulated after 50% epiboly in A.”
BackgroundWind, M., Gogolou, A., Manipur, I., Granata, I., Butler, L., Andrews, P. W., Barbaric, I., Ning, K., Guarracino, M. R., Placzek, M., et al. (2021) · Development · doi:10.1242/dev.194415 · Cited by 26
Intrinsic regulations in neural fate commitment
Tang, K., Peng, G., Qiao, Y., Song, L., & Jing, N. (2015) · Development Growth & Differentiation · doi:10.1111/dgd.12204 · Cited by 24
“(Rex et al. 1997; Wood & Episkopou 1999; Avilion et al. 2003; Bylund et al. 2003; Graham et al. 2003; Uchikawa et al. 2003; Tanaka et al. 2004).”
BackgroundStrategies to regenerate hair cells: Identification of progenitors and critical genes
Breuskin, I., Bodson, M., Thelen, N., Thiry, M., Nguyen, L., Belachew, S. M., Lefebvre, P. P., & Malgrange, B. (2007) · Hearing Research · doi:10.1016/j.heares.2007.08.007 · Cited by 25
“…the sensory epithelia and direct correlation between the number of HCs and the level of Sox2 expression Dong et al. (2002); Kiernan et al. (2005b); Wood and Episkopou (1999) Abbreviations: HC = hair cell; SC = supporting cell; E = embryonic day; GER = greater epithelial ridge; LER = lesser…”
Lee, B., Rizzoti, K., Kwon, D., Kim, S., Oh, S., Epstein, D. J., Son, Y., Yoon, J., Baek, K., & Jeong, Y. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.04.023 · Cited by 26
“The SoxB1 subfamily comprising Sox1, Sox2, and Sox3 are mainly expressed in the nervous system including the diencephalon (Collignon et al., 1996; Wood and Episkopou, 1999) and play important roles in the development of the hypothalamo-pituitary region (Rizzoti et al., 2004; Kelberman et al., 2006).”
The Role of Foxg1 in the Development of Neural Stem Cells of the Olfactory Epithelium
Kawauchi, S., Santos, R., Kim, J., Hollenbeck, P. L. W., Murray, R. C., & Calof, A. L. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04372.x · Cited by 25
Zhao, Y., Matsuo‐Takasaki, M., Tsuboi, I., Kimura, K., Salazar, G. T., Yamashita, T., & Ohneda, O. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0278 · Cited by 24
“Sox3 begins to appear at epiblast stage, and is then expressed in neuroepithelium, gut ectoderm, and prospective sensory placodes during embryogenesis [36].”
Xia, C., Wang, C., Zhang, K., Qian, C., & Jing, N. (2007) · Differentiation · doi:10.1111/j.1432-0436.2007.00188.x · Cited by 24
Neveu, M. M., Holder, G. E., Ragge, N., Sloper, J. J., Collin, J. R. O., & Jeffery, G. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04827.x · Cited by 24
Reeve, R. L., Yammine, S. Z., Morshead, C. M., & van der Kooy, D. (2017) · Stem Cells · doi:10.1002/stem.2662 · Cited by 26
N-cadherin stabilises neural identity by dampening anti-neural signals
Punovuori, K., Migueles, R. P., Malaguti, M., Blin, G., Macleod, K. G., Carragher, N. O., Pieters, T., Roy, F. M. V., Stemmler, M., & Lowell, S. (2019) · Development · doi:10.1242/dev.183269 · Cited by 22
“, 2003), a reporter for the earliest marker of neuroepithelial identity (Wood and Episkopou, 1999) (Fig.”
BackgroundThe Induction of the Otic Placode
Groves, A. K. (2006) · Springer eBooks · doi:10.1007/0-387-30678-1_2 · Cited by 24
Comparative assessment of Fgf's diverse roles in inner ear development: A zebrafish perspective
Riley, B. B. (2021) · Developmental Dynamics · doi:10.1002/dvdy.343 · Cited by 23
Chimeric 3D gastruloids – a versatile tool for studies of mammalian peri-gastrulation development
Wehmeyer, A. E., Schüle, K. M., Conrad, A., Schröder, C. M., Probst, S., & Arnold, S. J. (2022) · Development · doi:10.1242/dev.200812 · Cited by 23
Development of the Pituitary Gland
Alatzoglou, K. S., Gregory, L. C., & Dattani, M. (2020) · Comprehensive physiology · doi:10.1002/j.2040-4603.2020.tb00113.x · Cited by 23
Krox20 hindbrain regulation incorporates multiple modes of cooperation between cis-acting elements
Thierion, E., Men, J. L., Collombet, S., Hernandez, C., Coulpier, F., Torbey, P., Thomas‐Chollier, M., Noordermeer, D., Charnay, P., & Gilardi‐Hebenstreit, P. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006903 · Cited by 24
Neural stem cell heterogeneity in the mammalian forebrain
Adams, K. V., & Morshead, C. M. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.06.005 · Cited by 26
“Additional support for this lineage relationship was found using FloxedOct4-Sox1-Cre transgenic mouse (Wood and Episkopou, 1999).”
Neural Induction, Neural Fate Stabilization, and Neural Stem Cells
Moody, S. A., & Je, H. S. (2002) · The Scientific World JOURNAL · doi:10.1100/tsw.2002.217 · Cited by 23
Hirano, K., Nagata, S., Yamaguchi, S., Nakagawa, M., Okita, K., Kotera, H., Ainscough, J., & Tada, T. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0283 · Cited by 25
“Sox1 is the earliest specific marker of neuroectoderm in mouse embryos in vivo [25].”
Burnett, J. B., Lupu, F. I., & Eggenschwiler, J. T. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.07.012 · Cited by 23
“Whereas both SOX1 and SOX2 are normally co-expressed throughout the presumptive optic stalk, only SOX2 is additionally expressed in the presumptive NR (Wood and Episkopou, 1999).”
BackgroundTrask, M. C., Tremblay, K. D., & Mager, J. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.05.031 · Cited by 22
“E (Scholer et al., 1990; Wood and Episkopou, 1999)].”
Sox2 is not required for melanomagenesis, melanoma growth and melanoma metastasis in vivo
Cesarini, V., Guida, E., Todaro, F., Agostino, S. D., Tassinari, V., Nicolis, S. K., Favaro, R., Caporali, S., Lacal, P. M., Botti, E., et al. (2017) · Oncogene · doi:10.1038/onc.2017.53 · Cited by 22
Gao, J., Li, P., Zhang, W., Wang, Z., Wang, X., & Zhang, Q. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161126079 · Cited by 21
“Sox3 is critical for neural development in vertebrates [4,14,41,42], and Sox3 deficient mice have defects in CNS midline structures [43].”
Distinct SoxB1 networks are required for naïve and primed pluripotency
Corsinotti, A., Wong, F. C. K., Tatar, T., Szczerbinska, I., Halbritter, F., Colby, D., Gogolok, S., Pantier, R., Liggat, K., Mirfazeli, E. S., et al. (2017) · eLife · doi:10.7554/elife.27746 · Cited by 21
“However, Sox1 may be less relevant to pluripotency as, unlike Sox2 and Sox3, which are widely expressed in the pluripotent postimplantation epiblast, Sox1 expression is uniquely associated with neural fate in the epiblast (Wood & Episkopou, 1999; Uchikawa et al, 2011; Cajal et al, 2012); Figure 9).”
BackgroundInfluentialGlycans in Diseases and Therapeutics
Pavão, M. S. G. (2011) · Springer eBooks · doi:10.1007/978-3-642-16833-8 · Cited by 22
Genomic code for Sox2 binding uncovers its regulatory role in Six3 activation in the forebrain
Lee, B., Song, H., Rizzoti, K., Son, Y., Yoon, J., Baek, K., & Jeong, Y. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.06.016 · Cited by 20
“4; Bergsland et al., 2011; Bylund et al., 2003; Kamachi et al., 1999;Wood and Episkopou, 1999), they could act in a redundant fashion to control Six3 expression.”
BackgroundSox2: To crest or not to crest?
Mandalos, N. P., & Remboutsika, E. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.08.035 · Cited by 20
Kurokawa, D., Ohmura, T., Sakurai, Y., Inoue, K., Suda, Y., & Aizawa, S. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.01.011 · Cited by 19
Mojsin, M. M., Kovačević‐Grujičić, N., Nikčević, G., Krstić, A., Savić, T., & Stevanović, M. J. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.08.010 · Cited by 20
Patterning and gastrulation defects caused by the tw18 lethal are due to loss of Ppp2r1a
Lange, L., Marks, M., Liu, J., Wittler, L., Bauer, H., Piehl, S., Bläß, G., Timmermann, B., & Herrmann, B. G. (2017) · Biology Open · doi:10.1242/bio.023200 · Cited by 19
“We further thank Anna Dorothea Senft and Elizabeth J. Robertson for providing the template for the mouse Nodal in situ probe, Jill andAndrewMcMahon for theWnt3 probe, andCedric Pattheyand LenaGunhaga for SOX3 antibody.”
BackgroundInfluentialFunction of strawberry notch family genes in the zebrafish brain development.
Takano, A., Zochi, R., Hibi, M., Terashima, T., & Katsuyama, Y. (2011) · PubMed · doi:10.24546/81002689 · Cited by 19
Kim, D. K., Han, S. B., Hong, S. T., Choi, Y. J., Sun, W., Geum, D., & Kim, H. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.01.016 · Cited by 19
A Revised Staging of Mouse Development Before Organogenesis
Lawson, K. A., & Wilson, V. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800043-4.00003-8 · Cited by 19
Han, J. Y., Lee, H. G., Park, Y. H., Hwang, Y. S., Kim, S. K., Rengaraj, D., Cho, B. W., & Lim, J. M. (2018) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-018-0246-0 · Cited by 21
“Another core transcription factor, Sox2, which belongs to the SoxB1 subfamily of genes [35], is also essential for the maintenance of the undifferentiated state in ESCs [36, 37].”
Transcriptional control of pluripotency: decisions in early development
Johnson, B. V., Rathjen, J., & Rathjen, P. D. (2006) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.08.012 · Cited by 19
Initiation and early patterning of the endoderm
Clements, D., Rex, M., & Woodland, H. R. (2001) · International review of cytology · doi:10.1016/s0074-7696(01)03012-1 · Cited by 19
Lei, X., Liu, Y., Wang, J., Cai, Q., Yan, M., He, H., Liu, Q., Long, Z., & Guan, Z. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2513-1 · Cited by 18
Thoma, E., Wagner, T. U., Weber, I. P., Herpin, A., Fischer, A., & Schartl, M. (2010) · Stem Cells and Development · doi:10.1089/scd.2010.0290 · Cited by 18
“RT-PCR analysis further revealed activation of several neuronal marker genes in mash1 -transfected cells, namely atonal homolog 3 ( ath3 ) [51], lim only protein 3 ( lmo3 ) [52], neuronal cell adhesion molecule ( nrcam ) [53,54], pax6 [55,56], and sox1 [57,58].”
Kim, J., Muraoka, M., Ajima, R., Okada, H., Toyoda, A., Mori, H., & Saga, Y. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1009967 · Cited by 19
Disturbing endoderm signaling to anterior neural plate of vertebrates by the teratogen cadmium.
Fernández, E., Svenson, C., Dencker, L., & Gustafson, A. (2004) · Reproductive Toxicology · doi:10.1016/j.reprotox.2004.04.003 · Cited by 17
Expression of Sox family genes in early lamprey development
Uy, B. R., Simões-Costa, M., Sauka‐Spengler, T., & Bronner-Fraser, M. E. (2012) · The International Journal of Developmental Biology · doi:10.1387/ijdb.113416bu · Cited by 18
Nesbit, M. A., Bowl, M. R., Harding, B., Schlessinger, D., Whyte, M. P., & Thakker, R. V. (2004) · Genomics · doi:10.1016/j.ygeno.2004.08.003 · Cited by 18
Mammalian Neural Stem-Cell Renewal: Nature versus Nurture
Arsenijévic, Y. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:1:73 · Cited by 18
Selective RNA sequestration in biomolecular condensates directs cell fate transitions
Pessina, P., Nevo, M., Shi, J., Kodali, S., Casas, E., Cui, Y., Richards, A., Park, E. J., Chen, X., Levin-Ferreyra, F., et al. (2025) · Nature Biotechnology · doi:10.1038/s41587-025-02853-z · Cited by 23
Induced haploinsufficiency of Kit receptor tyrosine kinase impairs brain development
Aoki, H., Hara, A., & Kunisada, T. (2017) · JCI Insight · doi:10.1172/jci.insight.94385 · Cited by 16
Jiang, Y., Han, K., Wang, S., Chen, Y., Wang, Y., & Zhang, Z. (2018) · Theriogenology · doi:10.1016/j.theriogenology.2018.07.025 · Cited by 17
Klarić, T., Thomas, P. Q., Dottori, M., Leong, W. K., Koblar, S. A., & Lewis, M. D. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt453 · Cited by 17
“5 [50] when it is expressed specifically in the neural plate [51] and it continues to be expressed in the neural tube along the entire anterior/posterior axis at later stages of neurodevelopment [50].”
BackgroundInduction of Pluripotency in Astrocytes through a Neural Stem Cell-like State
Nakajima‐Koyama, M., Lee, J., Ohta, S., Yamamoto, T., & Nishida, E. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.683466 · Cited by 16
Zheng, H., Tsukahara, M., Liu, E., Ye, L., Xiong, H., Noguchi, S., Suzuki, K., & Ji, Z. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0077 · Cited by 16
Common binding by redundant group B Sox proteins is evolutionarily conserved in Drosophila
Carl, S. H., & Russell, S. R. H. (2015) · BMC Genomics · doi:10.1186/s12864-015-1495-3 · Cited by 14
“Although functional data suggests that the B1-B2 division may not be an appropriate classification in insects [45,50,51], a role for group B Sox genes in neural development appears to be conserved, making Drosophila an attractive system in which to study group B Sox function and evolution more closely [31,32,43].”
BackgroundInfluentialWillems, C., & Vankelecom, H. (2014) · Regenerative medicine · doi:10.2217/rme.14.19 · Cited by 17
The characteristics of sox gene in Dugesia japonica
Dong, Z., Shi, C.-Y., Zhang, H., He, D., Cheng, F., Chen, G., & Liu, D. (2014) · Gene · doi:10.1016/j.gene.2014.04.053 · Cited by 16
Nishimura, N., Kamimura, Y., Ishida, Y., Takemoto, T., Kondoh, H., & Uchikawa, M. (2012) · Biology · doi:10.3390/biology1030714 · Cited by 15
Derivation of Haploid Neurons from Mouse Androgenetic Haploid Embryonic Stem Cells
Xu, H. J., Yue, C., Zhang, T., Li, Y., Guo, A., Liao, J., Pei, G., Li, J., & Jing, N. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0110-9 · Cited by 15
Chen, J., Nefzger, C. M., Rossello, F. J., Sun, Y., Lim, S. M., Liu, X., de Boer, S., Knaupp, A. S., Li, J., Davidson, K. C., et al. (2018) · Stem Cells · doi:10.1002/stem.2794 · Cited by 15
Dentate gyrus development requires a cortical hem-derived astrocytic scaffold
Caramello, A., Galichet, C., Rizzoti, K., & Lovell-Badge, R. H. (2021) · eLife · doi:10.7554/elife.63904 · Cited by 15
“5 almost exclusively in the neural tube (Takashima et al., 2007; Wood and Episkopou, 1999), and compared these with Sox9; Nestin-Cre mutants.”
BackgroundBang, J., Han, M., Yoo, T.-J., Qiao, L., Jung, J., Na, J.-W., Carlson, B. A., Gladyshev, V. N., Hatfield, D. L., Kim, J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111647 · Cited by 15
“Sex determining region Y-box 2 (Sox2) encodes a transcription factor that is essential for maintaining pluripotency of undifferentiated embryonic stem cells, but is also known to be expressed specifically in the ectoderm of both embryonic and extraembryonic regions during the gastrulation stage [29].”
BackgroundEarly anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor
Gogolou, A., Souilhol, C., Granata, I., Wymeersch, F. J., Manipur, I., Wind, M., Frith, T. J. R., Guarini, M., Bertero, A., Bock, C., et al. (2022) · eLife · doi:10.7554/elife.74263 · Cited by 15
“We found that both early (days 0–3; NMP induction) and late (days 3–7; NMP differentiation) time window Tet treatments resulted in a marked reduction in TBXT transcript levels but had a minor impact on the levels of early and definitive neural identity markers (such as SOX2 and SOX1 , respectively) on day 7 of differe…”
BackgroundInfluentialCattell, M. V., Garnett, A. T., Klymkowsky, M. W., & Medeiros, D. M. (2012) · Evolution & Development · doi:10.1111/j.1525-142x.2011.00525.x · Cited by 16
“(Wood and Episkopou 1999), ascidians (Miya and Nishida 2003), and sea urchin, where soxB1 transcripts are selectively”
BackgroundStem Cell Therapy for Parkinson’s Disease
Takahashi, J. B. (2006) · Springer eBooks · doi:10.1007/3-540-31437-7_15 · Cited by 15
Mugele, D., MOULDING, D. A., Savery, D., Molè, M. A., Greene, N. D. E., Martı́nez-Barberá, J. P., & Copp, A. J. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/503854 · Cited by 15
Boyling, A., Pérez‐Siles, G., & Kennerson, M. L. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.842860 · Cited by 15
“This is perhaps unsurprising as this gene belongs to the SOXB1 family of transcription factors that are widely expressed in the early vertebrate embryo and developing nervous system (Uchikawa et al., 1999; Wood and Episkopou, 1999; Lefebvre et al., 2007).”
BackgroundImmunohistochemical Localization of Cytokeratins in the Junctional Region of Ectoderm and Endoderm
Hosoya, A., Kwak, S., Kim, E., Lunny, D. P., Lane, E. B., Cho, S. W., & Jung, H.-S. (2010) · The Anatomical Record · doi:10.1002/ar.21233 · Cited by 14
“There are some specific ectodermal cell differentiation markers, such as Sox2 and ectodemin (Rex et al., 1997; Wood and Episkopou, 1999; Dupont et al., 2005).”
BackgroundVanni, V., Salonna, M., Gasparini, F., Martini, M., Anselmi, C., Gissi, C., & Manni, L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.782722 · Cited by 14
Blassberg, R. A., Patel, H., Watson, T., Gouti, M., Metzis, V., Delàs, M. J., & Briscoe, J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.29.424684 · Cited by 14
“(B) Cluster 2 and 4 CREs are enriched for T/Bra occupancy.”
BackgroundInfluentialInomata, C., Yuikawa, T., Nakayama‐Sadakiyo, Y., Kobayashi, K., Ikeda, M., Chiba, M., Konishi, C., Ishioka, A., Tsuda, S., & Yamasu, K. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.09.002 · Cited by 13
Sur, A., Renfro, A., Bergmann, P. J., & Meyer, N. P. (2020) · BMC Evolutionary Biology · doi:10.1186/s12862-020-01636-1 · Cited by 12
Optic vesicle morphogenesis requires primary cilia
Fiore, L., Takata, N., Acosta, S., Ma, W., Pandit, T., Oxendine, M., & Oliver, G. C. (2020) · Developmental Biology · doi:10.1016/j.ydbio.2020.02.016 · Cited by 13
“3D) (Wood and Episkopou, 1999); however, we found that it is ectopically expanded into the distal portion of the evaginating mutant OVs (Fig.”
BackgroundTranscription factor sox‐2 inhibits co‐activator stimulated transcription
Bernadt, C. T., Nowling, T. K., & Rizzino, A. (2004) · Molecular Reproduction and Development · doi:10.1002/mrd.20168 · Cited by 13
SOX3 expression in the glial system of the developing and adult mouse cerebellum
Cheah, P.-S., & Thomas, P. Q. (2015) · SpringerPlus · doi:10.1186/s40064-015-1194-1 · Cited by 12
“1995; Wood and Episkopou 1999).”
BackgroundGeneration of neural crest progenitors from human embryonic stem cells
Chimge, N., & Bayarsaihan, D. (2009) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21321 · Cited by 14
A Nonredundant Role for the TRPM6 Channel in Neural Tube Closure
Komiya, Y., Bai, Z., Cai, N., Lou, L., Al-Saadi, N., Mezzacappa, C., Habas, R., & Runnels, L. W. (2017) · Scientific Reports · doi:10.1038/s41598-017-15855-y · Cited by 12
Sox2-Dependent Regulation of Neural Stem Cells and CNS Development
Bertolini, J. A., Mercurio, S., Favaro, R., Mariani, J., Ottolenghi, S., & Nicolis, S. K. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800352-7.00011-6 · Cited by 11
Khan, M. A. F., Soto-Jiménez, L. M., Howe, T., Streit, A., Sosinsky, A., & Stern, C. D. (2013) · genesis · doi:10.1002/dvg.22375 · Cited by 12
SOX1 Is a Backup Gene for Brain Neurons and Glioma Stem Cell Protection and Proliferation
Kanwore, K., Guo, X., Ayanlaja, A. A., Kambey, P. A., Nadeem, I., & Gao, D. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02240-6 · Cited by 13
Zhang, M., Niibe, K., Kondo, T., Limraksasin, P., Okawa, H., Miao, X., Kamano, Y., Yamada, M., Jiang, X., & Egusa, H. (2022) · Journal of Tissue Engineering · doi:10.1177/20417314221114616 · Cited by 12
Hassoun, R., Püschel, B., & Viebahn, C. (2009) · Cells Tissues Organs · doi:10.1159/000236044 · Cited by 12
“…possibly, in the differentiation of the foregut: sox2 is expressed in the gut endoderm in the chick and mouse, whereas sox 3 transcripts are detected in the posterior region of the foregut in mouse early somite-stage embryos [Wood and Episkopou, 1999] but not in chick embryos [Kimura et al., 2007].”
BackgroundBosnali, M., Münst, B., Thier, M. C., & Edenhofer, F. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0095-2 · Cited by 12
“After the start of neurogenesis Sox2 is exclusively expressed in the neural plate throughout embryogenesis [51–54], while in the adult organism Sox2 is expressed in neural stem cells of the ventricular zone in the emerging neural tube and their progeny [54–56].”
BackgroundPutative contributions of the sex chromosome proteins SOX3 and SRY to neurodevelopmental disorders
Tahira, A. C., Barbosa, A. R., Feltrin, A. S., Gastaldi, V. D., de Toledo, V. H. C., de Carvalho Pereira, J. G., Lisboa, B. C. G., de Souza Reis, V. N., dos Santos, A. C. F., Maschietto, M., et al. (2019) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32704 · Cited by 11
“…SOX3 had highly conserved HMG- box among species, according to protein alignment and literature evi- dence (Araujo et al., 2015; Collignon et al., 1996; Wood & Episkopou, 1999), we improved our datasets using mouse, rat and human data to identify the target genes and selected only those genes…”
MethodDevelopment of the Mammalian ‘Vestibular’ System
Fritzsch, B., Kopecky, B. J., & Duncan, J. S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-408088-1.00012-9 · Cited by 12
Liu, X., Fang, Z., Wen, J., Tang, F., Liao, B., Jing, N., Lai, D., & Jin, Y. (2020) · iScience · doi:10.1016/j.isci.2020.101475 · Cited by 12
Sakai, D., Sugawara, T., Kurokawa, T., Murakami, Y., Tomosugi, M., Masuta, H., Sakata‐Haga, H., Hatta, T., & Shoji, H. (2022) · Molecular Brain · doi:10.1186/s13041-022-00911-0 · Cited by 11
Xenopus cDNA microarray identification of genes with endodermal organ expression
Park, E. C., Hayata, T., Cho, K. W. Y., & Han, J. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21167 · Cited by 11
“In the mouse, Sox2 is also expressed in the developing gut endoderm (Wood and Episkopou, 1999).”
BackgroundMolecular Mechanisms Governing Embryonic Differentiation of Pituitary Somatotropes
Ellsworth, B. S., & Stallings, C. E. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.04.009 · Cited by 11
Molecular fingerprinting of BMP2‐ and BMP4‐treated embryonic maxillary mesenchymal cells
Mukhopadhyay, P., Singh, S., Greene, R., & Pisano, M. M. (2006) · Orthodontics and Craniofacial Research · doi:10.1111/j.1601-6343.2006.00356.x · Cited by 11
Gao, J., Zhang, W., Li, P., Liu, J., Song, H., Wang, X., & Zhang, Q. (2015) · Gene · doi:10.1016/j.gene.2015.08.013 · Cited by 10
“Previous studies have suggested that the SoxB1 group genes are critical for early processes in embryogenesis, particularly during early neural development (Wood and Episkopou, 1999; Avilion et al., 2003; Nitta et al., 2006).”
BackgroundWu, Y., & Zhang, W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031168 · Cited by 9
Metadata
- Authors
- Wood, H. B., & Episkopou, V.
- Affiliations
- Hammersmith Hospital (GB)
- Corresponding author
- Episkopou, Vasso
- Venue
- Mechanisms of Development
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 86
- Issue
- 1-2
- Pages
- 197-201
- ISSN
- 0925-4773 (ISSN-L)
- OpenAlex
- W2055664397
- Cited by
- 550
- References
- 16
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 15 · 2023: 5 · 2022: 17 · 2021: 16 · 2020: 11 · 2019: 15 · 2018: 18 · 2017: 23 · 2016: 14 · 2015: 31 · 2014: 29 · 2013: 24 · 2012: 30
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mechanisms of Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- SOX1, SOX2, SOX3, gene expression, mouse embryo, gastrulation, neural plate, neural fold, somitogenesis, primitive streak, chorion, extraembryonic ectoderm, neuroectoderm
- MeSH terms
- Animals, Central Nervous System, DNA-Binding Proteins, Ectoderm, Embryo, Mammalian, Gastrula, High Mobility Group Proteins, Nuclear Proteins, Rhombencephalon, Transcription Factors, Gene Expression Regulation, Developmental, HMGB Proteins, Mice, SOXB1 Transcription Factors
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