The DOI matches its Crossref record; 14 of the 16 references it cites were found in a registry or an index.
Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages
Open accessAbstract
Whole mount in situ hybridisation was used to study the embryonic expression of the mouse HMG box-containing genes Sox1, Sox2 and Sox3 between 6.5 and 9.0 days post coitum (dpc). Sox2 and Sox3 are expressed in the epiblast and extraembryonic ectoderm of the egg cylinder, becoming restricted to the prospective neural plate and chorion at the onset of gastrulation. Sox3 is upregulated in the posterior ectoderm during late streak and neural plate stages and is concomitantly downregulated in the chorion. Sox1 transcripts are first detected in the neural fold ectoderm at the headfold stage. During early somitogenesis, all three genes are expressed in the neuroectoderm, and Sox2 and Sox3 are also expressed in the primitive streak ectoderm, gut endoderm and prospective sensory placodes.
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“Similarly, Sox2 is expressed in both ectoderm and endoderm libraries corresponding to published expression patterns [38].”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [38]
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Cites
In situ hybridization; a practical approach
(1993) · International Journal of Biochemistry · doi:10.1016/0020-711x(93)90093-t · Cited by 1,240
Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope
Downs, K. M., & Davies, T. J. (1993) · Development · doi:10.1242/dev.118.4.1255 · Cited by 582
A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2
Collignon, J., Sockanathan, S., Hacker, A., Cohen‐Tannoudji, M., Norris, D. P., Rastan, S., Stevanović, M. J., Goodfellow, P. N., & Lovell-Badge, R. H. (1996) · Development · doi:10.1242/dev.122.2.509 · Cited by 496
Pevny, L., & Lovell-Badge, R. H. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80147-5 · Cited by 489
A role for SOX1 in neural determination
Pevny, L., Sockanathan, S., Placzek, M., & Lovell-Badge, R. H. (1998) · Development · doi:10.1242/dev.125.10.1967 · Cited by 475
Uwanogho, D., Rex, M., Cartwright, E. J., Pearl, G., Healy, C., Scotting, P. J., & Sharpe, P. T. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(94)00299-3 · Cited by 391
Sox1 directly regulates the gamma -crystallin genes and is essential for lens development in micePreprint
Nishiguchi, S., Wood, H. B., Kondoh, H., Lovell-Badge, R. H., & Episkopou, V. (1998) · Genes & Development · doi:10.1101/gad.12.6.776 · Cited by 290
Self-citationClonal Analysis of Cell Fate During Gastrulation and Early Neurulation in the Mouse
Lawson, K. A., & Pedersen, R. A. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514221.ch2 · Cited by 177
Preventing the loss of competence for neural induction: HGF/SF, L5 and Sox-2
Streit, A., Sockanathan, S., Pérez, L., Rex, M., Scotting, P. J., Sharpe, P. T., Lovell-Badge, R. H., & Stern, C. D. (1997) · Development · doi:10.1242/dev.124.6.1191 · Cited by 159
Establishment and Organization of Germ Layers in the Gastrulating Mouse Embryo
Tam, P., & Beddington, R. S. P. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514221.ch3 · Cited by 152
Cited by
Sorted by citations
Items 501–555 of 555
From stem cell to neuron : A sox perspective
Bergsland, M. (2010) · Figshare
The role of Hoxa2 and characterization of its new downstream targets in murine palatogenesis
Smith, T. M. (2009) · University Library - University of Saskatchewan (University of Saskatchewan)
Characteristics of genetic factors that influence gender in Atlantic salmon
Cheung, C. C. P. (2011) · UPT. Syiah Kuala University Library (Syiah Kuala University)
Eborn, D. R., Davis, D. L., & Grieger, D. M. (2009) · PubMed
Regulation of GABAergic neuron identity and diversity in the developing midbrain
Achim, K. (2010) · Työväentutkimus Vuosikirja
Cell reprogramming for the creation of patient-specific pluripotent stem cells by defined factors
Yin, H., Wang, H., Cao, H., Zhang, Y., Tao, Y., & Zhang, X. (2009) · Frontiers of Agriculture in China · doi:10.1007/s11703-009-0028-8
“It is expressed in the mature oocytes, ICM, epiblast of gastrulation, enteral mesoderm, branchial arch, and primary germ cells ( Wood and Episkopou, 1999 ).”
BackgroundPhenotypic Screening of Drug Library in Actively Differentiating Mouse Embryonic Stem Cells
Billard, B., Chang, C.-N., Singh, A. J., Gross, M. K., Allen, R., & Kioussi, C. (2016) · SLAS DISCOVERY · doi:10.1177/1087057115624093
“In contrast, Sox2 expression persists in anterior ectoderm that gives rise to anterior neuro- and surface ectoderm.(15) Of the six compounds that did not reduce Nanog levels significantly, two increased Nanog (compounds 14 and 27), two increased Sox2 (compounds 5 and 22), and one increased all three ES markers (compou…”
BackgroundRoles of Sox3 and Lmx 1b in early development of the inner ear
Khatri, S. B. (2009) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Lodato, M. A. (2012) · DSpace@MIT (Massachusetts Institute of Technology)
Hutton, S. R. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/871b-ky64
Hong, J. (2009) · K-State Research Exchange (Kansas State University)
Gracz, A. D. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/yjtt-y668
IL RUOLO DELL�HUNTINGTINA NELLA FISIOLOGIA DEL DIFFERENZIAMENTO NEURONALE E NELLA PATOLOGIA
Camnasio, S. (2014) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/camnasio-stefano_phd2014-01-16
Uchikawa, M., & Takemoto, T. (2009)
Önder, H., & Kurtulan, O. (2016) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12311
“Bergmann glial cells show SOX1 expression in mice, and also in humans.(6,7) Although it has been determined as a corresponder antigen for PNS, it was found in up to 41% of sera of patients with SCLC without neurological syndromes.”
Background, more than testis determination? Sry
Turner, M. E., Ely, D., Prokop, J. W., & Milsted, A. (2011)
Rogers, C. D. (2009) · DigitalGeorgetown (Georgetown University Library)
Posttranscriptional Modulation of Sox2 Activity by miRNAs
Prakash, N. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800352-7.00004-9
LaMantia, A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405945-0.00020-x
Primitive Neural Stem Cells in the Mouse Brain
Leeder, R. (2015)
Response of bovine fetal fibroblasts to pluripotency induction with in vitro transcribed mRNA
Adams, T. L. (2013) · doi:10.31390/gradschool_theses.3280
“SOX2 expression is not restricted to the inner cell mass and epiblast, but is also found to be expressed in neural tissues, extra-embryonic ectoderm, gut endoderm, esophagus, and trachea (Wood and Episkopou, 1999; Avilion et al., 2003; Williamson et al., 2006; Adachi et al., 2011).”
BackgroundExpression and functional analysis of SOX3 in murine neurogenesis.
Rogers, N. (2014) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
Pachernegg, S., Eilebrecht, S., Eilebrecht, E., Schöneborn, H., Neumann, S., Benecke, A., & Hollmann, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192242
“Since Sox1 is the earliest known neuroectodermal marker [21], the cells fluoresce greenly as soon as they are differentiated into neuroepithelial precursor cells (NEPs), which express Sox1.”
BackgroundUsing the mouse retina to model the role of SOX2 in neural induction
Heavner, W. E. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/7w15-fe17
Vaverková, H., Novotný, D., & Ficker, L. (1996) · PubMed
Desai, K. K. (2012) · University of Bedfordshire Repository (University of Bedfordshire)
Nakamura, H. (2003) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1011713.182119
Signaling Pathways in Mouse Embryo Stem Cell Self-Renewal
Quinlan, L. R. (2011) · InTech eBooks · doi:10.5772/22933
“However unlike Oct4, Sox2 has a major role to play also later in development and in adult stem cells (Wood and Episkopou, 1999; Zappone et al., 2000).”
Ogita, Y., Tamura, K., Mawaribuchi, S., Takamatsu, N., & Ito, M. (2021) · Research Square · doi:10.21203/rs.3.rs-157747/v1
Vanderhaeghen, P. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734249056.793552549
Galichet, C., Rizzoti, K., & Lovell-Badge, R. H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.26.550616
Zhao, R., Moore, E. L., Gogol, M. M., et al. (2024) · eLife · doi:10.7554/elife.92844.1.sa2
Zhao, R., Moore, E. L., Gogol, M. M., et al. (2024) · eLife · doi:10.7554/elife.92844.1.sa1
Hu, L., Xiao, X., Huang, W., Zhou, T., Chen, W., Zhang, C., & Ying, Q. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1415621
“Since the parental cell line of the Erk-IR KI ESCs carries a Sox1-GFP knock-in reporter (Ying et al., 2003) and Sox1 is a lineage-speci fi c marker of neuroectoderm in the mouse (Wood and Episkopou, 1999), we traced the neuroectoderm differentiation of Erk-IR KI ESCs by GFP expression.”
Sox21 homeologs autoregulate expression levels to control progression through neurogenesis
Damuth, D. L., Cunningham, D. D., & Casey, E. S. (2024) · genesis · doi:10.1002/dvg.23612
“…and self-renewal of neural stem cells (Archer et al., 2011; Bylund et al., 2003; Cimadamore et al., 2013; Collignon et al., 1996; Graham et al., 2003; Kishi et al., 2000; Nishimura et al., 2012; Okuda et al., 2010; Rogers et al., 2008, 2009; Uchikawa et al., 2011; Wood & Episkopou, 1999).”
Li, Z., Abram, L., & Peall, K. J. (2024) · Cells · doi:10.3390/cells13181520
Anophthalmia, Microphthalmia, and Uveal Coloboma
Brooks, P. M., & Brooks, B. P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-815234-8.00006-9
Signaling Centers Drive Brachyury Dynamics and Lineage Commitment in mESC Aggregates
Rabeling, A., & Goolam, M. (2025) · FASEB BioAdvances · doi:10.1096/fba.2024-00216
“Since Sox1 is the first pan-neuroectodermal marker in mice, while Sox2 is involved in later neural differentiation [20, 66], with the expression of both genes together indicating the presence of proliferating neural progenitor cells (NPCs) [67], it is evident that BMP4 pulsing in this protocol…”
Anophthalmia, Colobomatous Microphthalmia, and Optic Fissure Closure Defects
Benson, M. D., Traboulsi, E. I., & Brooks, B. P. (2025) · doi:10.1093/med/9780197659403.003.0008
Congenital Anomalies of the Optic Nerve
Benson, M. D., Traboulsi, E. I., & Brooks, B. P. (2025) · doi:10.1093/med/9780197659403.003.0012
Chrysostomou, E. (2012) · Doctoral thesis, UCL (University College London).
Lundie-Brown, J., Drummond, R., Ng-Blichfeldt, J.-P., Azzarelli, R., & Philpott, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.19.712999
Retinoic acid signaling in chordates : the evolutionary history of a morphogen-dependent signaling
Carvalho, J. E. (2017) · theses.fr (ABES) · doi:10.70675/d7ca0d25zbfe5z46caz8d50zcd071004e022
Daya, H. A. (2020) · theses.fr (ABES) · doi:10.70675/940ea21dz0f9cz491ez968cz64a92ef468a5
Molecular basis of competence for neural induction in the chick embryoPreprint
Colle, C., Arimia, V., Lu, H., Anderson, C., Dale, L., & Stern, C. D. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.03.729870
How to make a brain: new experiments challenge existing picture
Peeples, L. (2026) · Nature · doi:10.1038/d41586-026-02943-1
Spatiotemporal expression of Sox2 in chick embryo tongue development
Al-Beladi, A., & Al-Qudsi, F. (2026) · Journal of Biosciences · doi:10.1007/s12038-026-00615-w
“In the gastrulation stage, the expression of Sox2 is restricted to particular cell groups, including primordial germ cells, gut endoderm, neuroectoderm, sensory placodes, and pharyngeal arches (Wood and Episkopou 1999; Yabuta et al. 2006).”
Hamilton, J. A., Beites, C. L., Gokoffski, K. K., Hollenbeck, P. L. W., Kawauchi, S., Santos, R., Bonnin, A., Wu, H., Kim, J., & Calof, A. L. (2008) · Springer eBooks · doi:10.1007/978-1-4020-8502-4_3
Evolutionary patterns of group B Sox binding and function in Drosophila
Carl, S. H. (2015) · Apollo (University of Cambridge) · doi:10.17863/cam.16333
“A role for group B Sox genes in neural development appears to be conserved throughout the higher metazoa, making Drosophila an attractive system in which to study group B Sox function and evolution more closely 22 (Uwanogho et al., 1995; Wood and Episkopou, 1999; Wegner and Stolt, 2005).”
BackgroundInfluential
Metadata
- Authors
- Wood, H. B., & Episkopou, V.
- Affiliations
- Hammersmith Hospital (GB)
- Corresponding author
- Episkopou, Vasso
- Venue
- Mechanisms of Development
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 86
- Issue
- 1-2
- Pages
- 197-201
- ISSN
- 0925-4773 (ISSN-L)
- OpenAlex
- W2055664397
- Cited by
- 550
- References
- 16
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 15 · 2023: 5 · 2022: 17 · 2021: 16 · 2020: 11 · 2019: 15 · 2018: 18 · 2017: 23 · 2016: 14 · 2015: 31 · 2014: 29 · 2013: 24 · 2012: 30
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mechanisms of Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- SOX1, SOX2, SOX3, gene expression, mouse embryo, gastrulation, neural plate, neural fold, somitogenesis, primitive streak, chorion, extraembryonic ectoderm, neuroectoderm
- MeSH terms
- Animals, Central Nervous System, DNA-Binding Proteins, Ectoderm, Embryo, Mammalian, Gastrula, High Mobility Group Proteins, Nuclear Proteins, Rhombencephalon, Transcription Factors, Gene Expression Regulation, Developmental, HMGB Proteins, Mice, SOXB1 Transcription Factors
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