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Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages
Open accessAbstract
Whole mount in situ hybridisation was used to study the embryonic expression of the mouse HMG box-containing genes Sox1, Sox2 and Sox3 between 6.5 and 9.0 days post coitum (dpc). Sox2 and Sox3 are expressed in the epiblast and extraembryonic ectoderm of the egg cylinder, becoming restricted to the prospective neural plate and chorion at the onset of gastrulation. Sox3 is upregulated in the posterior ectoderm during late streak and neural plate stages and is concomitantly downregulated in the chorion. Sox1 transcripts are first detected in the neural fold ectoderm at the headfold stage. During early somitogenesis, all three genes are expressed in the neuroectoderm, and Sox2 and Sox3 are also expressed in the primitive streak ectoderm, gut endoderm and prospective sensory placodes.
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“Similarly, Sox2 is expressed in both ectoderm and endoderm libraries corresponding to published expression patterns [38].”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [38]
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Cites
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Cellular strategies for retinal repair by photoreceptor replacement
Jayakody, S. A., Gonzalez-Cordero, A., Ali, R. R., & Pearson, R. A. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.01.003 · Cited by 133
“Subsequently, neural progenitors contained within the neural tube can be characterised through the expression of several markers including, Sox1, Sox2, Nestin (Lendahl et al., 1990; Pevny et al., 1998; Wood and Episkopou, 1999), Musashi1 (Kaneko et al.”
The first steps towards hearing: mechanisms of otic placode induction
Ohyama, T., Groves, A. K., & Martin, K. (2007) · The International Journal of Developmental Biology · doi:10.1387/ijdb.072320to · Cited by 125
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“By stage 10, Sox1 is expressed exclusively in neural progenitor cells (Patthey et al., 2008; Wood and Episkopou, 1999), Snail2 (previously known as Slug) is preferentially expressed in premigratory and early migratory neural crest cells, HNK-1 is expressed in migratory neural crest (Del Barrio and…”
BackgroundInfluentialMouse models to study inner ear development and hereditary hearing loss
Friedman, L. M., Dror, A. A., & Avraham, K. B. (2007) · The International Journal of Developmental Biology · doi:10.1387/ijdb.072365lf · Cited by 123
“In the developing cochlea, Sox2 is normally expressed only in prosensory progenitor cells, as well as in differentiated hair cells and supporting cells in the developing organ of Corti (Wood and Episkopou, 1999; Kiernan et al., 2005).”
BackgroundSox2 and Pou2f1 interact to control lens and olfactory placode development
Donner, A. L., Episkopou, V., & Maas, R. L. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.10.047 · Cited by 122
“Keywords Sox2; Pax6; Pou2f1; Oct-1; lens placode; nasal placode; pre-placode; E-cadherin; cataract INTRODUCTION Vertebrate sensory structures, including the lens, ear and nose, develop through multistep inductive processes that involve the formation of a neural plate stage pre-placodal region (PPR) and the subsequent…”
BackgroundInfluentialSelf-citationLineage development and polar asymmetries in the peri-implantation mouse blastocyst
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Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6
Matsushima, D., Heavner, W. E., & Pevny, L. (2011) · Development · doi:10.1242/dev.055178 · Cited by 119
“…have been shown to be essential for the maintenance of multipotent retinal progenitor cells (RPCs) (Marquardt et al., 2001; Taranova et al., 2006; Xu et al., 1999) and studies in mouse illustrate that changes in SOX2 and PAX6 dosage result in developmental defects of the eye, no study has yet…”
BackgroundHaegele, L., Ingold, B., Naumann, H., Tabatabai, G., Ledermann, B., & Brandner, S. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00232-x · Cited by 119
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Early Development of the Pituitary Gland: Induction and Shaping of Rathke’s Pouch
Rizzoti, K., & Lovell-Badge, R. H. (2005) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-005-3047-7 · Cited by 116
“SOX3 is an HMG box transcription factor and it is expressed along with SOX1 and SOX2, the two other members of the subfamily in the mouse, in all neural precursors during CNS development from the earliest stages [66,67].”
Cellular and Molecular Specificity of Pituitary Gland Physiology
Perez-Castro, C., Renner, U., Haedo, M. R., Stalla, G. K., & ARZT, E. S. (2012) · Physiological Reviews · doi:10.1152/physrev.00003.2011 · Cited by 115
Ribes, V., Roux, I. L., Rhinn, M., Schuhbaur, B., & Dollé, P. (2009) · Development · doi:10.1242/dev.016204 · Cited by 114
“3A) (Wood and Episkopou, 1999; Delfino-Machin et al., 2005).”
Six1 is essential for early neurogenesis in the development of olfactory epithelium
Ikeda, K., Ookawara, S., Sato, S., Ando, Z., Kageyama, R., & Kawakami, K. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.08.020 · Cited by 113
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Interaction of Sox1, Sox2, Sox3 and Oct4 during primary neurogenesis
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“In contrast, sox2 expression is initiated in early gastrula embryos and expressed only in the neuroectoderm (Mizuseki et al., 1998; Nitta et al., 2006; Okuda et al., 2006; Rex et al., 1997; Wood and Episkopou, 1999), while sox1 is not expressed until the end of gastrulation in the anterior neuroectoderm (Nitta et al.”
InfluentialTsukamoto, T., Mizoshita, T., Mihara, M., Tanaka, H., Takenaka, Y., Yamamura, Y., Nakamura, S., Ushijima, T., & Tatematsu, M. (2005) · Histopathology · doi:10.1111/j.1365-2559.2005.02170.x · Cited by 111
“Those of group B1, including Sox1, Sox2, and Sox3, are important for gut development in mice.(38) In situ So x2”
BackgroundDistinct functions of BMP4 during different stages of mouse ES cell neural commitment
Zhang, K., Li, L., Huang, C., Shen, C., Tan, F., Xia, C., Liu, P., Rossant, J., & Jing, N. (2010) · Development · doi:10.1242/dev.049494 · Cited by 109
“These OCT4–/SOX+ cells were putative neural precursor cells (NPCs) (Wood and Episkopou, 1999; Xia et al., 2007), and this was further confirmed by the presence of another NPC marker nestin (Lendahl et al., 1990) (see Fig.”
Induction of the mammalian node requires Arkadia function in the extraembryonic lineages
Episkopou, V., Arkell, R. M., Timmons, P. M., Walsh, J. J., Andrew, R. L., & Swan, D. (2001) · Nature · doi:10.1038/35071095 · Cited by 110
“1 ) using the expression of the following neurectoderm marker genes: Sox3 , an early neural plate marke”
MethodSelf-citationThe β-catenin/VegT-regulated early zygotic gene Xnr5 is a direct target of SOX3 regulation
Zhang, C., Basta, T., Jensen, E. D., & Klymkowsky, M. W. (2003) · Development · doi:10.1242/dev.00798 · Cited by 110
“SOX3 is expressed together with SOX2 in the cell of the epiblast at day 5.5 (Avilion et al., 2003; Wood and Episkopou, 1999).”
BackgroundInfluentialProspective isolation and global gene expression analysis of definitive and visceral endoderm
Sherwood, R. I., Jitianu, C., Cleaver, O., Shaywitz, D. A., Lamenzo, J. O., Chen, A. E., Golub, T. R., & Melton, D. A. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.01.011 · Cited by 122
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Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear
Zou, D., Erickson, C. B., Kim, E., Jin, D., Fritzsch, B., & Xu, P. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn229 · Cited by 105
“In chick, Sox2 is expressed in the otic placode (27,28); however, the onset of Sox2 expression during mouse inner-ear development has not been examined.”
BackgroundAcloque, H., Ocaña, O. H., Matheu, A., Rizzoti, K., Wise, C., Lovell-Badge, R. H., & Nieto, M. A. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.005 · Cited by 105
Ancient duplicated conserved noncoding elements in vertebrates: A genomic and functional analysisPreprint
McEwen, G. K., Woolfe, A., Goode, D. K., Vavouri, T., Callaway, H., & Elgar, G. (2006) · Genome Research · doi:10.1101/gr.4143406 · Cited by 105
“Both genes are expressed in the early brain and play fundamental roles in placode formation in Xenopus (Wood and Episkopou 1999; Schlosser and Ahrens, 2004).”
BackgroundInfluentialWashington, J. M., Rathjen, J., Felquer, F. A., Lonic, A., Bettess, M. D., Hamra, N., Semendric, L., Tan, B. S. N., Lake, J.-A., Keough, R. A., et al. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00498.2009 · Cited by 104
“The maintenance of pluripotency within the primitive ectoderm is demonstrated by continued expression of the pluripotent markers, Oct4, Sox2, and alkaline phosphatase (29, 67, 69), and by the ability of the cell population to differentiate to all cell types of the embryo and adult (2, 3, 40).”
BackgroundNo backbone but lots of Sox: Invertebrate Sox genes
Phochanukul, N., & Russell, S. R. H. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.06.013 · Cited by 104
Consequence of the loss of Sox2 in the developing brain of the mouse
Miyagi, S., Masui, S., Niwa, H., Saito, T., Shimazaki, T., Okano, H., Nishimoto, M., Muramatsu, M., Iwama, A., & Okuda, A. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.07.011 · Cited by 105
“We assume that somewhat mild defect coupled to Sox2 deficiency which we observed is due to the extensive overlap of expression of Sox1, Sox2, and Sox3 in the developing brain [13].”
BackgroundSolomon, N. M., Ross, S. A., Morgan, T., Belsky, J. L., Hol, F. A., Karnes, P. S., Hopwood, N. J., Myers, S. E., Tan, A. S., Warne, G. L., et al. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2003.016949 · Cited by 103
Genetics of septo-optic dysplasia
Kelberman, D., & Dattani, M. (2007) · Pituitary · doi:10.1007/s11102-007-0055-5 · Cited by 103
“5 dpc (days post coitum), prior to the appearance of the primitive streak, throughout the epiblast and in a band of extraembryonic ectoderm at the boundary of the embryonic and extraembryonic tissues [85].”
BackgroundCdx2 regulation of posterior development through non-Hox targets
Savory, J. G. A., Bouchard, N., Pierre, V. J., Rijli, F. M., Repentigny, Y. D., Kothary, R., & Lohnes, D. (2009) · Development · doi:10.1242/dev.041582 · Cited by 102
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“Sox-2 expression is not restricted to ES cells and neural stem cells; it is also expressed in trophoblast stem cells (4, 55).”
BackgroundAra, L. B. I., Katugampola, H., & Dattani, M. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2020.600962 · Cited by 100
Kawauchi, S., Beites, C. L., Crocker, C. E., Wu, H., Bonnin, A., Murray, R. C., & Calof, A. L. (2004) · Developmental Neuroscience · doi:10.1159/000082135 · Cited by 99
Septo-Optic Dysplasia – Novel Insights into the Aetiology
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“In summary, both duplications of Xq27 encompassing SOX3 and loss-of-function polyalanine expansion mutations are essentially associated with similar phenotypes, predominantly infundibular hypoplasia, suggesting that gene dosage of SOX3 is critical for normal development of the diencephalon and infundibulum and, conseq…”
BackgroundInfluentialChen, B., Kim, E., & Xu, P. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.039 · Cited by 97
“Sox2 is not expressed in the early preplacodal region; it is expressed in the distinct lens, olfactory and otic placode (Kamachi et al., 1998; Wood and Episkopou, 1999).”
BackgroundSox3 regulates both neural fate and differentiation in the zebrafish ectoderm
Dee, C. T., Hirst, C. S., Shih, Y.-H., Tripathi, V. B., Patient, R. K., & Scotting, P. J. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.05.542 · Cited by 97
“Sox3 is one of the earliest and most generally expressed transcription factors in neural development of vertebrates (Penzel et al., 1997; Rex et al., 1997; Wood and Episkopou, 1999; Zhang et al., 2004, 2003).”
BackgroundOverview of the roles of Sox2 in stem cell and development
Feng, R., & Wen, J. (2015) · Biological Chemistry · doi:10.1515/hsz-2014-0317 · Cited by 101
Neural Stem Cell Niches in Health and Diseases
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“In vivo expression studies in mouse and chicken indicate that undifferentiated NEPs specifically express the transcription factors Sox1, Sox2 and Sox3 [5, 6].”
BackgroundHypothalamic and pituitary development: novel insights into the aetiology
Kelberman, D., & Dattani, M. (2007) · European Journal of Endocrinology · doi:10.1530/eje-07-0156 · Cited by 97
DAX1 origin, function, and novel role
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Gambaro, K., Aberdam, É., Virolle, T., Aberdam, D., & Rouleau, M. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401799 · Cited by 94
“Belonging to the family of the high-mobility group of transcription factors, it is first expressed in the neural plate and subsequently maintained in neuroepithelial cells throughout the entire neuraxis, but is downregulated during neuronal and glial differentiation.(26) Using Sox-1-gfp ES cells,(8) we quantify by flo…”
BackgroundHuman neural progenitor cells derived from embryonic stem cells in feeder-free cultures
Dhara, S. K., Hasneen, K., Machacek, D. W., Boyd, N. L., Rao, R. R., & Stice, S. L. (2008) · Differentiation · doi:10.1111/j.1432-0436.2007.00256.x · Cited by 92
“SOX2, a SOXB1 family transcription factor, is expressed early in the inner cell mass (source of ES cells) and expression continues throughout neural tube development (Wood and Episkopou, 1999).”
BackgroundPark, E. T., Gum, J. R., Kakar, S., Kwon, S. W., Deng, G., & Kim, Y. S. (2007) · International Journal of Cancer · doi:10.1002/ijc.23225 · Cited by 94
“SOX2 is also important for the development of stomach in mice.(9) In human gastrointestinal tissues, SOX2 expression was found in the nuclei of foveolar epithelial cells of the stomach but at very low levels in the intestine.”
BackgroundSox1 marks an activated neural stem/progenitor cell in the hippocampus
Venere, M., Han, Y.-G., Bell, R. J. A., Song, J. S., Álvarez-Buylla, A., & Blelloch, R. H. (2012) · Development · doi:10.1242/dev.081133 · Cited by 92
Dissecting Wnt/β-catenin signaling during gastrulation using RNA interference in mouse embryos
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“2I) (Wood and Episkopou, 1999), which was upregulated in the microarray experiments (Table 1).”
BackgroundPetracovici, A., & Bonasio, R. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.03.038 · Cited by 98
Microfluidic Perfusion for Regulating Diffusible Signaling in Stem Cells
Blagović, K., Kim, L. Y., & Joel Voldman, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022892 · Cited by 86
“To investigate the role of cell-secreted factors in neuroectodermal differentiation of mESCs, we differentiated cells to neuroectoderm in serum-free conditions, using a Sox1-GFP (46C) mESC cell line to report on differentiation status, where Sox1 is the earliest known marker of neuroectoderm in the mouse embryo [41].”
MethodBlassberg, R. A., Patel, H., Watson, T., Gouti, M., Metzis, V., Delàs, M. J., & Briscoe, J. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00910-2 · Cited by 93
Prospective Identification and Isolation of Enteric Nervous System Progenitors Using Sox2
Heanue, T. A., & Pachnis, V. (2010) · Stem Cells · doi:10.1002/stem.557 · Cited by 88
Olmsted, Z. T., & Paluh, J. L. (2021) · Nature Communications · doi:10.1038/s41467-021-23294-7 · Cited by 87
Differential and overlapping expression pattern of SOX2 and SOX9 in inner ear development
Mak, A. C. Y., Szeto, I. Y. Y., Fritzsch, B., & Cheah, K. S. E. (2009) · Gene Expression Patterns · doi:10.1016/j.gep.2009.04.003 · Cited by 86
“The expression pattern of Sox2/SOX2 in the inner ear has been described in chick (Uchikawa et al., 1999; Neves et al., 2007) and mouse (Wood and Episkopou, 1999; Kiernan et al., 2005; Hume et al., 2007).”
BackgroundHolland, L. Z., Schubert, M., Holland, N. D., & Neuman, T. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9810 · Cited by 86
Abelló, G., Khatri, S. B., Radosevic, M., Scotting, P. J., Giráldez, F., & Alsina, B. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.12.027 · Cited by 85
Iwafuchi, M., Matsuda, K., Murakami, K., Niwa, H., Tesar, P. J., Aruga, J., Matsuo, I., & Kondoh, H. (2012) · Development · doi:10.1242/dev.085936 · Cited by 83
“The strong expression of Sox1 (Uchikawa et al., 2011; Wood and Episkopou, 1999), Pou3f2 (Bouchard et al., 2005) and Otx1 (Suda et al., 1999) in the neural plate is known to occur in embryos after E8.”
BackgroundResultRogers, C. D., Harafuji, N., Archer, T. C., Cunningham, D. D., & Casey, E. S. (2008) · Mechanisms of Development · doi:10.1016/j.mod.2008.10.005 · Cited by 82
Formstone, C. J., & Little, P. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00515-9 · Cited by 83
Targeted removal of epigenetic barriers during transcriptional reprogramming
Baumann, V., Wiesbeck, M. F., Breunig, C., Braun, J. M., Köferle, A., Ninkovic, J., Götz, M., & Stricker, S. H. (2019) · Nature Communications · doi:10.1038/s41467-019-10146-8 · Cited by 82
Neuronal Migration and Ventral Subtype Identity in the Telencephalon Depend on SOX1
Ekonomou, A., Kazanis, I., Malas, S., Wood, H. B., Alifragis, P., Denaxa, M., Karagogeos, D., Constanti, A., Lovell-Badge, R. H., & Episkopou, V. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030186 · Cited by 81
Self-citationDetermination of the embryonic inner ear
Noramly, S., & Grainger, R. M. (2002) · Journal of Neurobiology · doi:10.1002/neu.10131 · Cited by 82
Gómez‐López, S., Wiskow, O., Favaro, R., Nicolis, S. K., Price, D. J., Pollard, S. M., & Smith, A. G. (2011) · Glia · doi:10.1002/glia.21201 · Cited by 81
“Sox2 is a high-mobility group (HMG)-box TF present throughout the neuroectoderm from the earliest stages of neural plate formation (Wood and Episkopou, 1999).”
BackgroundSOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis
Rizzoti, K., & Lovell-Badge, R. H. (2007) · Development · doi:10.1242/dev.007906 · Cited by 81
“We therefore examined SOX3 expression in the PA. RESEARCH ARTICLE Development 134 (19) D E V E LO P M E N T SOX3 and SOX2 start to be expressed early in the pharyngeal epithelia Sox2 and Sox3 are both expressed in the pharyngeal region (Wood and Episkopou, 1999).”
BackgroundRoles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells
Juan, A. H., Wang, S., Ko, K. D., Zare, H., Tsai, P.-F., Feng, X., Vivanco, K. O., Ascoli, A. M., Gutierrez-Cruz, G., Krebs, J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.087 · Cited by 77
“In contrast, transcripts for Sox1 and Pax6, two of the earliest neural markers (Mastick et al., 1997) (Schwarz et al., 1999) (Pevny et al., 1998) (Wood and Episkopou, 1999) were increased, whereas mesodermal markers brachyury (T) and desmin (Des), and endodermal Gata4 and Gata6 transcripts were…”
Uchikawa, M., Takemoto, T., Kamachi, Y., & Kondoh, H. (2004) · Mechanisms of Development · doi:10.1016/j.mod.2004.05.009 · Cited by 81
The Amphioxus SoxB Family: Implications for the Evolution of Vertebrate Placodes
Meulemans, D., & Bronner-Fraser, M. E. (2007) · International Journal of Biological Sciences · doi:10.7150/ijbs.3.356 · Cited by 79
“In vertebrates, SoxB1 genes are expressed in the foregut and posterior-most hindgut [37-40].”
BackgroundEngberg, N., Kahn, M., Petersen, D. R., Hansson, M. D., & Serup, P. (2010) · Stem Cells · doi:10.1002/stem.479 · Cited by 76
Panayi, H., Panayiotou, E., Orford, M., Genethliou, N., Mean, R. J., Lapathitis, G., Li, S., Xiang, M., Kessaris, N., Richardson, W. D., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2402-10.2010 · Cited by 76
“It is expressed by most neural progenitors in the embryonic spinal cord (Pevny et al., 1998; Wood and Episkopou, 1999; Genethliou et al., 2009) and forebrain in which it is required for correct differentiation of postmitotic GABAergic neurons that contribute to the ventral striatum (Malas et al.,…”
BackgroundLee, C., Fotovati, A., Triscott, J., Chen, J. Y., Venugopal, C., Singhal, A., Dunham, C. P., Kerr, J. M., Verreault, M., Yip, S. S. F., et al. (2012) · Stem Cells · doi:10.1002/stem.1081 · Cited by 78
Cdx1 Autoregulation Is Governed by a Novel Cdx1-LEF1 Transcription Complex
Béland, M., Pilon, N., Houle, M., Oh, K., Sylvestre, J.-R., Prinos, P., & Lohnes, D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.11.5028-5038.2004 · Cited by 76
“In this regard, Sox2 is expressed in a partially overlapping manner with Cdx1 in the neurectoderm and with the chicken Cdx2 homologue CdxA in the developing gut (31, 32, 41, 63 ).”
BackgroundSun, S.-K., Dee, C. T., Tripathi, V. B., Rengifo, A., Hirst, C. S., & Scotting, P. J. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.12.008 · Cited by 74
Hypopituitarism Oddities: Congenital Causes
Kelberman, D., & Dattani, M. (2007) · Hormone Research in Paediatrics · doi:10.1159/000110610 · Cited by 74
“SOX2 Sox2 (OMIM 184429) is a member of the same SOXB1 subfamily as Sox1 and Sox3 and is expressed early in mouse development(2.5 dpc at the morula stage and then in the inner cell mass of the blastocyst at 3.5 dpc). Sox2 is later expressed throughout the brain, central nervous system, sensory placodes, branchial arche…”
BackgroundInfluentialIwafuchi, M., Yoshida, Y., Onichtchouk, D., Leichsenring, M., Driever, W., Takemoto, T., Uchikawa, M., Kamachi, Y., & Kondoh, H. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.12.027 · Cited by 72
“Sox2 expression hallmarks the neural primordia from gastrulation stages (Rex et al., 1997; Uchikawa et al., 2003; Wood and Episkopou, 1999) to later neural stem cells (Bylund et al.”
BackgroundLee, R. T. H., Nagai, H., Nakaya, Y., Sheng, G., Trainor, P. A., Weston, J. A., & Thiery, J. P. (2013) · Development · doi:10.1242/dev.094680 · Cited by 73
“The neural ectoderm in embryos of both mouse and chicken is characterized by the expression of Sox1 and N-cadherin (cadherin 2), whereas the non-neural ectoderm is characterized by the expression of E-cadherin (cadherin 1) (Dady et al., 2012; Edelman et al., 1983; Hatta and Takeichi, 1986; Nose and Takeichi, 1986; Pev…”
BackgroundMarkers in vertebrate neurogenesis
del Corral, R. D., & Storey, K. G. (2001) · Nature reviews. Neuroscience · doi:10.1038/35097587 · Cited by 70
Yin, N., Yang, R., Liang, S., Liang, S., Hu, B., Ruan, T., & Faiola, F. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.04.011 · Cited by 73
Western, P. S., Maldonado‐Saldivia, J., van den Bergen, J., Hájková, P., Saitou, M., Barton, S. C., & Surani, M. A. (2005) · Stem Cells · doi:10.1634/stemcells.2005-0146 · Cited by 71
Veraitch, F. S., Scott, R., Wong, J. P. F., Lye, G. J., & Mason, C. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21673 · Cited by 68
“Sox1 is the earliest known marker for neuroectoderm in the mouse embryo (Wood and Episkopou, 1999).”
BackgroundMoya, N., Cutts, J., Gaasterland, T., Willert, K., & Brafman, D. A. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.10.004 · Cited by 70
“Together, these data suggested that these in vitro NPC cultures, as in the developing embryo (Pevny et al., 1998; Uwanogho et al., 1995; Wood and Episkopou, 1999), are exposed to patterning cues that impart distinct regional identities and neuronal differentiation potentials.”
BackgroundRao, R. R., & Stice, S. L. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.104.030395 · Cited by 69
“Additionally, Sox2 expression is characteristic of a neural tissue [57] and is a regulatory element expressed in both ES cells and neural progenitor populations [58].”
BackgroundUchikawa, M., Yoshida, M., Iwafuchi, M., Matsuda, K., Ishida, Y., Takemoto, T., & Kondoh, H. (2011) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2011.01286.x · Cited by 70
“5 (7–8 somites), Sox1 expression shows clear gaps in the r3 and r5 rhombomeres, as reported previously (Wood & Episkopou 1999) (Figs 3, 4A).”
BackgroundMethodInfluentialMiyoshi, T., Maruhashi, M., de Putte, T. V., Kondoh, H., Huylebroeck, D., & Higashi, Y. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20799 · Cited by 68
“4E), a gene encoding a transcription factor involved in neural plate development (Collignon et al., 1996; Wood and Episkopou, 1999; Ferri et al., 2004).”
BackgroundClonal and molecular analysis of the prospective anterior neural boundary in the mouse embryo
Cajal, M., Lawson, K. A., Hill, B., Moreau, A., Rao, J., Ross, A., Collignon, J., & Camus, A. (2011) · Development · doi:10.1242/dev.075499 · Cited by 68
PCGF5 is required for neural differentiation of embryonic stem cells
Yao, M., Zhou, X., Zhou, J., Gong, S., Hu, G., Li, J., Huang, K., Lai, P., Shi, G. W., Hutchins, A. P., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03781-0 · Cited by 66
Egea, J., Erlacher, C., Montañez, E., Burtscher, I., Yamagishi, S., Hess, M., Hampel, F., Sanchez, R., Rodriguez-Manzaneque, M., Bösl, M., et al. (2008) · Genes & Development · doi:10.1101/gad.486708 · Cited by 68
“Immunostaining with Sox2, a neuronal marker specific for epiblast cells in MS stage embryos (Wood and Episkopou 1999), confirmed that epiblast cells have reached the surface in mutant embryos where the surrounding endoderm had formed a hole (Fig.”
BackgroundSerafimidis, I., Rakatzi, I., Episkopou, V., Gouti, M., & Gavalas, A. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0194 · Cited by 66
Self-citationEx utero monkey embryogenesis from blastocyst to early organogenesis
Gong, Y., Bai, B., Sun, N., Ci, B., Shao, H., Zhang, T., Yao, H., Zhang, Y., Niu, Y., Liu, L., et al. (2023) · Cell · doi:10.1016/j.cell.2023.04.020 · Cited by 66
Transcription factors and neural stem cell self-renewal, growth and differentiation
Ahmed, S., Gan, H. T., Lam, C. S., Poonepalli, A., Ramasamy, S., Tay, Y., Tham, M., & Yu, Y. H. (2009) · Cell Adhesion & Migration · doi:10.4161/cam.3.4.8803 · Cited by 64
Brunelli, S., Casey, E. S., Bell, D. M., Harland, R. M., & Lovell-Badge, R. H. (2003) · genesis · doi:10.1002/gene.10193 · Cited by 65
A regulatory module embedded in the coding region of Hoxa2 controls expression in rhombomere 2
Tümpel, S., Cambronero, F., Sims, C., Krumlauf, R. K., & Wiedemann, L. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806360105 · Cited by 65
“Sox1, Sox2 and Sox3 are expressed in the developing hindbrain and there are generally much lower levels in r3 and r5 with high levels in the midbrain, r2 and r4 (29).”
BackgroundDavis, S. W., Miura, S., Hill, C., Mishina, Y. M., & Klingensmith, J. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.01.048 · Cited by 65
“, 1995), Sox2 (Wood and Episkopou, 1999), Sox10 (Kuhlbrodt et al.”
BackgroundLü, J., Tan, L., Li, P., Gao, H., Fang, B., Ye, S., Geng, Z., Zheng, P., & Song, H. (2009) · BMC Cell Biology · doi:10.1186/1471-2121-10-57 · Cited by 65
“Cells were harvested and analyzed by flow cytometry for Sox1GFP expression, which is the earliest known specific marker of neuroectoderm in the mouse embryo [11].”
MethodHedgehog Serves as a Mitogen and Survival Factor During Embryonic Stem Cell Neurogenesis
Cai, C., Thorne, J. T., & Grabel, L. B. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0684 · Cited by 64
Clark, E., & Peel, A. (2018) · Development · doi:10.1242/dev.155580 · Cited by 63
“Sox2 (a Dichaete orthologue) has conserved expression in the nervous system, but is also expressed in a posterior domain, where it is a key determinant of neuromesodermal progenitor (posterior stem cell) fate (Wood and Episkopou, 1999; Wymeersch et al., 2016).”
BackgroundMalas, S., Postlethwaite, M., Ekonomou, A., Whalley, B. J., Nishiguchi, S., Wood, H. B., Meldrum, B. S., Constanti, A., & Episkopou, V. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00158-1 · Cited by 62
Self-citationKelberman, D., & Dattani, M. (2006) · Annals of Medicine · doi:10.1080/07853890600994963 · Cited by 62
“the brain, CNS, sensory placodes, branchial arches, gut endoderm and the oesophagus and trachea (111,112).”
BackgroundErythropoietin production in neuroepithelial and neural crest cells during primitive erythropoiesis
Suzuki, N., Hirano, I., Pan, X., Minegishi, N., & Yamamoto, M. P. (2013) · Nature Communications · doi:10.1038/ncomms3902 · Cited by 61
Cell–cell interaction modulates neuroectodermal specification of embryonic stem cells
Parekkadan, B., Berdichevsky, Y., Irimia, D., Leeder, A., Yarmush, G., Toner, M., Levine, J. B., & Yarmush, M. L. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.03.094 · Cited by 60
Tcf15 Primes Pluripotent Cells for Differentiation
Davies, O. R., Lin, C., Radzisheuskaya, A., Zhou, X., Taube, J., Blin, G., Waterhouse, A., Smith, A. J. H., & Lowell, S. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.017 · Cited by 61
“Tcf15 is downregulated at around the time that cells commit to differentiation, as measured by the upregulation of overt neural marker Sox1 (Wood and Episkopou, 1999) (Figure 2C).”
BackgroundDirect development of neurons within foregut endoderm of sea urchin embryos
Zheng, W., Angerer, R. C., & Angerer, L. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018513108 · Cited by 60
“Interestingly, SoxB1 is most closely related to Sox1, Sox2, and Sox3, which have been shown to maintain a neural precursor state in mouse embryos (17, 18).”
BackgroundInfluential
Metadata
- Authors
- Wood, H. B., & Episkopou, V.
- Affiliations
- Hammersmith Hospital (GB)
- Corresponding author
- Episkopou, Vasso
- Venue
- Mechanisms of Development
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 86
- Issue
- 1-2
- Pages
- 197-201
- ISSN
- 0925-4773 (ISSN-L)
- OpenAlex
- W2055664397
- Cited by
- 550
- References
- 16
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 15 · 2023: 5 · 2022: 17 · 2021: 16 · 2020: 11 · 2019: 15 · 2018: 18 · 2017: 23 · 2016: 14 · 2015: 31 · 2014: 29 · 2013: 24 · 2012: 30
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mechanisms of Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- SOX1, SOX2, SOX3, gene expression, mouse embryo, gastrulation, neural plate, neural fold, somitogenesis, primitive streak, chorion, extraembryonic ectoderm, neuroectoderm
- MeSH terms
- Animals, Central Nervous System, DNA-Binding Proteins, Ectoderm, Embryo, Mammalian, Gastrula, High Mobility Group Proteins, Nuclear Proteins, Rhombencephalon, Transcription Factors, Gene Expression Regulation, Developmental, HMGB Proteins, Mice, SOXB1 Transcription Factors
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