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Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages
Open accessAbstract
Whole mount in situ hybridisation was used to study the embryonic expression of the mouse HMG box-containing genes Sox1, Sox2 and Sox3 between 6.5 and 9.0 days post coitum (dpc). Sox2 and Sox3 are expressed in the epiblast and extraembryonic ectoderm of the egg cylinder, becoming restricted to the prospective neural plate and chorion at the onset of gastrulation. Sox3 is upregulated in the posterior ectoderm during late streak and neural plate stages and is concomitantly downregulated in the chorion. Sox1 transcripts are first detected in the neural fold ectoderm at the headfold stage. During early somitogenesis, all three genes are expressed in the neuroectoderm, and Sox2 and Sox3 are also expressed in the primitive streak ectoderm, gut endoderm and prospective sensory placodes.
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“Similarly, Sox2 is expressed in both ectoderm and endoderm libraries corresponding to published expression patterns [38].”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [38]
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Development of the Pituitary Gland
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Gutiérrez-González, L., & Wright, N. A. (2008) · Digestive and Liver Disease · doi:10.1016/j.dld.2008.02.029 · Cited by 60
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BackgroundNeural induction takes a transcriptional twist
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“In mouse and chick, Sox2 shows a similar localization to presumptive neural tissue, suggesting a conserved role in vertebrate neurogenesis (Collignon et al., 1996; Rex et al., 1997; Wood and Episkopou, 1999).”
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Pauley, S., Kopecky, B. J., Beisel, K. W., Soukup, G. A., & Fritzsch, B. (2008) · PubMed · Cited by 51
MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells
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Edri, S., Hayward, P. C., Jawaid, W., & Arias, A. M. (2019) · Development · doi:10.1242/dev.180190 · Cited by 50
“5B) and shares many of the pattern of gene expression of the node (Jeong and Epstein, 2003b; Wood and Episkopou, 1999).”
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“1; Ahmed et al., 2009; Bylund et al., 2003; Collignon et al., 1996; Fuccillo et al., 2006; Gaiano et al., 2000; Hatakeyama et al., 2004; Ishibashi et al., 1995; Miyagi et al., 2008; Molofsky et al., 2005; Palma and Ruiz i Altaba, 2004; Sun et al., 2007; Wood and Episkopou, 1999).”
BackgroundThe role of SOX proteins in normal pituitary development
Alatzoglou, K. S., Kelberman, D., & Dattani, M. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0447 · Cited by 49
“After gastrulation, its expression is subsequently rapidly downregulated in extraembryonic tissues and remains restricted to the anterior ectoderm of the epiblast and to a posterior domain adjacent to the primitive streak (Wood & Episkopou 1999).”
BackgroundInfluentialSingle-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages
Sun, Y., Wang, L., Zhu, T., Wu, B., Wang, G., Luo, Z., Li, C., Wei, W., & Liu, Z. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110542 · Cited by 44
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“During embryo development, SOX1 is the earliest specific marker for NSCs [45, 46].”
BackgroundDual function of Sox1 in telencephalic progenitor cells
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“Sox1 has been used as a marker of embryonic neural stem cells (Aubert et al., 2003; Wood and Episkopou, 1999), and Sox1 expression is reportedly downregulated in progenitor cells as they exit cell cycle and terminally differentiate (Pevny et al., 1998).”
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Cell Aggregation-induced FGF8 Elevation Is Essential for P19 Cell Neural Differentiation
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“As shown in Figure 3H, FGF8 and RA together could promote the differentiation of pluripotent P19 EC cells (Oct4 Sox ) into neural stem cells (Oct4 Sox ; Wood and Episkopou, 1999).”
BackgroundCopper impairs zebrafish swimbladder development by down-regulating Wnt signaling
Xu, J., Zhang, R., Zhang, T., Zhao, G., Huang, Y., Wang, H., & Liu, J. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.09.018 · Cited by 45
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“The transcription factor Sox-2 is one of the earliest known markers of prospective neu-roectoderm (42).”
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“, 1993), is expressed in the central nervous system (CNS) from the earliest stages of development (Wood and Episkopou, 1999).”
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Expression of Sox1 during Xenopus early embryogenesis
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“F) 100 lm. neuroaxis prior to neurogenesis (Bylund et al., 2003; Collignon et al., 1996; Wood and Episkopou, 1999).”
InfluentialSox2 acts as a rheostat of epithelial to mesenchymal transition during neural crest development
Mandalos, N. P., Rhinn, M., Granchi, Z., Karampelas, I., Mitsiadis, T. A., Economides, A. N., Dollé, P., & Remboutsika, E. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00345 · Cited by 43
“…of the SoxB1 group (Sox1-3), which are predominantly expressed in the developing central nervous system (CNS) (Collignon et al., 1996; Wood and Episkopou, 1999), Sox3 activity is required for pharyngeal segmentation and for the pharyngeal epithelium to proceed toward…”
Cellular mechanisms of posterior neural tube morphogenesis in the zebrafish
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“In the mouse and chick embryo Sox3 is expressed throughout the epiblast and only later becomes restricted to the neurectoderm (Collignon et al., 1996; Penzel et al., 1997; Rex et al., 1997; Wood and Episkopou, 1999).”
BackgroundEpigenetic control on cell fate choice in neural stem cells
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Oncogenic activity of SOX1 in glioblastoma
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The absence ofPrep1causes p53-dependent apoptosis of mouse pluripotent epiblast cells
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Neural stem and progenitor cells in health and disease
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“Notably, these factors are also expressed in the post-implantation epiblast and its in vitro derivative EpiSC (Avilion et al., 2003; Brons et al., 2007; Downs, 2008; Hart et al., 2004; Scholer et al., 1990a; Tesar et al., 2007; Wood and Episkopou, 1999; Yeom et al., 1996).”
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“SOX1 is a specific marker of neuroectoderm (Wood and Episkopou, 1999).”
BackgroundDevelopmental gene expression profiling of mammalian, fetal orofacial tissue
Mukhopadhyay, P., Greene, R. M., Zacharias, W., Weinrich, M. C., Singh, S. P., Young, W. W., & Pisano, M. (2004) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20095 · Cited by 39
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“Within the ectoderm, sox3 expression then becomes restricted to the developing CNS, representing one of the earliest and most generally expressed transcription factors in vertebrate neural development (Penzel et al., 1997; Rex et al., 1997; Wood and Episkopou, 1999; Zhang et al., 2004; Zhang et al., 2003).”
BackgroundVianello, S., & Lütolf, M. P. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.07.138883 · Cited by 38
“5, Sox2; Nowotschin et al. (2019b); Wei & Condie (2011); Wood & Episkopou (1999); Zhang et al. (2005)) and posterior gut (e.g. Cdx2, TBra; Beck et al. (1995); Kispert & Herrmann (1994)) marks corresponding left and right regions in the UMAP (Figure 8A), and indeed plotting all 20 Transcription…”
BackgroundInduction of superficial cortical layer neurons from mouse embryonic stem cells by valproic acid
Juliandi, B., Abematsu, M., Sanosaka, T., Tsujimura, K., Smith, A. G., & Nakashima, K. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.09.012 · Cited by 37
Notch Prosensory Effects in the Mammalian Cochlea Are Partially Mediated by Fgf20
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“In the developing otic placode, Sox2 is present as early as E8 (Wood and Episkopou, 1999).”
BackgroundThe transgenic expression of LARGE exacerbates the muscle phenotype of dystroglycanopathy mice
Whitmore, C. L., Fernández-Fuente, M., Booler, H. S., Parr, C., Kavishwar, M., Ashraf, A., Lacey, E., Kim, J., Terry, R. L., Ackroyd, M. R., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt577 · Cited by 37
Allele-specific repression of Sox2 through the long non-coding RNA Sox2ot
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Investigating radial glia in vitro
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Regulatory genes controlling cell fate choice in embryonic and adult neural stem cells
Gangemi, R. M. R., Perera, M., & Corte, G. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2004.02310.x · Cited by 37
“…in developing or adult brain in several mammalian species (Suhonen et al. 1996; Brustle et al. 1997; Flax et al. 1998; Vescovi et al. 1999; Wichterle et al. 1999; Wu et al. 2002), although whether these cells can differentiate into the correct functional cell type remains to be determined.”
BackgroundNeural Induction Intermediates Exhibit Distinct Roles of Fgf Signaling
Sterneckert, J. L., Stehling, M., Bernemann, C., Araúzo-Bravo, M. J., Greber, B., Gentile, L., Ortmeier, C., Sinn, M., Wu, G., Ruau, D., et al. (2010) · Stem Cells · doi:10.1002/stem.498 · Cited by 36
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“…genes become restricted to subsets of cells alongside genes affiliated with different lineages: Oct4 and Nanog become associated with the primitive streak gene T/Bra, whilst Sox2 becomes associated with Sox1, which marks the neural fate (Wood and Episkopou, 1999; Rivera-Pérez and Magnuson, 2005).”
BackgroundInfluentialSOX-1 autoantibodies in patients with paraneoplastic neurological syndromes
Tschernatsch, M., Gross, O., Kneifel, N., Kaps, M., & Blaes, F. (2009) · Autoimmunity Reviews · doi:10.1016/j.autrev.2009.01.015 · Cited by 36
Flexibility of Neural Stem Cells
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“Sox2 hypomorphic mouse mutants exhibit impaired neurogenesis in the adult brain together with neurodegeneration (Ferri et al., 2004).”
BackgroundSingle-cell analysis reveals lineage segregation in early post-implantation mouse embryos
Wen, J., Zeng, Y., Fang, Z., Gu, J., Ge, L., Tang, F., Qu, Z., Hu, J., Cui, Y., Zhang, K., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.780585 · Cited by 37
Bergmann glia as putative stem cells of the mature cerebellum
Alcock, J., Scotting, P. J., & Sottile, V. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2007.01.006 · Cited by 35
“SoxB1 genes are involved in embryonic and adult neurogenesis, and are regarded as reliable markers of stem cells of the CNS [6,8,9,26,27].”
BackgroundGluA2 is rapidly edited at the Q/R site during neural differentiation in vitro
Pachernegg, S., nster, Y. M. ⁄., Eilebrecht, E., Fuhrmann, G., & Hollmann, M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00069 · Cited by 35
Soldati, C., Bithell, A., Johnston, C., Wong, K., Teng, S., Beglopoulos, V., Stanton, L. W., & Buckley, N. J. (2011) · Stem Cells · doi:10.1002/stem.1004 · Cited by 35
Developmental Genes and Malformations in the Hypothalamus
Dı́az, C., & Puelles, L. (2020) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2020.607111 · Cited by 35
“These transcription factors are highly expressed in the hypothalamus, including the infundibulum (Wood and Episkopou, 1999; Rizzoti, 2015), and their mutations are linked to septo-optic dysplasia (Kelberman and Dattani, 2006; Sato et al., 2007).”
BackgroundStepwise pluripotency transitions in mouse stem cells
Endoh, M., & Niwa, H. (2022) · EMBO Reports · doi:10.15252/embr.202255010 · Cited by 38
Mojsin, M. M., & Stevanović, M. J. (2009) · Biochemical Journal · doi:10.1042/bj20090694 · Cited by 36
Sry-box (Sox) transcription factors in gastrointestinal physiology and disease
Gracz, A. D., & Magness, S. T. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00489.2010 · Cited by 37
Sox15 enhances trophoblast giant cell differentiation induced by Hand1 in mouse placenta
Yamada, K., Kanda, H., Tanaka, S., Takamatsu, N., Shiba, T., & Ito, M. (2006) · Differentiation · doi:10.1111/j.1432-0436.2006.00070.x · Cited by 35
Sox3 Expression Defines a Common Primordium for the Epibranchial Placodes in Chick
Ishíi, Y., Abu-Elmagd, M. M., & Scotting, P. J. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0318 · Cited by 35
“, 2000) and many ectodermal placodes, such as olfactory, lens, otic, and lateral line placodes (Uwanogho et al., 1995; Penzel et al., 1997; Zygar et al., 1998; Kamachi et l., 1998; Wood and Episkopou, 1999; Groves and Bronnerraser, 2000; Köster et al., 2000).”
BackgroundPopovic, J., Ninković, D. S., Schwirtlich, M., Klajn, A., Marjanović, J., & Stevanović, M. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091852 · Cited by 34
The Preventive Effect of Oral EGCG in a Fetal Alcohol Spectrum Disorder Mouse Model
Long, L., Li, Y., Wang, Y. D., He, Q., Li, M., Cai, X. D., Peng, K., Li, X. P., Xie, D., Wen, Y. L., et al. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01282.x · Cited by 34
Molecular Basis of Inner Ear Induction
Brown, S. T., Martin, K., & Groves, A. K. (2003) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)57004-1 · Cited by 34
Bauters, M., Frints, S. G. M., Esch, H. V., Spruijt, L., Baldewijns, M. M. L. L., de Die-Smulders, C. E. M., Fryns, J., Marynen, P., & Froyen, G. (2014) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36580 · Cited by 34
Kokkinopoulos, I., Ishida, H., Saba, R., Ruchaya, P. J., Cabrera, C., Struebig, M., Barnes, M. R., Terry, A. V., Kaneko, M., Shintani, Y., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140831 · Cited by 34
Epithelial to mesenchymal transition during mammalian neural crest cell delamination
Zhao, R., & Trainor, P. A. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.02.018 · Cited by 32
Making a head: Neural crest and ectodermal placodes in cranial sensory development
Koontz, A., Urrutia, H. A., & Bronner-Fraser, M. E. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.06.009 · Cited by 33
Early Development of the Spiral Ganglion
Goodrich, L. V. (2015) · Springer handbook of auditory research · doi:10.1007/978-1-4939-3031-9_2 · Cited by 33
“For instance, Sox2 is expressed initially throughout the PNSD, which has the potential to produce hair cells, supporting cells, or neurons (Wood & Episkopou, 1999; Mak et al., 2009).”
BackgroundCRISPR/Cas9-mediated reporter knock-in in mouse haploid embryonic stem cells
Kimura, Y., Oda, M., Nakatani, T., Sekita, Y., Monfort, A., Wutz, A., Mochizuki, H., & Nakano, T. (2015) · Scientific Reports · doi:10.1038/srep10710 · Cited by 33
“To demonstrate the usefulness of our CRISPR/Cas9 strategy, we engineered a construct for the earliest neural precursor gene Sox1 locus 35–37 and established mouse haploid ESC lines carrying a Sox1-P2A-Venus reporter (Hap-SV) to monitor neural differentiation (Fig.”
Direct conversion of mouse astrocytes into neural progenitor cells and specific lineages of neurons
Ma, K., Deng, X., Xia, X., Fan, Z., Qi, X., Wang, Y., Li, Y., Ma, Y., Chen, Q., Peng, H., et al. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0132-x · Cited by 33
The Mutation in Chd7 Causes Misexpression of Bmp4 and Developmental Defects in Telencephalic Midline
Jiang, X., Zhou, Y., Li, X., Chen, W., Wu, H., & Gao, X. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.05.006 · Cited by 32
Congenital Hydrocephalus and Abnormal Subcommissural Organ Development in Sox3 Transgenic Mice
Lee, K., Tan, J., Morris, M. B., Rizzoti, K., Hughes, J., Cheah, P.-S., Felquer, F. A., Liu, X., Piltz, S., Lovell-Badge, R. H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029041 · Cited by 32
“In wild type embryos, Sox3 is expressed in neural progenitor cells along the entire neuraxis of vertebrate embryos [34] as well as a small subset of terminally differentiated neurons and glia in the postnatal mouse brain [22, P.”
BackgroundIshíi, Y., Weinberg, K., Oda‐Ishii, I., Coughlin, L. A., & Mikawa, T. (2009) · Development · doi:10.1242/dev.031344 · Cited by 32
“Memberspecific expression patterns in the eye and other organs (Collignon et al., 1996; Kamachi et al., 1998; Uchikawa et al., 1999; Wood and Episkopou, 1999) (Fig.”
BackgroundZhang, H., Wang, L., Wong, E. Y. M., Tsang, S. L., Xu, P., Lendahl, U., & Sham, M. H. (2017) · eLife · doi:10.7554/elife.30126 · Cited by 32
“Analysis of Sox2, which is an early marker for cranial placodes (Wood and Episkopou, 1999), revealed expression in the ros- tral-proximal part of the pharyngeal ectoderm (Figure 2J and J’) and a reduction of Sox2 expression in both Six1 and Eya1 knockout embryos (Figure 2K and L).”
BackgroundReprogramming Human Retinal Pigmented Epithelial Cells to Neurons Using Recombinant Proteins
Hu, Q., Chen, R., Teesalu, T., Ruoslahti, E. I., & Clegg, D. (2014) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0038 · Cited by 31
Adikusuma, F., Pederick, D. T., McAninch, D., Hughes, J., & Thomas, P. Q. (2017) · Genetics · doi:10.1534/genetics.117.202549 · Cited by 31
“To confirm that the observed increase in Sox2 transcript levels in Sox3Sox2KI/Y embryos resulted in increased protein levels, we performed immunostaining on the ventral diencephalon, where SOX3 and SOX2 are coexpressed in the infundibulum (Wood and Episkopou 1999; Rogers et al. 2013).”
BackgroundControl of gastruloid patterning and morphogenesis by the Erk and Akt signaling pathways
Underhill, E. J., & Toettcher, J. E. (2023) · Development · doi:10.1242/dev.201663 · Cited by 31
Defining pathways that enforce cell lineage specification in early development and stem cells
Roper, S. J., & Hemberger, M. (2009) · Cell Cycle · doi:10.4161/cc.8.10.8381 · Cited by 31
Novel SOX2 partner-factor domain mutation in a four-generation family
Mihelec, M., Abraham, P., Gibson, K., Krowka, R., Susman, R., Storen, R., Chen, Y., Donald, J. A., Tam, P., Grigg, J., et al. (2009) · European Journal of Human Genetics · doi:10.1038/ejhg.2009.79 · Cited by 31
Understanding pluripotency--how embryonic stem cells keep their options open
Johnson, B. V., Shindo, N., Rathjen, P. D., Rathjen, J., & Keough, R. A. (2008) · Molecular Human Reproduction · doi:10.1093/molehr/gan048 · Cited by 31
“Sox2 is expressed in both ICM and early primitive ectoderm (Wood and Episkopou, 1999; Avilion et al., 2003) and Sox2 mouse embryos arrest at a similar time to Oct4 and Nanog embryos (Avilion et al.”
The Role of SOX2 in Hypogonadotropic Hypogonadism
Tziaferi, V., Kelberman, D., & Dattani, M. (2008) · Sexual Development · doi:10.1159/000152035 · Cited by 31
“5 dpc it is widely expressed in the developing CNS, sensory placodes, in the branchial arches, and in the gut endoderm [Collignon et al., 1996; Wood and Episkopou, 1999; Williamson et al., 2006].”
BackgroundInfluentialIto, M. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.10.023 · Cited by 31
Pearton, D. J., Smith, C. S., Redgate, E. L., van Leeuwen, J., Donnison, M. J., & Pfeffer, P. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.05.012 · Cited by 30
A systems-level approach reveals new gene regulatory modules in the developing ear
Chen, J., Tambalo, M., Barembaum, M., Ranganathan, R., Simões-Costa, M., Bronner-Fraser, M. E., & Streit, A. (2017) · Development · doi:10.1242/dev.148494 · Cited by 29
“Dependent on the cellular context, Pax2 is likely to use different partners to impart cell fate (Kamachi and Kondoh, 2013; Stolt and Wegner, 2010): SoxE group members are prominent in otic cells, but they are absent from epibranchial placodes, where SoxB group members could represent major Pax2 partners (Ishii et al.,…”
BackgroundModeling Mammalian Commitment to the Neural Lineage Using Embryos and Embryonic Stem Cells
Shparberg, R. A., Glover, H. J., & Morris, M. B. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00705 · Cited by 39
“…Kunath et al., 2007; Storm et al., 2007, 2009; Chen et al., 2008; Medvedev et al., 2008; Niwa et al., 2009; Hall et al., 2009b; Hirai et al., 2011; Wray et al., 2011; Kim et al., 2012; Marks et al., 2012; Nichols and Smith, 2012; Romero-Lanman et al., 2012; Do et al., 2013; Lee, 2013; Hamilton…”
BackgroundThe role of redox environment in neurogenic development
Ostrakhovitch, E. A., & Semenikhin, O. A. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.08.002 · Cited by 30
Mechanisms of Cortical Differentiation
Adnani, L., Han, S., Li, S., Mattar, P. A., & Schuurmans, C. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.07.005 · Cited by 33
Metadata
- Authors
- Wood, H. B., & Episkopou, V.
- Affiliations
- Hammersmith Hospital (GB)
- Corresponding author
- Episkopou, Vasso
- Venue
- Mechanisms of Development
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 86
- Issue
- 1-2
- Pages
- 197-201
- ISSN
- 0925-4773 (ISSN-L)
- OpenAlex
- W2055664397
- Cited by
- 550
- References
- 16
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 15 · 2023: 5 · 2022: 17 · 2021: 16 · 2020: 11 · 2019: 15 · 2018: 18 · 2017: 23 · 2016: 14 · 2015: 31 · 2014: 29 · 2013: 24 · 2012: 30
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mechanisms of Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- SOX1, SOX2, SOX3, gene expression, mouse embryo, gastrulation, neural plate, neural fold, somitogenesis, primitive streak, chorion, extraembryonic ectoderm, neuroectoderm
- MeSH terms
- Animals, Central Nervous System, DNA-Binding Proteins, Ectoderm, Embryo, Mammalian, Gastrula, High Mobility Group Proteins, Nuclear Proteins, Rhombencephalon, Transcription Factors, Gene Expression Regulation, Developmental, HMGB Proteins, Mice, SOXB1 Transcription Factors
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