NALP Inflammasomes: a central role in innate immunity

The plant immune system

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The Inflammasome

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Gout-associated uric acid crystals activate the NALP3 inflammasome

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The Danger Model: A Renewed Sense of Self

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Cryopyrin activates the inflammasome in response to toxins and ATP

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NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

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Molecular identification of a danger signal that alerts the immune system to dying cells

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Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

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The leucine-rich repeat as a protein recognition motif

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Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

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Ancient Missense Mutations in a New Member of the RoRet Gene Family Are Likely to Cause Familial Mediterranean Fever

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A candidate gene for familial Mediterranean fever

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Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

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Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor

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Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

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Cytochrome C -Mediated Apoptosis

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Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

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The role of inflammation in CNS injury and disease

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Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

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Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

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Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

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Molecular Cloning of the Interleukin-1β Converting Enzyme

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Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

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The CD95(APO-1/Fas) DISC and beyond

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The P2X7 Receptor: A Key Player in IL-1 Processing and Release

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IL-1 is required for tumor invasiveness and angiogenesis

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Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

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NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease

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Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

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The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

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A Unified Model for Apical Caspase Activation

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Inflammatory Caspases

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Altered Cytokine Production in Mice Lacking P2X7Receptors

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Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition

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Plant disease-resistance proteins and the gene-for-gene concept

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Nod-like proteins in immunity, inflammation and disease

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Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation

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Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

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A Proposed Classification of the Immunological Diseases

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Inflammatory caspases and inflammasomes: master switches of inflammation

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TRIM family proteins: retroviral restriction and antiviral defence

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Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

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Nod2 Mutation in Crohn's Disease Potentiates NF-κB Activity and IL-1ß Processing

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Plant NBS-LRR proteins in pathogen sensing and host defense

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A pilot study of IL-1 inhibition by anakinra in acute gout

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NALPs: a novel protein family involved in inflammation

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Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation

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NLRs join TLRs as innate sensors of pathogens

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The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress

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NALP1 in Vitiligo-Associated Multiple Autoimmune Disease

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Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome

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The PYRIN-CARD Protein ASC Is an Activating Adaptor for Caspase-1

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Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf

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A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses

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Activation of the IL-1β-Processing Inflammasome Is Involved in Contact Hypersensitivity

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