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Ubiquitin. Not just for proteasomes anymore

Aguilar, Rubén Claudio, Wendland, Beverly·2003·Current Opinion in Cell Biology
DOI 10.1016/s0955-0674(03)00010-3
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Abstract

Ubiquitin is a small protein that can be covalently linked to itself or other proteins, either as single ubiquitin molecules or as chains of polyubiquitin. Addition of ubiquitin to a target protein requires a series of enzymatic activities (by ubiquitin-activating, -conjugating and -ligating enzymes). The first function attributed to ubiquitin was the covalent modification of misfolded cytoplasmic proteins, thereby directing proteasome-dependent proteolysis. More recently, additional functions have been ascribed to ubiquitin and ubiquitin-related proteins. Ubiquitin directs specific proteins through the endocytic pathway by modifying cargo proteins, and possibly also components of the cytoplasmic protein trafficking machinery.

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Cited by

Metadata

Authors
Aguilar, R. C., & Wendland, B.
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2003-04
Volume
15
Issue
2
Pages
184-190
ISSN
0955-0674
DOI
10.1016/s0955-0674(03)00010-3
Cited by
138
References
1
Language
en
Licence

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