Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 537

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

The biology of replicative senescence

Campisi, J.·1997·European Journal of Cancer

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/s0959-8049(96)00058-5

Cites

12 of 12 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 12 references

Research works printed but not linked: 56

  1. Hayflick, 1965, The limited in vitro lifetime of human diploid cell strains, Exp Cell Res, 37, 614, 10.1016/0014-4827(65)90211-9 · DOI · Paper page
  2. Stanulis-Praeger, 1987, Cellular senescence revisited: a review, Mech Ageing Dev, 38, 1, 10.1016/0047-6374(87)90109-6 · DOI
  3. Campisi, 1996, Replicative senescence: an old lives tale?, Cell, 84, 497, 10.1016/S0092-8674(00)81023-5 · DOI · Paper page
  4. Jazwinski, 1993, The genetics of aging in the yeast Saccharomyces cerevisiae, Genetica, 91, 35, 10.1007/BF01435986 · DOI
  5. McCormick, 1988, Towards an understanding of the malignant transformation of diploid human fibroblasts, Mutat Res, 199, 273, 10.1016/0027-5107(88)90209-6 · DOI
  6. Shay, 1991, Defining the molecular mechanisms of human cell immortalization, Biochim Biophys Acta, 1071, 1
  7. Pereira-Smith, 1983, Evidence for the recessive nature of cellular immortality, Science, 221, 964, 10.1126/science.6879195 · DOI · Paper page
  8. Hensler, 1994, A gene involved in control of human cellular senescence on human chromosome 1q, Mol Cell Biol, 14, 2292, 10.1128/MCB.14.4.2291 · DOI
  9. Ogata, 1993, Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1, Mol Cell Biol, 13, 6036, 10.1128/MCB.13.10.6036 · DOI
  10. Goldstein, 1990, Replicative senescence: the human fibroblast comes of age, Science, 249, 1129, 10.1126/science.2204114 · DOI · Paper page
  11. Seshadri, 1990, cfos repression and an altered genetic program in senescent human fibroblasts, Science, 247, 205, 10.1126/science.2104680 · DOI · Paper page
  12. Hara, 1994, Id related genes encoding helix loop helix proteins are required for G1 progression and are repressed in senescent human fibroblasts, J Biol Chem, 269, 2139, 10.1016/S0021-9258(17)42146-6 · DOI · Paper page
  13. Dimri, 1994, Regulation of two E2F related genes in presenescent and senescent human fibroblasts, J Biol Chem, 269, 16180, 10.1016/S0021-9258(17)33990-X · DOI
  14. Good, 1996, Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescence, J Cell Physiol, 168, 580, 10.1002/(SICI)1097-4652(199609)168:3<580::AID-JCP10>3.0.CO;2-3 · doi:10.1002/(sici)1097-4652(199609)168:3<580::aid-jcp10>3.0.co;2-3
  15. Stein, 1990, Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts, Science, 249, 666, 10.1126/science.2166342 · DOI · Paper page
  16. Hara, 1996, Regulation of p16 (CdkN2) expression and its implications for cell immortalization and senescence, Mol Cell Biol, 16, 859, 10.1128/MCB.16.3.859 · DOI · Paper page
  17. Dimri, 1996, Inhibition of E2F activity by the p21 inhibitor of cyclindependent protein kinases in cells expressing or lacking a functional retinoblastoma protein, Mol Cell Biol, 16, 2987, 10.1128/MCB.16.6.2987 · DOI
  18. Hara, 1996, The helixloop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts, Dev Genetics, 18, 161, 10.1002/(SICI)1520-6408(1996)18:2<161::AID-DVG9>3.0.CO;2-7 · DOI
  19. Wang, 1995, Senescent human fibroblasts resist programmed cell death and failure to suppress bcl2 is involved, Cancer Res, 55, 2284
  20. Linskens, 1995, Replicative senescence and cell death, Science, 267, 17, 10.1126/science.7848496 · DOI
  21. Maier, 1990, Extension of the lifespan of human endothelial cells by an interleukin-1α antisense oligomer, Science, 249, 1570, 10.1126/science.2218499 · DOI · Paper page
  22. Maier, 1993, Senescence stimulates U037-endothelial cell interactions, Exp Cell Res, 208, 270, 10.1006/excr.1993.1246 · DOI
  23. Swisshelm, 1994, Downregulation of retinoic acid receptor β in mammary carcinoma cell lines and its upregulation in senescing normal mammary epithelial cells, Cell Growth Diff, 5, 133
  24. West, 1989, Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity, Exp Cell Res, 184, 138, 10.1016/0014-4827(89)90372-8 · DOI · Paper page
  25. Millis, 1992, Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts, Exp Cell Res, 201, 373, 10.1016/0014-4827(92)90286-H · DOI
  26. Wick, 1994, A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation and senescence, J Biol Chem, 269, 18953, 10.1016/S0021-9258(17)32259-7 · DOI
  27. Campisi, 1997, Aging and cancer: the double-edged sword of replicative senescence, J Am Geriatrics Soc, 45, 1, 10.1111/j.1532-5415.1997.tb05175.x · DOI · Paper page
  28. Harley, 1995, Telomeres and telomerase in aging and cancer, Curr Opin Genet Dev, 5, 249, 10.1016/0959-437X(95)80016-6 · DOI · Paper page
  29. Hara, 1991, Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of lifespan in human diploid fibroblasts, TIG-1, Biochem Biophys Res Comm, 179, 528, 10.1016/0006-291X(91)91403-Y · DOI · Paper page
  30. Shay, 1993, E6 of human papillomavirus type-16 can overcome the M1 stage immortalization in human mammary epithelial cells but not in human fibroblasts, Oncogene, 8, 1407
  31. Tommerup, 1994, Unusual chromatin in human telomeres, Mol Cell Biol, 14, 5777, 10.1128/MCB.14.9.5777 · DOI · Paper page
  32. Blackburn, 1992, Telomerases, Ann Rev Biochem, 61, 113, 10.1146/annurev.bi.61.070192.000553 · DOI · Paper page
  33. Allshire, 1989, Human telomeres contain at least three types of G-rich repeat distributed non-randomly, Nucleic Acids Res, 17, 4611, 10.1093/nar/17.12.4611 · DOI · Paper page
  34. Hastie, 1990, Telomere reduction in human colorectal carcinoma and with aging, Nature, 346, 866, 10.1038/346866a0 · DOI · Paper page
  35. Allsopp, 1995, Evidence for a critical telomere length in senescent human fibroblasts, Exp Cell Res, 219, 130, 10.1006/excr.1995.1213 · DOI · Paper page
  36. Wright, 1996, Experimental elongation of telomeres extends the lifespan of immortal × normal cell hybrids, EMBO J, 15, 1734, 10.1002/j.1460-2075.1996.tb00519.x · DOI
  37. Counter, 1995, Telomerase activity in normal leukocytes and in hematologic malignancies, Blood, 85, 2315, 10.1182/blood.V85.9.2315.bloodjournal8592315 · DOI · Paper page
  38. Landsdorp, 1995, Telomere length and proliferation potential of hematopoietic stem cells, J Cell Sci, 108, 1, 10.1242/jcs.108.1.1 · DOI
  39. Wright, 1996, Telomerase activity in human germline and embryonic tissues and cells, Dev Genetics, 18, 173, 10.1002/(SICI)1520-6408(1996)18:2<173::AID-DVG10>3.0.CO;2-3 · DOI · Paper page
  40. Vaziri, 1993, Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes, Am J Hum Genet, 52, 661
  41. Buchkovich, 1996, Telomerase regulation during entry into the cell cycle in normal human T cells, Mol Cell Biol, 7, 1443, 10.1091/mbc.7.9.1443 · DOI · Paper page
  42. Effros, 1996, Insights on immunological aging derived from the T lymphocyte cellular senescence model, Exp Gerontol, 31, 21, 10.1016/0531-5565(95)00017-8 · DOI
  43. Weng, 1996, Regulated expression of telomerase activity in human T lymphocyte development and activation, J Exp Med, 183, 2471, 10.1084/jem.183.6.2471 · DOI · Paper page
  44. Bryan, 1995, Telomere elongation in immortal human cells without detectable telomerase activity, EMBO J, 14, 4240, 10.1002/j.1460-2075.1995.tb00098.x · DOI · Paper page
  45. Wright, 1995, Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?, Trends Cell Biol, 5, 293, 10.1016/S0962-8924(00)89044-3 · DOI
  46. Sandell, 1993, Loss of a yeast telomere: arrest, recovery and chromosome loss, Cell, 75, 729, 10.1016/0092-8674(93)90493-A · DOI · Paper page
  47. Afshari, 1993, Investigation of the role of G1/S cell cycle mediators in cellular senescence, Exp Cell Res, 209, 231, 10.1006/excr.1993.1306 · DOI · Paper page
  48. Oshima, 1995, Regulation of c-fos in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors, J Cell Physiol, 162, 277, 10.1002/jcp.1041620213 · DOI
  49. Wright, 1989, Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts, Mol Cell Biol, 9, 3088, 10.1128/MCB.9.7.3088 · DOI · Paper page
  50. Radna, 1989, Growth of immortal simian virus 40 ts-A transformed human fibroblasts is temperature dependent, Mol Cell Biol, 9, 3093, 10.1128/MCB.9.7.3093 · DOI
  51. Marcand, 1996, Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap1 protein, Genes Dev, 10, 1297, 10.1101/gad.10.11.1297 · DOI · Paper page
  52. Shay, 1995, You haven't heard the end of it: telomere loss may link human aging with cancer, Can J Aging, 14, 511, 10.1017/S0714980800009089 · DOI
  53. Wright, 1992, Telomere positional effects and the regulation of cellular senescence, Trends Genet, 8, 193, 10.1016/0168-9525(92)90232-S · DOI
  54. Laurenson, 1992, Silencers, silencing and heritable transcriptional states, Microbiol Rev, 56, 543, 10.1128/MR.56.4.543-560.1992 · doi:10.1128/mr.56.4.543-560.1992 · Paper page
  55. Kim, 1996, Effect of replicative age on transcriptional silencing near telomeres in Saccharomyces cerevisiae, Biochem Biophys Res Comm, 219, 370, 10.1006/bbrc.1996.0240 · DOI
  56. Smeal, 1996, Loss of transcriptional silencing causes sterility in old mother cells of S cerevisiae, Cell, 84, 633, 10.1016/S0092-8674(00)81038-7 · DOI · Paper page

Cited by

See all 537

Metadata

Authors
Campisi, J.
Venue
European Journal of Cancer
Publisher
Elsevier BV
Published
1997-04
Volume
33
Issue
5
Pages
703-709
ISSN
0959-8049 (ISSN-L)
OpenAlex
W2095114292
Cited by
537
References
12
FWCI
14.16
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: The biology of replicative senescence. https://app.cochat.ai/papers/10.1016/s0959-8049(96)00058-5
The paper
Campisi, J. (1997). The biology of replicative senescence. European Journal of Cancer. https://doi.org/10.1016/s0959-8049(96)00058-5

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.