In vivo loss of telomeric repeats with age in humans

Lindsey, Janet; McGill, Niolette I.; Lindsey, Leon A.; Green, Daryll K.; Cooke, Howard J.

doi:10.1016/0921-8734(91)90032-7

Cited by 463Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsChromosomal and Genetic Variations

In vivo loss of telomeric repeats with age in humans

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Lindsey, Janet, McGill, Niolette I., Lindsey, Leon A., Green, Daryll K., Cooke, Howard J.·1991·Mutation Research/DNAging

DOI 10.1016/0921-8734(91)90032-7

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Abstract

Telomeric DNA in the skin cells of 21 human subjects aged between 0 and 92 years was quantified by determining the length of the telomeric smear and the relative amount of TTAGGG repeat sequences. Both telomere length and quantity of telomeric repeat sequences were found to decrease significantly with age. Telomere loss has previously been postulated to be a caused of cell senescence.

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Telomere shortening accompanies aging in mitotically active human tissues with high turnover, including blood, liver, skin, testis, and kidneys.
“Telomere shortening also accompanies aging of mitotically active human tissues with high turnover, including blood, liver, skin, testis, and kidneys (Aikata et al., 2000; Friedrich et al., 2000; Lindsey et al., 1991; Takubo et al., 2000; Vaziri et al., 1993).”
From Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice (2010) · cites this paper as Lindsey et al., 1991

Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.
Moyzis, R. K., Buckingham, J. M., Cram, L. S., Dani, M. A. C., Deaven, L. L., Jones, M. D., Meyne, J., Ratliff, R. L., & Wu, J. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6622 · Cited by 2,326 · see citing works
Untitled work
Olovnikov (1973) · doi:10.1016/0022-5193(73)90198-7 · Cited by 1,847 · see citing works
Telomere reduction in human colorectal carcinoma and with ageing
Hastie, N. D., Dempster, M., Dunlop, M. G., Thompson, A. M., Green, D. K., & Allshire, R. C. (1990) · Nature · doi:10.1038/346866a0 · Cited by 1,650 · see citing works
Self-citation
A mutant with a defect in telomere elongation leads to senescence in yeast
Lundblad, V., & Szostak, J. W. (1989) · Cell · doi:10.1016/0092-8674(89)90132-3 · Cited by 909 · see citing works
Structure and variability of human chromosome ends.
de Lange, T., Shiue, L., Myers, R. M., Cox, D. R., Naylor, S. L., Killery, A. M., & Varmus, H. E. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.2.518 · Cited by 848 · see citing works
THE MOLECULAR STRUCTURE OF CENTROMERES AND TELOMERES
Blackburn, E. H., & Szostak, J. W. (1984) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.53.070184.001115 · Cited by 697 · see citing works
Hypervariable ultra-long telomeres in mice
Kipling, D., & Cooke, H. J. (1990) · Nature · doi:10.1038/347400a0 · Cited by 614 · see citing works
Self-citation
Human telomeres contain at least three types of G–rich repeat distributed non-randomly
Allshire, R. C., Dempster, M., & Hastie, N. D. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.12.4611 · Cited by 377 · see citing works
Variability at the Telomeres of the Human X/Y Pseudoautosomal Region
Cooke, H. J., & Smith, B. A. (1986) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1986.051.01.026 · Cited by 233 · see citing works
Self-citation
Dynamics of telomere length variation in tetrahymena thermophila
Dobbs, D. L., Spangler, E. A., & Blackburn, E. H. (1987) · Cell · doi:10.1016/0092-8674(87)90501-0 · Cited by 130 · see citing works
Automatic reading of DNA sequencing gel autoradiographs using a large format digital scanner
Elder, J., Green, D. K., & Southern, E. M. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.1.417 · Cited by 62 · see citing works
Self-citation

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · see citing works
The RNA Component of Human Telomerase
Feng, J., Funk, W. D., Wang, S.-S., Weinrich, S. L., Avilion, A. A., Chiu, C.-P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., et al. (1995) · Science · doi:10.1126/science.7544491 · Cited by 2,227 · see citing works
Telomere length predicts replicative capacity of human fibroblasts.
Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10114 · Cited by 2,200 · see citing works
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80580-2 · Cited by 1,349 · see citing works
Telomere elongation in immortal human cells without detectable telomerase activity
Bryan, T. M., Englezou, A., Gupta, J., Bacchetti, S., & Reddel, R. R. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00098.x · Cited by 1,279 · see citing works
Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells,
Stenderup, K. (2003) · Bone · doi:10.1016/j.bone.2003.07.005 · Cited by 1,207 · see citing works
Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.
Vaziri, H., Dragowska, W., Allsopp, R. C., Thomas, T. E., Harley, C. B., & Lansdorp, P. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9857 · Cited by 1,132 · see citing works
Telomeres and telomerase: three decades of progress
Shay, J. W., & Wright, W. E. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0099-1 · Cited by 924 · see citing works
Human Telomerase and Its Regulation
Cong, Y.-S., Wright, W. E., & Shay, J. W. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.407-425.2002 · Cited by 898 · see citing works
Telomerase activation by the E6 gene product of human papillomavirus type 16
Klingelhutz, A. J., Foster, S. A., & McDougall, J. K. (1996) · Nature · doi:10.1038/380079a0 · Cited by 823 · see citing works
Hayflick, his limit, and cellular ageing
Shay, J. W., & Wright, W. E. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036093 · Cited by 764 · see citing works
Senescence and immortalization: role of telomeres and telomerase
Shay, J. W., & Wright, W. E. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh296 · Cited by 729 · see citing works
<i>TLC1</i> : Template RNA Component of <i>Saccharomyces cerevisiae</i> Telomerase
Singer, M. S., & Gottschling, D. E. (1994) · Science · doi:10.1126/science.7545955 · Cited by 736 · see citing works
Normal human chromosomes have long G-rich telomeric overhangs at one endPreprint
Wright, W. E., Tesmer, V. M., Huffman, K. E., Levene, S. D., & Shay, J. W. (1997) · Genes & Development · doi:10.1101/gad.11.21.2801 · Cited by 735 · see citing works
Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood
Rufer, N., Brümmendorf, T. H., Kolvraa, S., Bischoff, C., Christensen, K., Wadsworth, L., Schulzer, M., & Lansdorp, P. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.2.157 · Cited by 709 · see citing works
Developmental and tissue-specific regulation of mouse telomerase and telomere length.
Prowse, K. R., & Greider, C. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.4818 · Cited by 686 · see citing works
Telomerase activity in human ovarian carcinoma.
Counter, C. M., Hirte, H. W., Bacchetti, S., & Harley, C. B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.2900 · Cited by 677 · see citing works
The rate of telomere sequence loss in human leukocytes varies with age
Frenck, R. W., Blackburn, E. H., & Shannon, K. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5607 · Cited by 675 · see citing works
Role of Telomeres and Telomerase in Aging and Cancer
Shay, J. W. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0062 · Cited by 668 · see citing works
Telomere length and replicative aging in human vascular tissues.
Chang, E., & Harley, C. B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11190 · Cited by 635 · see citing works
Correlating telomerase activity levels with human neuroblastoma outcomes
Hiyama, E., Hiyama, K., Yokoyama, T., Matsuura, Y., Piatyszek, M. A., & Shay, J. W. (1995) · Nature Medicine · doi:10.1038/nm0395-249 · Cited by 611 · see citing works
Telomerase activity in normal leukocytes and in hematologic malignancies
Counter, C. M., Gupta, J., Harley, C., Leber, B. F., & Bacchetti, S. (1995) · Blood · doi:10.1182/blood.v85.9.2315.bloodjournal8592315 · Cited by 604 · see citing works
Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression
Smith, J. R., & Pereira-Smith, O. M. (1996) · Science · doi:10.1126/science.273.5271.63 · Cited by 547 · see citing works
The biology of replicative senescence
Campisi, J. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(96)00058-5 · Cited by 538 · see citing works
Functional requirement of p23 and Hsp90 in telomerase complexes.Preprint
Holt, S., Aisner, D., Baur, J. A., Tesmer, V. M., Dy, M., Ouellette, M., Trager, J., Morin, G., Toft, D., Shay, J., et al. (1999) · Genes & Development · doi:10.1101/gad.13.7.817 · Cited by 589 · see citing works
Telomerase and cancer
Shay, J. W. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.7.677 · Cited by 517 · see citing works
Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice
Sacco, A., Mourkioti, F., Tran, R., Choi, J., Llewellyn, M., Kraft, P., Shkreli, M., Delp, S., Pomerantz, J. H., Artandi, S. E., et al. (2010) · Cell · doi:10.1016/j.cell.2010.11.039 · Cited by 512 · see citing works
Hallmarks of senescence in carcinogenesis and cancer therapy
Shay, J. W., & Roninson, I. B. (2004) · Oncogene · doi:10.1038/sj.onc.1207518 · Cited by 502 · see citing works
Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes.
Härle-Bachor, C., & Boukamp, P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6476 · Cited by 492 · see citing works
How and why we age
Hayflick, L. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00023-0 · Cited by 469 · see citing works
Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring
Sharma, R. K., Agarwal, A. K., Rohra, V. K., Assidi, M., Abu-Elmagd, M. M., & Turki, R. F. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0028-x · Cited by 469 · see citing works
Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect
Broer, L., Codd, V., Nyholt, D. R., Deelen, J., Mangino, M., Willemsen, G., Albrecht, E., Amin, N., Beekman, M., de Geus, E. J. C., et al. (2013) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.303 · Cited by 450 · see citing works
Do US Black Women Experience Stress-Related Accelerated Biological Aging?: A Novel Theory and First Population-Based Test of Black-White Differences in Telomere Length
Geronimus, A. T., Hicken, M. T., Pearson, J. A., Seashols, S. J., Brown, K. L., & Cruz, T. D. (2010) · Human Nature · doi:10.1007/s12110-010-9078-0 · Cited by 447 · see citing works
Brain age and other bodily ‘ages’: implications for neuropsychiatry
Cole, J. H., Marioni, R. E., Harris, S. E., & Deary, I. J. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0098-1 · Cited by 435 · see citing works
Profiling early head and neck cancer
Hunter, K. D., Parkinson, E. K., & Harrison, P. R. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1549 · Cited by 436 · see citing works
Telomerase Activity in Human Breast Tumors
Hiyama, E., Gollahon, L., Kataoka, T., Kuroi, K., Yokoyama, T., Gazdar, A. F., Hiyama, K., Piatyszek, M. A., & Shay, J. W. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.2.116 · Cited by 423 · see citing works
The biology of aging.
Troen, B. R. (2003) · PubMed · Cited by 403 · see citing works
Telomerase Activity in Hematopoietic Cells Is Associated with Self-Renewal Potential
Morrison, S. J., Prowse, K. R., Ho, P., & Weissman, I. L. (1996) · Immunity · doi:10.1016/s1074-7613(00)80316-7 · Cited by 394 · see citing works
Differential Expression of Telomerase Activity in Hematopoietic Progenitors from Adult Human Bone Marrow
Chiu, C., Dragowska, W., Kim, N. W., Vaziri, H., Yui, J., Thomas, T. E., Harley, C. B., & Lansdorp, P. M. (1996) · STEM CELLS · doi:10.1002/stem.140239 · Cited by 388 · see citing works
Telomere Biology and Human Phenotype
Turner, K. J., Vasu, V., & Griffin, D. K. (2019) · Cells · doi:10.3390/cells8010073 · Cited by 391 · see citing works
ATM‐dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post‐translational activation of p53 protein involving poly(ADP‐ribose) polymerase
Vaziri, H., West, M. D., Allsopp, R., Davison, T. S., Wu, Y., Arrowsmith, C. H., Poirier, G. G., & Benchimol, S. (1997) · The EMBO Journal · doi:10.1093/emboj/16.19.6018 · Cited by 384 · see citing works
The role of chondrocyte senescence in osteoarthritis
Price, J. S., Waters, J. G., Darrah, C., Pennington, C., Edwards, D. R., Donell, S. T., & Clark, I. M. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00008.x · Cited by 386 · see citing works
T cells and aging january 2002 update
Pawelec, G. (2002) · Frontiers in bioscience · doi:10.2741/a831 · Cited by 368 · see citing works
Deletion of Ku86 causes early onset of senescence in mice
Vogel, H., Lim, D.-S., Karsenty, G., Finegold, M., & Hasty, P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.19.10770 · Cited by 368 · see citing works
T cells and aging
Pawelec, G. (1998) · Frontiers in bioscience · doi:10.2741/a266 · Cited by 357 · see citing works
Historical claims and current interpretations of replicative aging
Wright, W. E., & Shay, J. W. (2002) · Nature Biotechnology · doi:10.1038/nbt0702-682 · Cited by 355 · see citing works
Telomere length and cardiovascular risk factors in a middle‐aged population free of overt cardiovascular disease
Bekaert, S., De Meyer, T., Rietzschel, E. R., De Buyzere, M. L., De Bacquer, D., Langlois, M., Segers, P., Cooman, L., Van Damme, P., Cassiman, P., et al. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00321.x · Cited by 348 · see citing works
Role of oxidatively induced DNA lesions in human pathogenesis
Sedelnikova, O. A., Redon, C. E., Dickey, J. S., Nakamura, A., Georgakilas, A. G., & Bonner, W. M. (2010) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2009.12.005 · Cited by 339 · see citing works
Telomerase: A target for cancer therapeutics
Shay, J. W., & Wright, W. E. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00159-9 · Cited by 330 · see citing works
Telomere lengths are characteristic in each human individual
Takubo, K., Izumiyama‐Shimomura, N., Honma, N., Sawabe, M., Arai, T., Kato, M., Oshimura, M., & Nakamura, K. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00218-2 · Cited by 326 · see citing works
T Cell Replicative Senescence in Human Aging
P. Chou, J., & B. Effros, R. (2013) · Current Pharmaceutical Design · doi:10.2174/138161213805219711 · Cited by 323 · see citing works
Regenerative potential of human skeletal muscle during aging
Renault, V. M., Thorne, L., Eriksson, P., Butler-Browne, G. S., & Mouly, V. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00017.x · Cited by 318 · see citing works
Stress, cell senescence and organismal ageing
de Magalhães, J. P., & Passos, J. F. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.07.001 · Cited by 316 · see citing works
Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA
Gross, A. M., Jaeger, P. A., Kreisberg, J. F., Licon, K., Jepsen, K., Khosroheidari, M., Morsey, B., Swindells, S., Shen, H., Ng, C. T., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.019 · Cited by 302 · see citing works
Cellular senescence as a tumor-protection mechanism: the essential role of counting
Wright, W. E., & Shay, J. W. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00163-5 · Cited by 306 · see citing works
Replicative Potential and Telomere Length in Human Skeletal Muscle: Implications for Satellite Cell-Mediated Gene Therapy
Decary, S., Mouly, V., Hamida, C. B., Sautet, A., Barbet, P., & Butler-Browne, G. S. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.12-1429 · Cited by 304 · see citing works
Comparison of telomere length measurement methods
Lai, T., Wright, W. E., & Shay, J. W. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0451 · Cited by 288 · see citing works
Progressive Telomere Shortening in Aplastic Anemia
Ball, S. E., Gibson, F. M., Rizzo, S., Tooze, J. A., Marsh, J. C. W., & Gordon‐Smith, E. C. (1998) · Blood · doi:10.1182/blood.v91.10.3582 · Cited by 288 · see citing works
Activation of telomerase in a human tumor.
de Lange, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.2882 · Cited by 282 · see citing works
The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting
Ramsey, M. J., Moore, D. H., Briner, J. F., Lee, D. A., Olsen, L. A., Senft, J. R., & Tucker, J. D. (1995) · Mutation Research/DNAging · doi:10.1016/0921-8734(95)00015-x · Cited by 278 · see citing works
Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals
Iwama, H., Ohyashiki, K., Ohyashiki, J. H., Hayashi, S., Yahata, N., Ando, K., Toyama, K., Hoshika, A., Takasaki, M., Mori, M., et al. (1998) · Human Genetics · doi:10.1007/s004390050711 · Cited by 264 · see citing works
Telomere-driven diseases and telomere-targeting therapies
Martínez, P., & Blasco, M. A. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201610111 · Cited by 257 · see citing works
“…to counteract telomere attrition associated with cell division throughout life, and therefore telomeres shorten with age in vitro and in vivo (Harley et al., 1990; Hastie et al., 1990; Lindsey et al., 1991; Collado et al., 2007; Liu et al., 2007; Flores et al., 2008; Marion et al., 2009).”
Background
Studies of the molecular mechanisms in the regulation of telomerase activity
Liu, J. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.15.2091 · Cited by 253 · see citing works
Race-Ethnicity, Poverty, Urban Stressors, and Telomere Length in a Detroit Community-based Sample
Geronimus, A. T., Pearson, J. A., Linnenbringer, E. L., Schulz, A. J., Reyes, A. G., Epel, E. S., Lin, J., & Blackburn, E. H. (2015) · Journal of Health and Social Behavior · doi:10.1177/0022146515582100 · Cited by 250 · see citing works
Biology of Human Umbilical Cord Blood‐Derived Hematopoietic Stem/Progenitor Cells
Mayani, H., & Lansdorp, P. M. (1998) · Stem Cells · doi:10.1002/stem.160153 · Cited by 246 · see citing works
Coexistence of Alternative Lengthening of Telomeres and Telomerase in hTERT-Transfected GM847 Cells
Perrem, K., Colgin, L. M., Neumann, A. A., Yeager, T. R., & Reddel, R. R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.12.3862-3875.2001 · Cited by 245 · see citing works
Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians
Atzmon, G., Cho, M., Cawthon, R., Budagov, T., Katz, M., Yang, X., Siegel, G., Bergman, A., Huffman, D. M., Schechter, C. B., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906191106 · Cited by 247 · see citing works
Paternal age is positively linked to telomere length of children
Unryn, B. M., Cook, L. S., & Riabowol, K. T. (2005) · Aging Cell · doi:10.1111/j.1474-9728.2005.00144.x · Cited by 224 · see citing works
Replicative Aging and Gene Expression in Long-Term Cultures of Human Bone Marrow Stromal Cells
Banfi, A., Bianchi, G., Notaro, R., Luzzatto, L., Cancedda, R., & Quarto, R. (2002) · Tissue Engineering · doi:10.1089/107632702320934001 · Cited by 227 · see citing works
Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase.
McEachern, M. J., & Blackburn, E. H. (1996) · Genes & Development · doi:10.1101/gad.10.14.1822 · Cited by 224 · see citing works
Telomere dynamics and telomerase activity in in vitro immortalised human cells
Bryan, T. M., & Reddel, R. R. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00065-8 · Cited by 222 · see citing works
Effects of male age on the frequencies of germinal and heritable chromosomal abnormalities in humans and rodents
Sloter, E. D., Nath, J., Eskenazi, B., & Wyrobek, A. J. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.07.043 · Cited by 212 · see citing works
Hallmarks of telomeres in ageing research
Shay, J., & Wright, W. E. (2007) · The Journal of Pathology · doi:10.1002/path.2090 · Cited by 208 · see citing works
Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging
Weng, N., Palmer, L. D., Levine, B. L., Lane, H. C., June, C. H., & Hodes, R. J. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01026.x · Cited by 203 · see citing works
Telomere length and heredity: Indications of paternal inheritance
Nordfjäll, K., Larefalk, Å., Lindgren, P., Holmberg, D., & Roos, G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501724102 · Cited by 201 · see citing works
The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people
Harris, S. E., Deary, I. J., MacIntyre, A., Lamb, K. J., Radhakrishnan, K., Starr, J. M., Whalley, L. J., & Shiels, P. G. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.07.055 · Cited by 200 · see citing works
Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation.
Harada, H., Nakagawa, H., Oyama, K., Takaoka, M., Andl, C. D., Jacobmeier, B., von Werder, A., Enders, G. H., Opitz, O. G., & Rustgi, A. K. (2003) · PubMed · Cited by 197 · see citing works
Telomerase regulation during entry into the cell cycle in normal human T cells.
Buchkovich, K. J., & Greider, C. W. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.9.1443 · Cited by 198 · see citing works
Shorter telomeres in dystrophic muscle consistent with extensive regeneration in young children
Decary, S., Ben Hamida, C., Mouly, V., Barbet, J. P., Hentati, F., & Butler-Browne, G. S. (2000) · Neuromuscular Disorders · doi:10.1016/s0960-8966(99)00093-0 · Cited by 195 · see citing works
The Telomere Lengthening Mechanism in Telomerase-Negative Immortal Human Cells Does Not Involve the Telomerase RNA Subunit
Bryan, T. M., Marusic, L., Bacchetti, S., Namba, M., & Reddel, R. R. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.6.921 · Cited by 192 · see citing works
Epigenetic age prediction
Simpson, D. J., & Chandra, T. (2021) · Aging Cell · doi:10.1111/acel.13452 · Cited by 182 · see citing works
Clinical implications of telomerase in cancer
Kim, N. W. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00057-9 · Cited by 180 · see citing works
Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis
Miura, N., Horikawa, I., Nishimoto, A., Ohmura, H., Ito, H., Hirohashi, S., Shay, J. W., & Oshimura, M. (1997) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(96)00329-9 · Cited by 174 · see citing works
Telomerase Activity Concentrates in the Mitotically Active Segments of Human Hair Follicles
Ramirez, R. D., Wright, W. E., Shay, J. W., & Taylor, R. S. (1997) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12285654 · Cited by 174 · see citing works
Mechanisms Limiting Body Growth in Mammals
Lui, J. C. K., & Baron, J. (2011) · Endocrine Reviews · doi:10.1210/er.2011-0001 · Cited by 167 · see citing works
Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes
Flanary, B. E., & Streit, W. J. (2004) · Glia · doi:10.1002/glia.10301 · Cited by 167 · see citing works
Restoration of Telomeres in Human Papillomavirus-Immortalized Human Anogenital Epithelial Cells
Klingelhutz, A. J., Barber, S. A., Smith, P. P., Dyer, K., & McDougall, J. K. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.2.961 · Cited by 166 · see citing works
Mammalian telomere dynamics: healing, fragmentation shortening and stabilization
Greider, C. W. (1994) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(05)80046-2 · Cited by 161 · see citing works
Telomere attrition as ageing biomarker.
Bekaert, S., Meyer, T. D., & Oostveldt, P. V. (2005) · PubMed · Cited by 158 · see citing works
Telomere shortening impairs organ regeneration by inhibiting cell cycle re‐entry of a subpopulation of cells
Satyanarayana, A., Wiemann, S. U., Buer, J., Lauber, J., Dittmar, K. E. J., Wüstefeld, T., Blasco, M. A., Manns, M. P., & Rudolph, K. L. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg367 · Cited by 158 · see citing works
Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids.
Wright, W. E., Brasiskyte, D., Piatyszek, M. A., & Shay, J. W. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00519.x · Cited by 158 · see citing works
Human diseases of telomerase dysfunction: insights into tissue aging
Garcia, C. K., Wright, W. E., & Shay, J. W. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm644 · Cited by 156 · see citing works
Regulation of Telomere Length and Telomerase in T and B Cells
Weng, N., Hathcock, K. S., & Hodes, R. J. (1998) · Immunity · doi:10.1016/s1074-7613(00)80597-x · Cited by 155 · see citing works
In situ analysis of changes in telomere size during replicative aging and cell transformation.
Henderson, S. C., Allsopp, R., Spector, D. L., Wang, S. S., & Harley, C. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.1.1 · Cited by 154 · see citing works
Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring
Kaltsas, A., Moustakli, E., Zikopoulos, A., Georgiou, I. A., Dimitriadis, F., Symeonidis, E. N., Markou, E., Michaelidis, T. M., Tien, D. M. B., Giannakis, I., et al. (2023) · Genes · doi:10.3390/genes14020486 · Cited by 149 · see citing works
The roles of telomeres and telomerase in cell life span
Counter, C. M. (1996) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/s0165-1110(96)90006-8 · Cited by 140 · see citing works
T cells and aging (update February 1999)
Pawelec, G. (1999) · Frontiers in bioscience · doi:10.2741/pawelec · Cited by 138 · see citing works
Telomerase Activity and Survival of Patients With Node-Positive Breast Cancer
Clark, G. M., Osborne, C. K., Levitt, D., Wu, F., & Kim, N. W. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.24.1874 · Cited by 139 · see citing works
Telomere Lengths and Telomerase Activity in Dog Tissues: A Potential Model System to Study Human Telomere and Telomerase Biology
Nasir, L., Devlin, P., McKevitt, T. P., Rutteman, G. R., & Argyle, D. J. (2001) · Neoplasia · doi:10.1038/sj.neo.7900173 · Cited by 135 · see citing works
Normal Human Telomeres Are Not Late Replicating
Wright, W. E., Tesmer, V. M., Liao, M., & Shay, J. W. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4602 · Cited by 134 · see citing works

The rate of telomere sequence loss in human leukocytes varies with age
Frenck, R. W., Blackburn, E. H., & Shannon, K. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5607 · Cited by 675 · see citing works
The Extent and Significance of Telomere Loss with Age
Baird, D. M., & Kipling, D. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.044 · Cited by 56 · see citing works
Analysis of Loss of Telomeric DNA During Replicative Aging of Human Cells and Examination of the Role of this Process in the Induction of Cell Senescence
Allsopp, C. R. (1995) · MacSphere (McMaster University) · doi:10.71548/24193
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.
Vaziri, H., Schächter, F., Uchida, I. A., Wei, L., Zhu, X., Effros, R. B., Cohen, D., & Harley, C. (1993) · PubMed · Cited by 734 · see citing works
Telomere loss and skin aging
Boukamp, P. (2004) · International Journal of Cosmetic Science · doi:10.1111/j.1467-2494.2004.213_3.x

Authors: Lindsey, J., McGill, N. I., Lindsey, L. A., Green, D. K., & Cooke, H. J.
Affiliations: Western General Hospital (GB)
Bangour Village Hospital (GB)
Corresponding author: Cooke, Howard J.
ORCID: Lindsey, Janet
Cooke, Howard J.
Venue: Mutation Research/DNAging
Publisher: Elsevier BV
Published: 1991-01
Volume: 256
Issue: 1
Pages: 45-48
ISSN: 0921-8734 (ISSN-L)
DOI: 10.1016/0921-8734(91)90032-7
OpenAlex: W1992520556
Cited by: 463
References: 12
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 16 · 2020: 10 · 2019: 11 · 2018: 9 · 2017: 10 · 2016: 7 · 2015: 12 · 2014: 9 · 2013: 10 · 2012: 13
FWCI: 3.99
Type: journal article
Language: en
Open access: green
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Mutation Research/DNAging (publishedVersion)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity)
Topics: Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Keywords: telomere length, telomeric repeats, aging, skin cells, TTAGGG repeats, cellular senescence, telomere loss
MeSH terms: Epidermal Cells, Adolescent, Adult, Aged, Aged, 80 and over, Aging, Child, Child, Preschool, Chromosomes, Humans, Infant, Infant, Newborn, Middle Aged, Repetitive Sequences, Nucleic Acid, Blotting, Southern, Telomere

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In vivo loss of telomeric repeats with age in humans

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