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Modular phosphoinositide-binding domains – their role in signalling and membrane trafficking

Cullen, Peter J, Cozier, Gyles E, Banting, George, Mellor, Harry·2001·Current Biology

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  • Sorting nexins characteristically localize to endosomes, predominantly early endosomes, in some cases via interaction between their PX domain and phosphoinositides in the endosomal membrane.

    “Sorting nexins characteristically localize to endosomes, predominantly early endosomes, in some cases via interaction between their PX domain and phosphoinositides in the endosomal membrane (reviewed in Ref. 25).”

    From Sorting Motifs in the Intracellular Domain of the Low Density Lipoprotein Receptor Interact with a Novel Domain of Sorting Nexin-17 (2004) · cites this paper as [25]

    The SNX3 discussion (indexed as Abstract; page unavailable) says that its PI(3)P-binding activity is necessary for endosomal association, supporting the PX-domain mechanism in some sorting nexins. It does not establish that sorting nexins characteristically localize predominantly to early endosomes; the SNX3-positive structure described contains early, recycling, and late endosomal markers. (LLM, conf=0.85)

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Research works printed but not linked: 100

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Metadata

Authors
Cullen, P. J., Cozier, G. E., Banting, G., & Mellor, H.
Venue
Current Biology
Publisher
Elsevier BV
Published
2001-10
Volume
11
Issue
21
Pages
R882-R893
ISSN
0960-9822
Cited by
150
References
2
Language
en
Funders
Wellcome Trust Centre for Mitochondrial Research

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