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Modular phosphoinositide-binding domains – their role in signalling and membrane trafficking
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Sorting nexins characteristically localize to endosomes, predominantly early endosomes, in some cases via interaction between their PX domain and phosphoinositides in the endosomal membrane.
“Sorting nexins characteristically localize to endosomes, predominantly early endosomes, in some cases via interaction between their PX domain and phosphoinositides in the endosomal membrane (reviewed in Ref. 25).”
From Sorting Motifs in the Intracellular Domain of the Low Density Lipoprotein Receptor Interact with a Novel Domain of Sorting Nexin-17 (2004) · cites this paper as [25]
The SNX3 discussion (indexed as Abstract; page unavailable) says that its PI(3)P-binding activity is necessary for endosomal association, supporting the PX-domain mechanism in some sorting nexins. It does not establish that sorting nexins characteristically localize predominantly to early endosomes; the SNX3-positive structure described contains early, recycling, and late endosomal markers. (LLM, conf=0.85)
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Localized Biphasic Changes in Phosphatidylinositol-4,5-Bisphosphate at Sites of Phagocytosis
Botelho, R. J., Teruel, M., Dierckman, R., Anderson, R., Wells, A., York, J. D., Meyer, T., & Grinstein, S. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.7.1353 · Cited by 539
Haft, C. R., de la Luz Sierra, M., Barr, V. A., Haft, D. H., & Taylor, S. I. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7278 · Cited by 244
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Metadata
- Authors
- Cullen, P. J., Cozier, G. E., Banting, G., & Mellor, H.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 11
- Issue
- 21
- Pages
- R882-R893
- ISSN
- 0960-9822
- Cited by
- 150
- References
- 2
- Language
- en
- Licence
- Funders
- Wellcome Trust Centre for Mitochondrial Research
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