Cited by 126Telomeres, Telomerase, and SenescenceCancer-related Molecular PathwaysGenetics, Aging, and Longevity in Model Organisms

Mice without telomerase: what can they teach us about human cancer?

Artandi, Steven E., DePinho, Ronald A.·2000·Nature Medicine

Abstract

Unicellular organisms, human cells and mice have provided insights into the processes of senescence, crisis, genomic instability and cancer in humans. Here, Artandi and DePinho discuss how studies in mice have uncovered a complex interplay between the ARF-p53 pathway, genomic instability due to telomere dysfunction, and the suppression or promotion of cancer.

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Crossref · 10.1038/78595

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41 of 41 references verified0 citation errors · 0 not checkable

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Authors
Artandi, S. E., & DePinho, R. A.
Affiliations
  • Dana-Farber Cancer Institute (US)
  • Harvard University (US)
Venue
Nature Medicine
Published
2000-08
Volume
6
Issue
8
Pages
852-855
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
OpenAlex
W1594827217
Cited by
126
References
41
Citations by year
2026: 1 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 5 · 2012: 5
FWCI
9.82
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
telomerase, telomere dysfunction, genomic instability, cellular senescence, ARF-p53 pathway, tumor suppression, tumor promotion, mouse tumor model, human cancer
MeSH terms
Animals, Cell Division, Humans, Neoplasms, Species Specificity, Genes, p53, Telomere, Cellular Senescence, Mice, Knockout, Telomerase, Mice

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