Cited by 389Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsAnesthesia and Neurotoxicity Research

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice

Open access

Sheng, J·2003·Neurobiology of Disease

DOI 10.1016/s0969-9961(03)00069-x

Open this paper in CoChat — free account

Abstract

The present study was designed to examine whether brain inflammation caused by systemic administration of lipopolysaccharides (LPS) alters the expression/processing of amyloid precursor protein (APP) and increases the generation of amyloid beta peptide (Abeta). APPswe transgenic (Tg) mice were treated with either LPS or phosphate-buffered saline (PBS). In LPS-treated APPswe mice, Abeta1-40/42 was 3-fold and APP was 1.8-fold higher than those in PBS-treated mice (P < 0.05) by ELISA, Western blots and immunoprecipitation-mass spectrometry (IP-MS) ProteinChip analysis. Numbers of Abeta- and APP-immunoreactive neurons (Abeta(+) and APP(+) neurons) increased significantly in LPS-treated APPswe mice; APP(+) and Abeta(+) neurons in neocortex were associated with an increased number of F4/80-immunoreactive microglia (F4/80(+) microglia) in their anatomical environment. Our findings demonstrate that experimental neuroinflammation increases APP expression/processing and causes intracellular accumulation of Abeta. It remains to be seen whether such events can cause neuronal dysfunction/degeneration and, with time, lead to extracellular Abeta deposits, as they occur in Alzheimer's disease.

Integrity signals

Registry

Crossref · 10.1016/s0969-9961(03)00069-x

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C.-M., Pérez‐Tur, J., Hutton, M., Buée, L., Harigaya, Y., Yager, D., et al. (1996) · Nature · doi:10.1038/383710a0 · Cited by 1,486
Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo
Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80230-5 · Cited by 1,478
Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor
Esch, F. S., Keim, P. S., Beattie, E. C., Blacher, R. W., Culwell, A. R., Oltersdorf, T., McClure, D., & Ward, P. J. (1990) · Science · doi:10.1126/science.2111583 · Cited by 1,403
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein
Weidemann, A., König, G., Bunke, D., Fischer, P. Q., Salbaum, J. M., Masters, C. L., & Beyreuther, K. T. (1989) · Cell · doi:10.1016/0092-8674(89)90177-3 · Cited by 1,233
Risk of Alzheimer's disease and duration of NSAID use
Stewart, W. F., Kawas, C., Corrada, M., & Metter, E. J. (1997) · Neurology · doi:10.1212/wnl.48.3.626 · Cited by 1,132
Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins
Borchelt, D. R., Ratovitski, T., van Lare, J., Lee, M. K., Gonzales, V., Jenkins, N. A., Copeland, N. G., Price, D. L., & Sisodia, S. S. (1997) · Neuron · doi:10.1016/s0896-6273(00)80974-5 · Cited by 1,023
Intraneuronal Aβ42 Accumulation in Human Brain
Gouras, G. K., Tsai, J., Naslund, J., Vincent, B., Edgar, M., Checler, F., Greenfield, J. P., Haroutunian, V., Buxbaum, J. D., Xu, H., et al. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64700-1 · Cited by 991

Show all 51 references

Sorted by citations

Items 201–300 of 389

Effects of high cholesterol diet on gliosis in apolipoprotein E knockout mice
Crisby, M., Rahman, S. M. A., Sylvén, C., Winblad, B. G., & Schultzberg, M. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.05.057 · Cited by 48
Inflammation and neurodegenerative disorders
Baune, B. T. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000140 · Cited by 49
Evaluation of Plant Phenolic Metabolites as a Source of Alzheimer's Drug Leads
Hassaan, Y., Handoussa, H., El‐Khatib, A. H., Linscheid, M. W., Sayed, N. S. E., & Ayoub, N. (2014) · BioMed Research International · doi:10.1155/2014/843263 · Cited by 47
IKKβ Deficiency in Myeloid Cells Ameliorates Alzheimer's Disease-Related Symptoms and Pathology
Liu, Y., Liu, X., Hao, W., Decker, Y., Schomburg, R., Fülöp, L., Pasparakis, M., Menger, M. D., & Fassbender, K. C. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1348-14.2014 · Cited by 46
Astrocytes deliver CK1 to neurons via extracellular vesicles in response to inflammation promoting the translation and amyloidogenic processing of APP
Li, Z., Moniruzzaman, M., Dastgheyb, R. M., Yoo, S., Wang, M., Hao, H., Liu, J., Casaccia, P., Nogueras‐Ortiz, C. J., Kapogiannis, D., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12035 · Cited by 45
Is Periodontitis Associated with Age-Related Cognitive Impairment? The Systematic Review, Confounders Assessment and Meta-Analysis of Clinical Studies
Dziedzic, A. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315320 · Cited by 49
Melatonin attenuated mediators of neuroinflammation and alpha-7 nicotinic acetylcholine receptor mRNA expression in lipopolysaccharide (LPS) stimulated rat astrocytoma cells, C6
Niranjan, R., Nath, C., & Shukla, R. (2012) · Free Radical Research · doi:10.3109/10715762.2012.697626 · Cited by 46
The value and limitations of transgenic mouse models used in drug discovery for Alzheimer's disease: an update
Bales, K. R. (2012) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2012.666234 · Cited by 46
Development of brain PET imaging agents: Strategies for imaging neuroinflammation in Alzheimer's disease
Janssen, B., & Mach, R. H. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.04.005 · Cited by 44
Targeting innate immunity to protect and cure Alzheimer’s disease: opportunities and pitfalls
Cisbani, G., & Rivest, S. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01083-4 · Cited by 44
Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer
Hang, Z., Lei, T., Zeng, Z., Cai, S., Bi, W., & Du, H. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112343 · Cited by 45
Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer’s Disease
Thygesen, C., Ilkjær, L., Kempf, S. J., Hemdrup, A. L., von Linstow, C. U., Babcock, A. A., Darvesh, S., Larsen, M. R., & Finsen, B. R. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00397 · Cited by 44
Ethanol Extract of Magnolia officinalis Prevents Lipopolysaccharide‐Induced Memory Deficiency via Its Antineuroinflammatory and Antiamyloidogenic Effects
Lee, Y., Choi, D., Yun, Y., Han, S., Kim, H. M., Lee, K., Choi, S. H., Yang, M., Jeon, H. S., Jeong, J., et al. (2012) · Phytotherapy Research · doi:10.1002/ptr.4740 · Cited by 43
Co-administration of 3-Acetyl-11-Keto-Beta-Boswellic Acid Potentiates the Protective Effect of Celecoxib in Lipopolysaccharide-Induced Cognitive Impairment in Mice: Possible Implication of Anti-inflammatory and Antiglutamatergic Pathways
Sayed, A. S., & Sayed, N. S. E. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0734-7 · Cited by 44
Inflammation Combined with Ischemia Produces Myelin Injury and Plaque-Like Aggregates of Myelin, Amyloid-β and AβPP in Adult Rat Brain
Zhan, X., Cox, C. D., Ander, B. P., Liu, D., Stamova, B. S., Jin, L., Jickling, G. C., & Sharp, F. R. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-143072 · Cited by 41
MicroRNAs and the Genetic Nexus of Brain Aging, Neuroinflammation, Neurodegeneration, and Brain Trauma
Sarkar, S. N., Russell, A. E., Engler-Chiurazzi, E. B., Porter, K. N., & Simpkins, J. W. (2018) · Aging and Disease · doi:10.14336/ad.2018.0409 · Cited by 43
Metabotropic glutamate receptor subtype 5 is altered in LPS-induced murine neuroinflammation model and in the brains of AD and ALS patients
Herde, A. M., Schibli, R., Weber, M., & Ametamey, S. M. (2018) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-018-4179-9 · Cited by 42
Recent Aspects of Periodontitis and Alzheimer’s Disease—A Narrative Review
Cichońska, D., Mazuś, M., & Kusiak, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052612 · Cited by 47
Critical role of intraneuronal Aβ in Alzheimer's disease: Technical challenges in studying intracellular Aβ
Gouras, G. K., Willén, K., & Tampellini, D. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.06.004 · Cited by 39
Does Infection-Induced Immune Activation Contribute to Dementia?
Tatiana, Jaqueline, Jessica, Allan, Pitcher, M. R., Simões, L. R., Quevedo, J., & Dal‐Pizzol, F. (2015) · Aging and Disease · doi:10.14336/ad.2015.0521 · Cited by 40
The role of microbial infection in the pathogenesis of Alzheimer’s disease and the opportunity for protection by anti-microbial peptides
Li, F., Hearn, M. T. W., & Bennett, L. E. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.1876630 · Cited by 38
Targeting Systemic Innate Immune Cells as a Therapeutic Avenue for Alzheimer Disease
Pons, V., & Rivest, S. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000400 · Cited by 41
Amyloid-β 1–24 C-terminal truncated fragment promotes amyloid-β 1–42 aggregate formation in the healthy brain
Mazzitelli, S., Filipello, F., Rasile, M., Lauranzano, E., Cucuzza, C. S., Tamborini, M., Pozzi, D., Barajon, I., Toni Giorgino, A., Natalello, A., et al. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0381-9 · Cited by 38
The novel DYRK1A inhibitor KVN93 regulates cognitive function, amyloid-beta pathology, and neuroinflammation
Lee, H., Woo, H., Lee, H.-E., Jeon, H., Ryu, K., Nam, J. H., Jeon, S. G., Park, H., Lee, J.-S., Han, K., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.08.030 · Cited by 39
Periodontitis Deteriorates Cognitive Function and Impairs Neurons and Glia in a Mouse Model of Alzheimer’s Disease
Qian, X., Zhang, S., Duan, L., Yang, F., Zhang, K., Yan, F., & Ge, S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201007 · Cited by 42
Modeling Alzheimer’s Disease in Mouse without Mutant Protein Overexpression: Cooperative and Independent Effects of Aβ and Tau
Guo, Q., Li, H., Cole, A. L., Hur, J., Li, Y., & Zheng, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080706 · Cited by 41
Novel approaches for immunotherapeutic intervention in Alzheimer's disease
Vasilevko, V., & Cribbs, D. H. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.03.019 · Cited by 37
Rhinacanthin C Alleviates Amyloid‐β Fibrils’ Toxicity on Neurons and Attenuates Neuroinflammation Triggered by LPS, Amyloid‐β, and Interferon‐γ in Glial Cells
Chuang, K., Li, M., Lin, N., Chang, C.-H., Lu, I.-H., Pan, I.-H., Takahashi, T., Perng, M., & Wen, S. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5414297 · Cited by 40
Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer’s disease models
Pardon, M., Lopez, M. Y., Ding, Y., Marjańska, M., Prior, M. J. W., Brignell, C. J., Parhizkar, S., Agostini, A., Bai, L., Auer, D. P., et al. (2016) · Scientific Reports · doi:10.1038/srep19880 · Cited by 38
Biological basis for amyloidogenesis in Alzheimer’S disease
Андреева, Т. В., Lukiw, W. J., & Rogaev, E. I. (2017) · Biochemistry (Moscow) · doi:10.1134/s0006297917020043 · Cited by 38
Overexpression of NMDAR2B in an inflammatory model of Alzheimer's disease: Modulation by NOS inhibitors
Maher, A., Sayed, N. S. E., Breitinger, H., & Gad, M. Z. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.10.007 · Cited by 35
Benzyl isothiocyanate inhibits inflammasome activation in E. coli LPS-stimulated BV2 cells
Lee, C.-M., Lee, D.-S., Jung, W., Yoo, J. S., Yim, M., Choi, Y. H., Park, S.-G., Seo, S., Choi, J. S., Lee, Y., et al. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2667 · Cited by 35
Geraniin Attenuates Lipopolysaccharide-Induced Cognitive Impairment in Mice by Inhibiting Toll-Like Receptor 4 Activation
Wang, D., Dong, X., Wang, B., Liu, Y., & Li, S. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b03977 · Cited by 34
Systemic and localized extra‐central nervous system bacterial infections and the risk of dementia among US veterans: A retrospective cohort study
Mawanda, F., Wallace, R. B., McCoy, K. D., & Abrams, T. E. (2016) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2016.08.004 · Cited by 36
Chronic Ethanol Causes Persistent Increases in Alzheimer’s Tau Pathology in Female 3xTg-AD Mice: A Potential Role for Lysosomal Impairment
Tucker, A. E., Pauneto, C. D. M. A., Barnett, A., & Coleman, L. G. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.886634 · Cited by 33
Microglia and Cholesterol Handling: Implications for Alzheimer’s Disease
Herrera, O. M. M., & Zivkovic, A. M. (2022) · Biomedicines · doi:10.3390/biomedicines10123105 · Cited by 38
Immunotherapy as treatment for Alzheimer’s disease
Hawkes, C. A., & McLaurin, J. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.11.1535 · Cited by 33
Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ‐on‐a‐Chip Technology
Pramotton, F. M., Spitz, S., & Kamm, R. D. (2024) · Advanced Science · doi:10.1002/advs.202403892 · Cited by 33
Inflammation condition sensitizes Piezo1 mechanosensitive channel in mouse cerebellum astrocyte
Yu, D., Ahmed, A., Jayasi, J., Womac, A., Sally, O., & Bae, C. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1200946 · Cited by 31
The Interplay of Inflammation and Gut-Microbiota Dysbiosis in Alzheimer’s Disease: Mechanisms and Therapeutic Potential
Samat, H. N. A., Razali, N. N., Mahadzir, H., Muhammad, T. S. T., Ling, K., Mansor, N. I., & Abidin, S. Z. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26188905 · Cited by 34
High-Resolution 3D Reconstruction Reveals Intra-Synaptic Amyloid Fibrils
Capetillo‐Zarate, E., Gracia, L., Yu, F., Banfelder, J. R., Lin, M. T. S., Tampellini, D., & Gouras, G. K. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.07.045 · Cited by 31
Involvement and relationship of bacterial lipopolysaccharides and cyclooxygenases levels in Alzheimer’s Disease and Mild Cognitive Impairment patients
Andreadou, E. G., Katsipis, G., Tsolaki, M., & Pantazaki, A. A. (2021) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2021.577561 · Cited by 31
6-Hydroxydopamine and lipopolysaccharides induced DNA damage in astrocytes: Involvement of nitric oxide and mitochondria
Gupta, S., Goswami, P., Biswas, J., Joshi, N., Sharma, S., Nath, C., & Singh, S. (2015) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2014.12.007 · Cited by 30
Associations between autoimmune diseases and amyotrophic lateral sclerosis: a register-based study
Cui, C., Longinetti, E., Larsson, H., Andersson, J., Yudi Pawitan, Y., Piehl, F., & Fang, F. (2020) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.1080/21678421.2020.1861022 · Cited by 31
Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson’s Disease
van Vuuren, M. J., Nell, T. A., Carr, J. A., Kell, D. B., & Pretorius, E. (2020) · Biomolecules · doi:10.3390/biom11010030 · Cited by 33
Celastrol Enhances Cell Viability and Inhibits Amyloid-β Production Induced by Lipopolysaccharide In Vitro
Zhao, Y. D., Zhao, H., Lobo, N., Guo, X., Gentleman, S., & Ma, D. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131799 · Cited by 31
Reversal of lipopolysaccharide-induced learning and memory deficits by agmatine in mice
Borikar, S. P., Dongare, S. I., & Danao, K. R. (2022) · International Journal of Neuroscience · doi:10.1080/00207454.2020.1830086 · Cited by 28
Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer’s disease
Erickson, M. A., Logsdon, A. F., Rhea, E. M., Hansen, K. M., Holden, S. J., Banks, W. A., Smith, J. L., German, C. N., Farr, S. A., Morley, J. E., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.01.010 · Cited by 29
The novel calpain inhibitor A-705253 prevents stress-induced tau hyperphosphorylation in vitro and in vivo
Nikkel, A. L., Martino, B. R., Markosyan, S., Brederson, J., Medeiros, R., Möller, A., & Bitner, R. S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.05.011 · Cited by 30
The Association of Mid- and Late-Life Systemic Inflammation with Brain Amyloid Deposition: The ARIC-PET Study
Walker, K. A., Windham, B. G., Brown, C. H., Knopman, D. S., Jack, C. R., Mosley, T. H., Selvin, E., Wong, D. F., Hughes, T. M., Zhou, Y., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180469 · Cited by 30
CD40L disruption enhances Aβ vaccine-mediated reduction of cerebral amyloidosis while minimizing cerebral amyloid angiopathy and inflammation
Obregon, D. F., Hou, H.-Y., Bai, Y., Nikolic, W. V., Mori, T., Luo, D., Zeng, J., Ehrhart, J. C., Fernandez, F., Morgan, D., et al. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.09.009 · Cited by 29
Gut dysbiosis as a potential driver of Parkinson’s and Alzheimer’s disease pathogenesis
Pfaffinger, J. M., Hays, K. E., Seeley, J., Babu, P. R., & Ryznar, R. J. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1600148 · Cited by 39
Astrocyte priming enhances microglial Aβ clearance and is compromised by APOE4
Lee, S. J., Yu, J. J., Lee, H. G., Kim, B., Jang, M. J., Jo, H., Kim, N. Y., Pak, M. E., Kim, J. K., Cho, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62995-1 · Cited by 28
Exosomes: A missing link between chronic systemic inflammation and Alzheimer’s disease?
Ozansoy, M., Mikati, H., Velioğlu, H. A., & Yuluğ, B. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114161 · Cited by 30
Intermittent systemic exposure to lipopolysaccharide-induced inflammation disrupts hippocampal long-term potentiation and impairs cognition in aging male mice
Engler-Chiurazzi, E. B., Russell, A. E., Povroznik, J. M., McDonald, K., Porter, K., Wang, D. S., Hammock, J., Billig, B. K., Felton, C. C., Yilmaz, A., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.12.013 · Cited by 29
Mechanisms of the Procognitive Effects of Xanthotoxin and Umbelliferone on LPS-Induced Amnesia in Mice
Kurach, Ł., Kulczycka-Mamona, S., Kowalczyk, J., Skalicka‐Woźniak, K., Boguszewska‐Czubara, A., Sayed, N. S. E., Osmani, M., Iwaniak, K., & Budzyńska, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041779 · Cited by 24
Is Drp1 a link between mitochondrial dysfunction and inflammation in Alzheimer’s disease?
Sbai, O., Bazzani, V., Tapaswi, S., McHale, J., Vascotto, C., & Perrone, L. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1166879 · Cited by 24
Preventive effects of arctigenin from Arctium lappa L against LPS-induced neuroinflammation and cognitive impairments in mice
Yuan, Q., Wu, Y., Wang, G., Zhou, X., Dong, X., Lou, Z., Li, S., & Wang, D. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01031-3 · Cited by 21
An Optimized Combination of Ginger and Peony Root Effectively Inhibits Amyloid-β Accumulation and Amyloid-β-Mediated Pathology in AβPP/PS1 Double-Transgenic Mice
Lim, S., Choi, J. G., Moon, M., Kim, H. G., Lee, W., Bak, H.-R., Sung, H.-C., Park, C. H., Kim, S. Y., & Oh, M. S. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150839 · Cited by 21
Effect of pioglitazone and simvastatin in lipopolysaccharide-induced amyloidogenesis and cognitive impairment in mice: possible role of glutamatergic pathway and oxidative stress
Ekladious, S. T., & Sayed, N. S. E. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000407 · Cited by 21
Pathogen Free Conditions Slow the Onset of Neurodegeneration in a Mouse Model of Nerve Growth Factor Deprivation
Capsoni, S., Carucci, N. M., & Cattaneo, A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120427 · Cited by 21
Association of hospitalization, critical illness, and infection with brain structure in older adults
Walker, K. A., Gottesman, R. F., Wu, A., Knopman, D. S., Mosley, T. H., Alonso, A., Kucharska‐Newton, A., & Brown, C. H. (2018) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15470 · Cited by 20
TDP43 ribonucleoprotein granules: physiologic function to pathologic aggregates
Corbet, G. A., Wheeler, J. R., Parker, R., & Weskamp, K. (2021) · RNA Biology · doi:10.1080/15476286.2021.1963099 · Cited by 21
Tannic acid inhibits lipopolysaccharide-induced cognitive impairment in adult mice by targeting multiple pathological features
Ullah, R., Ali, G., Baseer, A., Khan, S. I., Akram, M., Khan, S., Ahmad, N., Farooq, U., Nawaz, N. K., Shaheen, S., et al. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108970 · Cited by 20
Systemic LPS-induced Aβ-solubilization and clearance in AβPP-transgenic mice is diminished by heparanase overexpression
Jendresen, C., Digre, A., Cui, H., Zhang, X., Vlodavsky, I., Li, J.-P., & Nilsson, L. N. G. (2019) · Scientific Reports · doi:10.1038/s41598-019-40999-4 · Cited by 19
Bee Venom Soluble Phospholipase A2 Exerts Neuroprotective Effects in a Lipopolysaccharide-Induced Mouse Model of Alzheimer’s Disease via Inhibition of Nuclear Factor-Kappa B
Ham, H. J., Han, J. H., Lee, Y. S., Kim, K. C., Yun, J., Kang, S. K., Park, Y.-S., Kim, S. H., & Hong, J. T. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00287 · Cited by 22
Recent Understanding of the Molecular Mechanisms of Alzheimer?s Disease
Grimm, M. O. W., & Hartmann, T. (2011) · Journal of Addiction Research & Therapy · doi:10.4172/2155-6105.s5-004 · Cited by 20
Salmonella lipopolysaccharide (LPS) mediated neurodegeneration in hippocampal slice cultures
Johansson, S. M., Bohman, S., Radesäter, A., Öberg, C., & Luthman, J. (2005) · Neurotoxicity Research · doi:10.1007/bf03033974 · Cited by 19
Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
Khan, F. Z., Mostaid, M. S., & Apu, M. N. H. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09874 · Cited by 20
Paeoniflorin Attenuates Lipopolysaccharide-Induced Cognitive Dysfunction by Inhibition of Amyloidogenesis in Mice
Meng, H. W., Kim, J.-H., Kim, H. Y., Lee, A. Y., & Cho, E. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054838 · Cited by 18
Prostaglandin EP2 receptor antagonist ameliorates neuroinflammation in a two-hit mouse model of Alzheimer’s disease
Banik, A., Amaradhi, R., Lee, D. D., Sau, M., Wang, W., Dingledine, R. J., & Ganesh, T. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02297-7 · Cited by 18
Promising therapy for Alzheimer's disease targeting angiotensinconverting enzyme and the cyclooxygense-2 isoform.
Ns, E. S., La, K., & Oa, H. (2009) · PubMed · Cited by 17
Chronic Neuroinflammation Induced by Lipopolysaccharide Injection into the Third Ventricle Induces Behavioral Changes
Na, S., Duan, X., Wang, R., Fan, Y., Xue, K., Tian, S., Yang, Z., Li, K., & Yue, J. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01758-7 · Cited by 17
Recurrent systemic infections with Streptococcus pneumoniae do not aggravate the course of experimental neurodegenerative diseases
Ebert, S., Goos, M., Rollwagen, L., Baake, D., Zech, W., Esselmann, H., Wiltfang, J., Mollenhauer, B., Schliebs, R., Gerber, J., et al. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22270 · Cited by 17
The Gut-Brain Axis in Alzheimer’s Disease: Exploring Microbial Influences and Therapeutic Strategies
Mustafa, M. A., Vadia, N., Varma, P., Al‐Shaker, H., Mohanty, B., Dhyani, A., Kaur, I., Chauhan, A. S., & Garg, G. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05474-4 · Cited by 18
A Malva parviflora´s fraction prevents the deleterious effects resulting from neuroinflammation
Ramírez-Serrano, C. E., Jiménez‐Ferrer, E., Herrera-Ruiz, M. L., Zamilpa, A., Vargas-Villa, G., Carreto, R. J. R., Chavarría, A., Tortoriello, J., Pedraza‐Alva, G., & Pérez‐Martínez, L. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109349 · Cited by 16
MicroRNA-155-5p Targets SKP2, Activates IKKβ, Increases Aβ Aggregation, and Aggravates a Mouse Alzheimer Disease Model
Wang, W., Gu, X., Li, M., Cheng, Z., Tian, S., Liao, Y., & Liu, X. (2021) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlab116 · Cited by 16
Microbiome Alterations and Alzheimer’s Disease: Modeling Strategies with Transgenic Mice
López-Villodres, J. A., Escamilla, A., Mercado-Sáenz, S., Alba-Tercedor, C., Rodríguez‐Pérez, L., Arranz‐Salas, I., Sanchez-Varo, R. M., & Bermúdez, D. (2023) · Biomedicines · doi:10.3390/biomedicines11071846 · Cited by 16
Neuroinflammation increases oxygen extraction in a mouse model of Alzheimer’s disease
Liu, C., Cárdenas‐Rivera, A., Teitelbaum, S., Birmingham, A., Alfadhel, M. A. H., & Yaseen, M. A. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01444-5 · Cited by 15
The Hematopoietic Growth Factor “Erythropoietin” Enhances the Therapeutic Effect of Mesenchymal Stem Cells in Alzheimer’s Disease
Khairallah, M. I., Kassem, L. A., Yassin, N. A. E., Din, M. A. G. E., Zekri, M., & Attia, M. (2013) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2014.9.21 · Cited by 15
U.S. state correlations between oral health metrics and Alzheimer’s disease mortality, prevalence and subjective cognitive decline prevalence
Scherer, R. X., & Scherer, W. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-77937-8 · Cited by 17
A new acetylcholinesterase inhibitor with anti-PAF activity modulates oxidative stress and pro-inflammatory mediators release in stimulated RAW 264.7 macrophage cells. Comparison with tacrine
Ezoulin, M. J. M., Liu, Z., Dutertre-Catella, H., Wu, G., Dong, C., Heymans, F., Ombetta, J., Rat, P., & Massicot, F. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2007.08.023 · Cited by 15
The relationship between increased levels of microbiota-derived lipopolysaccharide in obesity and the pathophysiology of neurodegenerative diseases
Mehboodi, M., Namdari, M. P., Abdollahi, Z., Mobarezi, Z., Kiani, M., Chamani, F., Khanbabaie, H., Rabiei, S., Maleki, M. H., Sanati, H., et al. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107905 · Cited by 15
Human milk oligosaccharide 2′-fucosyllactose alleviates cognitive impairment via the vagal afferent pathway in Alzheimer's disease mice
Jia, M., Wang, X., Ning, F., Wang, W., Hu, X., Geng, K., Wen, J., Wu, S., Wang, B., & Liu, Z. (2025) · Food & Function · doi:10.1039/d4fo06272h · Cited by 12
Deficiency of IKKβ in neurons ameliorates Alzheimer's disease pathology in APP ‐ and tau‐transgenic mice
Schnöder, L., Quan, W., Yu, Y., Tomic, I., Luo, Q., Hao, W., Peng, G., Li, D., Fassbender, K. C., & Liu, Y. (2023) · The FASEB Journal · doi:10.1096/fj.202201512r · Cited by 12
Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation
Weiler, M., Stieger, K. C., Shroff, K., Klein, J. P., Wood, W. H., Zhang, Y., Chandrasekaran, P., Lehrmann, E., Camandola, S., Long, J. M., et al. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1215291 · Cited by 15
Gut microbiome‐derived metabolites in Alzheimer's disease: Regulation of immunity and potential for therapeutics
Chandra, S., & Vassar, R. J. (2024) · Immunological Reviews · doi:10.1111/imr.13412 · Cited by 17
(E)-2-Methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) Phenol Ameliorates LPS-Mediated Memory Impairment by Inhibition of STAT3 Pathway
Choi, J. Y., Hwang, C. J., Lee, D., Gu, S. M., Lee, H. P., Choi, D. Y., Oh, K. W., Han, S., & Hong, J. T. (2017) · NeuroMolecular Medicine · doi:10.1007/s12017-017-8469-3 · Cited by 13
Chemical Analysis of the Ingredients of 20% Aqueous Ethanol Extract of Nardostachys jatamansi through Phytochemical Study and Evaluation of Anti-Neuroinflammatory Component
Kim, K.-W., Yoon, C., Park, S., Bae, G., Kim, D., Kim, Y., & Oh, H. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/5901653 · Cited by 15
Neuroinflammatory mechanisms linking high‐fat diets to Alzheimer's disease vulnerability: Beyond the amyloid hypothesis
Mackey-Alfonso, S. E., & Barrientos, R. M. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70911 · Cited by 13
Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease
Gynther, M., Estrada, M. L., Loppi, S. H., Korhonen, P., Kanninen, K. M., Malm, T., Koıstınaho, J., Auriola, S. O. K., Fricker, G., & Puris, E. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112438 · Cited by 12
Unfolded p53 in non-neuronal cells supports bacterial etiology of Alzheimer’s disease
French, P. W. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.339476 · Cited by 12
The Potential Neuroprotective Effects of Extracts from Oat Seedlings against Alzheimer’s Disease
Lee, W. S., Lee, H., Yang, J. Y., Shin, H.-L., Choi, S., Kim, J.-K., Seo, W. D., & Kim, E. H. (2022) · Nutrients · doi:10.3390/nu14194103 · Cited by 12
Effect of acute lipopolysaccharide-induced inflammation in intracerebroventricular-streptozotocin injected rats
Murtishaw, A. S., Heaney, C. F., Bolton, M. M., Sabbagh, J. J., Langhardt, M. A., & Kinney, J. W. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.044 · Cited by 12
Neuroinflammation drives APOE genotype-dependent differential expression of neprilysin
Graykowski, D. R., Kasparian, K., Caniglia, J. L., Gritsaeva, Y., & Cudaback, E. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577315 · Cited by 12
Application of Bioaffinity Mass Spectrometry for Analysis of Ligands
Zhu, Y., Valdes, R., & Jortani, S. A. (2005) · Therapeutic Drug Monitoring · doi:10.1097/01.ftd.0000179851.32093.dc · Cited by 12
Loss of lysosomal acid lipase contributes to Alzheimer's disease pathology and cognitive decline
Barnett, A. M., McNair, E. M., Dawkins, L., Zou, J., Nikolova, V. D., Moy, S. S., Sutherland, G. T., Stevens, J., Colie, M., Katemboh, K., et al. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.70486 · Cited by 12
Metabolomic and lipidomic changes triggered by lipopolysaccharide-induced systemic inflammation in transgenic APdE9 mice
Puris, E., Kouřil, Š., Najdekr, L., Loppi, S. H., Korhonen, P., Kanninen, K. M., Malm, T., Koıstınaho, J., Friedecký, D., & Gynther, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-92602-4 · Cited by 11
Linderae Radix Ameliorates Cognitive Dysfunction by Inhibiting Neuroinflammation and Synaptic Damage in Alzheimer’s Disease Models
Kim, S. H., Ju, I. G., Kim, J. H., Eo, H., Son, S.-R., Jang, D. S., & Oh, M. S. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03544-z · Cited by 12
Lipopolysaccharide stimulates the secretion of the amyloid precursor protein via a protein kinase C-mediated pathway
Small, C. I., Lyles, G. A., & Breen, K. C. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.01.013 · Cited by 10

Authors: Sheng, J.
Affiliations: Johns Hopkins University (US)
Corresponding author: Sheng, J
Venue: Neurobiology of Disease
Publisher: Elsevier BV
Published: 2003-10
Volume: 14
Issue: 1
Pages: 133-145
ISSN: 0969-9961 (ISSN-L)
DOI: 10.1016/s0969-9961(03)00069-x
OpenAlex: W2023136593
Cited by: 388
References: 51
Citations by year: 2026: 6 · 2025: 18 · 2024: 17 · 2023: 18 · 2022: 27 · 2021: 26 · 2020: 23 · 2019: 15 · 2018: 23 · 2017: 14 · 2016: 24 · 2015: 18 · 2014: 20 · 2013: 18 · 2012: 26
FWCI: 6.71
Type: journal article
Language: en
Open access: green
doaj.org
Licence: cc-by-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Disease (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health
National Institute on Aging (P50AG005146, AG 05146)
National Institute of Neurological Disorders and Stroke (T32NS07435, T32NS007435)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
Keywords: lipopolysaccharide, neuroinflammation, amyloid precursor protein, amyloid-beta, microglia, F4/80, APP processing, Alzheimer's disease, neocortex
MeSH terms: Alzheimer Disease, Animals, Encephalitis, Intracellular Fluid, Lipopolysaccharides, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Transgenic, Peptide Fragments, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks