Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C.-M., Pérez‐Tur, J., Hutton, M., Buée, L., Harigaya, Y., Yager, D., et al. (1996) · Nature · doi:10.1038/383710a0 · Cited by 1,486

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80230-5 · Cited by 1,478

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

Esch, F. S., Keim, P. S., Beattie, E. C., Blacher, R. W., Culwell, A. R., Oltersdorf, T., McClure, D., & Ward, P. J. (1990) · Science · doi:10.1126/science.2111583 · Cited by 1,403

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

Weidemann, A., König, G., Bunke, D., Fischer, P. Q., Salbaum, J. M., Masters, C. L., & Beyreuther, K. T. (1989) · Cell · doi:10.1016/0092-8674(89)90177-3 · Cited by 1,233

Risk of Alzheimer's disease and duration of NSAID use

Stewart, W. F., Kawas, C., Corrada, M., & Metter, E. J. (1997) · Neurology · doi:10.1212/wnl.48.3.626 · Cited by 1,132

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

Borchelt, D. R., Ratovitski, T., van Lare, J., Lee, M. K., Gonzales, V., Jenkins, N. A., Copeland, N. G., Price, D. L., & Sisodia, S. S. (1997) · Neuron · doi:10.1016/s0896-6273(00)80974-5 · Cited by 1,023

Intraneuronal Aβ42 Accumulation in Human Brain

Gouras, G. K., Tsai, J., Naslund, J., Vincent, B., Edgar, M., Checler, F., Greenfield, J. P., Haroutunian, V., Buxbaum, J. D., Xu, H., et al. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64700-1 · Cited by 991

Gut microbiome alterations in Alzheimer’s disease

Vogt, N. M., Kerby, R. L., Dill-McFarland, K. A., Harding, S. J., Merluzzi, A. P., Johnson, S. C., Carlsson, C. M., Asthana, S., Zetterberg, H., Blennow, K., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13601-y · Cited by 2,137

Innate immune activation in neurodegenerative disease

Heneka, M. T., Kummer, M. P., & Latz, E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3705 · Cited by 1,437

Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease.

(2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2015.03.49 · Cited by 1,288

Age-dependent dysregulation of innate immunity

Shaw, A. C., Goldstein, D. R., & Montgomery, R. R. (2013) · Nature Reviews Immunology · doi:10.1038/nri3547 · Cited by 1,061

Innate immunity in Alzheimer's disease

Heneka, M. T., Golenbock, D. T., & Latz, E. (2015) · Nature Immunology · doi:10.1038/ni.3102 · Cited by 902

Microglia in Alzheimer's disease

Sarlus, H., & Heneka, M. T. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90606 · Cited by 911

Inflammatory processes in Alzheimer's disease

Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782

Microglia and neurodegeneration: The role of systemic inflammation

Cunningham, C. (2013) · Glia · doi:10.1002/glia.22350 · Cited by 769

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

Lee, J. W., Lee, Y. K., Yuk, D. Y., Choi, D. Y., Ban, S. B., Oh, K. W., & Hong, J. T. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-37 · Cited by 772

Does neuroinflammation fan the flame in neurodegenerative diseases?

Frank-Cannon, T. C., Alto, L. T., McAlpine, F. E., & Tansey, M. G. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-47 · Cited by 751

The role of microglia in amyloid clearance from the AD brain

Lee, C. Y. D., & Landreth, G. E. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0433-4 · Cited by 701

Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease

Kitazawa, M., Oddo, S., Yamasaki, T. R., Green, K. N., & LaFerla, F. M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2868-05.2005 · Cited by 697

Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue

Poole, S., Singhrao, S. K., Kesavalu, L. N., Curtis, M. A., & Crean, S. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121918 · Cited by 610

Brain Inflammation and Alzheimer's-Like Pathology in Individuals Exposed to Severe Air Pollution

Calderón‐Garcidueñas, L., Reed, W., Maronpot, R. R., Henríquez-Roldán, C. F., Delgado‐Chávez, R., Calderón‐Garcidueñas, A. L., Valdez, I. Y. D., Franco-Lira, M., Aragón-Flores, M., Solt, A. C., et al. (2004) · Toxicologic Pathology · doi:10.1080/01926230490520232 · Cited by 602

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

Shaftel, S. S., Griffin, W. S. T., & O'Banion, M. K. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-7 · Cited by 565

Lipopolysaccharide-induced neuroinflammation as a bridge to understand neurodegeneration

Batista, C. R. A., Gomes, G. F., Candelario-Jalil, E., Fiebich, B. L., & de Oliveira, A. C. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092293 · Cited by 529

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

Cribbs, D. H., Berchtold, N. C., Perreau, V., Coleman, P. D., Rogers, J., Tenner, A. J., & Cotman, C. W. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-179 · Cited by 499

Role of toll-like receptor signalling in A uptake and clearance

Tahara, K., Kim, H.-D., Jin, J.-J., Maxwell, J. A., Li, L., & Fukuchi, K.-I. (2006) · Brain · doi:10.1093/brain/awl249 · Cited by 493

Insulin in the Brain: Its Pathophysiological Implications for States Related with Central Insulin Resistance, Type 2 Diabetes and Alzheimer’s Disease

Blázquez, E., Velázquez, E., Hurtado-Carneiro, V., & Ruiz‐Albusac, J. M. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00161 · Cited by 523

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease

Depp, C., Sun, T., Sasmita, A. O., Spieth, L., Berghoff, S. A., Nazarenko, T., Overhoff, K., Steixner-Kumar, A. A., Subramanian, S., Arinrad, S., et al. (2023) · Nature · doi:10.1038/s41586-023-06120-6 · Cited by 493

The neuroinflammatory hypothesis of delirium

Cerejeira, J., Firmino, H., Vaz‐Serra, A., & Mukaetova‐Ladinska, E. B. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0674-1 · Cited by 494

Deciphering the mechanism underlying late-onset Alzheimer disease

Krstic, D., & Knuesel, I. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.236 · Cited by 457

Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain

Takahashi, R. H., Almeida, C. G., Kearney, P. F., Yu, F., Lin, M. T., Milner, T. A., & Gouras, G. K. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5167-03.2004 · Cited by 445

Inflammation, microglia, and alzheimer's disease

Cameron, B., & Landreth, G. E. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.10.006 · Cited by 452

The role of astrocytes in amyloid production and Alzheimer's disease

Frost, G. R., & Li, Y. (2017) · Open Biology · doi:10.1098/rsob.170228 · Cited by 448

Neuroinflammatory processes in Alzheimer’s disease

Heneka, M. T., O’Banion, M. K., Terwel, D., & Kummer, M. P. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0438-z · Cited by 433

Toll-like receptors in neurodegeneration

Okun, E., Griffioen, K. J. S., Lathia, J. D., Tang, S., Mattson, M. P., & Arumugam, T. V. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.09.001 · Cited by 444

Microglia and Inflammation in Alzheimers Disease

Mandrekar-Colucci, S., & Landreth, G. E. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791012071 · Cited by 421

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

Almeida, C. G., Tampellini, D., Takahashi, R. H., Greengard, P., Lin, M. T., Snyder, E. M., & Gouras, G. K. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.02.008 · Cited by 397

TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease

Yang, J., Wise, L., & Fukuchi, K.-I. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00724 · Cited by 387

Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

Ilievski, V., Zuchowska, P. K., Green, S. J., Toth, P. T., Ragozzino, M. E., Le, K., Aljewari, H. W., O’Brien-Simpson, N. M., Reynolds, E. C., & Watanabe, K. (2018) · PLOS ONE · doi:10.1371/journal.pone.0204941 · Cited by 372

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

Zhao, J. J., O’Connor, T., & Vassar, R. J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-150 · Cited by 379

Inflammasomes in neuroinflammation and changes in brain function: a focused review

Singhal, G., Jaehne, E. J., Corrigan, F., Toben, C. G., & Baune, B. T. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00315 · Cited by 372

LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals

Catorce, M. N., & Gevorkian, G. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666151204122017 · Cited by 368

Review: Systemic inflammation andAlzheimer's disease

Holmes, C. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01307.x · Cited by 356

Lipopolysaccharide Associates with Amyloid Plaques, Neurons and Oligodendrocytes in Alzheimer’s Disease Brain: A Review

Zhan, X., Stamova, B. S., & Sharp, F. R. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00042 · Cited by 361

A modified β‐amyloid hypothesis: intraneuronal accumulation of the β‐amyloid peptide – the first step of a fatal cascade

Wirths, O., Multhaup, G., & Bayer, T. A. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02737.x · Cited by 357

Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease

Gouras, G. K., Almeida, C. G., & Takahashi, R. H. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.022 · Cited by 338

Immunology and immunotherapy of Alzheimer's disease

Weiner, H. L., & Frenkel, D. (2006) · Nature Reviews Immunology · doi:10.1038/nri1843 · Cited by 335

The Impact of Systemic Inflammation on Alzheimer’s Disease Pathology

Xie, J., Van Hoecke, L., & Vandenbroucke, R. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.796867 · Cited by 324

Status of Acetylcholinesterase and Butyrylcholinesterase in Alzheimer's Disease and Type 2 Diabetes Mellitus

Mushtaq, G., Greig, N., Khan, J., & Kamal, M. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141023141545 · Cited by 331

Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to β-amyloid deposition in APP/PS1 double transgenic Alzheimer mice

Malm, T. M., Koistinaho, M., Pärepalo, M., Vatanen, T., Ooka, A., Karlsson, S., & Koistinaho, J. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.09.009 · Cited by 301

Microglia actions in Alzheimer's disease

Prokop, S., Miller, K. R., & Heppner, F. L. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1182-x · Cited by 291

Possible Implications of Insulin Resistance and Glucose Metabolism in Alzheimer's Disease Pathogenesis

Bosco, D., Fava, A., Plastino, M., Montalcini, T., & Pujia, A. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01318.x · Cited by 283

Lipopolysaccharide alters the blood–brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer’s disease

Jaeger, L. B., Dohgu, S., Sultana, R., Lynch, J. L., Owen, J. B., Erickson, M. A., Shah, G. N., Price, T. O., Fleegal-Demotta, M. A., Butterfiled, D. A., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.01.017 · Cited by 281

Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL‐1β drives amplified responses in primed astrocytes and neuronal network dysfunction

Lopez‐Rodriguez, A. B., Hennessy, E., Murray, C. L., Nazmi, A., Delaney, H. J., Healy, D., Fagan, S. G., Rooney, M., Stewart, E., Lewis, A., et al. (2021) · Alzheimer's & Dementia · doi:10.1002/alz.12341 · Cited by 293

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

McAlpine, F. E., Lee, J., Harms, A. S., Ruhn, K. A., Blurton-Jones, M. M., Hong, J. J., Das, P., Golde, T. E., LaFerla, F. M., Oddo, S., et al. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.01.006 · Cited by 274

Molecular mechanisms of cognitive dysfunction following traumatic brain injury

Walker, K. R., & Tesco, G. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00029 · Cited by 265

Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse Brain

Khan, A., Ali, T., Rehman, S. U., Khan, M. S., Alam, S. I., Ikram, M. A., Muhammad, T., Saeed, K. M., Badshah, H., & Kim, M. O. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01383 · Cited by 265

Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Abraham, D., Feher, J., Scuderi, G. L., Szabo, D., Dobolyi, A., Cservenak, M., Juhasz, J., Ligeti, B., Pongor, S., Gomez-Cabrera, M. C., et al. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2018.12.005 · Cited by 260

Aging‐dependent changes of microglial cells and their relevance for neurodegenerative disorders

Von Bernhardi, R., Tichauer, J. E., & Eugenín, J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06537.x · Cited by 258

Human Neural Stem Cell Grafts Ameliorate Motor Neuron Disease in SOD-1 Transgenic Rats

Xu, L., Yan, J., Chen, D., Welsh, A. M., Hazel, T. G., Johe, K. K., Hatfield, G. S., & Koliatsos, V. E. (2006) · Transplantation · doi:10.1097/01.tp.0000235532.00920.7a · Cited by 258

Impact of HMGB1, RAGE, and TLR4 in Alzheimer’s Disease (AD): From Risk Factors to Therapeutic Targeting

Paudel, Y. N., Angelopoulou, E., Piperi, C., Othman, I., Aamir, K., & Shaikh, M. F. (2020) · Cells · doi:10.3390/cells9020383 · Cited by 257

Targeting neuroinflammation in Alzheimer’s disease

Bronzuoli, M. R., Iacomino, A., Steardo, L., & Scuderi, C. (2016) · Journal of Inflammation Research · doi:10.2147/jir.s86958 · Cited by 261

Priming Microglia for Innate Immune Memory in the Brain

Neher, J. J., & Cunningham, C. M. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.02.001 · Cited by 263

Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer’s disease-related pathology

Michaud, J.-P., Hallé, M., Lampron, A., Thériault, P., Préfontaine, P., Filali, M., Tribout-Jover, P., Lanteigne, A.-M., Jodoin, R., Cluff, C. W., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215165110 · Cited by 255

Rodent models of neuroinflammation for Alzheimer’s disease

Nazem, A., Sankowski, R., Bacher, M., & Al‐Abed, Y. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0291-y · Cited by 257

Peripheral immune activation by lipopolysaccharide decreases neurotrophins in the cortex and hippocampus in rats

Guan, Z., & Fang, J. (2006) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.04.005 · Cited by 247

The roles of TNF in brain dysfunction and disease

Clark, I. A., Alleva, L. M., & Vissel, B. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.08.007 · Cited by 239

Hyperinsulinemia Provokes Synchronous Increases in Central Inflammation and β-Amyloid in Normal Adults

Fishel, M. A., Watson, G. S., Montine, T. J., Wang, Q., Green, P. S., Kulstad, J. J., Cook, D. G., Peskind, E. R., Baker, L. D., Goldgaber, D., et al. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.noc50112 · Cited by 222

Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function

Spiteri, A. G., Wishart, C. L., Pamphlett, R., Locatelli, G., & King, N. J. C. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02384-2 · Cited by 216

Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease

Farfara, D., Lifshitz, V., & Frenkel, D. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00314.x · Cited by 216

Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research

Cunningham, C., & Hennessy, E. (2015) · Alzheimer's Research & Therapy · doi:10.1186/s13195-015-0117-2 · Cited by 211

Inflammation Induced by Infection Potentiates Tau Pathological Features in Transgenic Mice

Sy, M., Kitazawa, M., Medeiros, R., Whitman, L., Cheng, D., Lane, T. E., & LaFerla, F. M. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.02.012 · Cited by 210

Systemic injection of LPS induces region-specific neuroinflammation and mitochondrial dysfunction in normal mouse brain

Noh, H., Jeon, J., & Seo, H. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.02.008 · Cited by 216

Resistin: A reappraisal

Acquarone, E., Monacelli, F., Borghi, R., Nencioni, A., & Odetti, P. R. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.01.004 · Cited by 199

Epigallocatechin-3-gallate prevents systemic inflammation-induced memory deficiency and amyloidogenesis via its anti-neuroinflammatory properties

Lee, Y., Choi, D., Yun, Y., Han, S., Oh, K., & Hong, J. T. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.06.011 · Cited by 196

Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease

Dionisio-Santos, D. A., Olschowka, J. A., & O’Banion, M. K. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1453-0 · Cited by 184

Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease

Lane, R. M., & Farlow, M. R. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400486-jlr200 · Cited by 186

Transgenic mouse models of alzheimer disease: Developing a better model as a tool for therapeutic interventions.

Kitazawa, M., Medeiros, R., & M. LaFerla, F. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799315786 · Cited by 178

Dynamic Complexity of the Microglial Activation Response in Transgenic Models of Amyloid Deposition: Implications for Alzheimer Therapeutics

Morgan, D., Gordon, M. N., Tan, J., Wilcock, D. M., & Rojiani, A. M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000178444.33972.e0 · Cited by 176

3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitors Attenuate β-Amyloid-Induced Microglial Inflammatory Responses

Cordle, A. C., & Landreth, G. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2544-04.2005 · Cited by 177

Involvement of Environmental Mercury and Lead in the Etiology of Neurodegenerative Diseases

Monnet‐Tschudi, F., Zurich, M., Boschat, C., Corbaz, A., & Honegger, P. (2006) · Reviews on Environmental Health · doi:10.1515/reveh.2006.21.2.105 · Cited by 176

The Role of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) in Alzheimer’s Disease

Jiang, Q., Heneka, M. T., & Landreth, G. E. (2008) · CNS Drugs · doi:10.2165/00023210-200822010-00001 · Cited by 176

BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease

Chami, L., & Checler, F. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-52 · Cited by 168

Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of Alzheimer’s Disease

ZAKARIA, R., WAN YAACOB, W. M. H., OTHMAN, Z., LONG, I., AHMAD, A. H., & AL-RAHBI, B. (2017) · Physiological Research · doi:10.33549/physiolres.933480 · Cited by 167

APOE‐modulated Aβ‐induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective

Tai, L. M., Ghura, S., Koster, K. P., Liakaite, V., Maienschein‐Cline, M., Kanabar, P., Collins, N., Ben‐Aissa, M., Lei, A. Z., Bahroos, N., et al. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13072 · Cited by 165

Role of Endogenous Lipopolysaccharides in Neurological Disorders

Kalyan, M., Hediyal, T. A., Sonali, S., Vichitra, C., Sunanda, T., Praveenraj, S. S., Ray, B., Gorantla, V. R., Rungratanawanich, W., Mahalakshmi, A. M., et al. (2022) · Cells · doi:10.3390/cells11244038 · Cited by 172

STAT1 drives M1 microglia activation and neuroinflammation under hypoxia.

Butturini, E., Boriero, D., de Prati, A. C., & Mariotto, S. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.05.011 · Cited by 149

Systemic inflammation and delirium: important co-factors in the progression of dementia

Cunningham, C. (2011) · Biochemical Society Transactions · doi:10.1042/bst0390945 · Cited by 153

Gut microbiome-targeted therapies for Alzheimer’s disease

Zhang, T., Gao, G., Kwok, L., & Sun, Z. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2271613 · Cited by 162

Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases

Jha, M. K., Kim, J.-H., Song, G. J., Lee, W., Lee, I. K., Lee, H., An, S. S. A., Kim, S., & Suk, K. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.12.003 · Cited by 156

Co-occurrence of Alzheimer's disease β-amyloid and tau pathologies at synapses

Takahashi, R. H., Capetillo-Zarate, E., Lin, M. T., Milner, T. A., & Gouras, G. K. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.07.021 · Cited by 150

Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease

Ferretti, M. T., Bruno, M. A., Ducatenzeiler, A., Klein, W. L., & Cuello, A. C. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.01.007 · Cited by 151

Time-dependent reduction in Aβ levels after intracranial LPS administration in APP transgenic mice

Herber, D. L., Roth, L. M., Wilson, D. H., Wilson, N., Mason, J. E., Morgan, D., & Gordon, M. N. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.07.007 · Cited by 151

Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta

Sheppard, O., Coleman, M. P., & Durrant, C. S. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1490-8 · Cited by 152

Lipopolysaccharide impairs amyloid beta efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood–brain barrier

Erickson, M. A., Hartvigson, P. E., Morofuji, Y., Owen, J. B., Butterfield, D. A., & Banks, W. A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-150 · Cited by 145

Oral Microbiota and Alzheimer’s Disease: Do All Roads Lead to Rome?

Sureda, A., Daglia, M., Argüelles Castilla, S., Sanadgol, N., Fazel Nabavi, S., Khan, H., Belwal, T., Jeandet, P., Marchese, A., Pistollato, F., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2019.104582 · Cited by 143

Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration

Hennessy, E., Gormley, S., López-Rodríguez, A. B., Murray, C., Murray, C., & Cunningham, C. M. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.09.011 · Cited by 147

Microglial Activation is Required for Aβ Clearance After Intracranial Injection of Lipopolysaccharide in APP Transgenic Mice

Herber, D. L., Mercer, M., Roth, L. M., Symmonds, K., Maloney, J. L., Wilson, N., Freeman, M. J., Morgan, D., & Gordon, M. N. (2007) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-007-9069-z · Cited by 143

Glial cell dysregulation: a new perspective on Alzheimer disease

Rommy von Bernhardi, M. (2007) · Neurotoxicity Research · doi:10.1007/bf03033906 · Cited by 141

Respiratory infection promotes T cell infiltration and amyloid-β deposition in APP/PS1 mice

McManus, R. M., Higgins, S. C., Mills, K. H. G., & Lynch, M. A. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.025 · Cited by 134

The endotoxin hypothesis of Alzheimer’s disease

Brown, G. C., & Heneka, M. T. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00722-y · Cited by 148

Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models

Lee, Y., Choi, D., Choi, I. S., Kim, K. H., Kim, Y. H., Kim, H. M., Lee, K., Cho, W. G., Jung, J. K., Han, S., et al. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-35 · Cited by 131

Copper Exposure Perturbs Brain Inflammatory Responses and Impairs Clearance of Amyloid-Beta

Kitazawa, M., Hsu, H.-W., & Medeiros, R. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw081 · Cited by 129

Functional Two-Way Crosstalk Between Brain and Lung: The Brain–Lung Axis

Li, C., Chen, W., Lin, F., Li, W., Wang, P., Liao, G., & Zhang, L. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01238-z · Cited by 129

The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease

Kokiko-Cochran, O. N., & Godbout, J. P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00672 · Cited by 128

Neuronal Mitochondria Modulation of LPS-Induced Neuroinflammation

Harland, M., Torres, S. L., Liu, J., & Wang, X. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2324-19.2020 · Cited by 131

Synaptic Activity Reduces Intraneuronal Aβ, Promotes APP Transport to Synapses, and Protects against Aβ-Related Synaptic Alterations

Tampellini, D., Rahman, N., Gallo, E. F., Huang, Z., Dumont, M., Capetillo-Zarate, E., Ma, T., Zheng, R., Lu, B., Nanus, D. M., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2292-09.2009 · Cited by 127

Inflammation as a potential mediator for the association between periodontal disease and Alzheimer’s disease

Watts, A. S., Gatz, M., & Crimmins, E. M. (2008) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s3610 · Cited by 129

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

Lee, J. W., Lee, Y. K., Yuk, D. Y., Choi, D. Y., Ban, S. B., Oh, K. W., & Hong, J. T. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-37 · Cited by 772

Neuroinflammation‐induced acceleration of amyloid deposition in the APPV717F transgenic mouse

Qiao, X., Cummins, D. J., & Paul, S. M. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01666.x · Cited by 119

Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain.

Brugg, B., Lemaigre‐Dubreuil, Y., Huber, G., Wollman, E. E., Delhaye‐Bouchaud, N., & Mariani, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.3032 · Cited by 191

Intrahippocampal LPS injections reduce Aβ load in APP+PS1 transgenic mice

DiCarlo, G. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00292-5 · Cited by 223

Microglial Activation is Required for Aβ Clearance After Intracranial Injection of Lipopolysaccharide in APP Transgenic Mice

Herber, D. L., Mercer, M., Roth, L. M., Symmonds, K., Maloney, J. L., Wilson, N., Freeman, M. J., Morgan, D., & Gordon, M. N. (2007) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-007-9069-z · Cited by 143