Involvement and relationship of bacterial lipopolysaccharides and cyclooxygenases levels in Alzheimer’s Disease and Mild Cognitive Impairment patients
Abstract
This study reports elevated levels of bacterial lipopolysaccharides (LPSs) and cyclooxygenases (COX-1/2) in blood serum and cerebrospinal fluid (CSF) of Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) patients compared to cognitively healthy individuals, indicating LPSs as promising biomarkers, especially in serum. LPSs, in both fluids, positively correlate with COX-1/2, Αβ 42 and tau and negatively with mental state. Furthermore, COX-2 is the main determinant of LPSs presence in serum, whereas COX-1 in CSF. These results underline the significance of microbial/ inflammatory involvement in dementia and offer novel perspectives on the roles of LPSs and COX in pathogenesis of AD.
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LPS is elevated in both the blood and brain of AD patients.
“LPS is elevated in both the blood and brain of AD patients.25–29”
From TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice (2025) · cites this paper as [27]
Cites
Faul, F., Erdfelder, E., Lang, A.-G., & Buchner, A. (2007) · Behavior Research Methods · doi:10.3758/bf03193146 · Cited by 65,971 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works
The neuropathological diagnosis of Alzheimer's disease
DeTure, M. A., & Dickson, D. W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0333-5 · Cited by 3,329 · see citing works
LPS/TLR4 signal transduction pathway
Lu, Y.-C., Yeh, W.-C., & Ohashi, P. S. (2008) · Cytokine · doi:10.1016/j.cyto.2008.01.006 · Cited by 3,301 · see citing works
Lane, C. A., Hardy, J., & Schott, J. M. (2018) · European Journal of Neurology · doi:10.1111/ene.13439 · Cited by 2,616 · see citing works
Dominy, S. S., Lynch, C., Ermini, F., Benedyk, M., Marczyk, A., Konradi, A., Nguyen, M., Haditsch, U., Raha, D., Griffin, C., et al. (2019) · Science Advances · doi:10.1126/sciadv.aau3333 · Cited by 1,966 · see citing works
Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice
Zhao, J., Bi, W., Xiao, S., Lan, X., Cheng, X., Zhang, J., Lu, D., Wei, W., Wang, Y., Li, H., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-42286-8 · Cited by 905 · see citing works
Cyclooxygenase-2 (COX-2) in Inflammatory and Degenerative Brain Diseases
Minghetti, L. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.9.901 · Cited by 780 · see citing works
Lee, J. W., Lee, Y. K., Yuk, D. Y., Choi, D. Y., Ban, S. B., Oh, K. W., & Hong, J. T. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-37 · Cited by 772 · see citing works
The blood-brain barrier in Alzheimer’s disease
Zenaro, E., Piacentino, G., & Constantin, G. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.07.007 · Cited by 767 · see citing works
Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock
van Amersfoort, E. S., van Berkel, T. J. C., & Kuiper, J. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.3.379-414.2003 · Cited by 750 · see citing works
Kitazawa, M., Oddo, S., Yamasaki, T. R., Green, K. N., & LaFerla, F. M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2868-05.2005 · Cited by 697 · see citing works
Minter, M. R., Zhang, C., Leone, V., Ringus, D. L., Zhang, X., Oyler-Castrillo, P., Musch, M. W., Liao, F., Ward, J. F., Holtzman, D. M., et al. (2016) · Scientific Reports · doi:10.1038/srep30028 · Cited by 655 · see citing works
Banks, W. A., Gray, A. M., Erickson, M. A., Salameh, T. S., Damodarasamy, M., Sheibani, N., Meabon, J. S., Wing, E. E., Morofuji, Y., Cook, D. G., et al. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0434-1 · Cited by 636 · see citing works
Why there are two cyclooxygenase isozymes
Smith, W. L., & Langenbach, R. J. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13271 · Cited by 612 · see citing works
Hoo, Z. H., Candlish, J., & Teare, M. D. (2017) · Emergency Medicine Journal · doi:10.1136/emermed-2017-206735 · Cited by 558 · see citing works
Lipopolysaccharide-induced neuroinflammation as a bridge to understand neurodegeneration
Batista, C. R. A., Gomes, G. F., Candelario-Jalil, E., Fiebich, B. L., & de Oliveira, A. C. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092293 · Cited by 529 · see citing works
Gram-negative bacterial molecules associate with Alzheimer disease pathology
Zhan, X., Stamova, B., Jin, L.-W., DeCarli, C., Phinney, B., & Sharp, F. R. (2016) · Neurology · doi:10.1212/wnl.0000000000003391 · Cited by 521 · see citing works
Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain
Balin, B. J., Gérard, H. C., Arking, E. J., Appelt, D. M., Branigan, P. J., Abrams, J. T., Whittum-Hudson, J. A., & Hudson, A. P. (1998) · Medical Microbiology and Immunology · doi:10.1007/s004300050071 · Cited by 506 · see citing works
Morales, I., Guzmán-MartÃnez, L., Cerda-Troncoso, C., FarÃas, G. A., & Maccioni, R. B. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00112 · Cited by 490 · see citing works
Distinct functions of COX-1 and COX-2
Morita, I. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00029-1 · Cited by 464 · see citing works
Phillis, J. W., Horrocks, L. A., & Farooqui, A. A. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.02.002 · Cited by 456 · see citing works
The antimicrobial protection hypothesis of Alzheimer’s disease
Moir, R. D., Lathe, R., & Tanzi, R. E. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.06.3040 · Cited by 456 · see citing works
Atashgahi, S., Hornung, B., van der Waals, M. J., da Rocha, U. N., Hugenholtz, F., Nijsse, B., Douwe Molenaar, B., van Spanning, R. J. M., Stams, A. J. M., Gerritse, J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22617-x · Cited by 449 · see citing works
Albillos, A., de la Hera, A., González, M., Moya, J. L., Calleja, J. L., Monserrat, J., Ruíz-del-Árbol, L., & Álvarez‐Mon, M. (2003) · Hepatology · doi:10.1053/jhep.2003.50038 · Cited by 445 · see citing works
Lassenius, M., Pietiläinen, K., Kaartinen, K., Pussinen, P., Syrjänen, J., Forsblom, C., Pörsti, I., Rissanen, A., Kaprio, J., Mustonen, J., et al. (2011) · Diabetes Care · doi:10.2337/dc10-2197 · Cited by 404 · see citing works
A Randomized, Double-Blind, Study of Rofecoxib in Patients with Mild Cognitive Impairment
on behalf of the Rofecoxib Protocol 078 study group, Thal, L. J., Ferris, S. H., Kirby, L., Block, G. A., Lines, C. R., Yuen, E., Assaid, C., Nessly, M. L., Norman, B. A., et al. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300690 · Cited by 402 · see citing works
The Infectious Etiology of Alzheimer’s Disease
Sochocka, M., Zwolińska, K., & Leszek, J. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170313122937 · Cited by 399 · see citing works
Sheng, J. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00069-x · Cited by 388 · see citing works
Zhao, Y., Jaber, V., & Lukiw, W. J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00318 · Cited by 379 · see citing works
Reines, S. A., Block, G. A., Morris, J. C., Liu, G., Nessly, M. L., Lines, C. R., Norman, B., & Baranak, C. C. (2004) · Neurology · doi:10.1212/wnl.62.1.66 · Cited by 378 · see citing works
Catorce, M. N., & Gevorkian, G. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666151204122017 · Cited by 361 · see citing works
Judith Miklossy, A. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-90 · Cited by 356 · see citing works
Zhan, X., Stamova, B. S., & Sharp, F. R. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00042 · Cited by 354 · see citing works
Jayashree, B., Bibin, Y. S., Prabhu, D., Shanthirani, C. S., Gokulakrishnan, K., Lakshmi, B. S., Mohan, V., & Balasubramanyam, M. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1911-4 · Cited by 353 · see citing works
Zhang, R., Miller, R. G., Gascon, R., Champion, S., Katz, J., Lancero, M., Narvaez, A., Honrada, R., Ruvalcaba, D., & McGrath, M. S. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.09.017 · Cited by 319 · see citing works
Michelena, J., Altamirano, J., Abraldeṣ, J. G., Affò, S., Morales‐Ibanez, O., Sancho‐Bru, P., Domínguez, M., García‐Pagán, J. C., Fernández, J., Arroyo, V., et al. (2015) · Hepatology · doi:10.1002/hep.27779 · Cited by 293 · see citing works
Astrocytes: Implications for Neuroinflammatory Pathogenesis of Alzheimers Disease
Li, C., Zhao, R., Gao, K., Wei, Z. Z., Yin, M. Y., Lau, L. T., Chui, D., & Yu, A. C. (2011) · Current Alzheimer Research · doi:10.2174/156720511794604543 · Cited by 291 · see citing works
Induction of COX‐2 by LPS in macrophages is regulated by Tpl2‐dependent CREB activation signals
Eliopoulos, A. G., Dumitru, C. D., Wang, C., Cho, J., & Tsichlis, P. N. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf478 · Cited by 284 · see citing works
Role of inducible cyclooxygenase (COX-2) in inflammation.
Seibert, K., & Masferrer, J. L. (1994) · PubMed · Cited by 273 · see citing works
Understanding the Role of Systemic Inflammation in Alzheimer’s Disease
Walker, K. A., Ficek, B. N., & Westbrook, R. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00333 · Cited by 259 · see citing works
Targeting cyclooxygenases-1 and -2 in neuroinflammation: Therapeutic implications
Aïd, S., & Bosetti, F. (2010) · Biochimie · doi:10.1016/j.biochi.2010.09.009 · Cited by 253 · see citing works
Cao, C., Matsumura, K., Yamagata, K., & Watanabe, Y. (1995) · Brain Research · doi:10.1016/0006-8993(95)00839-i · Cited by 252 · see citing works
Cyclooxygenase expression in microglia and neurons in Alzheimer's disease and control brain
Hoozemans, J. J. M., Rozemüller, A. J. M., Janssen, I., Groot, C. J. A. D., Veerhuis, R., & Eikelenboom, P. (2001) · Acta Neuropathologica · doi:10.1007/s004010000251 · Cited by 246 · see citing works
Measuring cytokine levels in blood
Thavasu, P. W., Longhurst, S., Joel, S. P., Slevin, M. L., & Balkwill, F. R. (1992) · Journal of Immunological Methods · doi:10.1016/0022-1759(92)90313-i · Cited by 241 · see citing works
Zughaier, S. M., Zimmer, S. M., Datta, A., Carlson, R. W., & Stephens, D. S. (2005) · Infection and Immunity · doi:10.1128/iai.73.5.2940-2950.2005 · Cited by 240 · see citing works
Expression and Regulation of Cyclooxygenase‐2 in Rat Microglia
Bauer, M. K. A., Lieb, K., Schulze‐Osthoff, K., Berger, T., Gebicke‐Haerter, P. J., Bauer, J., & Fiebich, B. L. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00726.x · Cited by 235 · see citing works
Effect of LPS on the permeability of the blood–brain barrier to insulin
Xaio, H., Banks, W. A., Niehoff, M. L., & Morley, J. E. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03247-9 · Cited by 231 · see citing works
Serum lipopolysaccharide-binding protein in endotoxemic patients with inflammatory bowel disease
Pastor, Ó., López–Sanromán, A., Albéniz, E., Martínez, A. D. L. H., Sevillano, E. R., & Albillos, A. (2006) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20019 · Cited by 229 · see citing works
Takeda, S., Sato, N., & Morishita, R. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00171 · Cited by 226 · see citing works
Alzheimer’s disease as an inflammatory disease
Bolós, M., Perea, J. R., & Avila, J. (2017) · BioMolecular Concepts · doi:10.1515/bmc-2016-0029 · Cited by 216 · see citing works
Inflammation Induced by Infection Potentiates Tau Pathological Features in Transgenic Mice
Sy, M., Kitazawa, M., Medeiros, R., Whitman, L., Cheng, D., Lane, T. E., & LaFerla, F. M. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.02.012 · Cited by 210 · see citing works
Font-Nieves, M., Sans-Fons, M. G., Gorina, R., Bonfill‐Teixidor, E., Salas-Perdomo, A., Márquez‐Kisinousky, L., Santalucı́a, T., & Planas, A. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.327874 · Cited by 204 · see citing works
Miklossy, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00046 · Cited by 203 · see citing works
Al-Obaide, M. A. I., Singh, R., Datta, P., Rewers-Felkins, K., Salguero, M. V., Al‐Obaidi, I., Kottapalli, K. R., & Vasylyeva, T. L. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6090086 · Cited by 200 · see citing works
Emerging roles of pathogens in Alzheimer disease
Miklossy, J. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411002006 · Cited by 199 · see citing works
Ho, L., Purohit, D. P., Haroutunian, V. H., Luterman, J. D., Willis, F., Näslund, J., Buxbaum, J. D., Mohs, R. C., Aisen, P. S. S., & Pasinetti, G. M. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.487 · Cited by 196 · see citing works
White, M. R., Kandel, R., Tripathi, S., Condon, D., Qi, L., Taubenberger, J., & Hartshorn, K. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101364 · Cited by 193 · see citing works
Raskin, J., Cummings, J. L., Hardy, J., Schuh, K. J., & Dean, R. A. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150701103107 · Cited by 190 · see citing works
Yermakova, A., Rollins, J., Callahan, L. M., Rogers, J., & O’Banion, M. K. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199911000-00003 · Cited by 187 · see citing works
Bacterial Infection and Alzheimer's Disease: A Meta-Analysis
Maheshwari, P., & Eslick, G. D. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-140621 · Cited by 183 · see citing works
COX-3 and the mechanism of action of paracetamol/acetaminophen
Botting, R. M., & Ayoub, S. S. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2004.10.005 · Cited by 180 · see citing works
Can a Bacterial Endotoxin be a Key Factor in the Kinetics of Amyloid Fibril Formation?
Asti, A., & Gioglio, L. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-131394 · Cited by 180 · see citing works
The Possibility of an Infectious Etiology of Alzheimer Disease
Ashraf, G. M., Tarasov, V. V., Makhmutovа, A., Chubarev, V. N., Avila-Rodriguez, M., Bachurin, S. O., & Aliev, G. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1388-y · Cited by 175 · see citing works
Cyclooxygenase 2 mRNA expression in rat brain after peripheral injection of lipopolysaccharide
Quan, N., Whiteside, M. B., & Herkenham, M. A. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00402-8 · Cited by 172 · see citing works
Zhao, Y., Cong, L., Jaber, V. R., & Lukiw, W. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01064 · Cited by 170 · see citing works
Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology
Hoozemans, J. J. M., Veerhuis, R., Rozemüller, A. J. M., & Eikelenboom, P. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.11.001 · Cited by 168 · see citing works
Lipopolysaccharide-Induced Memory Impairment in Rats: a Model of Alzheimer’s Disease
ZAKARIA, R., WAN YAACOB, W. M. H., OTHMAN, Z., LONG, I., AHMAD, A. H., & AL-RAHBI, B. (2017) · Physiological Research · doi:10.33549/physiolres.933480 · Cited by 167 · see citing works
Physiologic and pathophysiologic roles of lipid mediators in the kidney
Hao, C., & Breyer, M. D. (2007) · Kidney International · doi:10.1038/sj.ki.5002192 · Cited by 167 · see citing works
Choi, S., Langenbach, R. I., & Bosetti, F. (2007) · The FASEB Journal · doi:10.1096/fj.07-9411com · Cited by 158 · see citing works
Low‐grade endotoxemia and platelet activation in cirrhosis
Raparelli, V., Basili, S., Carnevale, R., Napoleone, L., Del Ben, M., Nocella, C., Bartimoccia, S., Lucidi, C., Talerico, G., Riggio, O., et al. (2017) · Hepatology · doi:10.1002/hep.28853 · Cited by 142 · see citing works
Aliev, G., Priyadarshini, M., Reddy, V., Grieg, N. H., Kaminsky, Y., Cacabelos, R., Ashraf, G., Jabir, N. R., Kamal, M. A., Nikolenko, V. N., et al. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666131227161303 · Cited by 138 · see citing works
Role of Toll Like Receptor 4 in Alzheimer’s Disease
Calvo-Rodriguez, M., García-Rodríguez, C., Villalobos, C., & Núñez, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01588 · Cited by 136 · see citing works
Alpizar, Y. A., Boonen, B., Sánchez, A., Jung, C., López‐Requena, A., Naert, R., Steelant, B., Luyts, K., Plata, C., Vooght, V. D., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01201-3 · Cited by 126 · see citing works
Zhang, F., Zhang, J.-G., Yang, W., Xu, P., Xiao, Y., & Zhang, H. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.136 · Cited by 123 · see citing works
Levin, E. C., Acharya, N. K., Han, M. C., Zavareh, S., Sedeyn, J. C., Venkataraman, V., & Nagele, R. G. (2010) · Brain Research · doi:10.1016/j.brainres.2010.05.038 · Cited by 113 · see citing works
Increased Cerebrospinal Fluid Helicobacter Pylori Antibody in Alzheimer’s Disease
Kountouras, J., Boziki, M. K., Gavalas, E., Zavos, C., Deretzi, G., Grigoriadis, N., Tsolaki, M., Chatzopoulos, D., Katsinelos, P., Tzilves, D., et al. (2009) · International Journal of Neuroscience · doi:10.1080/00207450902782083 · Cited by 113 · see citing works
Self-citationNymark, M., Pussinen, P. J., Tuomainen, A. M., Forsblom, C. M., Groop, P., Lehto, M. J., & on behalf of the FinnDiane Study Group (2009) · Diabetes Care · doi:10.2337/dc09-0467 · Cited by 111 · see citing works
Qin, W., Ho, L., Pompl, P. N., Peng, Y., Zhao, Z., Xiang, Z., Robakis, N. K. R. K., Shioi, J., Suh, J., & Pasinetti, G. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307699200 · Cited by 110 · see citing works
Periodontal Health Condition in Patients With Alzheimer’s Disease
Martande, S., Pradeep, A. R., Singh, S. P., Kumari, M., Suke, D. K., Raju, A. P., Naik, S. B., Singh, P., Guruprasad, C. N., & Chatterji, A. (2014) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317514549650 · Cited by 110 · see citing works
Woodling, N. S., Colas, D., Wang, Q., Minhas, P. S., Panchal, M., Liang, X., Mhatre, S. D., Brown, H. D., Ko, N., Zagol-Ikapitte, I. A., et al. (2016) · Brain · doi:10.1093/brain/aww117 · Cited by 108 · see citing works
Role of COX-2 in Inflammatory and Degenerative Brain Diseases
Minghetti, L. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/1-4020-5688-5_5 · Cited by 104 · see citing works
Technological advances and changing indications for lumbar puncture in neurological disorders
Costerus, J. M., Brouwer, M. C., & van de Beek, D. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30033-4 · Cited by 103 · see citing works
Aspirin and other non-steroidal anti-inflammatory drugs for the prevention of dementia
Jordan, F., Quinn, T. J., McGuinness, B., Passmore, P., Kelly, J. P., Smith, C. T., Murphy, K., & Devane, D. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011459.pub2 · Cited by 101 · see citing works
Ziegler, T. R., Luo, M., Estívariz, C. F., Moore, D. A., Sitaraman, S. V., Li, H., Bazargan, N., Klapproth, J. A., Tian, J. J., Galloway, J. R., et al. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00650.2007 · Cited by 96 · see citing works
Hao, L.-Y., Hao, X. Q., Li, S. H., & Li, X. H. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.01.006 · Cited by 93 · see citing works
Loss of tau rescues inflammation-mediated neurodegeneration
Maphis, N., Xu, G., Kokiko-Cochran, O. N., Cardona, A. E., Ransohoff, R. M., Lamb, B. T., & Bhaskar, K. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00196 · Cited by 91 · see citing works
Differential effects of lipopolysaccharide on mouse sensory TRP channels
Boonen, B., Alpizar, Y. A., Sánchez, A., López‐Requena, A., Voets, T., & Talavera, K. (2018) · Cell Calcium · doi:10.1016/j.ceca.2018.04.004 · Cited by 91 · see citing works
García‐Bueno, B., Serrats, J., & Sawchenko, P. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2373-09.2009 · Cited by 90 · see citing works
Wang, H., Hitron, I. M., Iadecola, C., & Pickel, V. M. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhi008 · Cited by 88 · see citing works
Go, M., Kou, J., Lim, J.-E., Yang, J., & Fukuchi, K.-I. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.073 · Cited by 87 · see citing works
Cyclooxygenase-1 null mice show reduced neuroinflammation in response to β-amyloid
Choi, S., & Bosetti, F. (2009) · Aging · doi:10.18632/aging.100021 · Cited by 84 · see citing works
Begcevic, I., Brinc, D., Drabovich, A. P., Batruch, I., & Diamandis, E. P. (2016) · Clinical Proteomics · doi:10.1186/s12014-016-9111-3 · Cited by 84 · see citing works
de Waal, G. M., Engelbrecht, L., Davis, T., de Villiers, W. J. S., Kell, D. B., & Pretorius, E. (2018) · Scientific Reports · doi:10.1038/s41598-018-35009-y · Cited by 79 · see citing works
Tao, Y., Han, Y., Yu, L., Wang, Q., Leng, S. X., & Zhang, H. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00233 · Cited by 78 · see citing works
Lipopolysaccharide endotoxemia induces amyloid-β and p-tau formation in the rat brain.
Wang, L., Wu, Q., Kirk, R. A., Horn, K. P., Salem, A. E., Hoffman, J. M., Yap, J. T., Sonnen, J. A., Towner, R. A., Bozza, F. A., et al. (2018) · Europe PMC (PubMed Central) · Cited by 73 · see citing works
Bezugla, Y., Kolada, A., Kamionka, S., Bernard, B., Scheibe, R., & Dieter, P. (2005) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2005.11.001 · Cited by 62 · see citing works
Thingore, C., Kshirsagar, V. V., & Juvekar, A. R. (2020) · Metabolic Brain Disease · doi:10.1007/s11011-020-00629-9 · Cited by 60 · see citing works
Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A
Liu, J., Wang, D., Li, S.-Q., Yu, Y., & Ye, R. D. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0493-y · Cited by 58 · see citing works
The last neuronal division: a unifying hypothesis for the pathogenesis of Alzheimer's disease
Nagy, Z. (2005) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2005.tb00485.x · Cited by 56 · see citing works
Shukuri, M., Mawatari, A., Ohno, M., Suzuki, M., Doi, H., Watanabe, Y., & Onoe, H. (2015) · Journal of Nuclear Medicine · doi:10.2967/jnumed.115.166116 · Cited by 55 · see citing works
Taraxerol inhibits LPS-induced inflammatory responses through suppression of TAK1 and Akt activation
Yao, X., Li, G., Bai, Q., Xu, H., & Lü, C. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2012.12.032 · Cited by 54 · see citing works
Miyauchi, M., Hiraoka, M., Oka, H., Sato, S., Kudo, Y., Ogawa, I., Noguchi, K., Ishikawa, I., & Takata, T. (2004) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2004.04.004 · Cited by 51 · see citing works
Hayashi, K., Hasegawa, Y., Takemoto, Y., Cao, C., Takeya, H., Komohara, Y., Mukasa, A., & Kim‐Mitsuyama, S. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.02.007 · Cited by 50 · see citing works
Paradowski, B., Jaremko, M., Dobosz, T., Leszek, J., & Noga, L. (2007) · Journal of Neurology · doi:10.1007/s00415-006-0298-5 · Cited by 48 · see citing works
Yang, J., Malone, F., Go, M., Kou, J., Lim, J.-E., Caughey, R. C., & Fukuchi, K.-I. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01750-1 · Cited by 46 · see citing works
Alzheimer CSF biomarkers in routine clinical setting
Tabaraud, F., Leman, J. P., Milor, A.-M., Roussie, J. M., Barrière, G., Tartary, M., Boutros-Toni, F., & Rigaud, M. (2011) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2011.01592.x · Cited by 44 · see citing works
Link Between Chronic Bacterial Inflammation and Alzheimer Disease
Bibi, F., Yasir, M., Sohrab, S. S., Azhar, E. I., Al-Qahtani, M., Abuzenadah, A. M., Kamal, M. A., & Naseer, M. I. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666140917115741 · Cited by 43 · see citing works
Inhibition of apoptosis in neuronal cells infected with Chlamydophila (Chlamydia) pneumoniae
Appelt, D. M., Roupas, M. R., Way, D. S., Bell, M. G., Albert, E. V., Hammond, C. J., & Balin, B. J. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-13 · Cited by 39 · see citing works
Cyclooxygenase (COX)-1 Activity Precedes the COX-2 Induction in Aβ-Induced Neuroinflammation
Dargahi, L., Nasiraei-Moghadam, S., Abdi, A., Khalaj, L., Moradi, F., & Ahmadiani, A. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9401-6 · Cited by 33 · see citing works
Rhamnolipids, Microbial Virulence Factors, in Alzheimer’s Disease
Andreadou, E. G., Pantazaki, Α. A., Daniilidou, M., & Tsolaki, M. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161020 · Cited by 30 · see citing works
Self-citationGardner, L. E., White, J. D., Eimerbrink, M. J., Boehm, G. W., & Chumley, M. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.007 · Cited by 29 · see citing works
Frontiers in Anti-Infective Drug Discovery
(2017) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/97816810829121170501 · Cited by 24 · see citing works
Alternative Anti-Infective/Anti-Inflammatory Therapeutic Options for Fighting Alzheimer’s Disease
(2017) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9781681084794117060003 · Cited by 7 · see citing works
Flagged first, then by citations
3 of the 119 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Implications of Gut Microbiota in Neurodegenerative Diseases
Zhang, H., Chen, Y., Wang, Z., Xie, G., Liu, M., Yuan, B., Chai, H., Wang, W., & Cheng, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.785644 · Cited by 157 · see citing works
The endotoxin hypothesis of Alzheimer’s disease
Brown, G. C., & Heneka, M. T. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00722-y · Cited by 140 · see citing works
Fecal Microbiota Transplantation Improves Cognitive Function of a Mouse Model of Alzheimer's Disease
Jiang, X., Zheng, Y., Sun, H., Dang, Y., Yin, M., Xiao, M., & Wu, T. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70259 · Cited by 35 · see citing works
Inaba, T., Yamashiro, K., Kurita, N., Ueno, Y., Miyamoto, N., Hira, K., Nakajima, S., Kijima, C., Nakaguro, R., Urabe, T., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14301 · Cited by 32 · see citing works
Xiao, T., Ji, H., Shangguan, X., Qu, S., Cui, Y., & Xu, J. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.02.092 · Cited by 26 · see citing works
Metagenomic association analysis of cognitive impairment in community-dwelling older adults
Li, J., Zhu, S., Wang, Y., Fan, M., Dai, J., Zhu, C., Xu, K., Cui, M., Suo, C., Li, J., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106081 · Cited by 26 · see citing works
Matatall, K. A., Wathan, T. K., Nguyen, M., Chen, H., McDonald, A., Qi, G., Belk, J. A., Florez, M. A., Le, D. T., Olarinde, T., et al. (2025) · Cell Stem Cell · doi:10.1016/j.stem.2025.06.006 · Cited by 23 · see citing works
Saji, N., Saito, Y., Yamashita, T., Murotani, K., Tsuduki, T., Hisada, T., Sugimoto, T., Niida, S., Toba, K., & Sakurai, T. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215653 · Cited by 20 · see citing works
Microbial Metabolomes in Alzheimer’s Disease: From Pathogenesis to Therapeutic Potential
Borrego-Ruiz, A., & Borrego, J. J. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47090724 · Cited by 20 · see citing works
Cai, M., Zhang, Y., Chen, S. X., Wu, Z., & Zhu, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.968444 · Cited by 18 · see citing works
Sârb, O. F., Sârb, A.-D., Iacobescu, M., Vlad, I. M., Milaciu, M. V., Ciumărnean, L., Văcăraș, V., & Tanțău, A. I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115676 · Cited by 19 · see citing works
Mehboodi, M., Namdari, M. P., Abdollahi, Z., Mobarezi, Z., Kiani, M., Chamani, F., Khanbabaie, H., Rabiei, S., Maleki, M. H., Sanati, H., et al. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107905 · Cited by 14 · see citing works
Chandra, S., & Vassar, R. J. (2024) · Immunological Reviews · doi:10.1111/imr.13412 · Cited by 14 · see citing works
The Microbiome–Neurodegeneration Interface: Mechanisms, Evidence, and Future Directions
Böckels, L., Alexa, D., Antal, D. C., Gațcan, C., Alecu, C., Kacani, K., Cretu, R. A., Piseru, E.-A., Bîlcu, R. V., & Cuciureanu, D. I. (2026) · Cells · doi:10.3390/cells15020135 · Cited by 12 · see citing works
Barbalace, M. C., Freschi, M., Rinaldi, I., Zallocco, L., Malaguti, M., Manera, C., Ortore, G., Zuccarini, M., Ronci, M., Cuffaro, D., et al. (2024) · Antioxidants · doi:10.3390/antiox13091074 · Cited by 12 · see citing works
Microbiota and Alzheimer’s disease: mechanistic insights from a multi-organ perspective
Liao, J., Mou, H., Luo, S., Shen, L., & Jiao, B. (2026) · Translational Neurodegeneration · doi:10.1186/s40035-026-00541-9 · Cited by 10 · see citing works
The Common Alzheimer's Disease Research Ontology (CADRO) for biomarker categorization
Osse, A. M. L., Kinney, J., & Cummings, J. L. (2025) · Alzheimer's & Dementia · doi:10.1002/trc2.70050 · Cited by 11 · see citing works
Cornò, M. D., Aureli, A., Varano, B., & Conti, L. (2026) · Biomolecules · doi:10.3390/biom16020226 · Cited by 7 · see citing works
Katsigianni, S., & Koutsouraki, E. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05914-9 · Cited by 7 · see citing works
Katsipis, G., Lavrentiadou, S. N., Geromichalos, G. D., Tsantarliotou, M. P., Halevas, E. G., Litsardakis, G., & Pantazaki, Α. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010282 · Cited by 4 · see citing works
Self-citationLocalization and Pathological Implications of Lipopolysaccharide in the Brains of 5XFAD Mice
Shin, S. J., Park, Y. H., Nam, Y., Chung, H., Kim, S.-J., & Moon, M. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05107-w · Cited by 4 · see citing works
Microbial Trojan Horses: Virulence Factors as Key Players in Neurodegenerative Diseases
Grahl, M. V. C., Hohl, K. S., Smaniotto, T. Â., & Carlini, C. R. (2025) · Molecules · doi:10.3390/molecules30030687 · Cited by 4 · see citing works
Andreadou, E. G., Katsipis, G., Tsolaki, M., & Pantazaki, Α. A. (2023) · Brain Disorders · doi:10.1016/j.dscb.2023.100091 · Cited by 3 · see citing works
Self-citationSolorzano, C. S., Festari, C., Mirabelli, P., Mombelli, E., Coppola, L., Luongo, D., Naviglio, D., Soricelli, A., Quattrini, G., Salvatore, M., et al. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1550333 · Cited by 3 · see citing works
Influence of postbiotics on the microbiota-gut-brain axis in cognitive impairment and dementia
Kang, T.-B., Lee, J. Y., & Cheon, S. Y. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107279 · Cited by 2 · see citing works
Zeamer, A. L., Lai, Y., Sanborn, V. E., Loew, E. B., Tracy, M., Jo, C., Ward, D. V., Bhattarai, S. K., Drake, J., McCormick, B. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.06.641911 · Cited by 2 · see citing works
Niu, L., Li, Y., Wu, H., Zhao, L., Zhang, J., Lü, F., Zhao, G., Jia, F., Zhu, J., & Liu, M. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251385589 · Cited by 1 · see citing works
Therapeutic potential of phytochemicals and role of gut microbiota in neurodegenerative diseases
Gupta, S. K., & Sharma, R. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-36372-6.00014-8 · Cited by 1 · see citing works
Katsipis, G., Lavrentiadou, S. N., Geromichalos, G. D., Tsantarliotou, M. P., Halevas, E. G., Litsardakis, G., & Pantazaki, Α. A. (2023) · Research Square · doi:10.21203/rs.3.rs-3148454/v1
Self-citationThe Link Between Periodontal Disease and Alzheimer's Disease: a narrative review
Gęborys, K., Burzykowska, K., Trela, K., Więcko, L., Tuteja, A., Olczyk, L., & Podleśna, D. (2025) · Quality in Sport · doi:10.12775/qs.2025.41.60400
Metabolic endotoxemia in metabolic and neurodegenerative diseases
Li, C., Jiang, W., & Lu, M. (2026) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2026130
- Authors
- Andreadou, E. G., Katsipis, G., Tsolaki, M., & Pantazaki, A. A.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- Corresponding author
- Andreadou, Eleni G.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 357
- Pages
- 577561
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W3142074816
- Cited by
- 31
- References
- 119
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 5 · 2023: 4 · 2022: 4
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Social Fund (MIS 5047901)
- European Commission
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- bacterial lipopolysaccharide, cyclooxygenase-2, cyclooxygenase-1, Alzheimer's disease, mild cognitive impairment, cerebrospinal fluid biomarkers, serum biomarkers, amyloid-beta 42, tau protein, neuroinflammation, dementia pathogenesis
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Bacterial Proteins, Female, Humans, Lipopolysaccharides, Male, Middle Aged, Prostaglandin-Endoperoxide Synthases, Biomarkers, Cognitive Dysfunction
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