The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Automated mass spectrometry imaging with a matrix-assisted laser desorption ionization time-of-flight instrument
Abstract
The automated use of a matrix-assisted laser desorption ionization (MALDI) mass spectrometer (MS) is described for image analysis of samples through implementation of new software for instrument control, data acquisition, and data analysis. The software permits automated acquisition of MS MALDI spectra to form an ordered data array and contains display features to provide images at one or more mass-to-charge ratio values. The technique can be used to scan tissue samples, blotted samples, gels, or other sample surfaces where the image analysis of that sample is required. The program achieves a time of typically 1 s per image point, permitting an analysis made up of large numbers of points with high spatial resolution up to 850 dpi. The features of the software are demonstrated in this paper with samples of printed images, where visible images can be compared to those obtained by mass spectrometry. Quantitative aspects are introduced by analyzing a series of sample spots containing different amounts of several proteins.
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Citations
Cites
Molecular Imaging of Biological Samples: Localization of Peptides and Proteins Using MALDI-TOF MS
Caprioli, R. M., Farmer, T. B., & Gile, J. (1997) · Analytical Chemistry · doi:10.1021/ac970888i · Cited by 2,234
Self-citation
Cited by
McDonnell, L. A., & Heeren, R. M. A. (2007) · Mass Spectrometry Reviews · doi:10.1002/mas.20124 · Cited by 1,082
Reyzer, M. L., Hsieh, Y., Ng, K., Korfmacher, W. A., & Caprioli, R. M. (2003) · Journal of Mass Spectrometry · doi:10.1002/jms.525 · Cited by 371
Self-citationProgress in monitoring, modeling and control of bioprocesses during the last 20 years
Schügerl, K. (2001) · Journal of Biotechnology · doi:10.1016/s0168-1656(00)00361-8 · Cited by 278
Proteomics in Diagnostic Pathology
Chaurand, P., Sanders, M. E., Jensen, R. A., & Caprioli, R. M. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63367-6 · Cited by 253
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Metadata
- Authors
- Stoeckli, M., Farmer, T. B., & Caprioli, R. M.
- Venue
- Journal of the American Society for Mass Spectrometry
- Publisher
- American Chemical Society (ACS)
- Published
- 1999-01-01
- Volume
- 10
- Issue
- 1
- Pages
- 67-71
- ISSN
- 1044-0305 (ISSN-L)
- OpenAlex
- W2016657862
- Cited by
- 201
- References
- 1
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Stoeckli, M., Farmer, T. B., & Caprioli, R. M. (1999). Automated mass spectrometry imaging with a matrix-assisted laser desorption ionization time-of-flight instrument. Journal of the American Society for Mass Spectrometry. https://doi.org/10.1016/s1044-0305(98)00126-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
