Cited by 117Phosphodiesterase function and regulationReceptor Mechanisms and SignalingNitric Oxide and Endothelin Effects

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Effects of Cyclic GMP on Smooth Muscle Relaxation

Warner, Timothy D., Mitchell, Jane A., Sheng, Hong, Murad, Ferid·1994·Advances in Pharmacology

DOI 10.1016/s1054-3589(08)60054-x

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Abstract

Cyclic GMP levels within smooth muscle are affected then by a number of different pathways. Physiologically NO and ANF are probably the two most important regulators for smooth muscle function, but a variety of other mediators and pharmacological agents may also influence this system. Because of the important role that cyclic GMP plays in the control of smooth muscle tone, which clearly includes vascular smooth muscle, it is now and will continue to be in the future an important physiological and biochemical target for research and a pharmacological target for therapeutic agents.

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Authors: Warner, T. D., Mitchell, J. A., Sheng, H., & Murad, F.
Affiliations: St Bartholomew's Hospital (GB)
University of California, Los Angeles (US)
ORCID: Warner, Timothy D.
Mitchell, Jane A.
Sheng, Hong
Venue: Advances in Pharmacology
Publisher: Elsevier
Published: 1994
Volume: 26
Pages: 171-194
ISSN: 1054-3589 (ISSN-L)
DOI: 10.1016/s1054-3589(08)60054-x
OpenAlex: W1437168237
Cited by: 117
References: 176
Citations by year: 2026: 2 · 2025: 2 · 2024: 1 · 2023: 6 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 5
FWCI: 3.34
Type: book chapter
Language: en
Open access: closed
Locations: Advances in pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: cyclic GMP, smooth muscle relaxation, guanylate cyclase, nitric oxide, atrial natriuretic peptide, smooth muscle tone, second messengers
MeSH terms: Animals, Cyclic GMP, Guanylate Cyclase, Humans, Isoenzymes, Muscle Relaxation, Muscle, Smooth

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Effects of Cyclic GMP on Smooth Muscle Relaxation

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