A study of nerve fibers and histopathology of postsurgical, postinfectious, and endometriosis-related adhesions
Abstract
OBJECTIVE: To evaluate the presence of nerve fibers and histopathology of endometriosis-related adhesions, postsurgical adhesions, and postinfectious adhesions in women with and without pelvic pain. METHODS: We evaluated the presence of nerve fibers and histopathology of endometriosis-related adhesions, postsurgical adhesions, and postinfectious adhesions in 50 women. The nerve fibers were identified by immunocytochemistry staining with an antibody to neurofilament. RESULTS: Nerve fibers were found in the intraabdominal adhesions in 39 of the total 50 patients with such adhesions (78%). There was no significant difference in the proportion and the mean nerve score in adhesions due to previous intra-abdominal infection, endometriosis, and previous uninfected intra-abdominal surgery. The degree of lymphocytes and edema in endometriosis-related adhesions was significantly higher than in postsurgical adhesions and postinfectious adhesions (P < .05). No difference was found in the amount of nerve fibers and the mean nerve score in adhesions from women with pelvic pain and from those without pelvic pain. CONCLUSION: Nerve fibers are found commonly in intraabdominal adhesions, and their presence are not related to the underlying pathology or pelvic pain. Endometriosis-related adhesions contain more inflammatory cells and tissue edema than postsurgical or postinfectious adhesions.
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Pelvic pain does not correlate with nerve fibers in adhesions, peritoneum, or endometriomas.
“pelvic pain is not correlated with nerve fibers in adhesions, peritoneum or within endometriomas”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Tulandi et al., 1998
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- Authors
- Tulandi, T.
- Affiliations
- McGill University (CA)
- Corresponding author
- Tulandi, T
- ORCID
- Tulandi, T
- Venue
- Obstetrics & Gynecology
- Published
- 1998-11
- Volume
- 92
- Issue
- 5
- Pages
- 766-768
- ISSN
- 0029-7844 (ISSN-L)
- OpenAlex
- W1969476201
- Cited by
- 71
- References
- 10
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2012: 8
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- peritoneal adhesions, nerve fibers, endometriosis, postoperative adhesions, pelvic pain, neurofilaments, lymphocytes, tissue edema, inflammation
- MeSH terms
- Abdomen, Tissue Adhesions, Adult, Endometriosis, Female, Humans, Infections, Nerve Fibers, Pain, Pelvis, Postoperative Complications
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