Spherical lactic acid bacteria activate plasmacytoid dendritic cells immunomodulatory function via tlr9-dependent crosstalk with myeloid dendritic cells

Jounai, Kenta; Ikado, Kumiko; Sugimura, Tetsu; Ano, Yasuhisa; Braun, Jonathan; Fujiwara, Daisuke

doi:10.1371/journal.pone.0032588

Cited by 133Immune Response and InflammationProbiotics and Fermented FoodsImmunotherapy and Immune Responses

Spherical lactic acid bacteria activate plasmacytoid dendritic cells immunomodulatory function via tlr9-dependent crosstalk with myeloid dendritic cells

Open access

Jounai, Kenta, Ikado, Kumiko, Sugimura, Tetsu, Ano, Yasuhisa, Braun, Jonathan, Fujiwara, Daisuke·2012·PLoS ONE

DOI 10.1371/journal.pone.0032588PMC PMC3323594

Open this paper in CoChat — free account Open PDF

Abstract

Plasmacytoid dendritic cells (pDC) are a specialized sensor of viral and bacterial nucleic acids and a major producer of IFN-α that promotes host defense by priming both innate and acquired immune responses. Although synthetic Toll-like receptor (TLR) ligands, pathogenic bacteria and viruses activate pDC, there is limited investigation of non-pathogenic microbiota that are in wide industrial dietary use, such as lactic acid bacteria (LAB). In this study, we screened for LAB strains, which induce pDC activation and IFN-α production using murine bone marrow (BM)-derived Flt-3L induced dendritic cell culture. Microbial strains with such activity on pDC were absent in a diversity of bacillary strains, but were observed in certain spherical species (Lactococcus, Leuconostoc, Streptococcus and Pediococcus), which was correlated with their capacity for uptake by pDC. Detailed study of Lactococcus lactis subsp. lactis JCM5805 and JCM20101 revealed that the major type I and type III interferons were induced (IFN-α, -β, and λ). IFN-α induction was TLR9 and MyD88-dependent; a slight impairment was also observed in TLR4(-/-) cells. While these responses occurred with purified pDC, IFN-α production was synergistic upon co-culture with myeloid dendritic cells (mDC), an interaction that required direct mDC-pDC contact. L. lactis strains also stimulated expression of immunoregulatory receptors on pDC (ICOS-L and PD-L1), and accordingly augmented pDC induction of CD4(+)CD25(+)FoxP3(+) Treg compared to the Lactobacillus strain. Oral administration of L. lactis JCM5805 induced significant activation of pDC resident in the intestinal draining mesenteric lymph nodes, but not in a remote lymphoid site (spleen). Taken together, certain non-pathogenic spherical LAB in wide dietary use has potent and diverse immunomodulatory effects on pDC potentially relevant to anti-viral immunity and chronic inflammatory disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0032588

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Phagocytosis of Lactococcus lactis JCM 5805 by plasmacytoid dendritic cells significantly stimulates interferon production via TLR9/MyD88 signaling.
“phagocytosis of the strain Lactococcus lactis JCM 5805 by pDCs significantly stimulated IFN production via TLR9/MyD88 signaling (Jounai et al., 2012).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Jounai et al., 2012

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial
Kalliomäki, M. A., Salminen, S., Arvilommi, H. S., Kero, P. O., Koskinen, P. J., & Isolauri, E. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04259-8 · Cited by 2,434 · see citing works
Interferon-inducible antiviral effectors
Sadler, A. J., & Williams, B. R. G. (2008) · Nature Reviews Immunology · doi:10.1038/nri2314 · Cited by 2,160 · see citing works
IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex
Kotenko, S. V., Gallagher, G. E., Baurin, V. V., Lewis-Antes, A., Shen, M., Shah, N. K., Langer, J. A., Sheikh, F. G., Dickensheets, H. L., & Donnelly, R. P. (2002) · Nature Immunology · doi:10.1038/ni875 · Cited by 1,867 · see citing works
Recognition of single-stranded RNA viruses by Toll-like receptor 7
Lund, J. M., Alexopoulou, L., Sato, A., Karow, M. L., Adams, N. C., Gale, N. W., Iwasaki, A., & Flavell, R. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400937101 · Cited by 1,854 · see citing works
Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial
Kalliomäki, M. A., Salminen, S., Poussa, T. A., Arvilommi, H. S., & Isolauri, E. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13490-3 · Cited by 1,340 · see citing works
Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
Jego, G., Palucka, A. K., Blanck, J.-P., Chalouni, C., Pascual, V., & Banchereau, J. (2003) · Immunity · doi:10.1016/s1074-7613(03)00208-5 · Cited by 1,067 · see citing works
Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology
Asselin‐Paturel, C., Boonstra, A., Dalod, M., Durand, I., Yessaad, N., Dezutter‐Dambuyant, C., Vicari, A. P., O’Garra, A., Biron, C. A., Brière, F., et al. (2001) · Nature Immunology · doi:10.1038/ni736 · Cited by 1,021 · see citing works
Type I Interferons Potently Enhance Humoral Immunity and Can Promote Isotype Switching by Stimulating Dendritic Cells In Vivo
Bon, A. L., Schiavoni, G., D’Agostino, G., Gresser, I., Belardelli, F., & Tough, D. F. (2001) · Immunity · doi:10.1016/s1074-7613(01)00126-1 · Cited by 973 · see citing works
Type I Interferon in Systemic Lupus Erythematosus and Other Autoimmune Diseases
Banchereau, J., & Pascual, V. (2006) · Immunity · doi:10.1016/j.immuni.2006.08.010 · Cited by 955 · see citing works
Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon
Bon, A. L., Etchart, N., Rossmann, C., Ashton, M., Hou, S., Gewert, D. R., Borrow, P., & Tough, D. F. (2003) · Nature Immunology · doi:10.1038/ni978 · Cited by 816 · see citing works
Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase
Sharma, M. D., Baban, B., Chandler, P., Hou, D., Singh, N., Yagita∥, H., Azuma, M., Blazar, B. R., Mellor, A. L., & Munn, D. H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31911 · Cited by 791 · see citing works
Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization
Cella, M., Facchetti, F., Lanzavecchia, A., & Colonna, M. (2000) · Nature Immunology · doi:10.1038/79747 · Cited by 790 · see citing works
Plasmacytoid dendritic cells prime IL-10–producing T regulatory cells by inducible costimulator ligand
Ito, T., Yang, M., Wang, Y.-H., Lande, R., Gregorio, J. D., Perng, O. A., Qin, X.-F. F., Liu, Y.-J., & Gilliet, M. (2007) · Journal of Experimental Medicine · doi:10.1084/jem.20061660 · Cited by 686 · see citing works
Interferons α and β as Immune Regulators—A New Look
Biron, C. A. (2001) · Immunity · doi:10.1016/s1074-7613(01)00154-6 · Cited by 670 · see citing works
Lipoteichoic Acid (LTA) of Streptococcus pneumoniaeand Staphylococcus aureus Activates Immune Cells via Toll-like Receptor (TLR)-2, Lipopolysaccharide-binding Protein (LBP), and CD14, whereas TLR-4 and MD-2 Are Not Involved
Schröder, N. W. J., Morath, S., Alexander, C., Hamann, L., Hartung, T., Zähringer, U., Göbel, U. B., Weber, J. R., & Schumann, R. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212829200 · Cited by 641 · see citing works
Links between innate and adaptive immunity via type I interferon
Bon, A. L., & Tough, D. F. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(02)00354-0 · Cited by 582 · see citing works
Type I interferons produced by dendritic cells promote their phenotypic and functional activation
Montoya, M., Schiavoni, G., Mattei, F., Gresser, I., Belardelli, F., Borrow, P., & Tough, D. F. (2002) · Blood · doi:10.1182/blood.v99.9.3263 · Cited by 534 · see citing works
Interleukin‐10 generation in atopic children following oral Lactobacillus rhamnosus GG
Pessi, T., Sütas, Y., Hurme, M., & Isolauri, E. (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00948.x · Cited by 432 · see citing works
Infection of Human Macrophages and Dendritic Cells with Mycobacterium tuberculosis Induces a Differential Cytokine Gene Expression That Modulates T Cell Response
Giacomini, E., Iona, E., Ferroni, L., Miettinen, M., Fattorini, L., Orefici, G., Julkunen, I., & Coccia, E. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7033 · Cited by 431 · see citing works
The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion
Levy, D. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00027-7 · Cited by 428 · see citing works
IFN-λ determines the intestinal epithelial antiviral host defense
Pott, J., Mahlakõiv, T., Mordstein, M., Duerr, C. U., Michiels, T., Stockinger, S., Staeheli, P., & Hornef, M. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100552108 · Cited by 418 · see citing works
Viral Infections Activate Types I and III Interferon Genes through a Common Mechanism
Onoguchi, K., Yoneyama, M., Takemura, A., Akira, S., Taniguchi, T., Namiki, H., & Fujita, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608618200 · Cited by 354 · see citing works
Type I interferon dependence of plasmacytoid dendritic cell activation and migration
Asselin‐Paturel, C., Brizard, G., Chemin, K., Boonstra, A., O’Garra, A., Vicari, A. P., & Trinchieri, G. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041930 · Cited by 343 · see citing works
Recruitment of immature plasmacytoid dendritic cells (plasmacytoid monocytes) and myeloid dendritic cells in primary cutaneous melanomas
Vermi, W., Bonecchi, R., Facchetti, F., Bianchi, D., Sozzani, S., Festa, S., Berenzi, A., Cella, M., & Colonna, M. (2003) · The Journal of Pathology · doi:10.1002/path.1344 · Cited by 295 · see citing works
Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen–specific IgE production by stimulation of IL-12 production in mice
Murosaki, S., Yamamoto, Y., Ito, K., Inokuchi, T., Kusaka, H., Ikeda, H., & Yoshikai, Y. (1998) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(98)70055-7 · Cited by 273 · see citing works
Lactobacillus casei Inhibits Antigen-Induced IgE Secretion through Regulation of Cytokine Production in Murine Splenocyte Cultures
Shida, K., Makino, K., Morishita, A., Takamizawa, K., Hachimura, S., Ametani, A., Sato, T., Kumagai, Y., Habu, S., & Kaminogawa, S. (1998) · International Archives of Allergy and Immunology · doi:10.1159/000069458 · Cited by 254 · see citing works
The Anti-Allergic Effects of Lactic Acid Bacteria Are Strain Dependent and Mediated by Effects on both Th1/Th2 Cytokine Expression and Balance
Fujiwara, D., Inoue, S., Wakabayashi, H., & Fujii, T. (2004) · International Archives of Allergy and Immunology · doi:10.1159/000081305 · Cited by 244 · see citing works
Self-citation
Lactic acid bacteria inhibit TH2 cytokine production by mononuclear cells from allergic patients
Pochard, P., Gosset, P., Grangette, C., André, C., Tonnel, A., Pestel, J., & Mercenier, A. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.128528 · Cited by 181 · see citing works
Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes
Wolk, K., Witte, K., Witte, E., Prösch, S., Schulze-Tanzil, G. G., Nasilowska, K., John, T., Asadullah, K., Sterry, W., Volk, H., et al. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0807525 · Cited by 157 · see citing works
Dendritic Cells and NK Cells Stimulate Bystander T Cell Activation in Response to TLR Agonists through Secretion of IFN-αβ and IFN-γ
Kamath, A. T., Sheasby, C. E., & Tough, D. F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.2.767 · Cited by 151 · see citing works
Interleukin 15–dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
Kuwajima, S., Sato, T., Ishida, K., Tada, H., Tezuka, H., & Ohteki, T. (2006) · Nature Immunology · doi:10.1038/ni1348 · Cited by 148 · see citing works
Impairment of Regulatory Capacity of CD4+CD25+ Regulatory T Cells Mediated by Dendritic Cell Polarization and Hyperthyroidism in Graves’ Disease
Mao, C., Wang, S., Xiao, Y., Xu, J., Jiang, Q., Jin, M., Jiang, X., Guo, H., Ning, G., & Zhang, Y. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.0904135 · Cited by 141 · see citing works
Attenuating Regulatory T Cell Induction by TLR Agonists through Inhibition of p38 MAPK Signaling in Dendritic Cells Enhances Their Efficacy as Vaccine Adjuvants and Cancer Immunotherapeutics
Jarnicki, A., Conroy, H., Brereton, C. F., Donnelly, G., Toomey, D., Walsh, K., Sweeney, C. M., Leavy, O., Fletcher, J. M., Lavelle, E. C., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.6.3797 · Cited by 137 · see citing works
Effect of intranasal administration of Lactobacillus pentosus S-PT84 on influenza virus infection in mice
Izumo, T., Maekawa, T., Ida, M., Noguchi, A., Kitagawa, Y., Shibata, H., Yasui, H., & Kiso, Y. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.06.012 · Cited by 134 · see citing works
Role of Peyer's patches in the induction of Helicobacter pylori -induced gastritis
Nagai, S., Mimuro, H., Yamada, T., Baba, Y., Moro, K., Nochi, T., Kiyono, H., Suzuki, T., Sasakawa, C., & Koyasu, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609014104 · Cited by 127 · see citing works
Mucosal co-application of lactic acid bacteria and allergen induces counter-regulatory immune responses in a murine model of birch pollen allergy
Repa, A., Grangette, C., Daniel, C., Hochreiter, R., Hoffmann‐Sommergruber, K., Thalhamer, J., Kraft, D., Breiteneder, H., Mercenier, A., & Wiedermann, U. (2003) · Vaccine · doi:10.1016/s0264-410x(03)00528-0 · Cited by 127 · see citing works
Modulation of human plasmacytoid DC function by IFN-λ1 (IL-29)
Megjugorac, N. J., Gallagher, G. E., & Gallagher, G. E. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0509347 · Cited by 102 · see citing works
Human plasmacytoid dendritic cells are unresponsive to bacterial stimulation and require a novel type of cooperation with myeloid dendritic cells for maturation
Piccioli, D., Sammicheli, C., Tavarini, S., Nuti, S., Frigimelica, E., Manetti, A. G. O., Nuccitelli, A., Aprea, S., Valentini, S. B., Borgogni, E., et al. (2009) · Blood · doi:10.1182/blood-2008-10-186890 · Cited by 83 · see citing works
Mycoplasma contamination in human tumor cell lines: effect on interferon induction and susceptibility to natural killing.
Birke, C., Peter, H. H., Langenberg, U., Müller, W., Peters, J. H., Heitmann, J., Leibold, W., Dallügge, H., Krapf, E. F., & Kirchner, H. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.127.1.94 · Cited by 79 · see citing works
Systemic Control of Plasmacytoid Dendritic Cells by CD8+ T Cells and Commensal Microbiota
Fujiwara, D., Wei, B., Presley, L. L., Brewer, S., McPherson, M., Lewinski, M. A., Borneman, J., & Braun, J. G. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.5843 · Cited by 70 · see citing works
Self-citation
Human monocyte-derived dendritic cells express TLR9 and react directly to the CpG-A oligonucleotide D19
Hoene, V., Peiser, M., & Wanner, R. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0106011 · Cited by 70 · see citing works
Staphylococcus aureus- Induced Plasmacytoid Dendritic Cell Activation Is Based on an IgG-Mediated Memory Response
Parčina, M., Wendt, C., Goetz, F., Zawatzky, R., Zähringer, U., Heeg, K. M., & Bekeredjian‐Ding, I. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.3823 · Cited by 67 · see citing works
Stimulation of Natural Interferon-α/β-Producing Cells by Staphylococcus aureus
Svensson, H., CEDERBLAD, B., Lindahl, M. G., & Alm, G. V. (1996) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1996.16.7 · Cited by 62 · see citing works
Dietary Supplementation with Lactic Acid Bacteria Attenuates the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice in a Strain-Dependent Manner
Wakabayashi, H., Nariai, C., Takemura, F., Nakao, W., & Fujiwara, D. (2007) · International Archives of Allergy and Immunology · doi:10.1159/000108139 · Cited by 49 · see citing works
Self-citation
A Fluorescence Reporter Model Defines “Tip-DCs” as the Cellular Source of Interferon β in Murine Listeriosis
Dresing, P., Borkens, S., Kocur, M., Kropp, S., & Scheu, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015567 · Cited by 41 · see citing works
Alternative induction of IFN-alpha and IFN-gamma by Listeria monocytogenes in human peripheral blood mononuclear leukocyte cultures.
Nakane, A., & Minagawa, T. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.126.6.2139 · Cited by 38 · see citing works
Expression of mRNA encoding IFNαin macrophages stimulated withLactobacillus gasseri
Kitazawa, H., Tomioka, Y., Matsumura, K., Aso, H., Mizugaki, M., Itoh, T., & Yamaguchi, T. (1994) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1994.tb07052.x · Cited by 38 · see citing works
Cloning and Characterization of a Prolinase Gene (pepR) fromLactobacillus rhamnosus
Varmanen, P., Rantanen, T., Palva, A., & Tynkkynen, S. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.5.1831-1836.1998 · Cited by 34 · see citing works
Conventional Bone Marrow-Derived Dendritic Cells Contribute to Toll-Like Receptor-Independent Production of Alpha/Beta Interferon in Response to Inactivated Parapoxvirus Ovis
Siegemund, S., Hartl, A., von Buttlar, H., Dautel, F., Raue, R., Freudenberg, M. A., Fejér, G., Büttner, M., Köhler, G., Kirschning, C. J., et al. (2009) · Journal of Virology · doi:10.1128/jvi.02362-08 · Cited by 33 · see citing works
A Double-blind Trial of Lactobacillus paracasei Strain KW3110 Administration for Immunomodulation in Patients with Pollen Allergy
Fujiwara, D., Wakabayashi, H., Watanabe, H., Nishida, S., & Iino, H. (2005) · Allergology International · doi:10.2332/allergolint.54.143 · Cited by 27 · see citing works
Self-citation
The induction of interferon production in fibroblasts by invasive bacteria: a comparison of Salmonella and Shigella species
Hess, C. B., Niesel, D. W., & Klimpel, G. R. (1989) · Microbial Pathogenesis · doi:10.1016/0882-4010(89)90030-2 · Cited by 23 · see citing works
Interferons induced by Chlamydia trachomatis in human lymphocyte cultures.
Duc-Goiran, P., & Zernicki, L. (1981) · PubMed · Cited by 15 · see citing works
In vivo and In vitro Regulation of Type I IFN Synthesis by Synergistic Effects of CD40 and Type II IFN
Greene, J. A., DeVecchio, J., Gould, M. P., Auletta, J. J., & Heinzel, F. P. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.10.5995 · Cited by 12 · see citing works
Effect ofLactobacillus pentosusS-PT84 Ingestion on IFN-α Production from Plasmacytoid Dendritic Cells by Virus Stimulation
Izumo, T., Maekawa, T., Ida, M., Kishi, A., Akatani, K., Kitagawa, Y., & Kiso, Y. (2011) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.100696 · Cited by 9 · see citing works

Flagged first, then by citations

Sorted by citations

Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease
Miura, K. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i23.7381 · Cited by 355 · see citing works
Emerging roles of lactic acid bacteria in protection against colorectal cancer
Zhong, L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i24.7878 · Cited by 257 · see citing works
Effects of dietary Lactobacillus rhamnosus JCM1136 and Lactococcus lactis subsp. lactis JCM5805 on the growth, intestinal microbiota, morphology, immune response and disease resistance of juvenile Nile tilapia, Oreochromis niloticus
Xia, Y. L., Lu, M., Chen, G., Cao, J., Gao, F., Wang, M., Liu, Z., Zhang, D., Zhu, H., & Yi, M. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.03.020 · Cited by 243 · see citing works
The effects of combined dietary probiotics Lactococcus lactis BFE920 and Lactobacillus plantarum FGL0001 on innate immunity and disease resistance in olive flounder (Paralichthys olivaceus)
Beck, B. R., Kim, D., Jeon, J., Lee, S.-M., Kim, H. K., Kim, O.-J., Lee, J. I., Suh, B. S., Do, H. K., Lee, K. H., et al. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.10.035 · Cited by 195 · see citing works
Viral Infections, the Microbiome, and Probiotics
Harper, A., Vijayakumar, V., Ouwehand, A. C., ter Haar, J., Obis, D., Espadaler, J., Binda, S., Desiraju, S., & Day, R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.596166 · Cited by 177 · see citing works
Probiotics and Paraprobiotics in Viral Infection: Clinical Application and Effects on the Innate and Acquired Immune Systems
Kanauchi, O., Andoh, A., AbuBakar, S., & Yamamoto, N. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612824666180116163411 · Cited by 168 · see citing works
The Role of Gut Dysbiosis in the Loss of Intestinal Immune Cell Functions and Viral Pathogenesis
Fakharian, F., Thirugnanam, S., Welsh, D. A., Kim, W., Rappaport, J., Bittinger, K. L., & Rout, N. (2023) · Microorganisms · doi:10.3390/microorganisms11071849 · Cited by 93 · see citing works
Intestinal Bacteria Modify Lymphoma Incidence and Latency by Affecting Systemic Inflammatory State, Oxidative Stress, and Leukocyte Genotoxicity
Yamamoto, M. L., Maier, I., Dang, A. T., Berry, D., Liu, J., Ruegger, P. M., Yang, J.-I., Soto, P. A., Presley, L. L., Reliene, R., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0022 · Cited by 93 · see citing works
Self-citation
Effects of oral intake of plasmacytoid dendritic cells-stimulative lactic acid bacterial strain on pathogenesis of influenza-like illness and immunological response to influenza virus
Sugimura, T., Takahashi, H., Jounai, K., Ohshio, K., Kanayama, M., Tazumi, K., Tanihata, Y., Miura, Y., Fujiwara, D., & Yamamoto, N. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002408 · Cited by 91 · see citing works
Self-citation
Surfacing role of probiotics in cancer prophylaxis and therapy: A systematic review
Dasari, S., Kathera, C., Janardhan, A., Kumar, A. P., & Viswanath, B. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.11.017 · Cited by 88 · see citing works
Immunomodulatory effect of Lactococcus lactis JCM5805 on human plasmacytoid dendritic cells
Sugimura, T., Jounai, K., Ohshio, K., Tanaka, T., Suwa, M., & Fujiwara, D. (2013) · Clinical Immunology · doi:10.1016/j.clim.2013.10.007 · Cited by 82 · see citing works
Self-citation
Proinflammatory cytokine interferon-γ and microbiome-derived metabolites dictate epigenetic switch between forkhead box protein 3 isoforms in coeliac disease
Serena, G., Yan, S., Camhi, S. S., Patel, S., Lima, R. S., Sapone, A., Leonard, M. M., Mukherjee, R., Nath, B. J., Lammers, K. M., et al. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12911 · Cited by 74 · see citing works
Efficacy of heat-killed <i>Lactococcus lactis</i> JCM 5805 on immunity and fatigue during consecutive high intensity exercise in male athletes: a randomized, placebo-controlled, double-blinded trial
Komano, Y., Shimada, K., Naito, H., Fukao, K., Ishihara, Y., Fujii, T., Kokubo, T., & Daida, H. (2018) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-018-0244-9 · Cited by 73 · see citing works
Effects of Immunostimulants, Prebiotics, Probiotics, Synbiotics, and Potentially Immunoreactive Feed Additives on Olive Flounder ( Paralichthys olivaceus ): A Review
Hasan, M. T., Jang, W. J., Lee, J. M., Lee, B., Hur, S. W., Lim, S. G., Kim, K., Han, H., & Kong, I. (2019) · Reviews in Fisheries Science & Aquaculture · doi:10.1080/23308249.2019.1622510 · Cited by 69 · see citing works
The Aryl Hydrocarbon Receptor Antagonist StemRegenin 1 Promotes Human Plasmacytoid and Myeloid Dendritic Cell Development from CD34 + Hematopoietic Progenitor Cells
Thordardottir, S., Hangalapura, B. N., Hutten, T. J. A., Cossu, M., Spanholtz, J., Schaap, N. P., Radstake, T. R. D. J., van der Voort, R., & Dolstra, H. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0521 · Cited by 68 · see citing works
Oral Administration of Lactococcus lactis Subsp. lactis JCM5805 Enhances Lung Immune Response Resulting in Protection from Murine Parainfluenza Virus Infection
Jounai, K., Sugimura, T., Ohshio, K., & Fujiwara, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119055 · Cited by 62 · see citing works
Self-citation
Neisseria gonorrhoeae Suppresses Dendritic Cell-Induced, Antigen-Dependent CD4 T Cell Proliferation
Zhu, W., Ventevogel, M. S., Knilans, K. J., Anderson, J. E., Oldach, L., McKinnon, K. P., Hobbs, M. M., Sempowski, G. D., & Duncan, J. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041260 · Cited by 55 · see citing works
Effects of Lactococcus lactis subsp. lactis JCM5805 on colonization dynamics of gut microbiota and regulation of immunity in early ontogenetic stages of tilapia
Xia, Y. L., Cao, J., Wang, M., Lu, M., Chen, G., Gao, F., Liu, Z., Zhang, D., Ke, X., & Yi, M. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.11.022 · Cited by 50 · see citing works
Neisseria gonorrhoeae Modulates Immunity by Polarizing Human Macrophages to a M2 Profile
Ortiz, M. C., Lefimil, C., Rodas, P. I., Vernal, R., López, M. N., Acuña‐Castillo, C., Imarai, M., & Escobar, A. F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130713 · Cited by 47 · see citing works
Health benefits of lactic acid bacteria isolated from kimchi, with respect to immunomodulatory effects
Choi, H., Lee, N., & Paik, H. (2015) · Food Science and Biotechnology · doi:10.1007/s10068-015-0102-3 · Cited by 49 · see citing works
Food-producing animals and their health in relation to human health
Téllez‐Isaías, G., Lauková, A., Latorre, J. D., Hernández-Velasco, X., Hargis, B. M., & Callaway, T. R. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.25876 · Cited by 45 · see citing works
Lactococcus lactis JCM5805 activates anti-viral immunity and reduces symptoms of common cold and influenza in healthy adults in a randomized controlled trial
Shibata, T., Kanayama, M., Haida, M., Fujimoto, S., Oroguchi, T., Sata, K., Mita, N., Kutsuzawa, T., Ikeuchi, M., Kondo, M., et al. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.03.035 · Cited by 45 · see citing works
DNA Transfer and Toll-like Receptor Modulation by Helicobacter pylori
Varga, M. G., & Peek, R. M. (2017) · Current topics in microbiology and immunology · doi:10.1007/978-3-319-50520-6_8 · Cited by 41 · see citing works
Lactic acid bacteria activating innate immunity improve survival in bacterial infection model of silkworm
Nishida, S., Ono, Y., & Sekimizu, K. (2016) · Drug Discoveries & Therapeutics · doi:10.5582/ddt.2016.01022 · Cited by 39 · see citing works
Lactobacillus helveticus SBT2171 Induces A20 Expression via Toll-Like Receptor 2 Signaling and Inhibits the Lipopolysaccharide-Induced Activation of Nuclear Factor-kappa B and Mitogen-Activated Protein Kinases in Peritoneal Macrophages
Kawano, M., Miyoshi, M., & Miyazaki, T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00845 · Cited by 39 · see citing works
Adjuvant Strategies for Lactic Acid Bacterial Mucosal Vaccines
Vilander, A. C., & Dean, G. A. (2019) · Vaccines · doi:10.3390/vaccines7040150 · Cited by 39 · see citing works
The Role of Mucosal Immunity and Recombinant Probiotics in SARS-CoV2 Vaccine Development
Moradi‐Kalbolandi, S., Majidzadeh‐A, K., Abdolvahab, M. H., Jalili, N., & Farahmand, L. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09773-9 · Cited by 34 · see citing works
Gut-associated lymphoid tissue, gut microbes and susceptibility to experimental autoimmune encephalomyelitis
Stanisavljević, S., Lukić, J., Momčilović, M. B., Miljković, M., Jevtić, B., Kojić, M., Golić, N., Stojković, M. M., & Miljković, D. M. (2016) · Beneficial Microbes · doi:10.3920/bm2015.0159 · Cited by 34 · see citing works
Effects of heat-killed Lactococcus lactis subsp. lactis JCM 5805 on mucosal and systemic immune parameters, and antiviral reactions to influenza virus in healthy adults; a randomized controlled double-blind study
Fujii, T., Jounai, K., Horie, A., Takahashi, H., Suzuki, H., Ohshio, K., Fujiwara, D., & Yamamoto, N. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.06.011 · Cited by 33 · see citing works
Self-citation
Umbilical cord blood–derived cellular products for cancer immunotherapy
Cany, J., Dolstra, H., & Shah, N. D. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2015.03.005 · Cited by 32 · see citing works
Newly isolated Lactobacillus paracasei strain modulates lung immunity and improves the capacity to cope with influenza virus infection
Kim, S., Lee, S., Kim, T.-Y., Lee, S.-H., Seo, S., & Kweon, M. (2023) · Microbiome · doi:10.1186/s40168-023-01687-8 · Cited by 30 · see citing works
Effect of the Lactococcus Lactis 11/19-B1 Strain on Atopic Dermatitis in a Clinical Test and Mouse Model
Suzuki, T., Nishiyama, K., Kawata, K., Sugimoto, K., Isome, M., Suzuki, S., Nozawa, R., Ichikawa, Y., Watanabe, Y., & Suzutani, T. (2020) · Nutrients · doi:10.3390/nu12030763 · Cited by 30 · see citing works
Oral immunization of trout fry with recombinant Lactococcus lactis NZ3900 expressing G gene of viral hemorrhagic septicaemia virus (VHSV)
Samani, M. N., Soltani, M., Dadar, M., Mirghaed, A. T., Zargar, A., Ahmadivand, S., Hassanzadeh, R., & Goudarzi, L. M. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.07.007 · Cited by 30 · see citing works
Pellet feed adsorbed with the recombinant Lactococcus lactis BFE920 expressing SiMA antigen induced strong recall vaccine effects against Streptococcus iniae infection in olive flounder (Paralichthys olivaceus)
Kim, D., Beck, B. R., Lee, S. M., Jeon, J., Lee, D. W., Lee, J. I., & Song, S. K. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.06.010 · Cited by 29 · see citing works
Characterization and evaluation of lactic acid bacteria candidates for intestinal epithelial permeability and Salmonella Typhimurium colonization in neonatal turkey poults
Yang, Y., Latorre, J. D., Khatri, B., Kwon, Y. M., Kong, B. ‐., Teague, K. D., Graham, D. B., Wolfenden, A. D., Mahaffey, B. D., Baxter, M. F. A., et al. (2017) · Poultry Science · doi:10.3382/ps/pex311 · Cited by 26 · see citing works
Probiotics as a biotherapeutics for the management and prevention of respiratory tract diseases
Debnath, N., Kumar, A., & Yadav, A. K. (2022) · Microbiology and Immunology · doi:10.1111/1348-0421.12980 · Cited by 28 · see citing works
Correlation between Type I Interferon Associated Factors and COVID-19 Severity
Bencze, D., Fekete, T., & Pázmándi, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810968 · Cited by 25 · see citing works
Virus Infection Is an Instigator of Intestinal Dysbiosis Leading to Type 1 Diabetes
Morse, Z. J., & Horwitz, M. S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.751337 · Cited by 22 · see citing works
Long-term administration of pDC stimulative lactic acid bacteria, Lactococcus lactis strain Plasma, prevents immune-senescence and decelerates individual senescence
Tsuji, R., Komano, Y., Ohshio, K., Ishii, N., & Kanauchi, O. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.06.028 · Cited by 20 · see citing works
Lactococcus lactissubsp. lactisJCM 5805 activates natural killer cells via dendritic cells
Suzuki, H., Ohshio, K., & Fujiwara, D. (2015) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2015.1116922 · Cited by 20 · see citing works
Self-citation
The Potential of Probiotics as Ingestible Adjuvants and Immune Modulators for Antiviral Immunity and Management of SARS-CoV-2 Infection and COVID-19
Tomkinson, S., Triscott, C., Schenk, E., & Foey, A. (2023) · Pathogens · doi:10.3390/pathogens12070928 · Cited by 22 · see citing works
Microbial pathogenesis and type III interferons
Cohen, T. S., & Parker, D. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.02.005 · Cited by 21 · see citing works
Unexpected effect of probiotics by Lactococcus lactis subsp. lactis against colitis induced by dextran sulfate sodium in mice
Komaki, S., Haque, A., Miyazaki, H., Matsumoto, T., & Nakamura, S. (2020) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2020.01.006 · Cited by 18 · see citing works
Role of probiotics in the management of cervical cancer: An update
Kandati, K., Belagal, P., Nannepaga, J. S., & Viswanath, B. (2022) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2022.02.017 · Cited by 18 · see citing works
Lactococcus lactis and Lactobacillus salivarius differently modulate early immunological response of Wistar rats co-administered with Listeria monocytogenes
Lukić, J., Jančić, I., Mirković, N., Bufan, B., Djokić, J., Milenković, M., Begović, J., Strahinić, I., & Lozo, J. (2017) · Beneficial Microbes · doi:10.3920/bm2017.0007 · Cited by 18 · see citing works
Are heat-killed probiotics more effective than live ones on colon length shortness, disease activity index, and the histological score of an inflammatory bowel disease-induced murine model? A meta-analysis
Ditengou, J. I. C. P., Ahn, S., Chae, B., & Choi, N. (2023) · Journal of Applied Microbiology · doi:10.1093/jambio/lxad008 · Cited by 16 · see citing works
Overview of anti-viral effects of probiotics via immune cells in pre-, mid- and post-SARS-CoV2 era
Kanauchi, O., Low, Z. X., Jounai, K., Tsuji, R. F., & AbuBakar, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1280680 · Cited by 20 · see citing works
Self-citation
Administration of Lactococcus lactis strain Plasma induces maturation of plasmacytoid dendritic cells and protection from rotavirus infection in suckling mice
Jounai, K., Sugimura, T., Morita, Y., Ohshio, K., & Fujiwara, D. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.01.034 · Cited by 16 · see citing works
Self-citation
Long-term administration of pDC-Stimulative Lactococcus lactis strain decelerates senescence and prolongs the lifespan of mice
Sugimura, T., Jounai, K., Ohshio, K., Suzuki, H., Kirisako, T., Sugihara, Y., & Fujiwara, D. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.03.024 · Cited by 16 · see citing works
Self-citation
Probiotic supplementation: A prospective approach in the treatment of COVID-19
Nayebi, A., Navashenaq, J. G., Soleimani, D., & Nachvak, S. M. (2021) · Nutrition and Health · doi:10.1177/02601060211049631 · Cited by 17 · see citing works
Prokaryotes Versus Eukaryotes: Who is Hosting Whom?
Téllez‐Isaías, G. (2014) · Frontiers in Veterinary Science · doi:10.3389/fvets.2014.00003 · Cited by 15 · see citing works
Administration of plasmacytoid dendritic cell-stimulative lactic acid bacteria enhances antigen-specific immune responses
Suzuki, H., Jounai, K., Ohshio, K., Fujii, T., & Fujiwara, D. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.07.042 · Cited by 14 · see citing works
Self-citation
Characterization of genomic DNA of lactic acid bacteria for activation of plasmacytoid dendritic cells
Horie, A., Tomita, Y., Ohshio, K., Fujiwara, D., & Fujii, T. (2019) · BMC Microbiology · doi:10.1186/s12866-019-1458-y · Cited by 13 · see citing works
Self-citation
Roles of Plasmacytoid Dendritic Cells in Gastric Cancer
Yang, J., Liu, X., Cheng, Y., Zhang, J., Ji, F., & Ling, Z. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.818314 · Cited by 13 · see citing works
Roles and Effects of Interferon Lambda Signaling in the Context of Bacterial Infections
Johnson, D., & Carbonetti, N. H. (2023) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2023.0037 · Cited by 13 · see citing works
Induction of anti-viral genes mediated by humoral factors upon stimulation with Lactococcus lactis strain plasma results in repression of dengue virus replication in vitro
Tsuji, R. F., Yamamoto, N., Yamada, S., Fujii, T., Yamamoto, N., & Kanauchi, O. (2018) · Antiviral Research · doi:10.1016/j.antiviral.2018.10.020 · Cited by 13 · see citing works
Immunomodulatory activity of heat‐killed Lacticaseibacillus paracasei MCC1849 based on the activation of plasmacytoid dendritic cells in the peripheral blood of healthy adults
Li, Y., Aoki, T., Iwabuchi, S., Arai, S., Iwabuchi, N., Motobayashi, H., Tanaka, M., & Hashimoto, S. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.4009 · Cited by 12 · see citing works
Glycerol supplementation enhances the protective effect of dietary FloraMax-B11 against Salmonella Enteritidis colonization in neonate broiler chickens
Delgado, R., Latorre, J. D., Vicuña, E. A., Hernández-Velasco, X., Vicente, J. L., Menconi, A., Kallapura, G., Layton, S. L., Hargis, B. M., & Téllez, G. (2014) · Poultry Science · doi:10.3382/ps.2014-03927 · Cited by 12 · see citing works
Overview of Anticancer activity of Lactic Acid bacteria
Delesa, D. A., Jimma, & Ethiopia, P. O. B. 3. (2017) · International Journal of Advanced Research in Biological Sciences (IJARBS) · doi:10.22192/ijarbs.2017.04.12.017 · Cited by 12 · see citing works
Effects of Ingesting Food Containing Heat-Killed Lactococcus lactis Strain Plasma on Fatigue and Immune-Related Indices after High Training Load: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Study
Komano, Y., Fukao, K., Shimada, K., Naıto, H., Ishihara, Y., Fujii, T., Kokubo, T., & Daida, H. (2023) · Nutrients · doi:10.3390/nu15071754 · Cited by 11 · see citing works
Heyndrickxia coagulans strain SANK70258 suppresses symptoms of upper respiratory tract infection via immune modulation: a randomized, double-blind, placebo-controlled, parallel-group, comparative study
Aida, M., Togawa, N., Mizuyama, K., Aoki, Y., Suehiro, S., Sakamoto, A., Uchida, N., & Yamada, R. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1389920 · Cited by 13 · see citing works
Enhancement of immunomodulative effect of lactic acid bacteria on plasmacytoid dendritic cells with sucrose palmitate
Kanayama, M., Kato, Y. H., Tsuji, T., Konoeda, Y., Hashimoto, A. S., Kanauchi, O., Fujii, T., & Fujiwara, D. (2018) · Scientific Reports · doi:10.1038/s41598-018-21527-2 · Cited by 11 · see citing works
Self-citation
Administration of plasmacytoid dendritic cell-stimulative lactic acid bacteria is effective against dengue virus infection in mice
Suzuki, H., Tsuji, R. F., Sugamata, M., Yamamoto, N., Yamamoto, N., & Kanauchi, O. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3955 · Cited by 11 · see citing works
The Effects of Plasmacytoid Dendritic Cell-Stimulative Lactic Acid Bacteria, Lactococcus lactis Strain Plasma, on Exercise-Induced Fatigue and Recovery via Immunomodulatory Action
Kokubo, T., Komano, Y., Tsuji, R. F., Fujiwara, D., Fujii, T., & Kanauchi, O. (2019) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0377 · Cited by 11 · see citing works
Self-citation
Lactobacillus helveticus Induces Two Types of Dendritic Cell Activation and Effectively Suppresses Onset of the Common Cold: A Randomized, Double-Blind, Placebo-Controlled Trial
Wada, H., Mawatari, T., Saito, Y., Azuma, N., & Iwama, Y. (2024) · Nutrients · doi:10.3390/nu17010101 · Cited by 10 · see citing works
Induction of ALDH Activity in Intestinal Dendritic Cells byLactobacillus plantarumNRIC0380
Yoshida, T., Enomoto, M., Nakayama, S., ADACHI, Y., Fujiwara, W., SUGIYAMA, H., Shimojoh, M., Okada, S., & Hattori, M. (2013) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.130144 · Cited by 10 · see citing works
Preventive Effect of Lactococcus lactis subsp. lactis JCM 5805 Yogurt Intake on Influenza Infection among Schoolchildren
Sakata, K., Sasaki, Y., Jounai, K., Fujii, T., & Fujiwara, D. (2017) · Health · doi:10.4236/health.2017.94054 · Cited by 9 · see citing works
Self-citation
Lactococcus lactis Strain Plasma Intake Suppresses the Incidence of Dengue Fever-like Symptoms in Healthy Malaysians: A Randomized, Double-Blind, Placebo-Controlled Trial
Khor, C., Tsuji, R. F., Lee, H. Y., Nor’e, S.-S., Sahimin, N., Azman, A. S., Tiong, V., Hassandarvish, P., Teoh, B., Soh, Y. H., et al. (2021) · Nutrients · doi:10.3390/nu13124507 · Cited by 9 · see citing works
Staphylococcus aureus Epicutaneous Infection Is Suppressed by Lactococcus lactis Strain Plasma via Interleukin 17A Elicitation
Tsuji, R. F., Fujii, T., Nakamura, Y., Yazawa, K., & Kanauchi, O. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz204 · Cited by 9 · see citing works
Amyloid β-induced Mesenteric Inflammation in an Alzheimer’s Disease Transgenic Mouse Model
Ano, Y., Ikado, K., Uchida, K., & Nakayama, H. (2020) · Current Alzheimer Research · doi:10.2174/1567205017666200212160343 · Cited by 8 · see citing works
Self-citation
Identification of novel lactic acid bacteria with enhanced protective effects against influenza virus
Sugimoto, A., Numaguchi, T., Chihama, R., Takenaka, Y., & Sato, Y. (2023) · PLoS ONE · doi:10.1371/journal.pone.0273604 · Cited by 8 · see citing works
Lactobacillus paragasseri SBT2055 Activates Plasmacytoid Dendritic Cells and Improves Subjective Symptoms of Common Cold in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Parallel-Group Comparative Trial
Kobatake, E., Iwama, Y., Arai, T., Tsukisaka, Y., & Kabuki, T. (2023) · Nutrients · doi:10.3390/nu15204458 · Cited by 8 · see citing works
Investigating the Role of Probiotics in Modulating T Cells and the Immune Response: A Systematic Review
Abbaszadeh, S. H., Hosseini, S. R. A., Mahmoodpoor, A., Yousefi, M., Lotfi‐Dizaji, L., & Ebrahimi‐Mameghani, M. (2024) · Indian Journal of Microbiology · doi:10.1007/s12088-024-01421-4 · Cited by 7 · see citing works
Bacteroides dorei RX2020-derived bile acid alleviates influenza virus infection through TGR5 signaling
He, S., Lu, S., Yang, T., Ma, H., He, Y., Mi, J., Yue, K., Huang, Y., Song, L., Xiao, Y., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02384-9 · Cited by 8 · see citing works
Targeted lung Lactobacillus johnsonii intervention alleviates virus-induced fibrosis post-HCT through PD-L1/PD-1 signaling
Perkins, J. B., Ravi, K., Guo, C., Oh, G. J., Rodriguez, B. G., Chen, C.-N., Jansons, S. I., Sun, F. C. S., Gurczynski, S. J., Weinberg, J. B., et al. (2026) · Science Advances · doi:10.1126/sciadv.adw4654 · Cited by 6 · see citing works
Lactococcus lactis Strain Plasma Improves Subjective Physical State and Presenteeism: A Randomized, Open-Label Crossover Study among Healthy Office Workers
Kokubo, T., Wakai, S., Fujiwara, D., Kanauchi, O., Jounai, K., Ichikawa, H., Takuma, M., Kanaya, Y., & Shiraoka, R. (2020) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2020.25.2.140 · Cited by 6 · see citing works
Self-citation
Assessment the of Anti-Obesity Effects and Safety of Lactobacillus paracasei AO356
Lee, S., Shin, D., Kim, S. Y., Eom, J.-E., Nam, Y., Shin, H.-S., Kim, J., & Woo, Y.-H. (2021) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2021.50.9.904 · Cited by 6 · see citing works
Oral priming with oligodeoxynucleotide particles from Lactobacillus rhamnosus GG attenuates symptoms of dextran sodium sulfate‐induced acute colitis in mice
Shigemori, S., Namai, F., Ogita, T., Sato, T., & Shimosato, T. (2020) · Animal Science Journal · doi:10.1111/asj.13468 · Cited by 6 · see citing works
DNA from Lactobacillus paragasseri SBT2055 Activates Plasmacytoid Dendritic Cells and Induces IFN-α via TLR9
Kobatake, E., & Arai, T. (2025) · Microorganisms · doi:10.3390/microorganisms13071440 · Cited by 5 · see citing works
Lactococcus lactis subsp. cremoris YRC3780 modifies function of mesenteric lymph node dendritic cells to modulate the balance of T cell differentiation inducing regulatory T cells
Nakagawa, R., Gu, W., Mizobuchi, H., Kodera, S., Takano, T., Wang, Y., Fujioka, I., Uchida, K., Nakajima‐Adachi, H., & Hachimura, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1395380 · Cited by 5 · see citing works
Draft Genome Sequence of Lactococcus lactis subsp. lactis JCM 5805 T , a Strain That Induces Plasmacytoid Dendritic Cell Activation
Fujii, T., Tomita, Y., Ikushima, S., Horie, A., & Fujiwara, D. (2015) · Genome Announcements · doi:10.1128/genomea.00113-15 · Cited by 5 · see citing works
Self-citation
Polysaccharide from black currant (Ribes nigrum L.) stimulates dendritic cells through TLR4 signaling
Ashigai, H., Komano, Y., Wang, G., Kawachi, Y., Sunaga, K., YAMAMOTO, R., Takata, R., Miyake, M., & Yanai, T. (2017) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.16-029 · Cited by 5 · see citing works
Immunomodulatory Factor of Lactobacillus Acidophilus in Pathogenesis of Chronic HCV
El-Gaaly, S. A. A., Radwan, H. H., & Attiha, M. Y. (2016) · The Egyptian Journal of Hospital Medicine · doi:10.12816/0023851 · Cited by 5 · see citing works
Effects of Heat-Killed Lactococcus lactis Strain Plasma on Skin Homeostasis-Related Genes and the Skin Microbiome among Healthy Adults: A Randomized Controlled Double-Blind Study
Fujii, T., Fujitomo, T., Tsuji, R. F., Kubo, R., Kato, Y. H., & Kanauchi, O. (2021) · Microorganisms · doi:10.3390/microorganisms9102029 · Cited by 4 · see citing works
The Antiviral Effects of Heat-Killed Lactococcus lactis Strain Plasma Against Dengue, Chikungunya, and Zika Viruses in Humans by Upregulating the IFN-α Signaling Pathway
Low, Z. X., Kanauchi, O., Tiong, V., Sahimin, N., Lani, R., Tsuji, R. F., AbuBakar, S., & Hassandarvish, P. (2024) · Microorganisms · doi:10.3390/microorganisms12112304 · Cited by 4 · see citing works
RNA and a cell wall component of Enterococcus faecalis IC-1 are required for phagocytosis and interleukin 12 production by the mouse macrophage cell line J774.1
Nakase, J., Ukawa, Y., Takemoto, S., Kubo, T., Sagesaka, Y. M., AOKI-YOSHIDA, A., & Totsuka, M. (2017) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2017.1295799 · Cited by 4 · see citing works
Env-independent protection of intrarectal SIV challenge by vaccine induction of Gag/Vif-specific CD8+ T cells but not CD4+ T cells
Ishii, H., Terahara, K., Nomura, T., Okazaki, M., Yamamoto, H., Shu, T., Sakawaki, H., Miura, T., Watkins, D. I., & Matano, T. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.02.023 · Cited by 4 · see citing works
A COMPREHENSIVE REVIEW OF PROBIOTICS AND THEIR USES FOR CONTROL OF VIRAL INFECTIONS IN THE WAKE OF PANDEMIC COVID-19
P, P. C. (2020) · Tropical Journal of Pharmaceutical and Life Sciences · doi:10.61280/tjpls.v7i2.37 · Cited by 4 · see citing works
The Effects of Dietary Supplementation of Lactococcus lactis Strain Plasma on Skin Microbiome and Skin Conditions in Healthy Subjects—A Randomized, Double-Blind, Placebo-Controlled Trial
Tsuji, R. F., Yazawa, K., Kokubo, T., Nakamura, Y., & Kanauchi, O. (2021) · Microorganisms · doi:10.3390/microorganisms9030563 · Cited by 4 · see citing works
Lactococcus lactis Strain Plasma Uniquely Induces IFN-α Production via Plasmacytoid Dendritic Cell Activation: A Comparative Study of Postbiotic Products
Fujimura, S., Kawamura, M., & Tamura, Y. (2025) · Microorganisms · doi:10.3390/microorganisms13102261 · Cited by 3 · see citing works
Lactococcus lactis strain Plasma activates plasmacytoid dendritic cells and mitigates common cold-like symptoms in healthy adults: a meta-analysis of individual participant data
Kato, Y. H., Kobayashi, K., Kuramochi, Y., Miyata, T., Ushida, Y., & Hayamizu, K. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1696989 · Cited by 3 · see citing works
Impact of Infectious Disease after Lactococcus lactis Strain Plasma Intake in Vietnamese Schoolchildren: A Randomized, Placebo-Controlled, Double-Blind Study
Thu, N. N., Tuyết, T., Trang, T. T. T., Tuấn, N. A., Quyen, T. C., Hanh, N. L., Hoan, N. H., Lan, B. T. H., Hau, P. T., Tue, H. H., et al. (2022) · Nutrients · doi:10.3390/nu14030552 · Cited by 3 · see citing works
Efficacy of Lactococcus lactis strain plasma (LC-Plasma) in easing symptoms in patients with mild COVID-19: protocol for an exploratory, multicentre, double-blinded, randomised controlled trial (PLATEAU study)
Yamamoto, K., Hosogaya, N., Inoue, T., Jounai, K., Tsuji, R. F., Fujiwara, D., Yanagihara, K., Izumikawa, K., & Mukae, H. (2022) · BMJ Open · doi:10.1136/bmjopen-2022-061172 · Cited by 3 · see citing works
Self-citation
Plasmacytoid dendritic cells stimulated with Lactococcus lactis strain Plasma produce soluble factors to suppress SARS-CoV-2 replication
Ishii, H., Jounai, K., Tsuji, R. F., Ohshio, K., Kaneda, D., Okazaki, M., Harada, S., Fujiwara, D., & Matano, T. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.04.046 · Cited by 3 · see citing works
Self-citation
Dysfunction of the Murine Liver with Aging and Its Improvement with the Continuous Consumption of Enterococcus faecalis EC-12
Makioka‐Itaya, Y., Inoüe, R., & Tsukahara, T. (2024) · Nutrients · doi:10.3390/nu16132031 · Cited by 3 · see citing works
Non-random Lymphocyte Distribution Among Virus-Infected Cells of the Respiratory Tract
Rudraraju, R., Sealy, R. E., Surman, S. L., Thomas, P. G., Dayton, B. H., & Hurwitz, J. L. (2013) · Viral Immunology · doi:10.1089/vim.2013.0033 · Cited by 3 · see citing works
Enterococcus casseliflavus KB1733 Isolated from a Traditional Japanese Pickle Induces Interferon-Lambda Production in Human Intestinal Epithelial Cells
Satomi, S., Kokubu, D., Inoue, T., Sugiyama, M., Mizokami, M., Suzuki, S., & Murata, K. (2022) · Microorganisms · doi:10.3390/microorganisms10040827 · Cited by 3 · see citing works
Interactions of Probiotics with the Immune Cells of Patients with COVID-19 Pneumonia
Mitrou, I., Dimοpoulos, G., Dakou, K., Koufargyris, P., Damoraki, G., Gkavogianni, T., & Giamarellos‐Bourboulis, E. J. (2025) · Journal of Innate Immunity · doi:10.1159/000545873 · Cited by 2 · see citing works
Efficacy of Lactococcus lactis Strain Plasma in Patients with Mild COVID-19: A Multicenter, Double-Blinded, Randomized-Controlled Trial (PLATEAU Study)
Yamamoto, K., Inoue, T., Ikeda, T., Sawai, T., Nagayoshi, Y., Hashiguchi, K., Futsuki, Y., Matsubara, Y., Harada, Y., Ashizawa, N., et al. (2025) · Infectious Diseases and Therapy · doi:10.1007/s40121-025-01246-8 · Cited by 2 · see citing works
Self-citation
The mechanism of intestinal-origin probiotics Lactococcus lactis M48 against sea perch iridovirus (SPIV) infection during sea perch Lateolabrax japonicus culture
Zhu, Z., Xu, Y.-M., Tang, P.-Q., Luo, W.-L., Yang, W.-F., Wu, S., Liu, M., Huang, X.-H., Huang, Y.-H., Sun, H.-Y., et al. (2026) · Aquaculture · doi:10.1016/j.aquaculture.2026.744060 · Cited by 2 · see citing works

Spherical Lactic Acid Bacteria Activate Plasmacytoid Dendritic Cells Immunomodulatory Function via TLR9- Dependent Crosstalk with
Cells, M. D., Jounai, K., Ikado, K., Sugimura, T., Ano, Y., Braun, J., & Fujiwara, D. (2016)
Self-citation
Immunomodulatory effect of Lactococcus lactis JCM5805 on human plasmacytoid dendritic cells
Sugimura, T., Jounai, K., Ohshio, K., Tanaka, T., Suwa, M., & Fujiwara, D. (2013) · Clinical Immunology · doi:10.1016/j.clim.2013.10.007 · Cited by 82 · see citing works
Self-citation
BDCA2-dependent phagocytosis enables strain-specific activation of plasmacytoid dendritic cells by lactic acid bacteria
Hori, S., Hirose, Y., Matsuo-Dapaah, J., Zheng, J., Tsuji, T., Fujita, H., Nanao, M., & Tsuji, R. F. (2026) · iScience · doi:10.1016/j.isci.2026.118033
Administration of plasmacytoid dendritic cell-stimulative lactic acid bacteria enhances antigen-specific immune responses
Suzuki, H., Jounai, K., Ohshio, K., Fujii, T., & Fujiwara, D. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.07.042 · Cited by 14 · see citing works
Self-citation
Differential effects of lactobacilli on activation and maturation of mouse dendritic cells
Elawadli, I., Brisbin, J. T., Mallard, B. A., Griffiths, M. W., Corredig, M., & Sharif, S. (2014) · Beneficial Microbes · doi:10.3920/bm2013.0066 · Cited by 22 · see citing works

Authors: Jounai, K., Ikado, K., Sugimura, T., Ano, Y., Braun, J., & Fujiwara, D.
Affiliations: Kirin (Japan) (JP)
University of California, Los Angeles (US)
Corresponding author: Fujiwara, Daisuke
ORCID: Sugimura, Tetsu
Ano, Yasuhisa
Braun, Jonathan
Fujiwara, Daisuke
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2012-04-10
Volume: 7
Issue: 4
Pages: e32588
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0032588
PMC: PMC3323594
OpenAlex: W2062007417
Cited by: 133
References: 54
Citations by year: 2026: 9 · 2025: 10 · 2024: 12 · 2023: 15 · 2022: 11 · 2021: 11 · 2020: 7 · 2019: 7 · 2018: 12 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 5 · 2013: 6 · 2012: 1
FWCI: 3.07
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Figshare (submittedVersion, cc-by)
Funders: National Institutes of Health (1ul1rr033176-01, UL1TR000124)
National Institute of Allergy and Infectious Diseases (R01AI078885)
National Center for Research Resources (UL1-RR-033176)
National Center for Advancing Translational Sciences
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: lactic acid bacteria, plasmacytoid dendritic cells, myeloid dendritic cells, TLR9, MyD88, interferon-alpha, Lactococcus lactis, type I interferon, interferon lambda, TLR4, ICOSL, PD-L1, regulatory T cells, oral administration, mesenteric lymph nodes, immunomodulation, probiotics, antiviral immunity
MeSH terms: Animals, Bone Marrow, Cell Communication, Cells, Cultured, Dendritic Cells, Female, Immunologic Factors, Leuconostoc, Mice, Inbred C57BL, Pediococcus, Streptococcus, Lactococcus lactis, Interferon-alpha, Coculture Techniques, Lactic Acid, Myeloid Cells, T-Lymphocytes, Regulatory, Toll-Like Receptor 9, Mice, Myeloid Differentiation Factor 88

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Spherical lactic acid bacteria activate plasmacytoid dendritic cells immunomodulatory function via tlr9-dependent crosstalk with myeloid dendritic cells

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks