Axial bone mineral density in patients with acromegaly
Abstract
Rationale and objectives The purpose of this study was to assess the influence of long-term elevated levels of growth hormone and insulin-like growth factor I on bone mineral density (BMD) of the spine in patients with acromegaly. Materials and methods The spinal BMD in 40 patients with acromegaly was measured with quantitative computed tomography. The result was expressed as the mean of six measurements of consecutive vertebral bodies and as a z score. Twenty age- and sex-matched healthy persons also underwent spinal BMD measurement and served as controls. Results In 36 of the 40 patients, the BMD z score ranged within 2 standard deviations (SDs) above or below the mean. Only two patients (one man and one woman) had enhanced BMD loss (below 2 SD). Two other female patients had BMD values of more than 2 SD above the mean. Differences between patient subgroups were not statistically significant, but a statistically significant (P Conclusion Hypersecretion of growth hormone in patients with acromegaly, regardless of other factors, has no evident effect on BMD of the lumbar spine.
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Information about the influence of GH excess on BMD varies in the literature: in some studies BMD was increased or within reference ranges, while in other papers it was decreased.
“Information about the influence of GH excess on BMD varies in the literature. In some studies BMD was reported to be increased or within the reference ranges, while in other papers it was decreased [17, 26, 34–37].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [37]
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- Authors
- Bolanowski, M., Wielgus, W., Milewicz, A., & Marciniak, R.
- Affiliations
- University of Wrocław (PL)
- ORCID
- Bolanowski, Marek
- Venue
- Academic Radiology
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 7
- Issue
- 8
- Pages
- 592-594
- ISSN
- 1076-6332 (ISSN-L)
- OpenAlex
- W2023522186
- Cited by
- 25
- References
- 9
- Citations by year
- 2024: 1 · 2022: 1 · 2020: 1 · 2018: 1 · 2015: 1 · 2014: 2
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Academic Radiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- acromegaly, bone mineral density, lumbar spine, growth hormone, insulin-like growth factor I, hypersecretion, vertebral body, Z-score, bone loss
- MeSH terms
- Acromegaly, Adult, Aged, Female, Humans, Insulin-Like Growth Factor I, Male, Middle Aged, Bone Density, Human Growth Hormone
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