p300/MDM2 Complexes Participate in MDM2-Mediated p53 Degradation

p53, the cellular gatekeeper for growth and division

Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693

High-Efficiency Transformation of Mammalian Cells by Plasmid DNA

Chen, C., & Okayama, H. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.8.2745 · Cited by 5,327

Mdm2 promotes the rapid degradation of p53

Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

Scheffner, M., Werness, B. A., Huibregtse, J. M., Levine, A. J., & Howley, P. M. (1990) · Cell · doi:10.1016/0092-8674(90)90409-8 · Cited by 3,995

Regulation of p53 stability by Mdm2

Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Momand, J., Zambetti, G. P., Olson, D. C., George, D., & Levine, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90644-r · Cited by 3,113

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H., & Nakatani, Y. (1996) · Cell · doi:10.1016/s0092-8674(00)82001-2 · Cited by 2,952

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

Scheffner, M., Huibregtse, J. M., Vierstra, R. D., & Howley, P. M. (1993) · Cell · doi:10.1016/0092-8674(93)90384-3 · Cited by 2,416

p53: puzzle and paradigm.Preprint

Ko, L. J., & Prives, C. L. (1996) · Genes & Development · doi:10.1101/gad.10.9.1054 · Cited by 2,346

AMF1 (GPS2) Modulates p53 Transactivation

Peng, Y., Kuo, F., Breiding, D. E., Wang, Y., Mansur, C. P., & Androphy, E. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5913-5924.2001 · Cited by 62

MDMX inhibits the p300/CBP-mediated acetylation of p53

Sabbatini, P., & McCormick, F. (2002) · DNA and Cell Biology · doi:10.1089/104454902320219077 · Cited by 62

Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV

Bean, L. J., & Stark, G. R. (2001) · Oncogene · doi:10.1038/sj.onc.1204204 · Cited by 63

p53 Transcriptional Activity Is Mediated through the SRC1-interacting Domain of CBP/p300

Livengood, J. A., Scoggin, K. E. S., Orden, K. V., McBryant, S. J., Edayathumangalam, R. S., Laybourn, P. J., & Nyborg, J. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108870200 · Cited by 61

p53 phosphorylation and association with murine double minute 2, c-Jun NH2-terminal kinase, p14ARF, and p300/CBP during the cell cycle and after exposure to ultraviolet irradiation.

Buschmann, T., Adler, V., Matusevich, E., Fuchs, S. Y., & Ronai, Z. A. (2000) · PubMed · Cited by 62

Deciphering the acetylation code of p53 in transcription regulation and tumor suppression

Xia, Z., Kon, N., Gu, A. P., Tavana, O., & Gu, W. (2022) · Oncogene · doi:10.1038/s41388-022-02331-9 · Cited by 60

Protein Kinase CK1δ Phosphorylates Key Sites in the Acidic Domain of Murine Double-Minute Clone 2 Protein (MDM2) That Regulate p53 Turnover

Winter, M., Milne, D., Dias, S., Kulikov, R., Knippschild, U., Blattner, C., & Meek, D. (2004) · Biochemistry · doi:10.1021/bi0489255 · Cited by 60

p400 Is Required for E1A to Promote Apoptosis

Samuelson, A. V., Narita, M., Chan, H., Jin, J., de Stanchina, E., McCurrach, M. E., Narita, M., Fuchs, M., Livingston, D. M., & Lowe, S. W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414564200 · Cited by 61

Inhibition of the 26S proteasome blocks progesterone receptor-dependent transcription through failed recruitment of RNA polymerase II

Dennis, A. P., Lonard, D. M., Nawaz, Z., & O’Malley, B. W. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2004.11.009 · Cited by 59

Function for p300 and not CBP in the apoptotic response to DNA damage

Yuan, Z.-M., Huang, Y., Ishiko, T., Nakada, S., Utsugisawa, T., Shioya, H., Utsugisawa, Y., Shi, Y., Weichselbaum, R. R., & Kufe, D. W. (1999) · Oncogene · doi:10.1038/sj.onc.1202930 · Cited by 59

Ubiquitin and control of transcription

Dhananjayan, S. C., Ismail, A., & Nawaz, Z. (2005) · Essays in Biochemistry · doi:10.1042/bse0410069 · Cited by 58

Mdm2: A Regulator of Cell Growth and Death

Alarcon-Vargas, D., Takahashi, S., & Ronai, Z. A. (2003) · Advances in cancer research · doi:10.1016/s0065-230x(03)01001-7 · Cited by 57

Charge Modification at Multiple C-terminal Lysine Residues Regulates p53 Oligomerization and Its Nucleus-Cytoplasm Trafficking

Kawaguchi, Y., Ito, A., Appella, E., & Yao, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505772200 · Cited by 57

Gps2, a Protein Partner for Human Papillomavirus E6 Proteins

Degenhardt, Y., & Silverstein, S. J. (2001) · Journal of Virology · doi:10.1128/jvi.75.1.151-160.2001 · Cited by 57

Mdm2 Mutant Defective in Binding p300 Promotes Ubiquitination but Not Degradation of p53

Zhu, Q., Yao, J., Wani, G., Wani, M. A., & Wani, A. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102634200 · Cited by 57

p53 ubiquitination by Mdm2: A never ending tail?

Coutts, A. S., Adams, C., & Thangue, N. B. L. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.01.008 · Cited by 56

MDM2 Mediates p300/CREB-binding Protein-associated Factor Ubiquitination and Degradation

Jin, Y., Zeng, S. X., Lee, H., & Lu, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309916200 · Cited by 56

The Human Tumor Suppressor ARF Interacts with Spinophilin/Neurabin II, a Type 1 Protein-phosphatase-binding Protein

Vivo, M., Calogero, R., Sansone, F., Calabrò, V., Parisi, T., Borrelli, L., Saviozzi, S., & Mantia, G. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006845200 · Cited by 57

The p53 response during DNA damage: impact of transcriptional cofactors

Coutts, A. S., & Thangue, N. B. L. (2006) · Biochemical Society Symposia · doi:10.1042/bss0730181 · Cited by 56

Molecular Cloning and Chromosomal Localization of the Human CITED2 Gene Encoding p35srj/Mrg1

Leung, M.-K., Jones, T. A., Michels, C. L., Livingston, D. M., & Bhattacharya, S. (1999) · Genomics · doi:10.1006/geno.1999.5970 · Cited by 53

Human T-cell Leukemia Virus Type I Tax Repression of p73β Is Mediated through Competition for the C/H1 Domain of CBP

Lemasson, I., & Nyborg, J. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100131200 · Cited by 54

Transcriptional Synergy between Melanoma Antigen Gene Protein-A11 (MAGE-11) and p300 in Androgen Receptor Signaling

Askew, E. B., Bai, S., Blackwelder, A. J., & Wilson, E. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.120600 · Cited by 53

Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation

Hallenborg, P., Feddersen, S., Francoz, S., Murano, I., Sundekilde, U. K., Petersen, R. K., Akimov, V., Olson, M. V., Lozano, G., Cinti, S., et al. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.15 · Cited by 52

Negative regulation of the p300-p53 interplay by DDX24

Shi, D.-D., Dai, C., Qin, J., & Gu, W. (2015) · Oncogene · doi:10.1038/onc.2015.77 · Cited by 47

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Protects Against Neuronal Apoptosis via Activation of Akt/MDM2/p53 Signaling Pathway in a Rat Model of Intracerebral Hemorrhage

Xu, W., Gao, L., Li, T., Zheng, J., Shao, A., & Zhang, J. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00176 · Cited by 51

The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression

Roche, K. C., Wiechens, N., Owen‐Hughes, T., & Perkins, N. D. (2004) · Oncogene · doi:10.1038/sj.onc.1208025 · Cited by 48

Tax1BP1 Interacts with Papillomavirus E2 and Regulates E2-Dependent Transcription and Stability

Wang, X., Naidu, S. R., Sverdrup, F. M., & Androphy, E. J. (2008) · Journal of Virology · doi:10.1128/jvi.01791-08 · Cited by 48

MiR-630 inhibits proliferation by targeting CDC7 kinase, but maintains the apoptotic balance by targeting multiple modulators in human lung cancer A549 cells

Cao, J.-X., Lu, Y., Qi, J.-J., An, G.-S., Mao, Z., Jia, H.-T., Li, S., & Ni, J.-H. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.386 · Cited by 47

Expression and Role of p53 in the Retina

Vuong, L., Conley, S. M., & Al‐Ubaidi, M. R. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8909 · Cited by 45

The leukemia-associated cytoplasmic nucleophosmin mutant is an oncogene with paradoxical functions: Arf inactivation and induction of cellular senescence

Cheng, K., Grisendi, S., Clohessy, J. G., Majid, S. M., Bernardi, R., Sportoletti, P., & Pandolfi, P. P. (2007) · Oncogene · doi:10.1038/sj.onc.1210549 · Cited by 46

Interferon-Inducible Protein IFIXα1 Functions as a Negative Regulator of HDM2

Ding, Y., Lee, J.-F., Lu, H., Lee, M., & Yan, D. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.5.1979-1996.2006 · Cited by 44

Mdm-2 binding and TAFII31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21

Jabbur, J. R., Tabor, A., Cheng, X., Wang, H., Uesugi, M., Lozano, G., & Zhang, W. (2002) · Oncogene · doi:10.1038/sj.onc.1205856 · Cited by 46

Stabilization and Activation of p53 by the Coactivator Protein TAFII31

Buschmann, T., Lin, Y., Aithmitti, N., Fuchs, S. Y., Lu, H., Resnick‐Silverman, L., Manfredi, J. J., Ronai, Z. A., & Wu, X. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007955200 · Cited by 43

The CBP/p300 TAZ1 domain in its native state is not a binding partner of MDM2

Dunzendorfer-Matt, T., Martinez‐Yamout, M. A., Dyson, H. J., & Wright, P. E. (2004) · Biochemical Journal · doi:10.1042/bj20040564 · Cited by 42

Impact of HDAC Inhibitors on Protein Quality Control Systems: Consequences for Precision Medicine in Malignant Disease

Kulka, L. A. M., Fangmann, P.-V., Panfilova, D., & Olzscha, H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00425 · Cited by 42

Knockdown of CITED2 using short‐hairpin RNA sensitizes cancer cells to cisplatin through stabilization of p53 and enhancement of p53‐dependent apoptosis

Wu, Z., Sun, N., & Chao, C. C. ‐. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22589 · Cited by 42

Rubinstein-Taybi syndrome caused by a de novo reciprocal translocation t(2;16)(q36.3;p13.3)

Petrij, F., Dorsman, J. C., Dauwerse, H. G., Giles, R. H., Peeters, T., Hennekam, R. C. M., Breuning, M. H., & Peters, D. J. M. (2000) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(20000501)92:1 · Cited by 79

Function of the p53 gene: choice between life and death.

Chumakov, P. M. (2000) · PubMed · Cited by 41

The Chromatin Remodeling Factor Mi-2α Acts as a Novel Co-activator for Human c-Myb

Sæther, T., Berge, T., Ledsaak, M., Matre, V., Alm‐Kristiansen, A. H., Dahle, Ø., Aubry, F., & Gabrielsen, O. S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700755200 · Cited by 41

POSSIBLE OSCILLATORY BEHAVIOR IN P53–MDM2 INTERACTION COMPUTER SIMULATION

Mihalaş, G. I., Simon, Z., Balea, G., & POPA, E. (2000) · Journal of Biological Systems · doi:10.1142/s0218339000000031 · Cited by 40

Human homologue of yeast Rad23 protein A interacts with p300/cyclic AMP-responsive element binding (CREB)-binding protein to down-regulate transcriptional activity of p53.

Zhu, Q., Wani, G., Wani, M. A., & Wani, A. A. (2001) · PubMed · Cited by 41

Analysis of JNK, Mdm2 and p14ARF contribution to the regulation of mutant p53 stability

Buschmann, T., Minamoto, T., Wagle, N., Fuchs, S. Y., Adler, V., Mai, M., & Ronai, Z. A. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3387 · Cited by 41

Anatomy of Mdm2 and Mdm4 in evolution

Tan, B. X., Liew, H. P., Chua, J. S., Ghadessy, F. J., Tan, Y. S., Lane, D. P., & Coffill, C. R. (2017) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjx002 · Cited by 40

Mechanisms of Mutant p53 Stabilization in Cancer

Frum, R. A., & Grossman, S. R. (2014) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-017-9211-0_10 · Cited by 44

Altered Expression of the Cell Cycle Regulatory Molecules pRb, p53 and MDM2 Exert a Synergetic Effect on Tumor Growth and Chromosomal Instability in Non-small Cell Lung Carcinomas (NSCLCs)

Gorgoulis, V. G., Zacharatos, P., Kotsinas, A., Mariatos, G., Liloglou, T., Vogiatzi, T., Foukas, P., Rassidakis, G. Z., Garinis, G. A., Ioannides, T., et al. (2000) · Molecular Medicine · doi:10.1007/bf03402115 · Cited by 38

MdmX inhibits Smad transactivation

Kadakia, M., Brown, T. L., McGorry, M. M., & Berberich, S. J. (2002) · Oncogene · doi:10.1038/sj.onc.1205993 · Cited by 39

Three Conformational States of the p300 CH1 Domain Define Its Functional Properties

Dial, R., Sun, Z., & Freedman, S. J. (2003) · Biochemistry · doi:10.1021/bi034989o · Cited by 38

A Novel Sulindac Derivative Inhibits Lung Adenocarcinoma Cell Growth through Suppression of Akt/mTOR Signaling and Induction of Autophagy

Gurpinar, E., Grizzle, W. E., Shacka, J. J., Mader, B. J., Nan, L., Piazza, N. A., Russo, S. M., Keeton, A. B., & Piazza, G. A. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-0785 · Cited by 39

Apoptosis in cerebellar granule neurons is associated with reduced interaction between CREB‐binding protein and NF‐κB

Yalcin, A., Koulich, E., Mohamed, S. A., Liu, L., & D’Mello, S. R. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01540.x · Cited by 40

An Intrinsically Disordered Region of the Acetyltransferase p300 with Similarity to Prion-Like Domains Plays a Role in Aggregation

Kirilyuk, A., Shimoji, M., Catania, J., Sahu, G., Pattabiraman, N., Giordano, A., Albanese, C., Mocchetti, I., Toretsky, J. A., Uversky, V. N., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048243 · Cited by 38

Proapoptotic p53-Interacting Protein 53BP2 Is Induced by UV Irradiation but Suppressed by p53

Lopez, C. D., Ao, Y., Rohde, L. H., Perez, T. D., O’Connor, D. J., Lü, X., Ford, J. M., & Naumovski, L. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.8018-8025.2000 · Cited by 38

Stabilization of p53 in Human Cytomegalovirus-initiated Cells Is Associated with Sequestration of HDM2 and Decreased p53 Ubiquitination

Chen, Z., Knutson, E. P., Wang, S., Martinez, L. A., & Albrecht, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705349200 · Cited by 37

SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity

Mizuguchi, Y., Specht, S. M., Lunz, J. G., Isse, K., Corbitt, N., Takizawa, T., & Demetris, A. J. (2012) · BMC Molecular Biology · doi:10.1186/1471-2199-13-20 · Cited by 37

Coordinate regulation of estrogen receptor β degradation by Mdm2 and CREB-binding protein in response to growth signals

Sanchez, M., Picard, N., Sauvé, K., & Tremblay, A. (2012) · Oncogene · doi:10.1038/onc.2012.19 · Cited by 37

Splicing Up Mdm2 for Cancer Proteome Diversity

Okoro, D. R., Rosso, M., & Bargonetti, J. (2012) · Genes & Cancer · doi:10.1177/1947601912455323 · Cited by 36

Transmissible gastroenteritis virus infection induces cell apoptosis via activation of p53 signalling

Huang, Y., Ding, L., Li, Z., Dai, M., Zhao, X., Li, W., Du, Q., Xu, X., & Tong, D. (2013) · Journal of General Virology · doi:10.1099/vir.0.051557-0 · Cited by 36

The coactivators p300 and CBP have different functions during the differentiation of F9 cells

Ugai, H., Uchida, K., Kawasaki, H., & Yokoyama, K. K. (1999) · Journal of Molecular Medicine · doi:10.1007/s001099900021 · Cited by 37

Double null cells reveal that CBP and p300 are dispensable for p53 targetsp21andMdm2but variably required for target genes of other signaling pathways

Kasper, L. H., Thomas, M. C., Zambetti, G. P., & Brindle, P. K. (2011) · Cell Cycle · doi:10.4161/cc.10.2.14542 · Cited by 34

Retinoblastoma protein modulates gankyrin–MDM2 in regulation of p53 stability and chemosensitivity in cancer cells

Qiu, W., Wu, J., Walsh, E. M., Zhang, Y., Chen, C. Y., Fujita, J., & Xiao, Z.-X. J. (2008) · Oncogene · doi:10.1038/onc.2008.43 · Cited by 35

The C/H3 Domain of p300 Is Required to Protect VRK1 and VRK2 from their Downregulation Induced by p53

Valbuena, A., Blanco, S., Vega, F. M. D. L., & Lazo, P. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002649 · Cited by 34

Effects of Depletion of CREB-binding Protein on c-Myc Regulation and Cell Cycle G1-S Transition

Rajabi, H. N., Baluchamy, S., Kolli, S., Nag, A., Srinivas, R., Raychaudhuri, P., & Thimmapaya, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408633200 · Cited by 34

Dual Role of p300 in the Regulation of p53 Stability

Kawai, H., Nie, L., Wiederschain, D., & Yuan, Z.-M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107770200 · Cited by 35

Chromatin modifiers and tumor suppression

Klochendler‐Yeivin, A., & Yaniv, M. (2001) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(01)00021-x · Cited by 36

The contribution of the RING finger domain of MDM2 to cell cycle progression

Argentini, M., Barboule, N., & Wasylyk, B. (2000) · Oncogene · doi:10.1038/sj.onc.1203737 · Cited by 35

Matrix Metalloproteinase-9 Regulates Survival of Neurons in Newborn Hippocampus

Murase, S., & McKay, R. D. G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.297671 · Cited by 36

c-Myc-induced Aberrant DNA Synthesis and Activation of DNA Damage Response in p300 Knockdown Cells

Natesan, S., Kadeppagari, R., & Thimmapaya, B. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900776200 · Cited by 32

Targeting of p300/CREB Binding Protein Coactivators by Simian Virus 40 Is Mediated through p53

Borger, D. R., & DeCaprio, J. A. (2006) · Journal of Virology · doi:10.1128/jvi.80.9.4292-4303.2006 · Cited by 36

pRB-Dependent, J Domain-Independent Function of Simian Virus 40 Large T Antigen in Override of p53 Growth Suppression

Gjoerup, O. V., Chao, H. H., DeCaprio, J. A., & Roberts, T. M. (2000) · Journal of Virology · doi:10.1128/jvi.74.2.864-874.2000 · Cited by 33

Endogenous Human MDM2-C Is Highly Expressed in Human Cancers and Functions as a p53-Independent Growth Activator

Okoro, D. R., Arva, N. C., Gao, C., Polotskaia, A., Puente, C., Rosso, M., & Bargonetti, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077643 · Cited by 32

Corepressor CtBP1 interacts with and specifically inhibits CBP activity

Senyuk, V. I., Sinha, K. K., & Nucifora, G. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2005.06.024 · Cited by 33

Wild-type and cancer-related p53 proteins are preferentially degraded by MDM2 as dimers rather than tetramersPreprint

Katz, C., Low-Calle, A. M., Choe, J. H., Laptenko, O., Tong, D., Joseph-Chowdhury, J.-S. N., Garofalo, F., Zhu, Y. Y., Friedler, A., & Prives, C. L. (2018) · Genes & Development · doi:10.1101/gad.304071.117 · Cited by 32

4-Hydroxyestrone, an Endogenous Estrogen Metabolite, Can Strongly Protect Neuronal Cells Against Oxidative Damage

Choi, H. J., Lee, A. J., Kang, K. S., Song, J. H., & Zhu, B. T. (2020) · Scientific Reports · doi:10.1038/s41598-020-62984-y · Cited by 29

CITED2 and the modulation of the hypoxic response in cancer

Fernandes, M. T., Calado, S. M., Mendes-Silva, L., & Bragança, J. (2020) · World Journal of Clinical Oncology · doi:10.5306/wjco.v11.i5.260 · Cited by 30

Differential Recognition of Phosphorylated Transactivation Domains of p53 by Different p300 Domains

Polley, S., Guha, S., Roy, N. S., Kar, S., Sakaguchi, K., Chuman, Y., Swaminathan, V., Kundu, T. K., & Roy, S. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.11.082 · Cited by 31

Modulation of p53 function in cellular regulation

Appella, E. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02224.x · Cited by 31

Knockdown of Akt1 Promotes Akt2 Upregulation and Resistance to Oxidative-Stress-Induced Apoptosis Through Control of Multiple Signaling Pathways

Zhang, L., Sun, S., Zhou, J., Liu, J., Lv, J.-H., Yu, X.-Q., Li, C., Gong, L., Yan, Q., Deng, M., et al. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3560 · Cited by 30

The histone acetyltransferases CBP/p300 are degraded in NIH 3T3 cells by activation of Ras signalling pathway

Sánchez-Molina, S., Oliva, J. L., Garcı́a-Vargas, S., Valls, E., Rojas, J. M., & Martínez‐Balbás, M. A. (2006) · Biochemical Journal · doi:10.1042/bj20060052 · Cited by 30

Identification of Acidic and Aromatic Residues in the Zta Activation Domain Essential for Epstein-Barr Virus Reactivation

Deng, Z., Chen, C., Zerby, D., Delecluse, H., & Lieberman, P. M. (2001) · Journal of Virology · doi:10.1128/jvi.75.21.10334-10347.2001 · Cited by 30

The P53 Pathway: Targets for the Development of Novel Cancer Therapeutics

Wang, S., & El‐Deiry, W. S. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/1-4020-7847-1_9 · Cited by 28

Constitutive mdmx Expression During Cell Growth, Differentiation, and DNA Damage

Jackson, M. W., & Berberich, S. J. (1999) · DNA and Cell Biology · doi:10.1089/104454999314971 · Cited by 27

Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters

Mungamuri, S. K., Wang, S., Manfredi, J. J., Gu, W., & Aaronson, S. A. (2014) · Oncogene · doi:10.1038/onc.2014.198 · Cited by 24

Defective p53 Post-translational Modification Required for Wild Type p53 Inactivation in Malignant Epithelial Cells with mdm2 Gene Amplification

Knights, C. D., Liu, Y., Appella, E., & Kulesz-Martin, M. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300279200 · Cited by 25

Downstream and Intermediate Interactions of Synovial Sarcoma-Associated Fusion Oncoproteins and Their Implication for Targeted Therapy

Przybył, J., Jurkowska, M., Rutkowski, P. L., Dêbiec‐Rychter, M., & SIEDLECKI, J. A. (2012) · Sarcoma · doi:10.1155/2012/249219 · Cited by 24

Mdm2 Regulates Estrogen Receptor and Estrogen-responsiveness in Breast Cancer Cells

Kim, K., Burghardt, R. C., Barhoumi, R., Lee, S., Liu, X., & Safe, S. H. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-10-0110 · Cited by 24

A New Model for Developmental Neuronal Death and Excitatory/Inhibitory Balance in Hippocampus

Murase, S. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8521-8 · Cited by 23

Apoptosis of tumoral and nontumoral lymphoid cells is induced by both mdm2 and p53 antisense oligodeoxynucleotides

Métay, C., Mir, L. M., Carlier, K., Lécluse, Y., Tétaud, C., Mishal, Z., & Wiels, J. (2001) · Blood · doi:10.1182/blood.v97.4.1043 · Cited by 23

Induction of endoreduplication by a JNK inhibitor SP600125 in human lung carcinoma A 549 cells

Yamasaki-Miyamoto, Y., Yamasaki, M., Tachibana, H., & Yamada, K. (2007) · Cell Biology International · doi:10.1016/j.cellbi.2007.07.002 · Cited by 23

The dual function steroid receptor coactivator/ubiquitin protein-ligase integrator E6-AP is overexpressed in mouse mammary tumorigenesis

Sivaraman, L., Nawaz, Z., Medina, D., Conneely, O. M., & O’Malley, B. W. (2000) · Breast Cancer Research and Treatment · doi:10.1023/a:1006410111706 · Cited by 22

Pcid2 Inactivates Developmental Genes in Human and Mouse Embryonic Stem Cells to Sustain Their Pluripotency by Modulation of EID1 Stability

Ye, B., Dai, Z., Liu, B., Wang, R., Li, C., Huang, G., Wang, S., Xia, P., Yang, X., Kuwahara, K., et al. (2013) · Stem Cells · doi:10.1002/stem.1580 · Cited by 22

Extracellular Matrix Enhances Heregulin-Dependent BRCA1 Phosphorylation and Suppresses BRCA1 Expression through Its C Terminus

Miralem, T., & Avraham, H. K. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.2.579-593.2003 · Cited by 21

Mdm2–SUMO1: is bigger better?

Melchior, F., & Hengst, L. (2000) · Nature Cell Biology · doi:10.1038/35023639 · Cited by 22

Preconditioning-Activated AKT Controls Neuronal Tolerance to Ischemia through the MDM2–p53 Pathway

Barrio, E., Vecino, R., Sánchez‐Morán, I., Rodríguez, C., Suárez-Pindado, A., Bolaños, J. P., Almeida, Á., & Delgado‐Esteban, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147275 · Cited by 21

S100A6 Competes with the TAZ2 Domain of p300 for Binding to p53 and Attenuates p53 Acetylation

Graczyk‐Jarzynka, A., Słomnicki, Ł. P., & Leśniak, W. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.06.007 · Cited by 21

Whole-exome sequencing to identify novel somatic mutations in squamous cell lung cancers

Zheng, C., Gu, Z., Han, B., Zhang, R., Pan, C., Xiang, Y., Rong, X., Chen, X., LI, Q.-Y., & Wan, H. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1991 · Cited by 21

Lessons from interconnected ubiquitylation and acetylation of p53: think metastable networks

Benkirane, M., Sardet, C., & Coux, O. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380098 · Cited by 24

Oligosaccharide G19 inhibits U-87 MG human glioma cells growth in vitro and in vivo by targeting epidermal growth factor (EGF) and activating p53/p21 signaling

Liu, H., Zhou, L., Shi, S., Wang, Y., Ni, X., Xiao, F., Wang, S., Li, P., & Ding, K. (2014) · Glycobiology · doi:10.1093/glycob/cwu038 · Cited by 21

The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors

Kannan, S., Partridge, A. W., Lane, D. P., & Verma, C. S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20235996 · Cited by 21

RUNX3 Meets the Ubiquitin-Proteasome System in Cancer

Toska, A., Modi, N., & Chen, L. (2023) · Cells · doi:10.3390/cells12050717 · Cited by 20

Cholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation

Qin, Q., Liao, G., Baudry, M., & Bi, X. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009999 · Cited by 20

Interactions with p300 enhance transcriptional activation by the PDZ-domain coactivator Bridge-1.

Lee, J. H., Volinic, J. L., Banz, C., Yao, K.-M., & Thomas, M. K. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06305 · Cited by 21

Mdm2 Mutant Defective in Binding p300 Promotes Ubiquitination but Not Degradation of p53

Zhu, Q., Yao, J., Wani, G., Wani, M. A., & Wani, A. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102634200 · Cited by 57

Analysis of the degradation function of Mdm2.

Kubbutat, M. H. G., Ludwig, R., Levine, A. J., & Vousden, K. H. (1999) · PubMed · Cited by 102

Dual Role of p300 in the Regulation of p53 Stability

Kawai, H., Nie, L., Wiederschain, D., & Yuan, Z.-M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107770200 · Cited by 35

Polyubiquitination of p53 by a Ubiquitin Ligase Activity of p300

Grossman, S. R., Deato, M. D. E., Brignone, C., Chan, H. M., Kung, A. L., Tagami, H., Nakatani, Y., & Livingston, D. M. (2003) · Science · doi:10.1126/science.1080386 · Cited by 454

The CBP/p300 TAZ1 domain in its native state is not a binding partner of MDM2

Dunzendorfer-Matt, T., Martinez‐Yamout, M. A., Dyson, H. J., & Wright, P. E. (2004) · Biochemical Journal · doi:10.1042/bj20040564 · Cited by 42