Cited by 359BRCA gene mutations in cancerDNA Repair MechanismsPARP inhibition in cancer therapy

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Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

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Scully, Ralph, Ganesan, Shridar, Vlasakova, Katerina, Chen, Junjie, Socolovsky, Merav, Livingston, David M·1999·Molecular Cell

DOI 10.1016/s1097-2765(00)80238-5

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Abstract

Retrovirally expressed, wild-type BRCA1 decreased the gamma radiation (IR) sensitivity and increased the efficiency of double-strand DNA break repair (DSBR) of the BRCA1-/- human breast cancer line, HCC1937. It also reduced its susceptibility to DSB generation by IR. By contrast, multiple, clinically validated, missense mutant BRCA1 products were nonfunctional in these assays. These data constitute the basis for a BRCA1 functional assay and suggest that efficient repair of double-strand DNA breaks is linked to BRCA1 tumor suppression function.

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BRCA1 required for transcription-coupled repair of oxidative DNA damage
Gowen, L. C., Avrutskaya, A. V., Latour, A. M., Koller, B. H., & Leadon, S. A. (1998) · Science · doi:10.1126/science.281.5379.1009 · Cited by 496
Retracted
Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells
Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459
Self-citation
Brca1 Controls Homology-Directed DNA Repair
Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80202-6 · Cited by 1,245
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,087
Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks
Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900
Self-citation
Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells
Xu, X., Ohler, Z. W., Linke, S. P., Li, C., Gotay, J., Wang, X. W., Harris, C. C., Ried, T., & Deng, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80466-9 · Cited by 819
Radiosensitivity in ataxia-telangiectasia: a new explanation.
Painter, R. B., & Young, B. R. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7315 · Cited by 795
Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?
Lü, X. (1993) · Cell · doi:10.1016/0092-8674(93)90496-d · Cited by 773
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
Xu, X., Wagner, K., Larson, D. M., Ohler, Z. W., Li, C., Ried, T., Hennighausen, L. G., Wynshaw-Boris, A. J., & Deng, C. (1999) · Nature Genetics · doi:10.1038/8743 · Cited by 766
Identification of a RING protein that can interact in vivo with the BRCA1 gene product
Wu, L. C., Wang, Z. W., Tsan, J. T., Spillman, M. A., Phung, A., Xu, X. L., Yang, M.-C. W., Hwang, L.-Y., Bowcock, A. M., & Baer, R. J. (1996) · Nature Genetics · doi:10.1038/ng1296-430 · Cited by 743
Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice
Socolovsky, M., Fallon, A. E. J., Wang, S., Brugnara, C., & Lodish, H. F. (1999) · Cell · doi:10.1016/s0092-8674(00)81013-2 · Cited by 708
Self-citation
The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.
Hakem, R., de la Pompa, J. L., Sirard, C., Mo, R., Woo, M., Hakem, A., Wakeham, A., Potter, J., Reitmair, A., Billia, F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81302-1 · Cited by 680
Involvement of Brca2 in DNA Repair
Patel, K. J., Yu, V. P. C. C., Lee, H., Corcoran, A. E., Thistlethwaite, F. C., Evans, M. J., Colledge, W. H., Friedman, L. S., Ponder, B. A. J., & Venkitaraman, A. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80035-0 · Cited by 646
Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells
Chen, J., Silver, D. P., Walpita, D., Cantor, S. B., Gazdar, A. F., Tomlinson, G. E., Couch, F. J., Weber, B. L., Ashley, T., Livingston, D. M., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80276-2 · Cited by 635
Self-citation
Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response
Zhong, Q., Chen, C.-F., Li, S., Chen, Y., Wang, C.-C., Xiao, J., Chen, P.-L., Sharp, Z. D., & Lee, W.-H. (1999) · Science · doi:10.1126/science.285.5428.747 · Cited by 626
Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1
Harkin, D. P., Bean, J. M., Miklos, D. B., Song, Y., Truong, V. B., Englert, C., Christians, F. C., Ellisen, L. W., Maheswaran, S., Oliner, J. D., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80769-2 · Cited by 562
Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.Preprint
Ludwig, T. E., Chapman, D. L., Papaioannou, V. E., & Efstratiadis, A. (1997) · Genes & Development · doi:10.1101/gad.11.10.1226 · Cited by 539
Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiPl
Somasundaram, K., Zhang, H., Zeng, Y., Houvras, Y. J., Peng, Y., Zhang, H., Wu, G. S., Licht, J. D., Weber, B. L., & El‐Deiry, W. S. (1997) · Nature · doi:10.1038/38291 · Cited by 509
BRCA1 is a component of the RNA polymerase II holoenzyme
Scully, R., Anderson, S. F., Chao, D. M., Wei, W., Ye, L., Young, R. A., Livingston, D. M., & Parvin, J. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5605 · Cited by 454
Self-citation
Evidence for a transcriptional activation function of BRCA1 C-terminal region
Monteiro, Á. N. A., August, A., & Hanafusa, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13595 · Cited by 447
Transcriptional activation by BRCA1
Chapman, M. S., & Verma, I. M. (1996) · Nature · doi:10.1038/382678a0 · Cited by 435
Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
Connor, F., Bertwistle, D., Mee, P. J., Ross, G. M., Swift, S., Grigorieva, E. F., Tybulewicz, V. L. J., & Ashworth, A. (1997) · Nature Genetics · doi:10.1038/ng1297-423 · Cited by 432
The C-terminal (BRCT) Domains of BRCA1 Interact in Vivo with CtIP, a Protein Implicated in the CtBP Pathway of Transcriptional Repression
Yu, X., Wu, L. C., Bowcock, A. M., Aronheim, A., & Baer, R. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.39.25388 · Cited by 389
A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability
Shen, S.-X., Ohler, Z. W., Xu, X., Li, C., Weinstein, M. B., Chen, L., Guan, X., Ried, T., & Deng, C. (1998) · Oncogene · doi:10.1038/sj.onc.1202243 · Cited by 329
Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier.
Tomlinson, G. E., Chen, T. T., Stastny, V., Virmani, A. K., Spillman, M. A., Tonk, V. S., Blum, J. L., Schneider, N. R., Wistuba, I. I., Shay, J. W., et al. (1998) · PubMed · Cited by 292
Synergistic cooperation of TFE3 and Smad proteins in TGF-β-induced transcription of the plasminogen activator inhibitor-1 genePreprint
Hua, X., Liu, X., Ansari, D. O., & Lodish, H. F. (1998) · Genes & Development · doi:10.1101/gad.12.19.3084 · Cited by 283
Partial rescue of Brca15–6 early embryonic lethality by p53 or p21 null mutation
Hakem, R., de la Pompa, J. L., Elia, A., Potter, J., & Mak, T. W. (1997) · Nature Genetics · doi:10.1038/ng0797-298 · Cited by 252
BRCA1 Expression Restores Radiation Resistance in BRCA1-defective Cancer Cells through Enhancement of Transcription-coupled DNA Repair
Abbott, D. W., Thompson, M. E., Robinson‐Benion, C., Tomlinson, G. E., Jensen, R. A., & Holt, J. T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18808 · Cited by 228
Location of BRCA1 in Human Breast and Ovarian Cancer Cells
Scully, R., Ganesan, S., Brown, M. A., Caprio, J. A. D., Cannistra, S. A., Feunteun, J., Schnitt, S. J., & Livingston, D. M. (1996) · Science · doi:10.1126/science.272.5258.123 · Cited by 217
Self-citation
Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-Δ11b
Wilson, C., Payton, M. N., Elliott, G., Buaas, F. W., Cajulis, E. E., Grosshans, D. R., Ramos, L., Reese, D., Slamon, D. J., & Calzone, F. J. (1997) · Oncogene · doi:10.1038/sj.onc.1200924 · Cited by 193
Radiosensitivity in ataxia-telangiectasia
Cunliffe, P. N., Mann, J. R., Cameron, A., Roberts, K. D., & Ward, H. W. C. (1975) · British Journal of Radiology · doi:10.1259/0007-1285-48-569-374 · Cited by 189
Induction of apoptosis by the tumor suppressor protein BRCA1.
Shao, N., Chai, Y. L., Shyam, E., Reddy, P., & Rao, V. N. (1996) · PubMed · Cited by 137
Induction and Rejoining of DNA Double-Strand Breaks and Interphase Chromosome Breaks after Exposure to X Rays in One Normal and Two Hypersensitive Human Fibroblast Cell Lines
Badie, C., Iliakis, G. E., Foray, N., Alsbeih, G., Cedervall, B., Chavaudra, N., Pantelias, G. E., Arlett, C. F., & Malaise, E. P. (1995) · Radiation Research · doi:10.2307/3579232 · Cited by 104
The Prolactin Receptor and Severely Truncated Erythropoietin Receptors Support Differentiation of Erythroid Progenitors
Socolovsky, M., Dusanter‐Fourt, I., & Lodish, H. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.22.14009 · Cited by 93
Self-citation
Mammary tumor formation in p53- and BRCA1-deficient mice.
Cressman, V. L., Backlund, D. C., Hicks, E., Gowen, L. C., Godfrey, V., & Koller, B. H. (1999) · PubMed · Cited by 82
Radiation-induced DNA double-strand breaks and the radiosensitivity of human cells: A closer look
Foray, N., Arlett, C. F., & Malaise, E. P. (1997) · Biochimie · doi:10.1016/s0300-9084(97)82005-6 · Cited by 68
SYBR Green I staining of pulsed field agarose gels is a sensitive and inexpensive way of quantitating DNA double-strand breaks in mammalian cells
Kiltie, A. E. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.14.2945 · Cited by 53
Structural changes in chromatin as the basis for radiosensitivity in ataxia telangiectasia
Painter, R. B. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000131738 · Cited by 39
Relationship between a chromatin anomaly in ataxia-telangiectasia cells and enhanced sensitivity to DNA damage
Smith, P. J. (1984) · Carcinogenesis · doi:10.1093/carcin/5.10.1345 · Cited by 35
Induction and Repair of DNA Double-Strand Breaks
Nevaldine, B. H., Longo, J. A., King, G. A., Vilenchik, M. M., Sagerman, R. H., & Hahn, P. J. (1993) · Radiation Research · doi:10.2307/3578224 · Cited by 31
Update on breast cancer susceptibility genes.
Weber, B. (1998) · Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · doi:10.1007/978-3-642-45769-2_5 · Cited by 27

Sorted by citations

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Involvement of the TIP60 Histone Acetylase Complex in DNA Repair and Apoptosis
Ikura, T., Ogryzko, V. V., Grigoriev, M., Groisman, R., Wang, J., Horikoshi, M., Scully, R., Qin, J., & Nakatani, Y. (2000) · Cell · doi:10.1016/s0092-8674(00)00051-9 · Cited by 1,029
Self-citation

See all 359

Authors: Scully, R., Ganesan, S., Vlasakova, K., Chen, J., Socolovsky, M., & Livingston, D. M.
Affiliations: Harvard University (US)
Massachusetts Institute of Technology (US)
Corresponding author: Livingston, David M
ORCID: Scully, Ralph
Ganesan, Shridar
Chen, Junjie
Socolovsky, Merav
Livingston, David M
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 1999-12
Volume: 4
Issue: 6
Pages: 1093-1099
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/s1097-2765(00)80238-5
OpenAlex: W1976960697
Cited by: 359
References: 45
Citations by year: 2026: 3 · 2025: 3 · 2024: 2 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 10 · 2019: 8 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 13 · 2014: 14 · 2013: 13 · 2012: 13
FWCI: 11.84
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4977 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (P01HL032262, HL-32262)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: BRCA1, DNA double-strand break repair, radiosensitivity, missense mutations, tumor suppression, retroviral gene expression, functional assays
MeSH terms: Breast Neoplasms, DNA Repair, Female, Genetic Vectors, Humans, Radiation Tolerance, Retroviridae, Tumor Cells, Cultured, Gene Expression Regulation, Neoplastic, Gene Transfer Techniques, BRCA1 Protein

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Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

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