Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459

Brca1 Controls Homology-Directed DNA Repair

Moynahan, M. E., Chiu, J. W., Koller, B. H., & Jasin, M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80202-6 · Cited by 1,245

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,087

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

Xu, X., Ohler, Z. W., Linke, S. P., Li, C., Gotay, J., Wang, X. W., Harris, C. C., Ried, T., & Deng, C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80466-9 · Cited by 819

Radiosensitivity in ataxia-telangiectasia: a new explanation.

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Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

Lü, X. (1993) · Cell · doi:10.1016/0092-8674(93)90496-d · Cited by 773

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

Xu, X., Wagner, K., Larson, D. M., Ohler, Z. W., Li, C., Ried, T., Hennighausen, L. G., Wynshaw-Boris, A. J., & Deng, C. (1999) · Nature Genetics · doi:10.1038/8743 · Cited by 766

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

Bunting, S. F., Callén, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.012 · Cited by 1,671

DNA double-strand break repair-pathway choice in somatic mammalian cells

Scully, R., Panday, A., Elango, R., & Willis, N. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0152-0 · Cited by 1,542

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221

Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

Garcia-Higuera, I., Taniguchi, T., Ganesan, S., Meyn, M. S., Timmers, C., Hejna, J., Grompe, M., & D'Andrea, A. D. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00173-3 · Cited by 1,198

Involvement of the TIP60 Histone Acetylase Complex in DNA Repair and Apoptosis

Ikura, T., Ogryzko, V. V., Grigoriev, M., Groisman, R., Wang, J., Horikoshi, M., Scully, R., Qin, J., & Nakatani, Y. (2000) · Cell · doi:10.1016/s0092-8674(00)00051-9 · Cited by 1,029

Efficacy of Neoadjuvant Cisplatin in Triple-Negative Breast Cancer

Silver, D. P., Richardson, A. L., Eklund, A. C., Wang, Z. C., Szállási, Z., Li, Q., Birkbak, N. J., Leong, C.-O., Calogrias, D., Buraimoh, A., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.4725 · Cited by 982

BRCA1 and BRCA2: 1994 and beyond

Narod, S. A., & Foulkes, W. D. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1431 · Cited by 967

Relevance of Breast Cancer Cell Lines as Models for Breast Tumours: An Update

Lacroix, M., & Leclercq, G. (2004) · Breast Cancer Research and Treatment · doi:10.1023/b:brea.0000014042.54925.cc · Cited by 805

Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage

Yoshida, K., & Miki, Y. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb02195.x · Cited by 753

BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function

Cantor, S. B., Bell, D. W., Ganesan, S., Kass, E. M., Drapkin, R., Grossman, S., Wahrer, D. C. R., Sgroi, D. C., Lane, W. S., Haber, D. A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00304-x · Cited by 674

In search of the tumour-suppressor functions of BRCA1 and BRCA2

Scully, R., & Livingston, D. M. (2000) · Nature · doi:10.1038/35044000 · Cited by 643

BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution

Deng, C. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl010 · Cited by 604

The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin

Bhattacharyya, A., Ear, U., Koller, B. H., Weichselbaum, R. R., & Bishop, D. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000276200 · Cited by 584

Regulation and mechanisms of mammalian double-strand break repair

Valerie, K. C., & Povirk, L. F. (2003) · Oncogene · doi:10.1038/sj.onc.1206679 · Cited by 594

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

Zhang, F., Ma, J., Wu, J., Ye, L., Cai, H., Xia, B., & Yu, X. (2009) · Current Biology · doi:10.1016/j.cub.2009.02.018 · Cited by 575

BRCA1 Is Associated with a Human SWI/SNF-Related Complex

Bochar, D. A., Wang, L., Beniya, H., Kinev, A. V., Xue, Y., Lane, W. S., Wang, W., Kashanchi, F., & Shiekhattar, R. (2000) · Cell · doi:10.1016/s0092-8674(00)00030-1 · Cited by 546

Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

Lee, J.-H., & Paull, T. T. (2007) · Oncogene · doi:10.1038/sj.onc.1210872 · Cited by 545

Involvement of Brca1 in S-Phase and G 2 -Phase Checkpoints after Ionizing Irradiation

Xu, B., Kim, S., & Kastan, M. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3445-3450.2001 · Cited by 550

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Tibbetts, R. S., Cortez, D., Brumbaugh, K. M., Scully, R., Livingston, D., Elledge, S. J., & Abraham, R. T. (2000) · Genes & Development · doi:10.1101/gad.851000 · Cited by 512

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

Yarden, R. I., Pardo-Reoyo, S., Sgagias, M. K., Cowan, K. H., & Brody, L. C. (2002) · Nature Genetics · doi:10.1038/ng837 · Cited by 483

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

Wu, X., Ranganathan, V., Weisman, D., Heine, W. F., Ciccone, D. N., O'Neill, T. B., Crick, K. E., Pierce, K. A., Lane, W. S., Rathbun, G. A., et al. (2000) · Nature · doi:10.1038/35013089 · Cited by 449

Homologous recombinational repair of DNA ensures mammalian chromosome stability

Thompson, L. H., & Schild, D. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00115-4 · Cited by 435

miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors

Moskwa, P., Buffa, F. M., Pan, Y., Panchakshari, R. A., Gottipati, P., Muschel, R. J., Beech, J. S., Kulshrestha, R., Abdelmohsen, K., Weinstock, D. M., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.12.005 · Cited by 436

Mutation in Brca2 stimulates error‐prone homology‐directed repair of DNA double‐strand breaks occurring between repeated sequences

Tutt, A. N. J., Bertwistle, D., Valentine, J., Gabriel, A., Swift, S., Ross, G., Griffin, C. S., Thacker, J., & Ashworth, A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4704 · Cited by 429

Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair

Chen, L., Nievera, C. J., Lee, A. Y., & Wu, X. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710245200 · Cited by 455

Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation.

Moynahan, M. E., Cui, T. Y., & Jasin, M. (2001) · PubMed · Cited by 382

Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation

Powell, S. N., & Kachnic, L. A. (2003) · Oncogene · doi:10.1038/sj.onc.1206678 · Cited by 364

Homologous repair of DNA damage and tumorigenesis:the BRCA connection

Jasin, M. (2002) · Oncogene · doi:10.1038/sj.onc.1206176 · Cited by 363

Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

Ruffner, H., Joazeiro, C. A. P., Hemmati, D., Hunter, T., & Verma, I. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081068398 · Cited by 359

BRCA1-Associated Protein-1 Is a Tumor Suppressor that Requires Deubiquitinating Activity and Nuclear Localization

Ventii, K., Devi, N. S., Friedrich, K. L., Chernova, T. A., Tighiouart, M., Meir, E. G. V., & Wilkinson, K. D. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0365 · Cited by 337

Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair

Zhang, J., Willers, H., Feng, Z., Ghosh, J. C., Kim, S., Weaver, D. T., Chung, J. H., Powell, S. N., & Xia, F. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.708-718.2004 · Cited by 323

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

Wong, K.-K., Chang, S., Weiler, S. R., Ganesan, S., Chaudhuri, J., Zhu, C., Artandi, S. E., Rudolph, K. L., Gottlieb, G. J., Chin, L., et al. (2000) · Nature Genetics · doi:10.1038/79232 · Cited by 309

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

Greenberg, R. A., Sobhian, B., Pathania, S., Cantor, S. B., Nakatani, Y., & Livingston, D. M. (2006) · Genes & Development · doi:10.1101/gad.1381306 · Cited by 308

BRCA1 Supports XIST RNA Concentration on the Inactive X Chromosome

Ganesan, S., Silver, D. P., Greenberg, R. A., Avni, D., Drapkin, R., Miron, A., Mok, S. C., Randrianarison-Huetz, V., Brodie, S. G., Salstrom, J. L., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01052-8 · Cited by 306

Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1.

Williams, R. S., Green, R., & Glover, J. N. M. (2001) · Nature Structural Biology · doi:10.1038/nsb1001-838 · Cited by 292

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

Gorrini, C., Baniasadi, P. S., Harris, I. S., Silvester, J., Inoue, S., Snow, B., Joshi, P. A., Wakeham, A., Molyneux, S. D., Martin, B., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20121337 · Cited by 289

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIPPreprint

Yu, X., Fu, S., Lai, M., Baer, R. J., & Chen, J. (2006) · Genes & Development · doi:10.1101/gad.1431006 · Cited by 302

Regulation of BRCC, a Holoenzyme Complex Containing BRCA1 and BRCA2, by a Signalosome-like Subunit and Its Role in DNA Repair

Dong, Y., Hakimi, M., Chen, X., Kumaraswamy, E., Cooch, N. S., Godwin, A. K., & Shiekhattar, R. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00424-6 · Cited by 279

Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients

Byrski, T., Huzarski, T., Dent, R. A., Marczyk, E., Jasiówka, M., Gronwald, J., Jakubowicz, J., Cybulski, C., Wiśniowski, R., Godlewski, D. D., et al. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-3100-x · Cited by 269

Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

Xia, F., Taghian, D. G., DeFrank, J. S., Zeng, Z., Willers, H., Iliakis, G. E., & Powell, S. N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151253498 · Cited by 263

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

Clapperton, J. A., Manke, I. A., Lowery, D. M., Ho, T., Haire, L. F., Yaffe, M. B., & Smerdon, S. J. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb775 · Cited by 244

The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations

Cantor, S., Drapkin, R., Zhang, F., Lin, Y., Han, J., Pamidi, S., & Livingston, D. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308717101 · Cited by 240

Functions of BRCA1 and BRCA2 in the biological response to DNA damage

Venkitaraman, A. R. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.20.3591 · Cited by 237

The role of BRCA1 in DNA damage response

Wu, J., Lu, L.-Y., & Yu, X. (2010) · Protein & Cell · doi:10.1007/s13238-010-0010-5 · Cited by 235

Distinct Roles of Chromatin-Associated Proteins MDC1 and 53BP1 in Mammalian Double-Strand Break Repair

Xie, A., Hartlerode, A. J., Stucki, M., Odate, S., Puget, N., Kwok, A., Nagaraju, G., Yan, C. T., Alt, F. W., Chen, J., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.12.005 · Cited by 242

Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1

Williams, R. S., Lee, M. S., Hau, D. D., & Glover, J. N. M. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb776 · Cited by 230

The BRCA1-RAP80 Complex Regulates DNA Repair Mechanism Utilization by Restricting End Resection

Coleman, K. A., & Greenberg, R. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.213728 · Cited by 234

STRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1

Hedgepeth, S. C., Rodriguez, A. M., Snyder, R. R., Hankins, G. D. V., & Boehning, D. F. (2012) · Computational and Structural Biotechnology Journal · doi:10.5936/csbj.201204005 · Cited by 237

The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers

Paul, A. (2014) · Frontiers in bioscience · doi:10.2741/4230 · Cited by 224

Interactions between BRCT repeats and phosphoproteins: tangled up in two

Glover, J. N. M., Williams, R. S., & Lee, M. S. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.09.010 · Cited by 212

The Role of the BRCA1 Tumor Suppressor in DNA Double-Strand Break Repair

Zhang, J., & Powell, S. N. (2005) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0192 · Cited by 213

BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations

Ye, Q., Hu, Y.-F., Zhong, H.-J., Nye, A. C., Belmont, A. S., & Li, R. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200108049 · Cited by 204

Lessons learned from BRCA1 and BRCA2

Zheng, L., Li, S., Boyer, T., & Lee, W. (2000) · Oncogene · doi:10.1038/sj.onc.1203968 · Cited by 187

4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone from Cigarette Smoke Stimulates Colon Cancer Growth via β-Adrenoceptors

Wu, W. K. K., Wong, H. P. S., Luo, S. W., Chan, K., Huang, F. Y., Hui, M. K. C., Lam, E. K. Y., Shin, V. Y., Ye, Y. N., Yang, Y. H., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0205 · Cited by 183

Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro

Lee, K., Wang, D., Lippard, S. J., & Sharp, P. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072068399 · Cited by 182

The human decatenation checkpoint

Deming, P. B., Cistulli, C. A., Zhao, H., Graves, P. R., Piwnica-Worms, H. M., Paules, R. S., Downes, C. S., & Kaufmann, W. K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221430898 · Cited by 182

Functional analysis of BRCA1 C-terminal missense mutations identified in breast and ovarian cancer families

Vallon‐Christersson, J. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.4.353 · Cited by 176

RAD51 Up-regulation Bypasses BRCA1 Function and Is a Common Feature of BRCA1 -Deficient Breast Tumors

Martin, R. W., Orelli, B. J., Yamazoe, M., Minn, A. J., Takeda, S., & Bishop, D. K. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0290 · Cited by 177

Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide

Shiozaki, E. N., Gu, L., Yan, N., & Shi, Y. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00238-2 · Cited by 174

The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response

Yan, J., Kim, Y. S., Yang, X.-P., Li, L., Liao, G., Xia, F., & Jetten, A. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0924 · Cited by 177

Analysis ofBRCA1andBRCA2genes in Spanish breast/ovarian cancer patients: A high proportion of mutations unique to Spain and evidence of founder effects

Dı́ez, O., Osório, A., Durán, M., Martínez‐Ferrandis, J. I., de la Hoya, M., Salazar, R., Vega, A. I., Campos, B., Rodríguez‐López, R., Velasco, E. A., et al. (2003) · Human Mutation · doi:10.1002/humu.10260 · Cited by 170

BRCA1-BARD1 Complexes Are Required for p53Ser-15 Phosphorylation and a G1/S Arrest following Ionizing Radiation-induced DNA Damage

Fabbro, M., Savage, K. I., Hobson, K., Deans, A. J., Powell, S. N., McArthur, G. A., & Khanna, K. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405372200 · Cited by 169

BRCA1 Directs a Selective p53-Dependent Transcriptional Response towards Growth Arrest and DNA Repair Targets

MacLachlan, T. K., Takimoto, R., & El‐Deiry, W. S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4280-4292.2002 · Cited by 160

Mechanisms of BRCA1 Tumor Suppression

Silver, D. P., & Livingston, D. M. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0221 · Cited by 159

BRCA1/BARD1 Ubiquitinate Phosphorylated RNA Polymerase II

Starita, L. M., Horwitz, A. A., Keogh, M., Ishioka, C., Parvin, J. D., & Chiba, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414020200 · Cited by 156

MERIT40 controls BRCA1–Rap80 complex integrity and recruitment to DNA double-strand breaksPreprint

Shao, G., Patterson-Fortin, J., Messick, T. E., Feng, D., Shanbhag, N. M., Wang, Y., & Greenberg, R. A. (2009) · Genes & Development · doi:10.1101/gad.1739609 · Cited by 153

BRCA1 Facilitates Microhomology-mediated End Joining of DNA Double Strand Breaks

Zhong, Q., Chen, C., Chen, P., & Lee, W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200748200 · Cited by 155

BRCA1 Facilitates Stress-induced Apoptosis in Breast and Ovarian Cancer Cell Lines

Thangaraju, M., Kaufmann, S. H., & Couch, F. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005824200 · Cited by 149

CCDC98 targets BRCA1 to DNA damage sites

Liu, Z., Wu, J., & Yu, X. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1279 · Cited by 148

BRCA1/BARD1 Orthologs Required for DNA Repair in Caenorhabditis elegans

Boulton, S. J., Martin, J. S., Polanowska, J., HILL, D. E., Gartner, A., & Vidal, M. (2004) · Current Biology · doi:10.1016/j.cub.2003.11.029 · Cited by 146

A conserved pathway to activate BRCA1‐dependent ubiquitylation at DNA damage sites

Polanowska, J., Martin, J. S., García‐Muse, T., Petalcorin, M. I. R., & Boulton, S. J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601102 · Cited by 147

Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development

Joukov, V., Chen, J., Fox, E. A., Green, J. B. A., & Livingston, D. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211427098 · Cited by 146

Detection of Protein Folding Defects Caused by BRCA1-BRCT Truncation and Missense Mutations

Williams, R. S., Chasman, D. I., Hau, D., Hui, B., Lau, A. Y., & Glover, J. N. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m310182200 · Cited by 138

Functional Characterization of a Novel BRCA1-Null Ovarian Cancer Cell Line in Response to Ionizing Radiation

DelloRusso, C., Welcsh, P. L., Wang, W., Garcia, R. L., King, M., & Swisher, E. M. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0234 · Cited by 134

Loss of Bard1, the Heterodimeric Partner of the Brca1 Tumor Suppressor, Results in Early Embryonic Lethality and Chromosomal Instability

McCarthy, E. E., Celebi, J. T., Baer, R. J., & Ludwig, T. E. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.14.5056-5063.2003 · Cited by 140

Chromosomal breakage syndromes and the BRCA1 genome surveillance complex

Futaki, M., & Liu, J. M. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02178-5 · Cited by 135

Analysis of the DNA Substrate Specificity of the Human BACH1 HelicaseAssociated with BreastCancer

Gupta, R., Sharma, S., Sommers, J. A., Jin, Z., Cantor, S. B., & Brosh, R. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501995200 · Cited by 131

Hereditary breast cancer

Robson, M. E., Boyd, J. A., Borgen, P. I., & Cody, H. S. (2001) · Current Problems in Surgery · doi:10.1016/s0011-3840(01)70035-4 · Cited by 133

A guide for functional analysis ofBRCA1variants of uncertain significance

Millot, G. A., Carvalho, M. A., Caputo, S. M., Vreeswijk, M. P. G., Brown, M. A., Webb, M., Rouleau, É., Neuhausen, S. L., Hansen, T. V. O., Galli, A., et al. (2012) · Human Mutation · doi:10.1002/humu.22150 · Cited by 140

Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts.

Zhong, Q., Boyer, T., Chen, P., & Lee, W. (2002) · PubMed · Cited by 128

A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway

Aglipay, J. A., Lee, S. W., Okada, S., Fujiuchi, N., Ohtsuka, T., Kwak, J. C., Wang, Y., Johnstone, R. W., Deng, C., Qin, J., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1207057 · Cited by 129

MiR-96 Downregulates REV1 and RAD51 to Promote Cellular Sensitivity to Cisplatin and PARP Inhibition

Wang, Y., Huang, J., Calses, P. C., Kemp, C. J., & Taniguchi, T. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0103 · Cited by 127

Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study

Borg, Å., Haile, R. W., Malone, K. E., Capanu, M., Diep, A., Törngren, T., Teraoka, S. N., Begg, C. B., Thomas, D. C., CONCANNON, P. J., et al. (2010) · Human Mutation · doi:10.1002/humu.21202 · Cited by 128

Identification of genes induced by BRCA1 in breast cancer cells

Atalay, A., Crook, T. J., Öztürk, M., & Yuluğ, I. G. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02751-1 · Cited by 126

Functional Evaluation and Cancer Risk Assessment of BRCA2 Unclassified Variants

Wu, K., Hinson, S. R., Ohashi, A., Farrugia, D. J., Wendt, P., Tavtigian, S. V., Deffenbaugh, A. M., Goldgar, D. E., & Couch, F. J. (2005) · Cancer Research · doi:10.1158/0008-5472.417.65.2 · Cited by 125

BRCA1 Is Required for Postreplication Repair after UV-Induced DNA Damage

Pathania, S., Nguyen, J., Hill, S. J., Scully, R., Adelmant, G., Marto, J. A., Feunteun, J., & Livingston, D. M. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.09.002 · Cited by 125

Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.

Wang, H., Zeng, Z., Bui, T. A., DiBiase, S. J., Qin, W., Xia, F., Powell, S. N., & Iliakis, G. E. (2001) · PubMed · Cited by 119

BRCA1 interacts directly with the Fanconi anemia protein FANCA

Folias, A. E. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.21.2591 · Cited by 118

BARD1 Participates with BRCA1 in Homology-Directed Repair of Chromosome Breaks

Westermark, U., Reyngold, M., Olshen, A. B., Baer, R. J., Jasin, M., & Moynahan, M. E. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7926-7936.2003 · Cited by 120

Checkpoint Kinase 2–Mediated Phosphorylation of BRCA1 Regulates the Fidelity of Nonhomologous End-Joining

Zhuang, J., Zhang, J., Willers, H., Wang, H., Chung, J. H., van Gent, D. C., Hallahan, D. E., Powell, S. N., & Xia, F. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3278 · Cited by 119

New complexities for BRCA1 and BRCA2

Kerr, P., & Ashworth, A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00389-x · Cited by 117

Impaired DNA Damage Response in Cells Expressing an Exon 11-Deleted Murine Brca1 Variant That Localizes to Nuclear Foci

Huber, L. J., Yang, T. W., Sarkisian, C. J., Master, S. R., Deng, C., & Chodosh, L. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.12.4005-4015.2001 · Cited by 112

Activation of BRCA1/BRCA2-Associated Helicase BACH1 Is Required for Timely Progression through S Phase

Kumaraswamy, E., & Shiekhattar, R. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00961-07 · Cited by 110

BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability

Aly, A., & Ganesan, S. (2011) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjq055 · Cited by 116

Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1

Cantor, S. B., & Guillemette, S. (2011) · Future Oncology · doi:10.2217/fon.10.191 · Cited by 106

BRCA1 Regulates RAD51 Function in Response to DNA Damage and Suppresses Spontaneous Sister Chromatid Replication Slippage: Implications for Sister Chromatid Cohesion, Genome Stability, and Carcinogenesis

Cousineau, I., Abaji, C., & Belmaaza, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2156 · Cited by 108

Ataxia Telangiectasia Mutated and Checkpoint Kinase 2 Regulate BRCA1 to Promote the Fidelity of DNA End-Joining

Wang, H., Chou, W., Shieh, S.-Y., & Shen, C. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3270 · Cited by 109

Minding the gap: The underground functions of BRCA1 and BRCA2 at stalled replication forks

Nagaraju, G., & Scully, R. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.02.020 · Cited by 103

Tumor Suppressor p53 Is Required To Modulate BRCA1 Expression

Arizti, P., Li, F., Park, I., Yin, Y., Solomon, E., Ouchi, T., Aaronson, S. A., & Lee, S. W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.20.7450-7459.2000 · Cited by 102

BRCA1 Promotes Induction of ssDNA by Ionizing Radiation

Schlegel, B. P., Jodelka, F. M., & Núñez, R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3209 · Cited by 107

211 BRCA1 functions as a differential modulator of chemotherapy induced apoptosis

Quinn, J. E., Kennedy, R. D., Mullan, P. B., Johnston, P. G., & Harkin, D. P. (2004) · European Journal of Cancer Supplements · doi:10.1016/s1359-6349(04)80219-2 · Cited by 215

Progress in role of breast cancer susceptibility gene 1 in DNA damage repair

Xi-pen, Z. (2014) · Zhongguo yaolixue yu dulixue zazhi

BRCA1 Expression Restores Radiation Resistance in BRCA1-defective Cancer Cells through Enhancement of Transcription-coupled DNA Repair

Abbott, D. W., Thompson, M. E., Robinson‐Benion, C., Tomlinson, G. E., Jensen, R. A., & Holt, J. T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18808 · Cited by 228

BRCA1 Promotes Induction of ssDNA by Ionizing Radiation

Schlegel, B. P., Jodelka, F. M., & Núñez, R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3209 · Cited by 107

The Role of BRCA1 in DNA Double-strand Break Repair

Dever, S. M. (2009) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/f775-c418