Chen, Junjie

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 1,459

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

Ward, I. M., & Chen, J. (2001) · Journal of Biological Chemistry

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 1,150

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 900

The BRCT Domain Is a Phospho-Protein Binding Domain

Yu, X., Chini, C. C. S., He, M., Mer, G., & Chen, J. (2003) · Science

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 862

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

Lim, J.-H., Lee, Y.-M., Chun, Y.-S., Chen, J., Kim, J.-E., & Park, J.-W. (2010) · Molecular Cell

Sirtuins and Resveratrol in MedicineCancer, Hypoxia, and Metabolism

Cited by 758

Genomic instability in laminopathy-based premature aging

Liu, B., Wang, J., Chan, K. M., Tjia, W. M., Deng, W., Guan, X., Huang, J.-D., Li, K. M., Chau, P. Y., Chen, D. J., et al. (2005) · Nature Medicine

Nuclear Structure and FunctionDNA Repair Mechanisms

Cited by 650

AMPK modulates Hippo pathway activity to regulate energy homeostasis

Wang, W., Xiao, Z.-D., Li, X., Aziz, K. E., Gan, B., Johnson, R. L., & Chen, J. (2015) · Nature Cell Biology

Hippo pathway signaling and YAP/TAZMetabolism, Diabetes, and Cancer

Cited by 549

Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA

Chen, J., Jackson, P. K., Kirschner, M. W., & Dutta, A. (1995) · Nature

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 548

Ubiquitin-Binding Protein RAP80 Mediates BRCA1-Dependent DNA Damage Response

Kim, H., Chen, J., & Yu, X. (2007) · Science

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 540

DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains

Yu, X., & Chen, J. (2004) · Molecular and Cellular Biology

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 410

Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

Scully, R., Ganesan, S., Vlasakova, K., Chen, J., Socolovsky, M., & Livingston, D. M. (1999) · Molecular Cell

BRCA gene mutations in cancerDNA Repair Mechanisms

Cited by 359

Cyclin-Binding Motifs Are Essential for the Function of p21 CIP1

Chen, J., Saha, P., Kornbluth, S., Dynlacht, B. D., & Dutta, A. (1996) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 320

H2AX Prevents DNA Breaks from Progressing to Chromosome Breaks and Translocations

Franco, S., Gostissa, M., Zha, S., Lombard, D. B., Murphy, M. M., Zarrin, A. A., Yan, C., Tepsuporn, S., Morales, J. C., Adams, M. M., et al. (2006) · Molecular Cell

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 282

Human Claspin Is Required for Replication Checkpoint Control

Chini, C. C. S., & Chen, J. (2003) · Journal of Biological Chemistry

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 244

Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains

Rodriguez, M., Yu, X., Chen, J., & Songyang, Z. (2003) · Journal of Biological Chemistry

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 234

CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response

Kim, H., Huang, J., & Chen, J. (2007) · Nature Structural & Molecular Biology

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 212

PTPN14 is required for the density-dependent control of YAP1

Wang, W., Huang, J., Wang, X., Yuan, J., Li, X., Feng, L., Park, J.-I., & Chen, J. (2012) · Genes & Development

Hippo pathway signaling and YAP/TAZProtein Tyrosine Phosphatases

Cited by 195

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

Zhang, W., Wu, K.-P., Sartori, M. A., Kamadurai, H. B., Ordureau, A., Jiang, C., Mercredi, P. Y., Murchie, R., Hu, J., Persaud, A., et al. (2016) · Molecular Cell

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 168

SLFN11 inhibits checkpoint maintenance and homologous recombination repair

Mu, Y., Lou, J., Srivastava, M., Zhao, B., Feng, X., Liu, T., Chen, J., & Huang, J. (2016) · The EMBO Reports

DNA Repair MechanismsPARP inhibition in cancer therapy

Cited by 160

BACH1/FANCJ Acts with TopBP1 and Participates Early in DNA Replication Checkpoint Control

Gong, Z., Kim, J.-E., Leung, C. C. Y., Glover, J. N. M., & Chen, J. (2010) · Molecular Cell

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 160

MDC1 collaborates with TopBP1 in DNA replication checkpoint control

Wang, J., Gong, Z., & Chen, J. (2011) · Journal of Cell Biology

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 118

The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.

Rai, R., Li, J.-M., Zheng, H., Lok, G. T.-M., Deng, Y., Huen, M. S.-Y., Chen, J., Jin, J., & Chang, S. (2011) · Nature Structural & Molecular Biology

Telomeres, Telomerase, and SenescenceUbiquitin and proteasome pathways

Cited by 88

Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage

Cleaver, J. E., Brennan-Minnella, A. M., Swanson, R. A., Fong, K.-W., Chen, J., Chou, K.-M., Chen, Y.-W., Revet, I., & Bezrookove, V. (2014) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsMitochondrial Function and Pathology

Cited by 65