ASPP Proteins Specifically Stimulate the Apoptotic Function of p53

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Factor Inhibiting HIF-1 (FIH-1) modulates protein interactions of Apoptosis-Stimulating p53 binding Protein 2 (ASPP2)

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Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage–response thresholds

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Insight into the Structural Basis of Pro- and Antiapoptotic p53 Modulation by ASPP Proteins

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Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2

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RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response

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Downregulated mRNA expression of ASPP and the hypermethylation of the 5′‐untranslated region in cancer cell lines retaining wild‐type p53

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The C-terminal Sterile α Motif and the Extreme C Terminus Regulate the Transcriptional Activity of the α Isoform of p73

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A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice

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Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax

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Downregulation of ASPP2 in pancreatic cancer cells contributes to increased resistance to gemcitabine through autophagy activation

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Apoptosis Stimulating Protein of p53 (ASPP2) Expression Differs in Diffuse Large B-cell and Follicular Center Lymphoma: Correlation with Clinical Outcome

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The changing face of p53 in head and neck cancer

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ASPP1/2 Regulate p53-Dependent Death of Retinal Ganglion Cells through PUMA and Fas/CD95 ActivationIn Vivo

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Inhaled resveratrol treatments slow ageing-related degenerative changes in mouse lung

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Versatile analysis of multiple macromolecular interactions by SPR imaging: application to p53 and DNA interaction

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Multiple response elements and differential p53 binding control Perp expression during apoptosis.

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MiRNAs Mediate GDNF-Induced Proliferation and Migration of Glioma Cells

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iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death

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Increased Expression of iASPP, Regulated by Hepatitis B Virus X Protein-Mediated NF-κB Activation, in Hepatocellular Carcinoma

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ASPP2 suppresses squamous cell carcinoma via RelA/p65–mediated repression of p63

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Intronic cleavage and polyadenylation regulates gene expression during DNA damage response through U1 snRNA

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Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth

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Interdependent Nuclear Co-Trafficking of ASPP1 and p53 Aggravates Cardiac Ischemia/Reperfusion Injury

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Breast Cancer Amplified Sequence 2, a Novel Negative Regulator of the p53 Tumor Suppressor

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Of flies and men; p53, a tumour suppressor

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p73, the “Assistant” Guardian of the Genome?

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Cranberry Proanthocyanidins Mediate Growth Arrest of Lung Cancer Cells through Modulation of Gene Expression and Rapid Induction of Apoptosis

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iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes

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Sam68 functions as a transcriptional coactivator of the p53 tumor suppressor

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Drosophila ASPP Regulates C-Terminal Src Kinase Activity

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The ASPP family: deciding between life and death after DNA damage

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Abnormal mRNA expression of ASPP members in leukemia cell lines

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Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2

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A role for Numb in p53 stabilization

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NuMA Is Required for the Selective Induction of p53 Target Genes

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Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts-Secreted Interferon Beta

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The Structure and Interactions of the Proline-rich Domain of ASPP2

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p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors

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Long Noncoding RNA KIF9-AS1 Regulates Transforming Growth Factor-β and Autophagy Signaling to Enhance Renal Cell Carcinoma Chemoresistance via microRNA-497-5p

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Physical and Functional Antagonism between Tumor Suppressor Protein p53 and Fortilin, an Anti-apoptotic Protein

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Changes in the neuropeptide content of Biomphalaria ganglia nervous system following Schistosoma infection

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Stochastic transcription in the p53‐mediated response to DNA damage is modulated by burst frequency

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Targeting p73 in cancer

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Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation

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Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors

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The Tumor Suppressor Gene TP53: Implications for Cancer Management and Therapy

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Gene regulation by SMAR1: Role in cellular homeostasis and cancer

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A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX

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Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib

Bessette, D. C., Tilch, E., Seidens, T., Quinn, M. C. J., Wiegmans, A. P., Shi, W., Cocciardi, S., Reed, A. E. M., Saunus, J. M., Simpson, P. T., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125232 · Cited by 36

ASPP2 inhibits APP‐BP1‐mediated NEDD8 conjugation to cullin‐1 and decreases APP‐BP1‐induced cell proliferation and neuronal apoptosis

Chen, Y., Liu, W., Naumovski, L., & Neve, R. L. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01727.x · Cited by 38

Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression

Budhram-Mahadeo, V. S., Bowen, S., Lee, S., Perez-Sanchez, C., Ensor, E. A., Morris, P. J., & Latchman, D. S. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl878 · Cited by 38

Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1

Xing, Y. (2011) · Oncology Reports · doi:10.3892/or.2011.1248 · Cited by 37

Controlling Ser/Thr protein phosphatase PP1 activity and function through interaction with regulatory subunits

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The relationship between DNA single-stranded damage response and double-stranded damage response

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Gene-trap expression screening to identify endothelial-specific genes

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Inhibitory Member of the Apoptosis-stimulating Proteins of the p53 Family (iASPP) Interacts with Protein Phosphatase 1 via a Noncanonical Binding Motif

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Activation of p53 Facilitates the Target Search in DNA by Enhancing the Target Recognition Probability

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Hypoxia-regulated microRNAs: the molecular drivers of tumor progression

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ASPP 2 enhances Oxaliplatin (L‐ OHP )‐induced colorectal cancer cell apoptosis in a p53‐independent manner by inhibiting cell autophagy

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ASPP2 Links the Apical Lateral Polarity Complex to the Regulation of YAP Activity in Epithelial Cells

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Battle Against Cancer: An Everlasting Saga of p53

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The IGF-1R/AKT pathway determines cell fate in response to p53

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ASPP2 suppresses invasion and TGF-β1-induced epithelial–mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer

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Early growth response-1: Key mediators of cell death and novel targets for cardiovascular disease therapy

Xie, Y., Li, Y., Chen, J., Ding, H., & Zhang, X. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1162662 · Cited by 36

Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence

Johnson, T. M., Meade, K. E., Pathak, N., Marques, M. R., & Attardi, L. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706764105 · Cited by 36

Inhibitor of Apoptosis-Stimulating Protein of p53 (iASPP) Is Required for Neuronal Survival after Axonal Injury

Wilson, A. M., Chiodo, V. A., Boye, S. L., Brecha, N. C., Hauswirth, W. W., & Polo, A. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094175 · Cited by 34

Loss of FBXO7 results in a Parkinson's‐like dopaminergic degeneration via an RPL23–MDM2–TP53 pathway

Stott, S., Randle, S. J., Rawi, S. A., Rowicka, P. A., Harris, R., Mason, B., Xia, J., Dalley, J. W., Barker, R. A., & Laman, H. (2019) · The Journal of Pathology · doi:10.1002/path.5312 · Cited by 34

The Role and Clinical Implications of the Retinoblastoma (RB)-E2F Pathway in Gastric Cancer

Wu, T., & Wu, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.655630 · Cited by 36

The variation game: Cracking complex genetic disorders with NGS and omics data

Cui, H., Dhroso, A., Johnson, N. T., & Korkin, D. (2015) · Methods · doi:10.1016/j.ymeth.2015.04.018 · Cited by 36

Forcing Cancer Cells to Commit Suicide

Vangestel, C., de Wiele, C. V., Mees, G., & Peeters, M. (2009) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2008.0598 · Cited by 33

ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma

Liang, B., Chen, R., Song, S., Wang, H., Sun, G., Yang, H., Jing, W., Zhou, X., Fu, Z., Huang, G., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2054-7 · Cited by 33

iASPP Inhibition: Increased Options in Targeting the p53 Family for Cancer Therapy

Bell, H. S., & Ryan, K. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0182 · Cited by 33

53BP2 induces apoptosis through the mitochondrial death pathway

Kobayashi, S., Kajino, S., Takahashi, N., Kanazawa, S., Imai, K., Hibi, Y., Ohara, H., Itoh, M., & Okamoto, T. (2005) · Genes to Cells · doi:10.1111/j.1365-2443.2005.00835.x · Cited by 33

Effect of RNA Interference of iASPP on the Apoptosis in MCF-7 Breast Cancer Cells

Liu, Z., Cai, Y., Hou, L., Gao, X., Xin, H., Lü, X., Zhong, S., Gu, S.-Z., & Chen, J. (2008) · Cancer Investigation · doi:10.1080/07357900801965042 · Cited by 33

The relevance of protein-protein interactions for p53 function: the CPE contribution

Fernández-Fernández, M. R., & Sot, B. (2010) · Protein Engineering Design and Selection · doi:10.1093/protein/gzq074 · Cited by 33

Molecular mechanisms underlying the interaction of protein phosphatase-1c with ASPP proteins

Skene-Arnold, T. D., Luu, H. A., Uhrig, R. G., Wever, V. D., Nimick, M., Maynes, J. T., Fong, A., James, M. N. G., Trinkle‐Mulcahy, L., Moorhead, G. B. G., et al. (2012) · Biochemical Journal · doi:10.1042/bj20120506 · Cited by 33

Stimulus-Specific Transcriptional Regulation Within the p53 Network

Donner, A. J., Hoover, J. M., Szostek, S. A., & Espinosa, J. M. (2007) · Cell Cycle · doi:10.4161/cc.6.21.4893 · Cited by 33

Control of ASPP2/53BP2L Protein Levels by Proteasomal Degradation Modulates p53 Apoptotic Function

Zhu, Z., Ramos, J. A., Kampa-Schittenhelm, K. M., Adimoolam, S., Sirisawad, M., Yu, Z., Chen, D., Naumovski, L., & Lopez, C. D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503736200 · Cited by 32

Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis

Cao, Y., Hamada, T., Matsui, T., Date, T., & Iwabuchi, K. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.01.124 · Cited by 32

The recently discovered Apoptosis Stimulating Proteins of p53

Sullivan, A., & Lu, X. (2013)

ASPP: a new family of oncogenes and tumour suppressor genes

Sullivan, A., & Lü, X. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603525 · Cited by 215

ASPPs and cancer

Trigiante, G., & Lü, X. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1818 · Cited by 135

ASPP--Apoptotic specific regulator of p53.

Liu, Z.-J., Lu, X., & Zhong, S. (2005) · Biochimica et Biophysica Acta · doi:10.1016/j.bbcan.2005.08.002 · Cited by 26

ASPP1 and ASPP2: Common Activators of p53 Family Members

Bergamaschi, D., Samuels, Y., Jin, B., Duraisingham, S., Crook, T., & Lü, X. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.3.1341-1350.2004 · Cited by 229