ASPP Proteins Specifically Stimulate the Apoptotic Function of p53

Antibodies, a laboratory manual

(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318

p53: puzzle and paradigm.Preprint

Ko, L. J., & Prives, C. L. (1996) · Genes & Development · doi:10.1101/gad.10.9.1054 · Cited by 2,346

Structure of the p53 Tumor Suppressor Bound to the Ankyrin and SH3 Domains of 53BP2

Gorina, S. S., & Pavletich, N. P. (1996) · Science · doi:10.1126/science.274.5289.1001 · Cited by 575

Two cellular proteins that bind to wild-type but not mutant p53.

Iwabuchi, K., Bartel, P. L., Li, B., Marraccino, R. L., & Fields, S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.13.6098 · Cited by 432

In vivo gene expression profile analysis of human breast cancer progression.

Sgroi, D. C., Teng, S., ROBINSON, G. C., LeVangie, R., Hudson, J. R., & Elkahloun, A. G. (1999) · PubMed · Cited by 390

Differential Activation of Target Cellular Promoters by p53 Mutants with Impaired Apoptotic Function

Ludwig, R. L., Bates, S., & Vousden, K. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4952 · Cited by 278

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction.Preprint

Hsieh, J.-K., Fredersdorf, S., Kouzarides, T., Martin, K., & Lü, X. (1997) · Genes & Development · doi:10.1101/gad.11.14.1840 · Cited by 278

A Mutant p53 That Discriminates between p53-Responsive Genes Cannot Induce Apoptosis

Friedlander, P. A., Haupt, Y., Prives, C. L., & Oren, M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4961 · Cited by 277

Stimulation of p53-mediated Transcriptional Activation by the p53-binding Proteins, 53BP1 and 53BP2

Iwabuchi, K., Li, B., Massa, H. F., Trask, B. J., Date, T., & Fields, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.26061 · Cited by 206

p53 mutation with frequent novel codons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

Crook, T., Brooks, L. A., Crossland, S., Osin, P., Barker, K. T., Waller, J., Philp, E., Smith, P. D., Yuluğ, I. G., Peto, J., et al. (1998) · Oncogene · doi:10.1038/sj.onc.1202106 · Cited by 179

Gene bi-targeting by viral and human miRNAs

Veksler‐Lublinsky, I., Shemer‐Avni, Y., Kedem, K., & Ziv-Ukelson, M. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-249 · Cited by 30

Expression of 53BP2 and ASPP2 proteins from TP53BP2 gene by alternative splicing

Takahashi, N., Kobayashi, S., Jiang, X., Kitagori, K., Imai, K., Hibi, Y., & Okamoto, T. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.01.079 · Cited by 31

Warburg meets non-coding RNAs: the emerging role of ncRNA in regulating the glucose metabolism of cancer cells

Yu, C., Xue, J., Zhu, W. J., Yang, J., Zhang, S., & Cao, J. (2014) · Tumor Biology · doi:10.1007/s13277-014-2875-z · Cited by 30

Distinct interactors define the p63 transcriptional signature in epithelial development or cancer

Pecorari, R., Bernassola, F., Melino, G., & Candi, E. (2022) · Biochemical Journal · doi:10.1042/bcj20210737 · Cited by 31

New insights into the expanding complexity of the tumor suppressor ASPP2

Kampa-Schittenhelm, K. M., von Bonin, M., & Lopez, C. D. (2009) · Cell Cycle · doi:10.4161/cc.8.18.9474 · Cited by 29

Elevated expression of iASPP in head and neck squamous cell carcinoma and its clinical significance

Liu, Z., Zhang, X., Huang, D., Liu, Y., Zhang, X., Liu, L., Guo, L., Dai, Y., Tan, H., Xiao, J., et al. (2012) · Medical Oncology · doi:10.1007/s12032-012-0306-9 · Cited by 29

Nuclear EGFR impairs ASPP2-p53 complex-induced apoptosis by inducing SOS1 expression in hepatocellular carcinoma

Liu, K., Jiang, T., Ouyang, Y., Shi, Y., Zang, Y., Li, N., Lu, S., & Chen, D. (2015) · Oncotarget · doi:10.18632/oncotarget.3757 · Cited by 29

BRCA1: a scaffold for p53 response?

Hohenstein, P., & Giles, R. H. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00193-8 · Cited by 29

Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcoma

Ternovoi, V. V., Curiel, D. T., Smith, B. F., & Siegal, G. P. (2006) · Laboratory Investigation · doi:10.1038/labinvest.3700444 · Cited by 29

The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis

Uhlmann‐Schiffler, H., Kiermayer, S., & Stahl, H. D. (2009) · Oncogene · doi:10.1038/onc.2009.75 · Cited by 29

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition

Chen, S., Wu, J.-L., Zhong, S., Li, Y.-T., Zhang, P., Ma, J., Ren, J.-S., Tan, Y., Wang, Y.-H., Au, K., et al. (2019) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1909393116 · Cited by 29

Functional analysis of p53 tumor suppressor in yeast

Šmardová, J., Šmarda, J., & Koptíková, J. (2005) · Differentiation · doi:10.1111/j.1432-0436.2005.00028.x · Cited by 29

How cells choose to die

Lane, D. P. (2001) · Nature · doi:10.1038/35102132 · Cited by 29

ASPP 2 attenuates triglycerides to protect against hepatocyte injury by reducing autophagy in a cell and mouse model of non‐alcoholic fatty liver disease

Xie, F., Jia, L., Lin, M., Shi, Y., Yin, J., Liu, Y., Chen, D., & Meng, Q. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12364 · Cited by 28

53BP2S, Interacting with Insulin Receptor Substrates, Modulates Insulin Signaling

Hakuno, F., Kurihara, S., Watson, R. T., Pessin, J. E., & Takahashi, S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702472200 · Cited by 28

KeePin’ the p53 Family in Good Shape

Mantovani, F., Gostissa, M., Collavin, L., & Sal, G. D. (2004) · Cell Cycle · doi:10.4161/cc.3.7.999 · Cited by 28

p53: A Key Player in Tumoral and Evolutionary Adaptation: A Lesson from the Israeli Blind Subterranean Mole Rat

Avivi, A., Ashur‐Fabian, O., Amariglio, N., Nevo, E., & Rechavi, G. (2005) · Cell Cycle · doi:10.4161/cc.4.3.1534 · Cited by 29

The P53 Pathway: Targets for the Development of Novel Cancer Therapeutics

Wang, S., & El‐Deiry, W. S. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/1-4020-7847-1_9 · Cited by 28

Monomeric but not trimeric clathrin heavy chain regulates p53-mediated transcription

Ohmori, K., Endo, Y., Yoshida, Y., Ohata, H., Taya, Y., & Enari, M. (2007) · Oncogene · doi:10.1038/sj.onc.1210854 · Cited by 27

Gene‐specific mechanisms of p53 transcriptional control and prospects for cancer therapy

Resnick‐Silverman, L., & Manfredi, J. J. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20925 · Cited by 27

‘Centennial’ Nobel Conference on apoptosis and human disease

Robertson, J. D., Fadeel, B., Zhivotovsky, B., & Orrenius, S. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401014 · Cited by 26

MdmX Is Required for p53 Interaction with and Full Induction of the Mdm2 Promoter after Cellular Stress

Biderman, L., Poyurovsky, M. V., Assia, Y., Manley, J. L., & Prives, C. L. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06150-11 · Cited by 27

Solution Structure of ASPP2 N-terminal Domain (N-ASPP2) Reveals a Ubiquitin-like Fold

Tidow, H., Andreeva, A. E., Rutherford, T. J., & Fersht, A. R. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.05.024 · Cited by 26

Regulation of the DNA Damage Response by p53 Cofactors

Zhang, X. P., Liu, F., & Wang, W. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.04.002 · Cited by 25

Regulation of hematopoietic stem cell integrity through p53 and its related factors

Yamashita, M., Nitta, E., & Suda, T. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12986 · Cited by 26

Lycorine Induces Apoptosis and G1 Phase Arrest Through ROS/p38 MAPK Signaling Pathway in Human Osteosarcoma Cells In Vitro and In Vivo

Ning, L., Wan, S., Jie, Z., Xie, Z., Li, X., Pan, X., Wan, X., Chen, W., Huang, H., Wang, J., et al. (2019) · Spine · doi:10.1097/brs.0000000000003217 · Cited by 25

Inhibitory member of the apoptosis-stimulating protein of p53 (ASPP) family promotes growth and tumorigenesis in human p53-deficient prostate cancer cells

Zhang, B., Xiao, H. J., Chen, J., Tao, X., & Cai, L. H. (2011) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2011.25 · Cited by 25

Oncogene iASPP enhances self‐renewal of hematopoietic stem cells and facilitates their resistance to chemotherapy and irradiation

Jia, Y., Peng, L., Rao, Q., Xing, H., Huai, L., Yu, P., Chen, Y., Wang, C., Wang, M., Mi, Y., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-244632 · Cited by 25

An indirect role for ASPP1 in limiting p53‐dependent p21 expression and cellular senescence

Vigneron, A. M., & Vousden, K. H. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.402 · Cited by 25

siRNA-mediated down-regulation of iASPP promotes apoptosis induced by etoposide and daunorubicin in leukemia cells expressing wild-type p53

Liu, H., Wang, M., Diao, S., Rao, Q., Zhang, X., Xing, H., & Wang, J. (2009) · Leukemia Research · doi:10.1016/j.leukres.2009.02.016 · Cited by 25

Protective effect of p53 in vascular smooth muscle cells against nitric oxide-induced apoptosis is mediated by up-regulation of heme oxygenase-2

Kim, Y., Choi, B.-M., Kim, Y., Kwon, Y., Kibbe, M. R., Billiar, T. R., & Tzeng, E. (2008) · BMB Reports · doi:10.5483/bmbrep.2008.41.2.164 · Cited by 25

A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons

Li, R., Yang, Y., Gao, Y., Wang, Z., & Tong, W. (2012) · Cell Research · doi:10.1038/cr.2012.3 · Cited by 26

Behind the scenes: Unravelling the molecular mechanisms of p53 target gene selectivity (Review)

Lohrum (2010) · International Journal of Oncology · doi:10.3892/ijo_00000757 · Cited by 24

p18HamletMediates Different p53-Dependent Responses to DNA Damage Inducing Agents

Lafarga, V., Cuadrado, A., & Nebreda, Á. R. (2007) · Cell Cycle · doi:10.4161/cc.6.19.4741 · Cited by 27

SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein

Browne, G. J., Fardilha, M., Oxenham, S. K., Wu, W., Helps, N. R., Silva, O. A. B. D. C. E., Cohen, P. T. W., & Silva, E. F. D. C. E. (2007) · Biochemical Journal · doi:10.1042/bj20060600 · Cited by 25

Identification of a splice acceptor site mutation in p16INK4A/p14ARF within a breast cancer, melanoma, neurofibroma prone kindred

Prowse, A. H., Schultz, D. C., Guo, S., Vanderveer, L., Dangel, J., Bove, B., Cairns, P., Daly, M., & Godwin, A. K. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.8.e102 · Cited by 25

Correction: Up-Regulation of MicroRNA-21 Correlates with Lower Kidney Cancer Survival

Zaman, M. S., Shahryari, V., Deng, G., Thamminana, S., Saini, S., Majid, S., Chang, I., Hirata, H., Ueno, K., Yamamura, S., et al. (2012) · PLoS ONE · doi:10.1371/annotation/6662579f-3a41-4bce-9298-9d15f6582ef5 · Cited by 26

Sufentanil Protects the Liver from Ischemia/Reperfusion-Induced Inflammation and Apoptosis by Inhibiting ATF4-Induced TP53BP2 Expression

Zhou, L., Yang, X., Shu, S., Wang, S., Guo, F., Yin, Y., Zhou, W., Han, H., & Chai, X. (2021) · Inflammation · doi:10.1007/s10753-020-01410-x · Cited by 24

Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability

Kim, H., Claps, G., Möller, A., Bowtell, D. D. L., Lü, X., & Ronai, Z. A. (2013) · Oncogene · doi:10.1038/onc.2013.149 · Cited by 24

Downregulation of ASPP2 in choriocarcinoma contributes to increased migratory potential through Src signaling pathway activation

Mak, V. C. Y., Lee, L., Siu, M. K. Y., Wong, O. G., Lü, X., Ngan, H., Wong, E. S. Y., & Cheung, A. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt161 · Cited by 24

Epigenetic Regulation of iASPP-p63 Feedback Loop in Cutaneous Squamous Cell Carcinoma

Robinson, D. J., Patel, A. A., Purdie, K. J., Wang, J., Rizvi, H., Hufbauer, M., Ostano, P., Akgũl, B., Chiorino, G., Harwood, C. A., et al. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.01.020 · Cited by 24

Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis

Zhou, Y., Millott, R., Kim, H. J., Peng, S., Edwards, R. A., Skene-Arnold, T. D., Hammel, M., Lees‐Miller, S. P., Tainer, J. A., Holmes, C. F. B., et al. (2019) · Structure · doi:10.1016/j.str.2019.07.012 · Cited by 24

Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genes

Gomes, N. P., & Espinosa, J. M. (2010) · Cell Cycle · doi:10.4161/cc.9.17.12998 · Cited by 24

Putting the brakes on p53-driven apoptosis

Höpker, K., Hagmann, H., Khurshid, S., Chen, S., Schermer, B., Benzing, T. R., & Reinhardt, H. C. (2012) · Cell Cycle · doi:10.4161/cc.21997 · Cited by 24

Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-κB

Hu, Y., Ge, W., Wang, X., Sutendra, G., Zhao, K., Dedeić, Z., Slee, E. A., Baer, C., & Lü, X. (2015) · Oncotarget · doi:10.18632/oncotarget.6478 · Cited by 23

JAZ mediates G1 cell-cycle arrest and apoptosis by positively regulating p53 transcriptional activity

Yang, M., Wu, S., Su, X., & May, W. S. (2006) · Blood · doi:10.1182/blood-2006-06-029645 · Cited by 23

Mechanisms underlying the pro-survival pathway of p53 in suppressing mitotic death induced by adriamycin

Lin, Y., & Wang, F.-F. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.10.017 · Cited by 26

S179D Prolactin Primarily Uses the Extrinsic Pathway and Mitogen-Activated Protein Kinase Signaling to Induce Apoptosis in Human Endothelial Cells

Ueda, E. K. M., Lo, H., Bartolini, P., & Walker, A. M. (2006) · Endocrinology · doi:10.1210/en.2006-0348 · Cited by 23

Mir‐30b‐5p Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells via Targeting ASPP2

Wu, T., Song, H., Xie, D., Hua, K., Hu, J., Deng, Y., Ji, C., & Fang, L. (2020) · BioMed Research International · doi:10.1155/2020/7907269 · Cited by 22

Structural Basis for ASPP2 Recognition by the Tumor Suppressor p73

Canning, P., von Delft, F., & Bullock, A. N. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.08.005 · Cited by 22

Downregulation of ASPP1 in gestational trophoblastic disease: correlation with hypermethylation, apoptotic activity and clinical outcome

Mak, V. C. Y., Lee, L., Siu, M. K. Y., Wong, O. G., Lü, X., Ngan, H., Wong, E. S. Y., & Cheung, A. (2010) · Modern Pathology · doi:10.1038/modpathol.2010.216 · Cited by 22

A model for the interaction between NF‐kappa‐B and ASPP2 suggests an I‐kappa‐B‐like binding mechanism

Benyamini, H., Leonov, H., Rotem, S., Katz, C., Arkin, I. T., & Friedler, A. (2009) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.22473 · Cited by 22

Tumour suppressors—a fly's perspective

Sutcliffe, J. E., Korenjak, M., & Brehm, A. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(03)00263-6 · Cited by 22

Deficiency of apoptosis‐stimulating protein two of p53 ameliorates acute kidney injury induced by ischemia reperfusion in mice through upregulation of autophagy

Ji, J., Zhou, X., Xu, P., Li, Y., Shi, H., Chen, D., Li, R., & Shi, H. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14094 · Cited by 21

Recursive-YOLOv5 Network for Edible Mushroom Detection in Scenes With Vertical Stick Placement

Wei, B., Zhang, Y., Pu, Y., Sun, Y., Zhang, S., Lin, H., Zeng, C., Zhao, Y., Wang, K., & Chen, Z. (2022) · IEEE Access · doi:10.1109/access.2022.3165160 · Cited by 21

ASPP2 suppresses tumour growth and stemness characteristics in HCC by inhibiting Warburg effect via WNT /β‐catenin/ HK2 axis

Liang, B., Jiang, Y., Song, S., Jing, W., Yang, H., Zhao, L., Chen, Y., Tang, Q., Li, X., Zhang, L., et al. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17687 · Cited by 21

Attenuated Expression of Apoptosis Stimulating Protein of p53-2 (ASPP2) in Human Acute Leukemia Is Associated with Therapy Failure

Schittenhelm, M. M., Illing, B., Ahmut, F., Rasp, K. H., Blumenstock, G., Döhner, K., Lopez, C. D., & Kampa-Schittenhelm, K. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080193 · Cited by 21

PPM1D exerts its oncogenic properties in human pancreatic cancer through multiple mechanisms

Wu, B., Guo, B., Kang, J., Deng, X., Fan, Y., Zhang, X., & Ai, K. (2015) · APOPTOSIS · doi:10.1007/s10495-015-1211-4 · Cited by 21

TP53BP2 locus is associated with gastric cancer susceptibility

Ju, H., Lee, K., Yang, M., Kim, H., Kang, C. P., Sohn, T., Rhee, J., Kang, C., & Kim, J. (2005) · International Journal of Cancer · doi:10.1002/ijc.21281 · Cited by 21

Cancer

Hahn, W. C. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.007 · Cited by 21

A Novel p53 Transcriptional Repressor Element (p53TRE) and the Asymmetrical Contribution of Two p53 Binding Sites Modulate the Response of the Placental Transforming Growth Factor-β Promoter to p53

Wong, J., Li, P.-X., & Klamut, H. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203020200 · Cited by 22

Arsenic Trioxide Induces Apoptosis and Incapacitates Proliferation and Invasive Properties of U87MG Glioblastoma Cells through a Possible NF-κB-Mediated Mechanism

Ghaffari, S. H., Yousefi, M., Zaki‐Dizaji, M., Momeny, M., Bashash, D., Zekri, A., Alimoghaddam, K., & Ghavamzadeh, A. (2016) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2016.17.3.1553 · Cited by 20

Identification of novel target genes specifically activated by deregulated E2F in human normal fibroblasts

Kitamura, H., Ozono, E., Iwanaga, R., Bradford, A. P., Okuno, J., Shimizu, E., Kurayoshi, K., Kugawa, K., Toh, H., & Ohtani, K. (2015) · Genes to Cells · doi:10.1111/gtc.12268 · Cited by 20

Epigenetic silencing of ASPP1 confers 5‐FU resistance in clear cell renal cell carcinoma by preventing p53 activation

Wang, X., Cheng, Y., Zhu, Y., Li, H., Ge, W., Wu, X., Zhao, K., Yuan, J., Li, Z., Jiang, S., et al. (2017) · International Journal of Cancer · doi:10.1002/ijc.30852 · Cited by 20

The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas

Miyazaki, M., Otomo, R., Matsushima‐Hibiya, Y., Suzuki, H., Nakajima, A., Abe, N., Tomiyama, A., Ichimura, K., Matsuda, K., Watanabe, T., et al. (2018) · Cell Death Discovery · doi:10.1038/s41420-018-0059-0 · Cited by 20

Alternative splicing of the tumor suppressor ASPP2 results in a stress-inducible, oncogenic isoform prevalent in acute leukemia

Schittenhelm, M. M., Walter, B., Tsintari, V., Federmann, B., Saipi, M. B., Akmut, F., Illing, B., Mau-Holzmann, U. A., Fend, F., Lopez, C. D., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.028 · Cited by 20

ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis

Royer, C., Sandham, E., Slee, E. A., Schneider, F., Lagerholm, B. C., Godwin, J., Veits, N., Hathrell, H., Zhou, F., Leonavicius, K., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28590-4 · Cited by 20

Abnormal expression pattern of the ASPP family of proteins in human non-small cell lung cancer and regulatory functions on apoptosis through p53 by iASPP

Li, S. (2012) · Oncology Reports · doi:10.3892/or.2012.1778 · Cited by 20

p73-Binding Partners and Their Functional Significance

Ozaki, T., Kubo, N., & Nakagawara, A. (2010) · International Journal of Proteomics · doi:10.1155/2010/283863 · Cited by 20

ASPP--Apoptotic specific regulator of p53.

Liu, Z.-J., Lu, X., & Zhong, S. (2005) · Biochimica et Biophysica Acta · doi:10.1016/j.bbcan.2005.08.002 · Cited by 26

Papillomaviruses: death-defying acts in skin cancer

Storey, A. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02387-0 · Cited by 20

Regulation of p53-dependent transcription

Jõers, A. (2004) · DSpace repository (University of Tartu) · Cited by 20

HDAC1-induced epigenetic silencing of ASPP2 promotes cell motility, tumour growth and drug resistance in renal cell carcinoma

Li, H., Wang, X., Zhang, C., Cheng, Y., Yu, M., Zhao, K., Ge, W., Cai, A., Zhang, Y., Han, F., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.06.009 · Cited by 19

TP53BP2: Roles in suppressing tumorigenesis and therapeutic opportunities

Huo, Y., Cao, K., Kou, B., Chai, M., Dou, S., Chen, D., Shi, Y., & Liu, X. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.08.014 · Cited by 19

E2F1 inhibits MDM2 expression in a p53-dependent manner

Tian, X., Chen, Y., Hu, W., & Wu, M. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.09.003 · Cited by 18

Co-chaperon DnaJC7/TPR2 enhances p53 stability and activity through blocking the complex formation between p53 and MDM2

Kubo, N., Wu, D., Yoshihara, Y., Sang, M., Nakagawara, A., & Ozaki, T. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.11.121 · Cited by 20

Inhibition of the 53BP2S‐mediated apoptosis by nuclear factor κB and Bcl‐2 family proteins

Takahashi, N., Kobayashi, S., Kajino, S., Imai, K., Tomoda, K., Shimizu, S., & Okamoto, T. (2005) · Genes to Cells · doi:10.1111/j.1365-2443.2005.00878.x · Cited by 19

Protein serine/threonine phosphatase PPEF-1 suppresses genotoxic stress response via dephosphorylation of PDCD5

Park, S., Seo, J., Choi, H., Oh, H.-J., Guk, G., Lee, Y., Lee, J., Jun, W. J., Choi, K., & Yoon, H. (2017) · Scientific Reports · doi:10.1038/srep39222 · Cited by 19

EGR-1/ASPP1 inter-regulatory loop promotes apoptosis by inhibiting cyto-protective autophagy

Zhao, K., Yu, M., Zhu, Y., Liu, D., Wu, Q., & Hu, Y. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.268 · Cited by 18

Silencing of ASPP2 promotes the proliferation, migration and invasion of triple-negative breast cancer cells via the PI3K/AKT pathway

Wu, T., Song, H., Xie, D., Zhao, B., Xu, H., Wu, C., Hua, K., Deng, Y., Ji, C., Hu, J., et al. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4331 · Cited by 19

Intracellular signalling and cancer: complex pathways lead to multiple targets

Bell, H. S., & Ryan, K. M. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2004.10.022 · Cited by 20

Binding sequence-dependent regulation of the human proliferating cell nuclear antigen promoter by p53

Shan, B., & MORRIS, G. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.09.033 · Cited by 19

Identification of a Novel Isoform of iASPP and its Interaction with p53

Zhang, X., Diao, S., Rao, Q., Xing, H., Liu, H., Liao, X., Wang, M., & Wang, J. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.03.001 · Cited by 19

Coexpression of Brn‐3a POU protein with p53 in a population of neuronal progenitor cells is associated with differentiation and protection against apoptosis

Hudson, C. D., Podesta, J. E., Henderson, D. J., Latchman, D. S., & Budhram-Mahadeo, V. S. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20299 · Cited by 19

Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter

Perez-Sanchez, C. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf610 · Cited by 19

Studies on modulation of the activity of tumor suppressor protein p53

Kadaja, L. (2004) · DSpace repository (University of Tartu) · Cited by 19

Deletion of ASPP1 in myofibroblasts alleviates myocardial fibrosis by reducing p53 degradation

Li, S., Yang, M., Zhao, Y., Zhai, Y., Sun, C., Guo, Y., Zhang, X., Zhang, L., Tian, T., Yang, Y., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52739-y · Cited by 19

PIG3 Regulates p53 Stability by Suppressing Its MDM2-Mediated Ubiquitination

Jin, M., Park, S., Kim, S. W., Kim, H., Hyun, J. W., & Lee, J.-H. (2017) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2017.086 · Cited by 17

The Roles of Tricellular Tight Junction Protein Angulin-1/Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Endometriosis and Endometrioid-Endometrial Carcinoma

Shimada, H., Kohno, T., Konno, T., Okada, T., Saito, K., Shindo, Y., Kikuchi, S., Tsujiwaki, M., Ogawa, M., Matsuura, M., et al. (2021) · Cancers · doi:10.3390/cancers13246341 · Cited by 19

Regulation of ASPP2 Interaction with p53 Core Domain by an Intramolecular Autoinhibitory Mechanism

Rotem‐Bamberger, S., Katz, C., & Friedler, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058470 · Cited by 18

ASPP2 Is a Novel Pan-Ras Nanocluster Scaffold

Posada, I. M. D., Serulla, M., Zhou, Y., Oetken-Lindholm, C., Abankwa, D., & Lectez, B. L. P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159677 · Cited by 18

Phosphoproteomics Reveals the AMPK Substrate Network in Response to DNA Damage and Histone Acetylation

Jiang, Y., Cong, X., Jiang, S., Dong, Y., Zhao, L., Zang, Y., Tan, M., & Li, J. X. (2021) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2020.09.003 · Cited by 19

Lysines in the tetramerization domain of p53 selectively modulate G1 arrest

Beckerman, R., Yoh, K. E., Mattia-Sansobrino, M., Zupnick, A., Laptenko, O., Karni-Schmidt, O., Ahn, J., Byeon, I. L., Keezer, S. M., & Prives, C. L. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1170270 · Cited by 19

The family of apoptosis-stimulating proteins of p53 is dysregulated in colorectal cancer patients

Yin, L., Lin, Y., Wang, X., Su, Y., Hu, H. H., Li, C., Wang, L., & Jiang, Y. (2018) · Oncology Letters · doi:10.3892/ol.2018.8151 · Cited by 19

The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo

Thornton, J. K., Dalgleish, C., Venables, J. P., Sergeant, K. A., Ehrmann, I. E., Lü, X., Saunders, P. T. K., & Elliott, D. J. (2006) · Oncogene · doi:10.1038/sj.onc.1209341 · Cited by 18

Thioredoxin-1 regulates self-renewal and differentiation of murine hematopoietic stem cells through p53 tumor suppressor

Jabbar, S., Mathews, P., Wang, X., Sundaramoorthy, P., Chu, E., Piryani, S. O., Ding, S., Shen, X., Doan, P. L., & Kang, Y. (2022) · Experimental Hematology and Oncology · doi:10.1186/s40164-022-00329-3 · Cited by 18

Protein Phosphatase 1γ Isoforms Linked Interactions in the Brain

Esteves, S. L. C., Korrodi‐Gregório, L., Cotrim, C. Z., van Kleeff, P. J. M., Domingues, S. C., Silva, O. A. B. D. C. E., Fardilha, M., & Silva, E. F. D. C. E. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9902-6 · Cited by 18

Helicobacter pylori infection and expressions of apoptosis-related proteins p53, ASPP2 and iASPP in gastric cancer and precancerous lesions

Meng, W.-D., Chu, R.-X., Wang, B.-Z., Wang, L.-P., Ma, L., & Wang, L.-X. (2013) · Pathologie Biologie · doi:10.1016/j.patbio.2013.02.002 · Cited by 17

Introducing STRaNDs: shuttling transcriptional regulators that are non-DNA binding

Lu, M. M., Muers, M. R., & Lü, X. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.41 · Cited by 18

p53 and PPP1R13L (alias iASPP or RAI) form a feedback loop to regulate genotoxic stress responses

Laska, M. J., Vogel, U. B., Jensen, U. B., & Nexø, B. A. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2010.09.002 · Cited by 17

The recently discovered Apoptosis Stimulating Proteins of p53

Sullivan, A., & Lu, X. (2013)

ASPP: a new family of oncogenes and tumour suppressor genes

Sullivan, A., & Lü, X. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603525 · Cited by 215

ASPPs and cancer

Trigiante, G., & Lü, X. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1818 · Cited by 135

ASPP--Apoptotic specific regulator of p53.

Liu, Z.-J., Lu, X., & Zhong, S. (2005) · Biochimica et Biophysica Acta · doi:10.1016/j.bbcan.2005.08.002 · Cited by 26

ASPP1 and ASPP2: Common Activators of p53 Family Members

Bergamaschi, D., Samuels, Y., Jin, B., Duraisingham, S., Crook, T., & Lü, X. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.3.1341-1350.2004 · Cited by 229